iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aca-005312

Ensembl Protein ID

ENSACAP00000016682.2

UniProt Accession

H9GNS0; H9GNS0_ANOCA

Protein Name

Tyrosine-protein kinase

Gene Name

ABL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000016905.2	ENSACAT00000017012.2	ENSACAP00000016682.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.30e-14	53.0	65	122

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            +++ +lyd+ a+ d++L+++kG++++v+  ++++++W+++  ++++ +G +P+n+++ ++
   Q: 65   PNLFVALYDFVASGDNTLSITKGEKLRVL-GYNHNGEWCEA--QTKNGQGWVPSNYITPVN 122
           68899************************.***********..79999**********997 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MKMLEICLKL VGCKSKKGLS SSSSCYLEEA LQRPVASEFE PQGLSEAARW NSKENLLSGP 60
SENDPNLFVA LYDFVASGDN TLSITKGEKL RVLGYNHNGE WCEAQTKNGQ GWVPSNYITP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAAATGT TGGAGATTTG TCTGAAATTA GTAGGTTGCA AGTCGAAGAA AGGACTCTCC 60
TCTTCTTCCA GCTGCTATTT GGAAGGTAAC TTTGAAGGGA CGGCTGTTTG AAGATCATGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR033221--ABL1
IPR015015--F-actin_binding
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF08919--F_actin_bind
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00109--TYRKINASE

SMART

SM00808--FABD
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0031252--C:cell leading edge
GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0016604--C:nuclear body
GO:0005730--C:nucleolus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0030145--F:manganese ion binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0090135--P:actin filament branching
GO:0050798--P:activated T cell proliferation
GO:1990051--P:activation of protein kinase C activity
GO:0046632--P:alpha-beta T cell differentiation
GO:0002322--P:B cell proliferation involved in immune response
GO:0050853--P:B cell receptor signaling pathway
GO:0001922--P:B-1 B cell homeostasis
GO:0060020--P:Bergmann glial cell differentiation
GO:0072358--P:cardiovascular system development
GO:0030154--P:cell differentiation
GO:0070301--P:cellular response to hydrogen peroxide
GO:0071222--P:cellular response to lipopolysaccharide
GO:0021587--P:cerebellum morphogenesis
GO:0048668--P:collateral sprouting
GO:0006975--P:DNA damage induced protein phosphorylation
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0045184--P:establishment of protein localization
GO:0045087--P:innate immune response
GO:0030035--P:microspike assembly
GO:0030514--P:negative regulation of BMP signaling pathway
GO:0022408--P:negative regulation of cell-cell adhesion
GO:2000773--P:negative regulation of cellular senescence
GO:2000352--P:negative regulation of endothelial cell apoptotic process
GO:0070373--P:negative regulation of ERK1 and ERK2 cascade
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045930--P:negative regulation of mitotic cell cycle
GO:1900275--P:negative regulation of phospholipase C activity
GO:0071901--P:negative regulation of protein serine/threonine kinase activity
GO:0051444--P:negative regulation of ubiquitin-protein transferase activity
GO:0001843--P:neural tube closure
GO:0060563--P:neuroepithelial cell differentiation
GO:0050885--P:neuromuscular process controlling balance
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0006909--P:phagocytosis
GO:0035791--P:platelet-derived growth factor receptor-beta signaling pathway
GO:1904531--P:positive regulation of actin filament binding
GO:0043065--P:positive regulation of apoptotic process
GO:0007204--P:positive regulation of cytosolic calcium ion concentration
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:1902715--P:positive regulation of interferon-gamma secretion
GO:1900042--P:positive regulation of interleukin-2 secretion
GO:1904528--P:positive regulation of microtubule binding
GO:0045931--P:positive regulation of mitotic cell cycle
GO:1901216--P:positive regulation of neuron death
GO:0033690--P:positive regulation of osteoblast proliferation
GO:0051353--P:positive regulation of oxidoreductase activity
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0051281--P:positive regulation of release of sequestered calcium ion into cytosol
GO:2000096--P:positive regulation of Wnt signaling pathway, planar cell polarity pathway
GO:0009791--P:post-embryonic development
GO:0032956--P:regulation of actin cytoskeleton organization
GO:0030516--P:regulation of axon extension
GO:0042127--P:regulation of cell proliferation
GO:1903053--P:regulation of extracellular matrix organization
GO:0031113--P:regulation of microtubule polymerization
GO:2001020--P:regulation of response to DNA damage stimulus
GO:0042770--P:signal transduction in response to DNA damage
GO:0048536--P:spleen development
GO:0034446--P:substrate adhesion-dependent cell spreading
GO:0048538--P:thymus development
GO:0002333--P:transitional one stage B cell differentiation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001550	Ailuropoda melanoleuca	80.76	0.00e+00	1262.00
IUUC-Atr-002778	Amborella trichopoda	32.99	2.00e-23	103.00
IUUC-Apl-003452	Anas platyrhynchos	77.57	0.00e+00	1545.00
IUUC-Ame-011903	Astyanax mexicanus	86.35	0.00e+00	1013.00
IUUC-Bta-012351	Bos taurus	80.67	0.00e+00	1297.00
IUUC-Cja-019491	Callithrix jacchus	74.46	0.00e+00	1476.00
IUUC-Cfa-021256	Canis familiaris	80.42	0.00e+00	1291.00
IUUC-Cpo-022046	Cavia porcellus	82.13	0.00e+00	1297.00
IUUC-Csa-023046	Chlorocebus sabaeus	75.17	0.00e+00	1516.00
IUUC-Cho-024714	Choloepus hoffmanni	67.37	0.00e+00	950.00
IUUC-Dre-028190	Danio rerio	85.48	0.00e+00	971.00
IUUC-Dno-029853	Dasypus novemcinctus	73.67	0.00e+00	1452.00
IUUC-Dor-030635	Dipodomys ordii	75.09	0.00e+00	1149.00
IUUC-Dme-032098	Drosophila melanogaster	75.11	0.00e+00	779.00
IUUC-Ete-032899	Echinops telfairi	84.62	3.00e-116	413.00
IUUC-Eca-033720	Equus caballus	80.53	0.00e+00	1290.00
IUUC-Eeu-035173	Erinaceus europaeus	78.17	0.00e+00	1202.00
IUUC-Fca-035967	Felis catus	80.16	0.00e+00	1278.00
IUUC-Fal-036723	Ficedula albicollis	77.84	0.00e+00	1543.00
IUUC-Gmo-039550	Gadus morhua	76.64	0.00e+00	1075.00
IUUC-Gga-040481	Gallus gallus	77.34	0.00e+00	1513.00
IUUC-Gac-041643	Gasterosteus aculeatus	86.58	0.00e+00	1045.00
IUUC-Ggo-045299	Gorilla gorilla	73.87	0.00e+00	1496.00
IUUC-Hsa-047033	Homo sapiens	97.33	2.00e-41	159.00
IUUC-Itr-047935	Ictidomys tridecemlineatus	83.40	0.00e+00	1269.00
IUUC-Lch-050530	Latimeria chalumnae	78.54	0.00e+00	1236.00
IUUC-Loc-052430	Lepisosteus oculatus	91.20	0.00e+00	970.00
IUUC-Laf-053609	Loxodonta africana	73.81	0.00e+00	1441.00
IUUC-Mcc-055654	Macaca mulatta	74.60	0.00e+00	1517.00
IUUC-Meu-056488	Macropus eugenii	67.74	0.00e+00	1290.00
IUUC-Mga-059270	Meleagris gallopavo	77.77	0.00e+00	1544.00
IUUC-Mmr-060593	Microcebus murinus	79.47	0.00e+00	1290.00
IUUC-Mdo-062227	Monodelphis domestica	86.99	0.00e+00	1211.00
IUUC-Mmu-064002	Mus musculus	79.72	0.00e+00	1307.00
IUUC-Mac-064649	Musa acuminata	32.18	7.00e-22	99.40
IUUC-Mpu-066197	Mustela putorius furo	82.46	0.00e+00	1281.00
IUUC-Mlu-067255	Myotis lucifugus	80.72	0.00e+00	1288.00
IUUC-Nle-069977	Nomascus leucogenys	77.63	0.00e+00	1149.00
IUUC-Opr-070327	Ochotona princeps	74.75	0.00e+00	1129.00
IUUC-Ont-072307	Oreochromis niloticus	69.42	0.00e+00	1067.00
IUUC-Oan-073100	Ornithorhynchus anatinus	81.50	0.00e+00	1353.00
IUUC-Ocu-074892	Oryctolagus cuniculus	80.75	0.00e+00	1158.00
IUUC-Ogl-077331	Oryza glaberrima	32.50	2.00e-23	103.00
IUUC-Oni-082734	Oryza nivara	32.16	2.00e-23	104.00
IUUC-Opu-083538	Oryza punctata	33.00	3.00e-23	103.00
IUUC-Osa-085779	Oryza sativa	32.50	2.00e-23	104.00
IUUC-Ola-087389	Oryzias latipes	68.74	0.00e+00	1066.00
IUUC-Oga-088145	Otolemur garnettii	74.75	0.00e+00	1463.00
IUUC-Oar-090432	Ovis aries	83.44	0.00e+00	1276.00
IUUC-Ptr-090800	Pan troglodytes	74.51	0.00e+00	1507.00
IUUC-Pan-092279	Papio anubis	66.28	0.00e+00	962.00
IUUC-Psi-093078	Pelodiscus sinensis	76.61	0.00e+00	1542.00
IUUC-Pma-094420	Petromyzon marinus	77.80	0.00e+00	899.00
IUUC-Pfo-096979	Poecilia formosa	87.04	0.00e+00	978.00
IUUC-Pab-097949	Pongo abelii	66.20	0.00e+00	960.00
IUUC-Pca-100874	Procavia capensis	97.91	0.00e+00	666.00
IUUC-Pva-102415	Pteropus vampyrus	82.97	0.00e+00	1291.00
IUUC-Rno-105370	Rattus norvegicus	74.30	0.00e+00	1484.00
IUUC-Sha-106711	Sarcophilus harrisii	80.32	0.00e+00	1321.00
IUUC-Sit-110444	Setaria italica	31.66	4.00e-19	89.70
IUUC-Sbi-114480	Sorghum bicolor	31.66	1.00e-23	105.00
IUUC-Ssc-115472	Sus scrofa	85.10	0.00e+00	1263.00
IUUC-Tgu-117037	Taeniopygia guttata	77.37	0.00e+00	1538.00
IUUC-Tru-118324	Takifugu rubripes	69.62	0.00e+00	1075.00
IUUC-Tsy-119216	Tarsius syrichta	93.75	0.00e+00	1047.00
IUUC-Tni-119950	Tetraodon nigroviridis	68.19	0.00e+00	1045.00
IUUC-Tca-121389	Theobroma cacao	33.33	3.00e-23	103.00
IUUC-Tae-122912	Triticum aestivum	28.21	6.00e-20	92.40
IUUC-Tbe-127362	Tupaia belangeri	64.57	0.00e+00	948.00
IUUC-Ttr-128209	Tursiops truncatus	74.32	0.00e+00	1485.00
IUUC-Vpa-130800	Vicugna pacos	66.28	0.00e+00	961.00
IUUC-Vvi-131057	Vitis vinifera	30.85	2.00e-22	101.00
IUUC-Xtr-132477	Xenopus tropicalis	72.78	0.00e+00	1107.00
IUUC-Xma-133740	Xiphophorus maculatus	87.48	0.00e+00	983.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence