iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053893

UUCD1 version

UUC-LoA-00568

Ensembl Protein ID

ENSLAFP00000013728.3

UniProt Accession

G3TGU8; G3TGU8_LOXAF

Protein Name

Uncharacterized protein

Gene Name

VHLL

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000016353.3	ENSLAFT00000016349.3	ENSLAFP00000013728.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	25.86	2.00e-03	38.90	IUUC-Dme-031988
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	91.77	2.00e-81	298.00	IUUC-Hsa-046547

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Loxodonta africana

Protein Sequence
(Fasta)

SGAEEPGPEE SDAEESGAEE NMEAGQRRPV LRSVNSREPS QVIFCNYSPR VVLPVWLNFD 60
GEPQPYPTLP PGKGRRIHSY RGHLWLFRDA GTYDGLLVNQ TELFVPSLNV DGQPIFANIT 120

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Nucleotide Sequence
(Fasta)

TCGGGCGCCG AGGAGCCCGG CCCGGAAGAG TCCGACGCAG AGGAGTCGGG CGCTGAGGAA 60
AACATGGAGG CGGGGCAGCG GCGGCCGGTG CTGCGCTCGG TGAACTCGCG CGAGCCGTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR002714--VHL
IPR024048--VHL_alpha_dom
IPR024053--VHL_beta_dom
IPR022772--VHL_tumour_suppress_b/a_dom

Pfam

PF01847--VHL
PF17211--VHL_C

Gene Ontology

GO:0005929--C:cilium
GO:0031462--C:Cul2-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0001525--P:angiogenesis
GO:0043534--P:blood vessel endothelial cell migration
GO:0061073--P:ciliary body morphogenesis
GO:0030198--P:extracellular matrix organization
GO:0048069--P:eye pigmentation
GO:0048877--P:homeostasis of number of retina cells
GO:0061072--P:iris morphogenesis
GO:0006582--P:melanin metabolic process
GO:0045602--P:negative regulation of endothelial cell differentiation
GO:0010629--P:negative regulation of gene expression
GO:1902072--P:negative regulation of hypoxia-inducible factor-1alpha signaling pathway
GO:0070244--P:negative regulation of thymocyte apoptotic process
GO:0006607--P:NLS-bearing protein import into nucleus
GO:0003310--P:pancreatic A cell differentiation
GO:0050679--P:positive regulation of epithelial cell proliferation
GO:0010498--P:proteasomal protein catabolic process
GO:2001233--P:regulation of apoptotic signaling pathway
GO:1903827--P:regulation of cellular protein localization
GO:0003309--P:type B pancreatic cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002327	Ailuropoda melanoleuca	82.53	2.00e-73	268.00
IUUC-Apl-003580	Anas platyrhynchos	68.29	4.00e-26	108.00
IUUC-Aca-004492	Anolis carolinensis	77.17	1.00e-55	208.00
IUUC-Ang-009806	Aspergillus niger	37.50	4.70e-01	25.40
IUUC-Ame-011818	Astyanax mexicanus	52.94	1.00e-43	169.00
IUUC-Bta-013459	Bos taurus	92.07	1.00e-86	311.00
IUUC-Cel-018173	Caenorhabditis elegans	31.87	2.00e-04	38.50
IUUC-Cja-019826	Callithrix jacchus	90.30	2.00e-85	307.00
IUUC-Cfa-021280	Canis familiaris	93.83	2.00e-86	311.00
IUUC-Cpo-022544	Cavia porcellus	87.28	2.00e-85	307.00
IUUC-Cre-022809	Chlamydomonas reinhardtii	41.67	1.00e-07	50.80
IUUC-Csa-023644	Chlorocebus sabaeus	91.77	4.00e-83	300.00
IUUC-Cho-024479	Choloepus hoffmanni	64.62	1.00e-40	157.00
IUUC-Cin-025505	Ciona intestinalis	28.12	4.00e-06	43.90
IUUC-Cme-027232	Cyanidioschyzon merolae	35.14	3.00e-06	45.10
IUUC-Dre-028350	Danio rerio	47.40	2.00e-33	135.00
IUUC-Dno-029207	Dasypus novemcinctus	95.24	8.00e-56	209.00
IUUC-Dor-030912	Dipodomys ordii	66.45	4.00e-50	190.00
IUUC-Dme-031988	Drosophila melanogaster	25.86	9.00e-05	39.70
IUUC-Eca-034007	Equus caballus	100.00	2.00e-20	89.70
IUUC-Fca-036350	Felis catus	94.27	9.00e-83	299.00
IUUC-Fal-037192	Ficedula albicollis	64.63	2.00e-56	211.00
IUUC-Gmo-038921	Gadus morhua	56.41	7.00e-45	172.00
IUUC-Gga-041016	Gallus gallus	67.61	4.00e-53	200.00
IUUC-Gac-042560	Gasterosteus aculeatus	50.00	3.00e-36	144.00
IUUC-Ggo-045419	Gorilla gorilla	92.86	1.00e-81	295.00
IUUC-Hsa-046547	Homo sapiens	92.86	2.00e-81	295.00
IUUC-Itr-048225	Ictidomys tridecemlineatus	94.41	7.00e-88	315.00
IUUC-Lch-050463	Latimeria chalumnae	64.43	2.00e-54	204.00
IUUC-Loc-052053	Lepisosteus oculatus	56.08	5.00e-47	179.00
IUUC-Mcc-055347	Macaca mulatta	74.13	3.00e-56	211.00
IUUC-Mtr-058490	Medicago truncatula	44.44	2.40e-02	32.30
IUUC-Mdo-062169	Monodelphis domestica	73.40	8.00e-37	144.00
IUUC-Mmu-064366	Mus musculus	92.09	1.00e-73	268.00
IUUC-Mpu-066593	Mustela putorius furo	92.31	5.00e-89	319.00
IUUC-Mlu-066926	Myotis lucifugus	86.91	3.00e-88	317.00
IUUC-Nle-069724	Nomascus leucogenys	93.51	2.00e-82	298.00
IUUC-Opr-070679	Ochotona princeps	79.88	2.00e-76	278.00
IUUC-Ont-071332	Oreochromis niloticus	50.90	8.00e-43	166.00
IUUC-Ola-086869	Oryzias latipes	49.68	1.00e-39	155.00
IUUC-Oga-089124	Otolemur garnettii	89.29	1.00e-84	305.00
IUUC-Oar-089799	Ovis aries	97.96	5.00e-53	198.00
IUUC-Ptr-091186	Pan troglodytes	91.92	2.00e-49	187.00
IUUC-Pan-092150	Papio anubis	92.81	1.00e-81	295.00
IUUC-Psi-094039	Pelodiscus sinensis	61.04	2.00e-50	191.00
IUUC-Pma-094129	Petromyzon marinus	44.76	2.00e-29	121.00
IUUC-Pfo-096892	Poecilia formosa	48.99	2.00e-36	144.00
IUUC-Pab-097822	Pongo abelii	93.51	2.00e-82	298.00
IUUC-Pca-101058	Procavia capensis	89.31	2.00e-77	281.00
IUUC-Pva-102932	Pteropus vampyrus	95.00	5.00e-87	313.00
IUUC-Rno-105050	Rattus norvegicus	85.08	3.00e-87	313.00
IUUC-Sha-106738	Sarcophilus harrisii	80.21	8.00e-43	164.00
IUUC-Ssc-115973	Sus scrofa	89.27	1.00e-89	322.00
IUUC-Tgu-116663	Taeniopygia guttata	69.00	2.00e-33	132.00
IUUC-Tru-118654	Takifugu rubripes	52.83	5.00e-43	166.00
IUUC-Tca-121306	Theobroma cacao	38.89	3.00e-02	30.00
IUUC-Ttr-128418	Tursiops truncatus	90.06	5.00e-88	316.00
IUUC-Vpa-130268	Vicugna pacos	89.11	4.00e-48	183.00
IUUC-Xtr-132506	Xenopus tropicalis	63.33	3.00e-54	203.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence