iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046345

UUCD1 version

UUC-HoS-00032

Ensembl Protein ID

ENSP00000348299.4

UniProt Accession

O60858; B2RB49; Q5UBW0; Q5W0U8; Q5W0U9; Q9BQ47; Q9C021; TRI13_HUMAN

Genbank Protein ID

CAA12136.1; AAK13059.1; AAG53500.1; AAG53501.1; AAO38979.1; AAK51624.1; AAF91315.1; AAR31110.1; AAV51406.1; BAG37096.1; CAC43391.1; CAH72825.1; CAH72826.1; EAX08844.1; EAX08845.1; AAH03579.1; AAH63407.1

Protein Name

E3 ubiquitin-protein ligase TRIM13; B-cell chronic lymphocytic leukemia tumor suppressor Leu5; Leukemia-associated protein 5; Putative tumor suppressor RFP2; RING finger protein 77; RING-type E3 ubiquitin transferase TRIM13; Ret finger protein 2; Tripartite motif-containing protein 13

Genbank Nucleotide ID

AJ224819; AF279660; AF220127; AF220128; AY191002; AF241849; AF241850; AY455758; AY764035; AK314496; AL137060; AL137060; AL137060; CH471075; CH471075; BC003579; BC063407

Gene Name

TRIM13; LEU5; RFP2; RNF77

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000204977.9	ENST00000356017.8	ENSP00000348299.4

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	RepTar
miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18248090; 21333377; 20100910; 17314412

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	6.80e-08	34.6	13	61

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw....pglknssskefrCPlCr 46
           C+iC++ f+d p+vlpC H f+++Cl+ +    +  +      f+CP+Cr
   Q: 13   CPICCSLFDD-PRVLPCSHNFCKKCLEGIlegsVRNSLWRPAPFKCPTCR 61
           ********99.**************97776666666666999999****8 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor.

Protein Sequence
(Fasta)

MDVMELLEED LTCPICCSLF DDPRVLPCSH NFCKKCLEGI LEGSVRNSLW RPAPFKCPTC 60
RKETSATGIN SLQVNYSLKG IVEKYNKIKI SPKMPVCKGH LGQPLNIFCL TDMQLICGIC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTTCTCCCA AGATCGTAAA TTCTGGAGGA GCCATTCCTT CATCATCCAT GTTTGCATCC 60
TTCACACCGT TCACTGGTTA AGTGCTTAGT ACGTTTGCTA TTGGGCAAGG TCCTCAAACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00643--zf-B_box
PF13445--zf-RING_UBOX

SMART

SM00336--BBOX
SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005789--C:endoplasmic reticulum membrane
GO:0044322--C:endoplasmic reticulum quality control compartment
GO:0016021--C:integral component of membrane
GO:0097038--C:perinuclear endoplasmic reticulum
GO:0004871--F:signal transducer activity
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0009653--P:anatomical structure morphogenesis
GO:1904380--P:endoplasmic reticulum mannose trimming
GO:0045087--P:innate immune response
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0010942--P:positive regulation of cell death
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0016239--P:positive regulation of macroautophagy
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0010332--P:response to gamma radiation
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

hsa:10206

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002269	Ailuropoda melanoleuca	92.67	0.00e+00	743.00
IUUC-Apl-004168	Anas platyrhynchos	76.23	0.00e+00	635.00
IUUC-Aca-004395	Anolis carolinensis	70.10	3.00e-165	574.00
IUUC-Ame-011325	Astyanax mexicanus	46.44	3.00e-68	252.00
IUUC-Bta-012613	Bos taurus	92.63	0.00e+00	738.00
IUUC-Cja-018856	Callithrix jacchus	96.58	0.00e+00	798.00
IUUC-Cfa-021019	Canis familiaris	92.18	0.00e+00	736.00
IUUC-Cpo-021845	Cavia porcellus	92.14	0.00e+00	728.00
IUUC-Csa-023380	Chlorocebus sabaeus	97.54	0.00e+00	761.00
IUUC-Cho-024733	Choloepus hoffmanni	83.26	2.00e-89	323.00
IUUC-Dre-028675	Danio rerio	59.80	4.00e-109	388.00
IUUC-Dno-030018	Dasypus novemcinctus	90.44	0.00e+00	720.00
IUUC-Dor-030599	Dipodomys ordii	89.14	3.00e-126	444.00
IUUC-Dse-031522	Dothistroma septosporum	35.53	2.00e-06	46.60
IUUC-Ete-033134	Echinops telfairi	88.29	0.00e+00	728.00
IUUC-Eca-033931	Equus caballus	93.64	0.00e+00	738.00
IUUC-Eeu-034903	Erinaceus europaeus	90.46	0.00e+00	722.00
IUUC-Fca-035642	Felis catus	92.87	0.00e+00	734.00
IUUC-Fal-037108	Ficedula albicollis	76.72	0.00e+00	639.00
IUUC-Gga-040903	Gallus gallus	74.50	2.00e-177	615.00
IUUC-Ggo-044635	Gorilla gorilla	99.51	0.00e+00	772.00
IUUC-Itr-048220	Ictidomys tridecemlineatus	90.98	0.00e+00	704.00
IUUC-Lch-050599	Latimeria chalumnae	61.14	7.00e-138	483.00
IUUC-Loc-052378	Lepisosteus oculatus	64.71	3.00e-119	421.00
IUUC-Laf-053332	Loxodonta africana	91.67	0.00e+00	728.00
IUUC-Mcc-054705	Macaca mulatta	96.83	0.00e+00	765.00
IUUC-Meu-056825	Macropus eugenii	83.66	0.00e+00	697.00
IUUC-Mga-059528	Meleagris gallopavo	75.25	0.00e+00	629.00
IUUC-Mmr-060688	Microcebus murinus	94.13	0.00e+00	742.00
IUUC-Mdo-061882	Monodelphis domestica	82.89	0.00e+00	701.00
IUUC-Mmu-064352	Mus musculus	88.94	0.00e+00	742.00
IUUC-Mpu-066712	Mustela putorius furo	92.08	0.00e+00	679.00
IUUC-Mlu-068093	Myotis lucifugus	90.66	0.00e+00	719.00
IUUC-Nle-069310	Nomascus leucogenys	98.53	0.00e+00	763.00
IUUC-Ont-071759	Oreochromis niloticus	58.96	7.00e-110	390.00
IUUC-Oan-073673	Ornithorhynchus anatinus	80.73	0.00e+00	682.00
IUUC-Ocu-074192	Oryctolagus cuniculus	91.69	0.00e+00	740.00
IUUC-Ola-087424	Oryzias latipes	58.44	4.00e-108	384.00
IUUC-Oga-088808	Otolemur garnettii	93.37	0.00e+00	743.00
IUUC-Oar-089553	Ovis aries	92.67	0.00e+00	741.00
IUUC-Ptr-090518	Pan troglodytes	99.27	0.00e+00	769.00
IUUC-Pan-092781	Papio anubis	96.58	0.00e+00	761.00
IUUC-Psi-093914	Pelodiscus sinensis	75.79	0.00e+00	626.00
IUUC-Ppa-095862	Physcomitrella patens	37.33	6.00e-06	44.30
IUUC-Pfo-096346	Poecilia formosa	57.32	1.00e-108	386.00
IUUC-Pca-100914	Procavia capensis	89.51	0.00e+00	741.00
IUUC-Pva-102728	Pteropus vampyrus	92.42	0.00e+00	734.00
IUUC-Rno-105922	Rattus norvegicus	87.47	0.00e+00	685.00
IUUC-Sha-107124	Sarcophilus harrisii	83.86	0.00e+00	710.00
IUUC-Sar-113607	Sorex araneus	88.26	0.00e+00	704.00
IUUC-Ssc-116355	Sus scrofa	93.12	0.00e+00	741.00
IUUC-Tgu-116476	Taeniopygia guttata	76.96	0.00e+00	637.00
IUUC-Tru-118737	Takifugu rubripes	59.93	3.00e-112	398.00
IUUC-Tsy-118908	Tarsius syrichta	93.64	0.00e+00	749.00
IUUC-Tbe-127258	Tupaia belangeri	94.87	0.00e+00	753.00
IUUC-Vpa-130138	Vicugna pacos	91.93	0.00e+00	741.00
IUUC-Xtr-132100	Xenopus tropicalis	59.56	4.00e-136	477.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence