iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-046531

Ensembl Protein ID

ENSP00000360821.3

UniProt Accession

Q9BSL1; O75500; Q9UMW7; UBAC1_HUMAN

Genbank Protein ID

AAD51084.1; AAH04967.1; AAH11822.1; AAC21559.1

Protein Name

Ubiquitin-associated domain-containing protein 1; E3 ubiquitin-protein ligase subunit KPC2; Glialblastoma cell differentiation-related protein 1; Kip1 ubiquitination-promoting complex protein 2

Genbank Nucleotide ID

AF176796; AL355574; BC011822; AF068195

Gene Name

UBAC1; GBDR1; KPC2; UBADC1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000130560.8	ENST00000371756.3	ENSP00000360821.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
microRNA	TRANSFAC	TargetScan	RepTar
miRNAMap	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	16227581
ULD/UDP/UBQ/UBQ_PIM	UBQ_PIM	15531880; 16227581

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	3.70e-18	66.7	294	326
ULD/UDP/UBQ/UBQ_PIM	1.50e-17	65.0	14	98

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 7    leqlveMGFdreealqaLraannnleaAveyLl 39
           +  l+eMGFd++e++ aLr +nn+ +aA+e+Ll
   Q: 294  VISLMEMGFDEKEVIDALRVNNNQQNAACEWLL 326
           5679****************************9 PP

ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgkefelevseddtveelKekiakesg...vp....peqqkLIyaG..kiLkDdttLselgikdgsvvhlvvkksks 76
           ++l++++++g+e+ +e++ed++ve+lKe++ k++    ++    ++++kLI+a+  ++L+D++t+ e +i+d++v++l++k+++s
   Q: 14   LRLHICASDGAEWLEEATEDTSVEKLKERCLKHCAhgsLEdpksITHHKLIHAAseRVLSDARTILEENIQDQDVLLLIKKRAPS 98
           589********************************888446677*************************************9875 PP

Organism

Homo sapiens

Functional Description
(View)

Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.

Protein Sequence
(Fasta)

MFVQEEKIFA GKVLRLHICA SDGAEWLEEA TEDTSVEKLK ERCLKHCAHG SLEDPKSITH 60
HKLIHAASER VLSDARTILE ENIQDQDVLL LIKKRAPSPL PKMADVSAEE KKKQDQKAPD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGCGACGGC GCGCCCCCGG CGGCTGCTGC GGCGGCGGGA GCGAGGCGAC CGCTGAGGCC 60
GCGGAGAGTG ACGGCGGCCC GGCCGACGGG AGCCGGGGCG GGGCGGCGGC CCAGCGAAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR006636--STI1_HS-bd
IPR015940--UBA
IPR009060--UBA-like
IPR029071--Ubiquitin-rel_dom

PROSITE

PS50030--UBA

Pfam

PF00627--UBA

SMART

SM00727--STI1
SM00165--UBA

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0005886--C:plasma membrane
GO:0016567--P:protein ubiquitination

KEGG

hsa:10422

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002260	Ailuropoda melanoleuca	88.62	2.00e-170	591.00
IUUC-Apl-003707	Anas platyrhynchos	83.54	4.00e-132	464.00
IUUC-Aca-004298	Anolis carolinensis	78.72	1.00e-16	77.80
IUUC-Ame-010990	Astyanax mexicanus	74.41	3.00e-155	541.00
IUUC-Bta-012350	Bos taurus	87.41	0.00e+00	639.00
IUUC-Cja-019641	Callithrix jacchus	83.15	2.00e-147	514.00
IUUC-Cfa-020817	Canis familiaris	90.51	0.00e+00	684.00
IUUC-Cpo-022281	Cavia porcellus	88.86	4.00e-178	617.00
IUUC-Csa-023235	Chlorocebus sabaeus	99.01	0.00e+00	707.00
IUUC-Cho-024473	Choloepus hoffmanni	85.36	1.00e-130	459.00
IUUC-Cin-025423	Ciona intestinalis	30.61	2.00e-44	172.00
IUUC-Csv-026357	Ciona savignyi	30.18	4.00e-35	142.00
IUUC-Dre-028611	Danio rerio	75.42	1.00e-161	562.00
IUUC-Dno-029898	Dasypus novemcinctus	90.58	1.00e-162	565.00
IUUC-Dor-030157	Dipodomys ordii	89.97	3.00e-155	541.00
IUUC-Dme-032139	Drosophila melanogaster	28.44	2.00e-24	107.00
IUUC-Ete-032241	Echinops telfairi	81.31	9.00e-37	147.00
IUUC-Eca-033465	Equus caballus	90.27	0.00e+00	661.00
IUUC-Eeu-034757	Erinaceus europaeus	90.78	2.00e-96	345.00
IUUC-Fca-035878	Felis catus	86.21	1.00e-175	608.00
IUUC-Fal-037270	Ficedula albicollis	79.78	2.00e-149	521.00
IUUC-Gmo-038625	Gadus morhua	76.85	2.00e-164	571.00
IUUC-Gga-041270	Gallus gallus	80.62	3.00e-175	607.00
IUUC-Gac-041881	Gasterosteus aculeatus	75.90	3.00e-164	571.00
IUUC-Ggo-045434	Gorilla gorilla	99.51	0.00e+00	707.00
IUUC-Itr-048688	Ictidomys tridecemlineatus	89.66	8.00e-160	556.00
IUUC-Lch-050375	Latimeria chalumnae	80.99	6.00e-169	587.00
IUUC-Loc-052806	Lepisosteus oculatus	77.70	2.00e-159	555.00
IUUC-Laf-054021	Loxodonta africana	88.64	0.00e+00	691.00
IUUC-Mcc-054798	Macaca mulatta	95.58	0.00e+00	676.00
IUUC-Meu-056193	Macropus eugenii	62.47	1.00e-103	369.00
IUUC-Mga-059853	Meleagris gallopavo	75.37	4.00e-156	544.00
IUUC-Mmr-061109	Microcebus murinus	92.57	0.00e+00	674.00
IUUC-Mdo-062799	Monodelphis domestica	83.70	5.00e-172	597.00
IUUC-Mmu-063873	Mus musculus	88.26	0.00e+00	631.00
IUUC-Mpu-066105	Mustela putorius furo	87.83	7.00e-126	443.00
IUUC-Mlu-067997	Myotis lucifugus	87.35	2.00e-97	348.00
IUUC-Nle-070022	Nomascus leucogenys	99.01	0.00e+00	704.00
IUUC-Ont-072395	Oreochromis niloticus	74.94	1.00e-161	562.00
IUUC-Oan-073631	Ornithorhynchus anatinus	86.63	1.00e-147	515.00
IUUC-Ola-086861	Oryzias latipes	75.82	6.00e-75	274.00
IUUC-Oga-088505	Otolemur garnettii	92.10	0.00e+00	686.00
IUUC-Oar-090395	Ovis aries	86.17	0.00e+00	641.00
IUUC-Ptr-091265	Pan troglodytes	98.77	0.00e+00	698.00
IUUC-Pan-091760	Papio anubis	99.01	0.00e+00	707.00
IUUC-Psi-092977	Pelodiscus sinensis	82.77	4.00e-119	421.00
IUUC-Pfo-097495	Poecilia formosa	76.64	4.00e-97	348.00
IUUC-Pab-097995	Pongo abelii	96.25	2.00e-176	611.00
IUUC-Pca-100468	Procavia capensis	66.48	2.00e-107	382.00
IUUC-Pva-102145	Pteropus vampyrus	88.89	0.00e+00	635.00
IUUC-Rno-105119	Rattus norvegicus	88.51	0.00e+00	632.00
IUUC-Sha-106496	Sarcophilus harrisii	84.28	8.00e-166	576.00
IUUC-Tgu-116846	Taeniopygia guttata	78.80	3.00e-163	567.00
IUUC-Tru-118687	Takifugu rubripes	73.63	2.00e-160	558.00
IUUC-Tni-119838	Tetraodon nigroviridis	78.52	1.00e-164	572.00
IUUC-Tbe-127323	Tupaia belangeri	71.65	1.00e-109	389.00
IUUC-Ttr-129174	Tursiops truncatus	73.33	1.00e-145	509.00
IUUC-Vpa-130792	Vicugna pacos	75.73	4.00e-132	464.00
IUUC-Xtr-132912	Xenopus tropicalis	73.64	4.00e-127	447.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence