iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052574

Ensembl Protein ID

ENSLOCP00000004806.1

UniProt Accession

W5M8U7; W5M8U7_LEPOC

Genbank Protein ID

ENSLOCP00000004806

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AHAT01025369

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000004021.1	ENSLOCT00000004814.1	ENSLOCP00000004806.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.40e-110	368.6	148	679

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tG+kN+gN+CYmN++LQ+Lsn+p+l++++le     +    ++++k +l+ks+qkl++elw k++ ++v p++l + +k ++++f+gy+
   Q: 148  TGMKNIGNSCYMNAALQALSNCPPLTQFFLE-----CGGLVRTDKKPALCKSYQKLISELWhKKRPSYVVPTSLSHGIKLVNPMFRGYA 231
           7******************************.....999999*******************99999*********************** PP
   S: 89   qqDaqEflaflldqleeelkk......eknkpkeeeeeedkselsde.......................................... 129
           qqD+qEfl++l+dql+eelk+      e   + e  +e d+s ++de                                          
   Q: 232  QQDTQEFLRCLMDQLHEELKEplvecgE--PEGEARREGDRSPSEDEflscdsgsssdrgegpegrgageaellitdecggggrggise 318
           *******************887775330..22223333333344444788888888889****************************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 319  kerlkerrfsgsphrtgsqemdedadvdtaaeegrgasragdeevtasnnqcsqslsrtpepdneaamhcnsrpcspihglqdshpkls 407
           ***************************************************************************************** PP
   S: 130  ....................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke............. 185
                               +++kk+ +++s+isd+F+g++ s ++cl+cd+vs++ e+f+dlslp+pgke+ +k+             
   Q: 408  ssplrsgatyslkkaqlllgSKKKKQFRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLhssihqnlpvkag 496
           ********************999************************************************99888************* PP
   S: 186  ....................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfs 238
                                               +l+dcL++f++++el+g+n+y+ce+ckk+++ +k +k+ +lPe+L++hLkRf 
   Q: 497  tcsdtyssqgwisfimdyirrfvvscipnwfwgpvvTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRF- 584
           ****************************************************************************************. PP
   S: 239  fseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevlee 325
            ++e + + kin++v+fple Ldl+pf+++++ +q   ++Y+L++v++H+G+++sGHY+ay++n  +g+W++fdD++Vtev+e+ v++ 
   Q: 585  -RHEVMYSFKINSHVSFPLEgLDLRPFLAKESPSQ--ITTYDLLSVICHHGTAGSGHYIAYCQNvINGQWYEFDDQYVTEVHETVVQN- 669
           .9999*************************88887..9**************************78999*******************. PP
   S: 326  tgstaYvlfYkr 337
             ++aYvlfY++
   Q: 670  --AEAYVLFYRK 679
           ..********98 PP

Organism

Lepisosteus oculatus

Protein Sequence
(Fasta)

MTENGELCPH LDSIGEVTKE ELLQKSKGTC QSCGAGGPNL WACLQKDCPY VGCGESYADH 60
STLHAQAKTH NLTVNLTTFR IWCYVCEREV FLEQRPVTPV PSSHQCKHSE QEAVPQTGSH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTAAACGTCA AAGGAGATGA CGGAAAACGG AGAGCTTTGC CCTCATTTAG ATTCTATAGG 60
TGAGGTTACC AAGGAGGAAT TACTGCAGAA ATCCAAGGTG AGAACACATA TCTGTTGTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002209	Ailuropoda melanoleuca	76.45	0.00e+00	1389.00
IUUC-Apl-003351	Anas platyrhynchos	79.07	0.00e+00	1444.00
IUUC-Aca-005077	Anolis carolinensis	73.52	0.00e+00	1055.00
IUUC-Ame-011777	Astyanax mexicanus	81.28	0.00e+00	1456.00
IUUC-Bta-013063	Bos taurus	77.98	0.00e+00	1410.00
IUUC-Cja-019868	Callithrix jacchus	77.59	0.00e+00	1435.00
IUUC-Cfa-020761	Canis familiaris	77.09	0.00e+00	1416.00
IUUC-Cpo-022267	Cavia porcellus	74.62	0.00e+00	1356.00
IUUC-Csa-024251	Chlorocebus sabaeus	77.80	0.00e+00	1434.00
IUUC-Cho-024483	Choloepus hoffmanni	92.92	2.00e-119	423.00
IUUC-Csv-025889	Ciona savignyi	41.92	1.00e-34	138.00
IUUC-Dre-028061	Danio rerio	81.63	0.00e+00	1321.00
IUUC-Dno-029423	Dasypus novemcinctus	77.51	0.00e+00	1437.00
IUUC-Dor-030877	Dipodomys ordii	78.80	0.00e+00	946.00
IUUC-Dme-031837	Drosophila melanogaster	49.89	3.00e-137	483.00
IUUC-Ete-032802	Echinops telfairi	66.76	4.00e-116	412.00
IUUC-Eca-034283	Equus caballus	76.67	0.00e+00	1402.00
IUUC-Eeu-034620	Erinaceus europaeus	72.71	0.00e+00	943.00
IUUC-Fca-036357	Felis catus	77.79	0.00e+00	1400.00
IUUC-Fal-037411	Ficedula albicollis	79.24	0.00e+00	1452.00
IUUC-Gga-041101	Gallus gallus	78.70	0.00e+00	1435.00
IUUC-Gac-041315	Gasterosteus aculeatus	81.95	0.00e+00	1452.00
IUUC-Ggo-045600	Gorilla gorilla	77.47	0.00e+00	1403.00
IUUC-Hsa-045825	Homo sapiens	77.67	0.00e+00	1417.00
IUUC-Itr-048549	Ictidomys tridecemlineatus	66.95	0.00e+00	1177.00
IUUC-Lch-050002	Latimeria chalumnae	76.65	0.00e+00	1346.00
IUUC-Laf-054428	Loxodonta africana	78.43	0.00e+00	1433.00
IUUC-Mcc-055736	Macaca mulatta	77.69	0.00e+00	1436.00
IUUC-Mga-059781	Meleagris gallopavo	78.58	0.00e+00	1432.00
IUUC-Mdo-063048	Monodelphis domestica	79.11	0.00e+00	1402.00
IUUC-Mmu-064079	Mus musculus	76.72	0.00e+00	1396.00
IUUC-Mpu-066616	Mustela putorius furo	77.30	0.00e+00	1435.00
IUUC-Mlu-067294	Myotis lucifugus	77.24	0.00e+00	1375.00
IUUC-Nle-070015	Nomascus leucogenys	77.78	0.00e+00	1407.00
IUUC-Opr-070328	Ochotona princeps	76.64	0.00e+00	1411.00
IUUC-Ont-071464	Oreochromis niloticus	85.03	0.00e+00	1435.00
IUUC-Oan-073259	Ornithorhynchus anatinus	71.34	0.00e+00	1222.00
IUUC-Ocu-074630	Oryctolagus cuniculus	74.97	0.00e+00	1345.00
IUUC-Ola-087240	Oryzias latipes	82.24	0.00e+00	1417.00
IUUC-Oga-088761	Otolemur garnettii	76.53	0.00e+00	1421.00
IUUC-Oar-089490	Ovis aries	74.73	0.00e+00	1300.00
IUUC-Ptr-091662	Pan troglodytes	77.89	0.00e+00	1418.00
IUUC-Pan-092199	Papio anubis	77.63	0.00e+00	1422.00
IUUC-Psi-093726	Pelodiscus sinensis	79.59	0.00e+00	1446.00
IUUC-Pma-094389	Petromyzon marinus	65.17	1.00e-101	362.00
IUUC-Pab-098632	Pongo abelii	77.78	0.00e+00	1418.00
IUUC-Pca-100614	Procavia capensis	73.23	0.00e+00	1118.00
IUUC-Rno-105215	Rattus norvegicus	76.51	0.00e+00	1389.00
IUUC-Sce-106176	Saccharomyces cerevisiae	33.58	1.00e-25	112.00
IUUC-Sha-106601	Sarcophilus harrisii	78.27	0.00e+00	1396.00
IUUC-Ssc-115533	Sus scrofa	76.36	0.00e+00	1407.00
IUUC-Tgu-117364	Taeniopygia guttata	79.07	0.00e+00	1442.00
IUUC-Tru-117770	Takifugu rubripes	81.37	0.00e+00	1427.00
IUUC-Tni-120001	Tetraodon nigroviridis	79.51	0.00e+00	1390.00
IUUC-Ttr-128732	Tursiops truncatus	78.12	0.00e+00	1418.00
IUUC-Xtr-132157	Xenopus tropicalis	73.62	0.00e+00	1319.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence