iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ggo-045254

Ensembl Protein ID

ENSGGOP00000012950.3

UniProt Accession

G3RBT6; G3RBT6_GORGO

Protein Name

Uncharacterized protein

Gene Name

FAF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000013273.3	ENSGGOT00000013324.3	ENSGGOP00000012950.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UBA	1.20e-07	32.0	5	45
ULD/UDP/UFD/UBX	1.10e-19	71.1	570	647
ULD/UDP/UBQ/UBQ_Other	3.10e-10	40.2	111	170

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 1    sededkleqlve.MGF.dreealqaLraannnleaAveyLl 39
           +++e++l+ +++ +G+ + +ea++ L+++n++l aA++ ++
   Q: 5    MDREMILADFQAcTGIeNIDEAITLLEQNNWDLVAAINGVI 45
           689**********************************9875 PP

ULD/UDP/UFD/UBX

   S: 2    tteqatlqiRlpdGkrlvrkFpssttleqiyqfveyllvessdpFeLvspfPrrtlkpeehmstlqeagLvpsgsllve 80
           +++ ++l+iR+p+G++l+r+F +s++l+ +++fv+ ++++++d+++L+s+fPrr++++ + +++l e +L+p+++l++e
   Q: 570  AEPVSKLRIRTPSGEFLERRFLASNKLQIVFDFVA-SKGFPWDEYKLLSTFPRRDVTQLDPNKSLLEVKLFPQETLFLE 647
           56799******************************.****************************************986 PP

ULD/UDP/UBQ/UBQ_Other

   S: 12   eltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiL...eddktLadyglkdgstihll 70
           + ++ ++ s+tV+e+K+ +e +l ip   +++++kG      ed   L++++l+ ++ +++l
   Q: 111  NVDVVLEDSCTVGEIKQILENELQIP--VSKMLLKGWKTgdvEDSTVLKSLHLPKNNSLYVL 170
           5566678999****************..55899997776777***************99987 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MASNMDREMI LADFQACTGI ENIDEAITLL EQNNWDLVAA INGVIPQENG ILQSEYGGET 60
IPGPAFNPAS HPASAPTSSS SSAFRPVMPS RQIVERQPRM LDFRVEYRDR NVDVVLEDSC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CACGCTTCGC TCCCGGAGCC GCGGAACTCG GCGGCCGCCA TGGCGTCCAA CATGGACCGA 60
GAGATGATCC TGGCGGATTT TCAGGTGAAG TATCTGGCCC TCTTCCCCTC CCACTTCCAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR033043--FAF1_UBX
IPR012336--Thioredoxin-like_fold
IPR006577--UAS
IPR029071--Ubiquitin-rel_dom
IPR001012--UBX_dom

PROSITE

PS50033--UBX

Pfam

PF00789--UBX

SMART

SM00594--UAS
SM00166--UBX

Gene Ontology

GO:0005829--C:cytosol
GO:0005635--C:nuclear envelope
GO:0048471--C:perinuclear region of cytoplasm
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0008219--P:cell death
GO:0007253--P:cytoplasmic sequestering of NF-kappaB
GO:1902043--P:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0031334--P:positive regulation of protein complex assembly
GO:0030155--P:regulation of cell adhesion
GO:0042176--P:regulation of protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002153	Ailuropoda melanoleuca	97.85	0.00e+00	1225.00
IUUC-Apl-004127	Anas platyrhynchos	91.38	0.00e+00	1139.00
IUUC-Aca-005188	Anolis carolinensis	90.58	0.00e+00	1130.00
IUUC-Ame-010696	Astyanax mexicanus	77.76	0.00e+00	871.00
IUUC-Bta-012965	Bos taurus	97.85	0.00e+00	1230.00
IUUC-Cel-018420	Caenorhabditis elegans	29.12	9.00e-30	125.00
IUUC-Cja-019128	Callithrix jacchus	98.01	0.00e+00	1249.00
IUUC-Cfa-021201	Canis familiaris	96.88	0.00e+00	909.00
IUUC-Cpo-021475	Cavia porcellus	96.27	0.00e+00	904.00
IUUC-Csa-024076	Chlorocebus sabaeus	97.85	0.00e+00	1238.00
IUUC-Cho-025067	Choloepus hoffmanni	83.69	0.00e+00	1065.00
IUUC-Cin-025663	Ciona intestinalis	43.79	5.00e-69	254.00
IUUC-Csv-025894	Ciona savignyi	34.76	6.00e-71	261.00
IUUC-Dre-027508	Danio rerio	75.26	0.00e+00	943.00
IUUC-Dno-029336	Dasypus novemcinctus	97.23	0.00e+00	1211.00
IUUC-Dor-030218	Dipodomys ordii	88.92	0.00e+00	1100.00
IUUC-Dme-031581	Drosophila melanogaster	32.63	3.00e-94	339.00
IUUC-Ete-032860	Echinops telfairi	76.19	0.00e+00	680.00
IUUC-Eca-034321	Equus caballus	98.58	0.00e+00	1060.00
IUUC-Eeu-034844	Erinaceus europaeus	75.47	2.00e-146	512.00
IUUC-Fca-036575	Felis catus	98.94	0.00e+00	732.00
IUUC-Fal-037128	Ficedula albicollis	91.71	0.00e+00	1160.00
IUUC-Gmo-038694	Gadus morhua	74.27	0.00e+00	905.00
IUUC-Gga-040826	Gallus gallus	92.01	0.00e+00	1169.00
IUUC-Gac-042125	Gasterosteus aculeatus	75.23	0.00e+00	971.00
IUUC-Hsa-046722	Homo sapiens	99.85	0.00e+00	1251.00
IUUC-Itr-048149	Ictidomys tridecemlineatus	98.28	5.00e-103	365.00
IUUC-Lch-050312	Latimeria chalumnae	81.53	0.00e+00	672.00
IUUC-Loc-051990	Lepisosteus oculatus	81.71	0.00e+00	969.00
IUUC-Laf-054375	Loxodonta africana	98.41	0.00e+00	730.00
IUUC-Mcc-054627	Macaca mulatta	99.37	0.00e+00	1212.00
IUUC-Meu-056611	Macropus eugenii	73.47	6.00e-134	471.00
IUUC-Mga-059400	Meleagris gallopavo	89.71	0.00e+00	1143.00
IUUC-Mmr-060882	Microcebus murinus	97.85	0.00e+00	1199.00
IUUC-Mdo-061874	Monodelphis domestica	92.31	0.00e+00	1181.00
IUUC-Mmu-063444	Mus musculus	95.23	0.00e+00	1218.00
IUUC-Mpu-065713	Mustela putorius furo	96.54	0.00e+00	1186.00
IUUC-Mlu-068122	Myotis lucifugus	96.57	0.00e+00	1165.00
IUUC-Nle-069025	Nomascus leucogenys	99.23	0.00e+00	1236.00
IUUC-Opr-071089	Ochotona princeps	86.15	0.00e+00	1096.00
IUUC-Ont-072421	Oreochromis niloticus	74.70	0.00e+00	951.00
IUUC-Oan-073092	Ornithorhynchus anatinus	89.09	0.00e+00	857.00
IUUC-Ola-086497	Oryzias latipes	75.71	0.00e+00	961.00
IUUC-Oga-088854	Otolemur garnettii	96.31	0.00e+00	1217.00
IUUC-Oar-090120	Ovis aries	98.00	0.00e+00	1209.00
IUUC-Ptr-091554	Pan troglodytes	100.00	0.00e+00	1253.00
IUUC-Pan-091985	Papio anubis	99.38	0.00e+00	1219.00
IUUC-Psi-093548	Pelodiscus sinensis	91.67	0.00e+00	1097.00
IUUC-Pma-094123	Petromyzon marinus	52.45	8.00e-52	196.00
IUUC-Pfo-096729	Poecilia formosa	74.33	0.00e+00	951.00
IUUC-Pab-097810	Pongo abelii	99.85	0.00e+00	1249.00
IUUC-Pca-101079	Procavia capensis	89.75	0.00e+00	905.00
IUUC-Pva-102534	Pteropus vampyrus	89.61	0.00e+00	932.00
IUUC-Rno-105127	Rattus norvegicus	94.63	0.00e+00	1100.00
IUUC-Sha-106667	Sarcophilus harrisii	93.28	0.00e+00	1033.00
IUUC-Ssl-108656	Sclerotinia sclerotiorum	24.63	1.20e-02	33.50
IUUC-Sar-113424	Sorex araneus	82.83	0.00e+00	653.00
IUUC-Ssc-115974	Sus scrofa	97.64	0.00e+00	1175.00
IUUC-Tgu-116495	Taeniopygia guttata	91.71	0.00e+00	1162.00
IUUC-Tru-118727	Takifugu rubripes	73.20	0.00e+00	934.00
IUUC-Tsy-118906	Tarsius syrichta	91.69	0.00e+00	1112.00
IUUC-Tni-119717	Tetraodon nigroviridis	76.53	0.00e+00	952.00
IUUC-Tbe-127849	Tupaia belangeri	82.91	0.00e+00	731.00
IUUC-Ttr-128660	Tursiops truncatus	93.40	0.00e+00	1159.00
IUUC-Vpa-130359	Vicugna pacos	98.11	0.00e+00	1206.00
IUUC-Xtr-132212	Xenopus tropicalis	86.87	0.00e+00	722.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence