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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Dme-032117
Ensembl Protein ID FBpp0310643
UniProt Accession X2JAU8; X2JAU8_DROME
Genbank Protein ID AHN58019.1
Protein Name Nervous wreck, isoform I
Genbank Nucleotide ID AE014296
Gene Name nwk; DmelCG43479; NWK; Nwk; CG43479; CG4641; CG4684; Dmel_CG43479
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0263456 FBtr0331857 FBpp0304241
FBgn0263456 FBtr0344240 FBpp0310644
FBgn0263456 FBtr0309277 FBpp0301204
FBgn0263456 FBtr0344242 FBpp0310646
FBgn0263456 FBtr0344239 FBpp0310643
FBgn0263456 FBtr0344241 FBpp0310645
FBgn0263456 FBtr0309280 FBpp0301207
FBgn0263456 FBtr0344238 FBpp0310642
FBgn0263456 FBtr0309276 FBpp0301203
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 5.20e-26 90.4 661 718
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlvi..ekeeqdegWlkgvkelegkrGlfPenFvek 61
           e +++lydy+a+ +deLt+++Gd++++i    +  d gW++g  el gk G fP+  ve+
   Q: 661  EWCIALYDYDATAEDELTFEEGDKIKIItkTAHGVDDGWWEG--ELDGKFGNFPSLVVEE 718
           5699************************6555667*******..9*********876665 PP
   
Organism Drosophila melanogaster
Protein Sequence
(Fasta)
MQPPPRKGNY VKFLKNLHTE QVAKLQLKNQ HECDLLEDIR QFTIKRSAVE KSYSESLLKI 60
SSQYLNKKIP NIPDIKMEGM EERWNMWSVW RTVLEENEKL ARARLAAIEV FQQQIADEAK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-032117|UBD,SH3|Drosophila melanogaster
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CACAAACGTC GTGAAAATCG AAATCGATAA GTAAGCAACG GATTTTAGCT GCCCAGAAAA 60
AGACCACAAA TTTCAGTGAA AACCCAGCGA TAAGAATCCC AAAAAGTACT AATCCAGCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-032117|UBD,SH3|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0728--SH3 domain
Interpro

IPR031160--F_BAR
IPR001060--FCH_dom
IPR001452--SH3_domain
PROSITE

PS51741--F_BAR
PS50002--SH3
Pfam

PF00611--FCH
PF00018--SH3_1
PRINTS

PR00452--SH3DOMAIN
SMART

SM00055--FCH
SM00326--SH3
Gene Ontology

GO:0005737--C:cytoplasm
GO:0031594--C:neuromuscular junction
GO:0055037--C:recycling endosome
GO:0005543--F:phospholipid binding
GO:0045886--P:negative regulation of synaptic growth at neuromuscular junction
GO:0007274--P:neuromuscular synaptic transmission
GO:0001881--P:receptor recycling
GO:0030833--P:regulation of actin filament polymerization
GO:0030510--P:regulation of BMP signaling pathway
GO:0008582--P:regulation of synaptic growth at neuromuscular junction
GO:0030111--P:regulation of Wnt signaling pathway
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001547 Ailuropoda melanoleuca 24.71 7.00e-26 111.00
IUUC-Apl-003986 Anas platyrhynchos 35.81 2.00e-57 216.00
IUUC-Aca-004327 Anolis carolinensis 38.23 5.00e-78 285.00
IUUC-Acl-008089 Aspergillus clavatus 28.16 3.00e-11 63.20
IUUC-Afu-009118 Aspergillus fumigatus 27.22 8.00e-08 51.60
IUUC-Ani-009217 Aspergillus nidulans 27.22 2.00e-09 56.60
IUUC-Ang-009697 Aspergillus niger 25.44 2.00e-11 63.90
IUUC-Ame-011182 Astyanax mexicanus 33.86 1.00e-69 257.00
IUUC-Bgr-012268 Blumeria graminis 29.76 2.00e-11 63.50
IUUC-Bta-012452 Bos taurus 38.52 2.00e-79 289.00
IUUC-Bci-013732 Botrytis cinerea 48.08 2.00e-10 59.70
IUUC-Cja-019215 Callithrix jacchus 36.70 1.00e-75 277.00
IUUC-Cfa-020842 Canis familiaris 38.52 2.00e-78 285.00
IUUC-Cpo-022039 Cavia porcellus 36.92 1.00e-75 276.00
IUUC-Csa-024127 Chlorocebus sabaeus 37.53 4.00e-78 285.00
IUUC-Cho-024425 Choloepus hoffmanni 34.19 7.00e-14 71.60
IUUC-Cin-025501 Ciona intestinalis 32.26 1.00e-55 210.00
IUUC-Csv-026219 Ciona savignyi 29.31 9.00e-47 180.00
IUUC-Dre-028162 Danio rerio 33.80 2.00e-61 229.00
IUUC-Dno-029364 Dasypus novemcinctus 32.46 2.00e-52 199.00
IUUC-Dor-030539 Dipodomys ordii 27.64 1.00e-18 87.80
IUUC-Dse-031521 Dothistroma septosporum 46.55 9.00e-11 60.80
IUUC-Ete-032798 Echinops telfairi 34.05 1.00e-53 204.00
IUUC-Eca-033846 Equus caballus 36.71 2.00e-57 216.00
IUUC-Eeu-034467 Erinaceus europaeus 36.66 4.00e-59 221.00
IUUC-Fca-035626 Felis catus 38.52 1.00e-78 286.00
IUUC-Fal-036970 Ficedula albicollis 36.57 4.00e-62 232.00
IUUC-Gmo-039217 Gadus morhua 34.36 7.00e-61 228.00
IUUC-Gga-040621 Gallus gallus 35.98 9.00e-66 244.00
IUUC-Gac-042146 Gasterosteus aculeatus 35.59 5.00e-67 248.00
IUUC-Ggo-044698 Gorilla gorilla 25.24 5.00e-30 125.00
IUUC-Hsa-045745 Homo sapiens 36.70 2.00e-75 276.00
IUUC-Itr-048931 Ictidomys tridecemlineatus 36.70 6.00e-75 274.00
IUUC-Kpa-049168 Komagataella pastoris 31.40 6.00e-14 72.00
IUUC-Lch-050016 Latimeria chalumnae 32.35 7.00e-47 181.00
IUUC-Loc-052657 Lepisosteus oculatus 36.42 1.00e-76 280.00
IUUC-Lma-052966 Leptosphaeria maculans 43.40 6.00e-10 58.20
IUUC-Laf-054111 Loxodonta africana 36.20 1.00e-71 263.00
IUUC-Mcc-055812 Macaca mulatta 35.29 3.00e-72 265.00
IUUC-Meu-056700 Macropus eugenii 34.23 2.00e-52 199.00
IUUC-Mga-059428 Meleagris gallopavo 29.77 2.00e-48 186.00
IUUC-Mmr-060778 Microcebus murinus 36.26 1.00e-71 263.00
IUUC-Mdo-062298 Monodelphis domestica 38.75 8.00e-79 287.00
IUUC-Mmu-063604 Mus musculus 36.70 4.00e-75 275.00
IUUC-Mpu-066897 Mustela putorius furo 36.92 3.00e-75 275.00
IUUC-Mlu-068021 Myotis lucifugus 35.36 2.00e-58 219.00
IUUC-Nfi-068456 Neosartorya fischeri 27.59 7.00e-13 68.60
IUUC-Ncr-068717 Neurospora crassa 51.85 6.00e-07 48.10
IUUC-Nle-070181 Nomascus leucogenys 35.89 2.00e-68 253.00
IUUC-Opr-070415 Ochotona princeps 36.52 3.00e-21 96.30
IUUC-Ont-072633 Oreochromis niloticus 37.28 1.00e-76 280.00
IUUC-Oan-073048 Ornithorhynchus anatinus 28.39 9.00e-19 87.40
IUUC-Ocu-074473 Oryctolagus cuniculus 38.00 8.00e-79 287.00
IUUC-Ola-086966 Oryzias latipes 34.02 4.00e-51 195.00
IUUC-Oga-088575 Otolemur garnettii 36.26 1.00e-74 273.00
IUUC-Oar-090216 Ovis aries 38.52 2.00e-79 289.00
IUUC-Ptr-091373 Pan troglodytes 38.28 7.00e-79 287.00
IUUC-Pan-091923 Papio anubis 38.00 4.00e-78 285.00
IUUC-Psi-093073 Pelodiscus sinensis 37.21 1.00e-71 263.00
IUUC-Pno-094834 Phaeosphaeria nodorum 43.40 8.00e-10 57.80
IUUC-Pfo-097397 Poecilia formosa 35.82 3.00e-73 269.00
IUUC-Pab-098002 Pongo abelii 36.70 2.00e-75 276.00
IUUC-Pca-100813 Procavia capensis 30.29 2.00e-43 169.00
IUUC-Pva-102581 Pteropus vampyrus 35.80 4.00e-50 192.00
IUUC-Pte-104363 Pyrenophora teres 43.40 1.00e-10 60.50
IUUC-Pyt-104548 Pyrenophora triticirepentis 43.40 9.00e-11 60.80
IUUC-Rno-105326 Rattus norvegicus 35.97 2.00e-69 256.00
IUUC-Sha-106973 Sarcophilus harrisii 38.98 4.00e-50 191.00
IUUC-Sar-112935 Sorex araneus 35.65 1.00e-35 144.00
IUUC-Sre-115217 Sporisorium reilianum 25.68 2.00e-09 56.60
IUUC-Ssc-116379 Sus scrofa 36.55 3.00e-65 242.00
IUUC-Tgu-117496 Taeniopygia guttata 35.18 3.00e-53 202.00
IUUC-Tru-117826 Takifugu rubripes 34.73 4.00e-70 258.00
IUUC-Tsy-119549 Tarsius syrichta 27.54 5.00e-34 138.00
IUUC-Tni-120259 Tetraodon nigroviridis 33.62 7.00e-58 218.00
IUUC-Tae-123839 Triticum aestivum 25.93 8.20e-01 29.60
IUUC-Tme-127219 Tuber melanosporum 42.31 1.00e-08 53.90
IUUC-Tbe-128036 Tupaia belangeri 33.94 4.00e-19 88.60
IUUC-Ttr-128541 Tursiops truncatus 36.63 7.00e-59 221.00
IUUC-Uma-129502 Ustilago maydis 45.00 4.00e-09 56.60
IUUC-Vda-129687 Verticillium dahliae 46.77 1.00e-10 60.50
IUUC-Vpa-130212 Vicugna pacos 35.92 8.00e-59 221.00
IUUC-Xtr-132890 Xenopus tropicalis 37.89 3.00e-71 262.00
IUUC-Xma-133811 Xiphophorus maculatus 36.45 3.00e-72 265.00
Created Date 25-Jun-2017

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