iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Spo-108119

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Probable ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16

Genbank Nucleotide ID

CU329672

Gene Name

ubp16; SPCC1682.12c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPCC1682.12c	SPCC1682.12c.1	SPCC1682.12c.1:pep

Annotation

mRNA Expression
GEO
Post-translational Modifications (PTMs)
dbPAF	dbPTM	UniProt
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	7.50e-82	273.3	126	429

Active Site

Position(s)	Description	Evidence
134	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
388	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw....kskkkavsprellkalkkeaeefsgye 88
           Gl NlgNtC+mNSvLQ ++++p+l ++ll+  +++l+      +++++l+ +++ ++  +    +++ +a++p+ + ++lk ++++f+ y+
   Q: 126  GLVNLGNTCFMNSVLQLMTQTPPLVQYLLS-GQHSLSC----RMNACVLCRMEQHVARAYpnkgTKRASAFKPSGIQSMLKVISSHFRPYR 211
           9*****************************.5555554....47899999**99999999888888889********************** PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           q+Da+Ef+++l+d+ ++++                  l+++++ +++++++s+++++F+g l++qi c  c++ s++++  ldls++ +g+
   Q: 212  QEDAHEFMRYLVDAWQKSC------------------LQNHKNLDHPSRETSVVHRIFGGYLRQQILCSVCKKPSNTYQALLDLSVDAKGS 284
           *******************..................56677889******************************************9999 PP
   S: 180  eetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspee 270
           +      l d+L++f+ +e+l+++nky ce+ck++++a+k++++ + P++L++h+kRf+f+    +++ki+k++++p++++l p++++p+ 
   Q: 285  S------LADSLKHFVHAEKLTKQNKYRCENCKQLVDASKQMTIYRAPNILTIHFKRFTFNG--FQSSKISKQISYPESFNLGPYMSDPNC 367
           8......99*************************************************8866..7889********************885 PP
   S: 271  kqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkrr 338
               ++ YeLi+v+vH G s++sGHY++++k+++g Wl+fdD+ V+ ++ ++vl+   ++aY+l Ykr+
   Q: 368  ----SCWYELIGVLVHAGgSTRSGHYYSFCKSSNGVWLKFDDDFVSNSSIDRVLN---QQAYILQYKRK 429
           ....68*************************************************...********985 PP

Organism

Schizosaccharomyces pombe

Protein Sequence
(Fasta)

MSLATLQGQS LDFAVKHSLD DLLKNPVRFR PAVVSSPSVP EGTYTVLNNP KQSTVSRKSF 60
SAPTSPTRNK RSGSSSQEYK KSSGTRGDGA NDFVDEDPAF IPPARILFPE EKLSMEWDNI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTCACAGTA CCGGCGAGAC AATTGGGGAA GGACTTGAGG AAGATATTAC TTTTGGATCC 60
ATAAAGTTGT TTTCGTACAT TAGATATCCA TATCCTTTTC CGACTTTTTT GTCTTTCGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

spo:SPCC1682.12c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000401	Aegilops tauschii	39.66	2.00e-62	232.00
IUUC-Aml-002092	Ailuropoda melanoleuca	44.44	4.00e-80	291.00
IUUC-Atr-003102	Amborella trichopoda	42.46	3.00e-66	245.00
IUUC-Apl-003459	Anas platyrhynchos	43.24	1.00e-75	276.00
IUUC-Aca-005360	Anolis carolinensis	45.13	2.00e-87	315.00
IUUC-Aly-005983	Arabidopsis lyrata	40.83	8.00e-65	239.00
IUUC-Ath-006707	Arabidopsis thaliana	41.94	1.00e-66	245.00
IUUC-Ago-007836	Ashbya gossypii	29.81	2.00e-38	152.00
IUUC-Ame-011358	Astyanax mexicanus	46.08	6.00e-83	300.00
IUUC-Bta-013047	Bos taurus	41.48	2.00e-82	299.00
IUUC-Bdi-014036	Brachypodium distachyon	46.28	5.00e-68	250.00
IUUC-Bol-015086	Brassica oleracea	42.21	6.00e-66	244.00
IUUC-Bra-018046	Brassica rapa	42.53	2.00e-67	248.00
IUUC-Cel-018186	Caenorhabditis elegans	30.53	2.00e-38	151.00
IUUC-Cja-019203	Callithrix jacchus	43.41	5.00e-85	307.00
IUUC-Cfa-020586	Canis familiaris	43.73	2.00e-79	288.00
IUUC-Cpo-021804	Cavia porcellus	43.41	1.00e-79	290.00
IUUC-Cre-022988	Chlamydomonas reinhardtii	41.70	2.00e-42	164.00
IUUC-Csa-023137	Chlorocebus sabaeus	42.78	2.00e-85	308.00
IUUC-Cho-024575	Choloepus hoffmanni	38.64	3.00e-50	191.00
IUUC-Cin-025230	Ciona intestinalis	41.96	2.00e-60	223.00
IUUC-Cne-027049	Cryptococcus neoformans	35.11	2.00e-42	164.00
IUUC-Cme-027339	Cyanidioschyzon merolae	36.02	5.00e-54	203.00
IUUC-Dre-028587	Danio rerio	42.46	2.00e-85	308.00
IUUC-Dno-029149	Dasypus novemcinctus	41.52	5.00e-80	290.00
IUUC-Dor-030836	Dipodomys ordii	36.22	1.00e-58	219.00
IUUC-Dme-032119	Drosophila melanogaster	33.88	1.00e-54	206.00
IUUC-Ete-033088	Echinops telfairi	39.58	8.00e-70	256.00
IUUC-Eca-033600	Equus caballus	45.59	2.00e-77	282.00
IUUC-Eeu-035019	Erinaceus europaeus	34.09	6.00e-50	189.00
IUUC-Fca-035792	Felis catus	43.24	3.00e-80	291.00
IUUC-Fal-037075	Ficedula albicollis	44.28	6.00e-80	290.00
IUUC-Gmo-039033	Gadus morhua	40.92	2.00e-83	302.00
IUUC-Gga-040664	Gallus gallus	46.42	2.00e-78	285.00
IUUC-Gac-042176	Gasterosteus aculeatus	45.07	4.00e-83	301.00
IUUC-Gma-044075	Glycine max	44.41	8.00e-68	249.00
IUUC-Ggo-045437	Gorilla gorilla	43.93	2.00e-79	289.00
IUUC-Hsa-046863	Homo sapiens	43.93	1.00e-79	289.00
IUUC-Hvu-047620	Hordeum vulgare	40.00	9.00e-63	233.00
IUUC-Itr-048655	Ictidomys tridecemlineatus	42.23	5.00e-82	297.00
IUUC-Lch-049867	Latimeria chalumnae	43.08	2.00e-85	309.00
IUUC-Lpe-051574	Leersia perrieri	42.68	2.00e-61	228.00
IUUC-Loc-052796	Lepisosteus oculatus	45.78	3.00e-78	285.00
IUUC-Laf-054243	Loxodonta africana	41.71	3.00e-79	288.00
IUUC-Mcc-055762	Macaca mulatta	43.26	3.00e-85	308.00
IUUC-Meu-056697	Macropus eugenii	44.41	5.00e-79	287.00
IUUC-Mtr-058537	Medicago truncatula	42.86	4.00e-66	244.00
IUUC-Mla-059049	Melampsora laricipopulina	37.00	7.00e-49	186.00
IUUC-Mga-059501	Meleagris gallopavo	42.66	1.00e-74	273.00
IUUC-Mvi-060547	Microbotryum violaceum	40.75	6.00e-73	266.00
IUUC-Mmr-060966	Microcebus murinus	40.53	7.00e-79	287.00
IUUC-Mdo-062733	Monodelphis domestica	44.99	9.00e-80	290.00
IUUC-Mmu-064331	Mus musculus	44.57	4.00e-80	291.00
IUUC-Mac-065039	Musa acuminata	40.62	4.00e-68	251.00
IUUC-Mpu-065759	Mustela putorius furo	44.70	3.00e-80	291.00
IUUC-Mlu-067371	Myotis lucifugus	45.59	4.00e-77	281.00
IUUC-Nle-070087	Nomascus leucogenys	41.71	4.00e-76	278.00
IUUC-Opr-070729	Ochotona princeps	37.50	3.00e-67	248.00
IUUC-Ont-071346	Oreochromis niloticus	41.07	1.00e-83	302.00
IUUC-Oan-072931	Ornithorhynchus anatinus	46.08	4.00e-83	301.00
IUUC-Ocu-074596	Oryctolagus cuniculus	43.24	2.00e-81	294.00
IUUC-Oba-075742	Oryza barthii	44.76	1.00e-65	243.00
IUUC-Obr-076408	Oryza brachyantha	43.49	3.00e-65	241.00
IUUC-Ogl-077559	Oryza glaberrima	45.08	1.00e-67	249.00
IUUC-Ogu-078260	Oryza glumaepatula	44.76	1.00e-65	243.00
IUUC-Oin-079471	Oryza indica	45.08	1.00e-67	249.00
IUUC-Olo-080231	Oryza longistaminata	43.49	1.00e-63	236.00
IUUC-Ome-081700	Oryza meridionalis	44.44	3.00e-65	241.00
IUUC-Oni-082935	Oryza nivara	44.76	3.00e-65	241.00
IUUC-Opu-083194	Oryza punctata	43.81	3.00e-64	239.00
IUUC-Oru-085192	Oryza rufipogon	44.76	1.00e-65	243.00
IUUC-Osa-085395	Oryza sativa	45.08	2.00e-67	249.00
IUUC-Ola-087255	Oryzias latipes	44.78	3.00e-83	301.00
IUUC-Olu-087773	Ostreococcus lucimarinus	42.24	1.00e-64	238.00
IUUC-Oga-088818	Otolemur garnettii	42.78	2.00e-79	288.00
IUUC-Oar-089410	Ovis aries	43.06	4.00e-81	294.00
IUUC-Ptr-090680	Pan troglodytes	43.93	1.00e-79	290.00
IUUC-Pan-092482	Papio anubis	43.26	2.00e-85	308.00
IUUC-Psi-093277	Pelodiscus sinensis	44.44	4.00e-85	308.00
IUUC-Ppa-095853	Physcomitrella patens	46.33	5.00e-75	273.00
IUUC-Pfo-096807	Poecilia formosa	41.45	3.00e-84	305.00
IUUC-Pab-098724	Pongo abelii	41.77	2.00e-85	308.00
IUUC-Pop-099611	Populus trichocarpa	39.94	6.00e-67	246.00
IUUC-Pca-100117	Procavia capensis	37.50	2.00e-43	169.00
IUUC-Ppe-101980	Prunus persica	39.02	2.00e-62	231.00
IUUC-Pva-103238	Pteropus vampyrus	37.54	2.00e-64	239.00
IUUC-Pgr-103270	Puccinia graminis	39.88	5.00e-63	233.00
IUUC-Ptt-103887	Puccinia triticina	38.97	2.00e-62	231.00
IUUC-Rno-105340	Rattus norvegicus	42.49	1.00e-79	289.00
IUUC-Sha-107019	Sarcophilus harrisii	42.82	5.00e-80	291.00
IUUC-Sja-107805	Schizosaccharomyces japonicus	62.05	6.00e-170	588.00
IUUC-Smo-108763	Selaginella moellendorffii	45.95	1.00e-75	273.00
IUUC-Sit-109895	Setaria italica	41.50	5.00e-66	244.00
IUUC-Sly-111722	Solanum lycopersicum	44.89	5.00e-64	237.00
IUUC-Stu-112912	Solanum tuberosum	42.82	3.00e-63	234.00
IUUC-Sar-113340	Sorex araneus	43.24	2.00e-80	292.00
IUUC-Sbi-114477	Sorghum bicolor	44.55	2.00e-66	245.00
IUUC-Sre-114924	Sporisorium reilianum	39.35	7.00e-59	219.00
IUUC-Ssc-116022	Sus scrofa	43.18	2.00e-77	282.00
IUUC-Tgu-116976	Taeniopygia guttata	44.03	2.00e-74	271.00
IUUC-Tru-118391	Takifugu rubripes	41.58	3.00e-84	305.00
IUUC-Tsy-118974	Tarsius syrichta	43.54	3.00e-81	295.00
IUUC-Tni-120064	Tetraodon nigroviridis	41.87	8.00e-84	303.00
IUUC-Tca-120936	Theobroma cacao	46.45	2.00e-71	262.00
IUUC-Tae-122827	Triticum aestivum	45.63	7.00e-68	250.00
IUUC-Tur-126014	Triticum urartu	44.62	1.00e-64	239.00
IUUC-Tbe-127377	Tupaia belangeri	35.98	3.00e-42	165.00
IUUC-Ttr-128764	Tursiops truncatus	40.06	2.00e-63	236.00
IUUC-Uma-129416	Ustilago maydis	38.33	1.00e-56	213.00
IUUC-Vvi-131130	Vitis vinifera	41.30	9.00e-69	253.00
IUUC-Xtr-132544	Xenopus tropicalis	45.17	6.00e-84	303.00
IUUC-Xma-133735	Xiphophorus maculatus	41.73	2.00e-84	305.00
IUUC-Yli-134636	Yarrowia lipolytica	31.29	2.00e-42	164.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence