• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045761
UUCD1 version UUC-HoS-00824
Ensembl Protein ID ENSP00000352028.4
UniProt Accession Q8TEC5; A8K961; Q08AM9; Q6GMR9; Q8N5S8; Q96LP8; SH3R2_HUMAN
Genbank Protein ID BAB71639.1; BAB85025.1; BAF85265.1; AAH31650.2; AAH73914.1; AAI25107.1
Protein Name Putative E3 ubiquitin-protein ligase SH3RF2; Heart protein phosphatase 1-binding protein; Protein phosphatase 1 regulatory subunit 39; RING finger protein 158; RING-type E3 ubiquitin transferase SH3RF2; SH3 domain-containing RING finger protein 2
Genbank Nucleotide ID AK058046; AK074234; AK292576; AC005216; BC073914; BC125106
Gene Name SH3RF2; PPP1R39; RNF158
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000156463.17 ENST00000359120.8 ENSP00000352028.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 1.70e-07 33.3 12 53
UBD/SH3 8.40e-30 104.2 383 437
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++C+e ++   +vlpC+H+f++ Clq++     ++ ke rCP Cr
   Q: 12   CPVCFEKLDVTAKVLPCQHTFCKPCLQRV----FKAHKELRCPECR 53
           ********88899****************....99**********8 PP
   

   UBD/SH3
   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
           + + +l++y+a   deL l+kG+ v+v+  ++qd gWl+gv+  +g+ G+fP+n+v 
   Q: 383  NMFVALHSYSAHGPDELDLQKGEGVRVL-GKCQD-GWLRGVSLVTGRVGIFPNNYVI 437
           7889************************.77776.9*******************96 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Inhibits PPP1CA phosphatase activity. May be a E3 ubiquitin-protein ligase (Potential). May play a role in cardiac function.
 Inhibits PPP1CA phosphatase activity. May be a E3 ubiquitin-protein ligase (Potential). May play a role in cardiac function.
Protein Sequence
(Fasta)
MDDLTLLDLL ECPVCFEKLD VTAKVLPCQH TFCKPCLQRV FKAHKELRCP ECRTPVFSNI 60
EALPANLLLV RLLDGVRSGQ SSGRGGSFRR PGTMTLQDGR KSRTNPRRLQ ASPFRLVPNV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045761|E3,RING;UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAAGCGGTTG GCAGCAGCGG CGCTTGGAGG AAAGGAAGCC GGTTGGAGGG CGCAGCGCAC 60
CCCTGCTGCG CGGAGGAGGG GGCTGAGCTG AACTCAGCAG AAGTTACATG CACAAGGTTA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045761|E3,RING;UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0650--Protein phosphatase inhibitor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011511--SH3_2
IPR001452--SH3_domain
IPR028511--SH3RF2
IPR027370--Znf-RING_LisH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50002--SH3
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00018--SH3_1
PF07653--SH3_2
PF14604--SH3_9
PF13445--zf-RING_UBOX
PRINTS

PR00452--SH3DOMAIN
SMART

SM00184--RING
SM00326--SH3
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0019902--F:phosphatase binding
GO:0008157--F:protein phosphatase 1 binding
GO:0004864--F:protein phosphatase inhibitor activity
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0010923--P:negative regulation of phosphatase activity
GO:0016567--P:protein ubiquitination
KEGG hsa:153769
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001594 Ailuropoda melanoleuca 87.38 0.00e+00 1109.00
IUUC-Apl-003443 Anas platyrhynchos 60.34 4.00e-170 591.00
IUUC-Aca-004632 Anolis carolinensis 52.97 1.00e-173 603.00
IUUC-Bta-013400 Bos taurus 89.32 0.00e+00 1082.00
IUUC-Cel-018180 Caenorhabditis elegans 27.51 6.00e-23 103.00
IUUC-Cja-019686 Callithrix jacchus 82.50 0.00e+00 1033.00
IUUC-Cfa-020893 Canis familiaris 89.90 0.00e+00 1128.00
IUUC-Cpo-021638 Cavia porcellus 83.47 0.00e+00 1055.00
IUUC-Csa-023846 Chlorocebus sabaeus 96.24 0.00e+00 1225.00
IUUC-Cho-024609 Choloepus hoffmanni 85.79 2.00e-163 569.00
IUUC-Dno-028940 Dasypus novemcinctus 86.09 0.00e+00 1078.00
IUUC-Dor-030491 Dipodomys ordii 79.71 2.00e-135 476.00
IUUC-Dse-031414 Dothistroma septosporum 32.84 1.00e-07 52.40
IUUC-Ete-032513 Echinops telfairi 84.74 0.00e+00 1052.00
IUUC-Eca-034241 Equus caballus 90.44 0.00e+00 1157.00
IUUC-Eeu-034636 Erinaceus europaeus 81.72 0.00e+00 944.00
IUUC-Fca-035862 Felis catus 86.46 0.00e+00 1087.00
IUUC-Gga-040748 Gallus gallus 54.53 6.00e-146 511.00
IUUC-Ggo-045267 Gorilla gorilla 99.17 0.00e+00 1286.00
IUUC-Itr-048226 Ictidomys tridecemlineatus 85.46 0.00e+00 1079.00
IUUC-Lch-050498 Latimeria chalumnae 44.57 6.00e-122 431.00
IUUC-Laf-054061 Loxodonta africana 79.35 0.00e+00 842.00
IUUC-Mcc-054746 Macaca mulatta 95.45 0.00e+00 1200.00
IUUC-Meu-056390 Macropus eugenii 60.64 1.00e-93 337.00
IUUC-Mmr-061390 Microcebus murinus 86.57 0.00e+00 929.00
IUUC-Mdo-062951 Monodelphis domestica 72.84 0.00e+00 962.00
IUUC-Mmu-063840 Mus musculus 80.58 0.00e+00 1021.00
IUUC-Mpu-065840 Mustela putorius furo 87.55 0.00e+00 1130.00
IUUC-Mlu-067378 Myotis lucifugus 84.75 0.00e+00 1056.00
IUUC-Ncr-068956 Neurospora crassa 33.33 1.00e-07 52.80
IUUC-Nle-069535 Nomascus leucogenys 95.27 0.00e+00 1182.00
IUUC-Opr-070739 Ochotona princeps 83.38 0.00e+00 1040.00
IUUC-Oan-073468 Ornithorhynchus anatinus 66.80 0.00e+00 783.00
IUUC-Ocu-074343 Oryctolagus cuniculus 85.44 0.00e+00 1031.00
IUUC-Oga-088276 Otolemur garnettii 81.08 0.00e+00 1019.00
IUUC-Oar-090315 Ovis aries 87.21 0.00e+00 1070.00
IUUC-Ptr-091119 Pan troglodytes 99.17 0.00e+00 1285.00
IUUC-Pan-092158 Papio anubis 95.91 0.00e+00 896.00
IUUC-Psi-092959 Pelodiscus sinensis 58.78 0.00e+00 728.00
IUUC-Pab-097675 Pongo abelii 98.05 0.00e+00 1259.00
IUUC-Pca-101021 Procavia capensis 77.90 0.00e+00 953.00
IUUC-Pva-102619 Pteropus vampyrus 88.49 0.00e+00 1064.00
IUUC-Rno-105918 Rattus norvegicus 80.85 0.00e+00 1028.00
IUUC-Sha-107391 Sarcophilus harrisii 68.94 0.00e+00 874.00
IUUC-Sja-107661 Schizosaccharomyces japonicus 44.83 3.00e-10 60.10
IUUC-Sar-113148 Sorex araneus 80.46 0.00e+00 638.00
IUUC-Ssc-116219 Sus scrofa 83.00 3.00e-128 451.00
IUUC-Tgu-116584 Taeniopygia guttata 56.49 3.00e-109 388.00
IUUC-Tsy-118968 Tarsius syrichta 83.91 2.00e-164 573.00
IUUC-Tbe-128007 Tupaia belangeri 90.22 0.00e+00 816.00
IUUC-Ttr-128499 Tursiops truncatus 86.15 0.00e+00 1102.00
IUUC-Vpa-130075 Vicugna pacos 84.47 3.00e-81 296.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved