iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Laf-053353

Ensembl Protein ID

ENSLAFP00000012180.2

UniProt Accession

G3TDF8; G3TDF8_LOXAF

Protein Name

Inhibitor of growth protein

Gene Name

ING2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000014542.2	ENSLAFT00000014540.2	ENSLAFP00000012180.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	2.40e-09	37.6	158	204

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCek..Cr.ewfHpaClklsveeelpnsekwiCpkCr 52
           ++C +C + + +e  ++ C++  C  ewfH+ C++l+    +p+ + w+CpkCr
   Q: 158  TYC-LCNQVSYGE--MIGCDNeqCPiEWFHFSCVSLT---YKPKGK-WYCPKCR 204
           69*.*******99..*****999*99***********...888886.******8 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

FLETLKEIDD VYERYKKEED LNQKKRLQQH LQRALINSQE LGDEKIQIVT QMLELVENRA 60
RQMELHSQCF QDPAESERAS DKAKMDSSQP ERSSRRPRRQ RTSESRDLCH MTNGVEDCDD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTTTAGAAA CGTTAAAGGA AATTGATGAT GTCTATGAAA GATACAAAAA AGAAGAAGAT 60
TTAAACCAGA AAAAACGTCT ACAGCAGCAT CTCCAGAGAG CACTAATCAA TAGTCAAGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR028639--ING2
IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF12998--ING

SMART

SM00249--PHD

Gene Ontology

GO:0016602--C:CCAAT-binding factor complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005886--C:plasma membrane
GO:0016580--C:Sin3 complex
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0035091--F:phosphatidylinositol binding
GO:0008270--F:zinc ion binding
GO:0016569--P:covalent chromatin modification
GO:0030317--P:flagellated sperm motility
GO:0048133--P:male germ-line stem cell asymmetric division
GO:0007141--P:male meiosis I
GO:2001234--P:negative regulation of apoptotic signaling pathway
GO:0008285--P:negative regulation of cell proliferation
GO:0031065--P:positive regulation of histone deacetylation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0030511--P:positive regulation of transforming growth factor beta receptor signaling pathway
GO:2000772--P:regulation of cellular senescence
GO:0072520--P:seminiferous tubule development
GO:0007286--P:spermatid development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002213	Ailuropoda melanoleuca	98.04	1.00e-90	325.00
IUUC-Apl-003705	Anas platyrhynchos	87.50	9.00e-91	325.00
IUUC-Aca-004990	Anolis carolinensis	83.41	1.00e-84	305.00
IUUC-Bta-012721	Bos taurus	98.53	3.00e-91	327.00
IUUC-Cja-018960	Callithrix jacchus	96.89	9.00e-83	299.00
IUUC-Cfa-020869	Canis familiaris	97.55	5.00e-90	323.00
IUUC-Cpo-021414	Cavia porcellus	96.08	7.00e-89	320.00
IUUC-Csa-023304	Chlorocebus sabaeus	98.95	4.00e-83	301.00
IUUC-Dno-029945	Dasypus novemcinctus	98.04	8.00e-91	326.00
IUUC-Dor-030141	Dipodomys ordii	97.06	1.00e-88	318.00
IUUC-Ete-032709	Echinops telfairi	96.00	6.00e-100	356.00
IUUC-Eca-033432	Equus caballus	99.02	5.00e-91	327.00
IUUC-Eeu-035285	Erinaceus europaeus	98.53	1.00e-90	325.00
IUUC-Fca-036467	Felis catus	98.53	1.00e-90	325.00
IUUC-Fal-036700	Ficedula albicollis	87.11	7.00e-91	326.00
IUUC-Gga-040175	Gallus gallus	87.44	2.00e-90	324.00
IUUC-Hsa-045837	Homo sapiens	98.95	4.00e-83	301.00
IUUC-Itr-049062	Ictidomys tridecemlineatus	98.04	2.00e-90	325.00
IUUC-Lch-049965	Latimeria chalumnae	81.78	9.00e-84	302.00
IUUC-Mcc-055155	Macaca mulatta	98.85	4.00e-73	266.00
IUUC-Meu-056470	Macropus eugenii	92.44	8.00e-94	336.00
IUUC-Mga-059570	Meleagris gallopavo	87.44	8.00e-90	322.00
IUUC-Mmr-061385	Microcebus murinus	99.47	1.00e-83	302.00
IUUC-Mdo-062144	Monodelphis domestica	92.89	3.00e-94	338.00
IUUC-Mmu-063215	Mus musculus	97.06	2.00e-90	324.00
IUUC-Mpu-065749	Mustela putorius furo	97.55	5.00e-90	323.00
IUUC-Nle-069968	Nomascus leucogenys	98.05	7.00e-82	296.00
IUUC-Ocu-074870	Oryctolagus cuniculus	99.02	2.00e-91	328.00
IUUC-Oga-088336	Otolemur garnettii	98.95	4.00e-83	300.00
IUUC-Oar-090136	Ovis aries	98.04	9.00e-91	326.00
IUUC-Ptr-091348	Pan troglodytes	98.54	2.00e-82	298.00
IUUC-Pan-092819	Papio anubis	98.95	4.00e-83	301.00
IUUC-Psi-093854	Pelodiscus sinensis	85.06	1.00e-61	228.00
IUUC-Pab-098346	Pongo abelii	98.42	9.00e-83	299.00
IUUC-Pca-100278	Procavia capensis	95.11	3.00e-99	354.00
IUUC-Pva-103190	Pteropus vampyrus	99.51	1.00e-91	329.00
IUUC-Rno-104940	Rattus norvegicus	96.57	3.00e-89	321.00
IUUC-Sha-107533	Sarcophilus harrisii	92.44	4.00e-95	340.00
IUUC-Sar-113630	Sorex araneus	96.57	7.00e-90	322.00
IUUC-Ssc-115734	Sus scrofa	99.51	1.00e-91	329.00
IUUC-Tgu-117034	Taeniopygia guttata	87.56	3.00e-91	327.00
IUUC-Tsy-119494	Tarsius syrichta	99.02	4.00e-83	300.00
IUUC-Ttr-128442	Tursiops truncatus	99.02	5.00e-91	326.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence