iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sha-106683

Ensembl Protein ID

ENSSHAP00000005335.1

UniProt Accession

G3VQ80; G3VQ80_SARHA

Genbank Protein ID

ENSSHAP00000005335

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01069225

Gene Name

VAV1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000004661.1	ENSSHAT00000005388.1	ENSSHAP00000005335.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	6.00e-20	71.1	789	840

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ yd+ a +  eL+lk+Gd++++i  ++  +gW++g  e  g+ G fP+n+ve+
   Q: 789  KARYDFCARDRTELSLKEGDIIKII-SKKGHQGWWRG--EIYGRIGWFPSNYVEE 840
           688**********************.89999******..9*************86 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MELWRQCAHW LIQCRVLPPN HRVTWDGAQV CELAQALRDG VLLCQLLNNL LPHAVNLREI 60
NLRPQMSQFL CLKNIRTFLA ACCEKFGLRR NQLFEVFDLF DVQDFGKVIY TLSALSWTTI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGACTTGGTG GCAGAGAACT GGGCTCCAGA CCTGCTCATT TCTGTGTCCC ATTTTTCCAG 60
CCTCCCCTGG GGAGGTGAGA CTGAACTGGG CCTTATAGAA CTGGGCATTA ATGACCAGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR022613--CAMSAP_CH
IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR001452--SH3_domain
IPR028530--Vav

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF11971--CAMSAP_CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00109--C1
SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005622--C:intracellular
GO:0046872--F:metal ion binding
GO:0030676--F:Rac guanyl-nucleotide exchange factor activity
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0006955--P:immune response
GO:0007229--P:integrin-mediated signaling pathway
GO:0030593--P:neutrophil chemotaxis
GO:0006909--P:phagocytosis
GO:0045785--P:positive regulation of cell adhesion
GO:0045954--P:positive regulation of natural killer cell mediated cytotoxicity
GO:0072593--P:reactive oxygen species metabolic process
GO:0008361--P:regulation of cell size
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction
GO:0030217--P:T cell differentiation

KEGG

shr:100933888

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-013049	Bos taurus	73.89	0.00e+00	1132.00
IUUC-Cja-020009	Callithrix jacchus	86.17	0.00e+00	1503.00
IUUC-Cfa-020768	Canis familiaris	87.94	0.00e+00	1479.00
IUUC-Dno-029602	Dasypus novemcinctus	86.76	0.00e+00	1470.00
IUUC-Eca-033682	Equus caballus	87.47	0.00e+00	1480.00
IUUC-Fca-035629	Felis catus	86.54	0.00e+00	1526.00
IUUC-Gmo-039693	Gadus morhua	60.80	0.00e+00	989.00
IUUC-Gac-041567	Gasterosteus aculeatus	66.00	0.00e+00	1026.00
IUUC-Hsa-045886	Homo sapiens	86.76	0.00e+00	1509.00
IUUC-Itr-048730	Ictidomys tridecemlineatus	83.12	0.00e+00	1386.00
IUUC-Loc-051761	Lepisosteus oculatus	72.08	0.00e+00	1208.00
IUUC-Laf-054537	Loxodonta africana	86.76	0.00e+00	1481.00
IUUC-Mcc-054726	Macaca mulatta	86.64	0.00e+00	1510.00
IUUC-Mmr-060980	Microcebus murinus	85.86	0.00e+00	1471.00
IUUC-Mdo-061926	Monodelphis domestica	93.45	0.00e+00	1414.00
IUUC-Mmu-063942	Mus musculus	85.46	0.00e+00	1457.00
IUUC-Mpu-066000	Mustela putorius furo	87.71	0.00e+00	1477.00
IUUC-Mlu-067818	Myotis lucifugus	85.23	0.00e+00	1450.00
IUUC-Ont-072213	Oreochromis niloticus	66.98	0.00e+00	1127.00
IUUC-Ocu-074830	Oryctolagus cuniculus	72.17	0.00e+00	1085.00
IUUC-Ola-087345	Oryzias latipes	64.12	0.00e+00	1066.00
IUUC-Oga-089104	Otolemur garnettii	87.47	0.00e+00	1491.00
IUUC-Oar-089459	Ovis aries	86.29	0.00e+00	1480.00
IUUC-Ptr-090766	Pan troglodytes	86.12	0.00e+00	1390.00
IUUC-Pan-091994	Papio anubis	85.48	0.00e+00	1483.00
IUUC-Psi-093595	Pelodiscus sinensis	77.31	0.00e+00	1274.00
IUUC-Pfo-097210	Poecilia formosa	67.33	0.00e+00	1109.00
IUUC-Pab-098630	Pongo abelii	86.51	0.00e+00	1472.00
IUUC-Pva-102406	Pteropus vampyrus	86.41	0.00e+00	1424.00
IUUC-Pte-104123	Pyrenophora teres	57.14	4.00e-11	63.90
IUUC-Pyt-104567	Pyrenophora triticirepentis	57.14	4.00e-11	63.90
IUUC-Rno-105763	Rattus norvegicus	82.98	0.00e+00	1400.00
IUUC-Sar-113457	Sorex araneus	74.66	0.00e+00	882.00
IUUC-Ssc-115338	Sus scrofa	86.52	0.00e+00	1394.00
IUUC-Tru-118199	Takifugu rubripes	64.84	0.00e+00	1039.00
IUUC-Tni-120548	Tetraodon nigroviridis	65.22	0.00e+00	1064.00
IUUC-Tbe-127235	Tupaia belangeri	64.10	6.00e-124	437.00
IUUC-Vpa-130066	Vicugna pacos	65.55	2.00e-77	283.00
IUUC-Xtr-132410	Xenopus tropicalis	70.66	0.00e+00	1223.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence