iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028350

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Von Hippel-Lindau tumor suppressor

Genbank Nucleotide ID

BX936393

Gene Name

vhl

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000070617.4	ENSDART00000103878.4	ENSDARP00000094654.4

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	30.00	2.00e-08	55.80	IUUC-Dme-031988
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	53.42	7.00e-32	134.00	IUUC-Hsa-046547

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Danio rerio

Protein Sequence
(Fasta)

MPQDSQEGQQ PLPLVRSLIS RIQVNVLFCN CSPRVVKPVW INFLGEPQPY VNIQPYTGRR 60
ITTFVGHPWM FRDAETDDPM VVNNKEMYLP ASLENGQVAN AKITLPVLTL RDRCLQVVRR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCATTCTGT CTTCTTCACC GACTCTCACA AGATTACGCA ATCAAAACAA ACGCAGCCAG 60
CAGCACGGAC GTATGTGTGA CAGTCACGTA CACAGTCTTT CTCTCCGTTC GTGTTATTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR002714--VHL
IPR024048--VHL_alpha_dom
IPR024053--VHL_beta_dom
IPR022772--VHL_tumour_suppress_b/a_dom

Pfam

PF01847--VHL
PF17211--VHL_C

Gene Ontology

GO:0005634--C:nucleus
GO:0030891--C:VCB complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0030218--P:erythrocyte differentiation
GO:0030097--P:hemopoiesis
GO:0039022--P:pronephric duct development
GO:0048793--P:pronephros development
GO:0016567--P:protein ubiquitination
GO:0045765--P:regulation of angiogenesis
GO:0043576--P:regulation of respiratory gaseous exchange
GO:0030947--P:regulation of vascular endothelial growth factor receptor signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002327	Ailuropoda melanoleuca	44.65	4.00e-28	117.00
IUUC-Apl-003580	Anas platyrhynchos	50.00	1.00e-13	67.80
IUUC-Aca-004492	Anolis carolinensis	51.61	1.00e-33	135.00
IUUC-Ame-011818	Astyanax mexicanus	74.39	2.00e-69	255.00
IUUC-Bta-013459	Bos taurus	53.85	6.00e-40	156.00
IUUC-Cel-018173	Caenorhabditis elegans	31.18	2.00e-03	35.80
IUUC-Cja-019826	Callithrix jacchus	50.98	5.00e-39	154.00
IUUC-Cfa-021280	Canis familiaris	50.64	3.00e-39	154.00
IUUC-Cpo-022544	Cavia porcellus	52.60	3.00e-41	161.00
IUUC-Cre-022809	Chlamydomonas reinhardtii	42.31	7.00e-07	48.50
IUUC-Csa-023644	Chlorocebus sabaeus	53.42	9.00e-41	159.00
IUUC-Cho-024479	Choloepus hoffmanni	35.25	3.00e-15	73.90
IUUC-Cin-025505	Ciona intestinalis	28.79	9.00e-07	46.20
IUUC-Cme-027232	Cyanidioschyzon merolae	35.71	3.00e-06	45.40
IUUC-Dno-029207	Dasypus novemcinctus	49.44	7.00e-20	90.50
IUUC-Dor-030912	Dipodomys ordii	38.31	2.00e-21	95.90
IUUC-Dme-031988	Drosophila melanogaster	28.15	8.00e-11	60.10
IUUC-Eca-034007	Equus caballus	47.50	3.00e-06	43.10
IUUC-Fca-036350	Felis catus	50.00	1.00e-37	149.00
IUUC-Fal-037192	Ficedula albicollis	42.94	3.00e-31	127.00
IUUC-Gmo-038921	Gadus morhua	57.23	2.00e-50	191.00
IUUC-Gga-041016	Gallus gallus	44.97	8.00e-31	126.00
IUUC-Gac-042560	Gasterosteus aculeatus	59.49	4.00e-51	194.00
IUUC-Ggo-045419	Gorilla gorilla	53.42	3.00e-40	158.00
IUUC-Hsa-046547	Homo sapiens	53.42	3.00e-40	158.00
IUUC-Itr-048225	Ictidomys tridecemlineatus	51.97	1.00e-39	155.00
IUUC-Lch-050463	Latimeria chalumnae	55.78	3.00e-45	174.00
IUUC-Loc-052053	Lepisosteus oculatus	61.39	2.00e-53	201.00
IUUC-Laf-053893	Loxodonta africana	47.95	1.00e-40	159.00
IUUC-Mcc-055347	Macaca mulatta	46.73	3.00e-21	94.70
IUUC-Mdo-062169	Monodelphis domestica	48.94	1.00e-22	97.80
IUUC-Mmu-064366	Mus musculus	53.24	3.00e-37	147.00
IUUC-Mpu-066593	Mustela putorius furo	49.10	4.00e-40	157.00
IUUC-Mlu-066926	Myotis lucifugus	52.05	1.00e-39	155.00
IUUC-Nle-069724	Nomascus leucogenys	53.42	2.00e-40	158.00
IUUC-Opr-070679	Ochotona princeps	50.33	3.00e-38	150.00
IUUC-Ont-071332	Oreochromis niloticus	62.20	1.00e-54	205.00
IUUC-Ola-086869	Oryzias latipes	52.44	1.00e-46	179.00
IUUC-Oga-089124	Otolemur garnettii	52.98	7.00e-40	156.00
IUUC-Oar-089799	Ovis aries	52.22	3.00e-22	96.30
IUUC-Ptr-091186	Pan troglodytes	50.56	9.00e-21	92.40
IUUC-Pan-092150	Papio anubis	53.42	2.00e-40	158.00
IUUC-Psi-094039	Pelodiscus sinensis	45.65	7.00e-29	119.00
IUUC-Pma-094129	Petromyzon marinus	44.20	9.00e-27	113.00
IUUC-Pfo-096892	Poecilia formosa	57.96	3.00e-48	184.00
IUUC-Pab-097822	Pongo abelii	53.42	2.00e-40	158.00
IUUC-Pca-101058	Procavia capensis	52.74	7.00e-38	150.00
IUUC-Pva-102932	Pteropus vampyrus	52.35	3.00e-40	157.00
IUUC-Rno-105050	Rattus norvegicus	47.73	1.00e-40	159.00
IUUC-Sha-106738	Sarcophilus harrisii	53.93	6.00e-23	98.60
IUUC-Ssc-115973	Sus scrofa	53.02	2.00e-40	158.00
IUUC-Tgu-116663	Taeniopygia guttata	48.31	2.00e-18	84.00
IUUC-Tru-118654	Takifugu rubripes	62.75	5.00e-51	193.00
IUUC-Ttr-128418	Tursiops truncatus	52.29	2.00e-41	162.00
IUUC-Vpa-130268	Vicugna pacos	49.00	3.00e-22	97.80
IUUC-Xtr-132506	Xenopus tropicalis	50.32	3.00e-38	150.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence