iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tru-118241

Ensembl Protein ID

ENSTRUP00000037679.1

UniProt Accession

H2UL58; H2UL58_TAKRU

Protein Name

Tyrosine-protein kinase

Gene Name

fyna; LOC101063191

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000014739.1	ENSTRUT00000037815.1	ENSTRUP00000037679.1
ENSTRUG00000014739.1	ENSTRUT00000037816.1	ENSTRUP00000037680.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.90e-14	54.0	91	146

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + +lydyea ++d+L+++kG+  +++  ++++++W+++ + ++g  G +P+n+v+ ++
   Q: 91   FVALYDYEARTEDDLSFRKGERFQIL--NSTEGDWWEARSLTTGGTGYIPSNYVAPVD 146
           789***********************..8999**********************9987 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MGCVQCKDKE AAKLTDDRET SLSHHSGYRY GSDPTPQHYP SFGVTTIPNY NNFHGTASQG 60
VTVFGGVHTS SQSGTLRSRG GTGISVGVTL FVALYDYEAR TEDDLSFRKG ERFQILNSTE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGCTGTG TCCAATGTAA GGATAAAGAA GCAGCGAAAC TCACCGACGA CCGGGAGACC 60
AGCCTCTCGC ACCATTCGGG CTACCGCTAT GGGTCCGACC CCACGCCGCA GCACTACCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0034334--P:adherens junction maintenance
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0007417--P:central nervous system development
GO:0060027--P:convergent extension involved in gastrulation
GO:0001702--P:gastrulation with mouth forming second
GO:0045087--P:innate immune response
GO:0042552--P:myelination
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042981--P:regulation of apoptotic process
GO:0042127--P:regulation of cell proliferation
GO:0051480--P:regulation of cytosolic calcium ion concentration
GO:0045859--P:regulation of protein kinase activity
GO:0042110--P:T cell activation
GO:0050852--P:T cell receptor signaling pathway
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002009	Ailuropoda melanoleuca	90.39	0.00e+00	1013.00
IUUC-Apl-003716	Anas platyrhynchos	85.27	0.00e+00	941.00
IUUC-Aca-005065	Anolis carolinensis	90.57	0.00e+00	1012.00
IUUC-Ame-011533	Astyanax mexicanus	98.03	0.00e+00	938.00
IUUC-Bta-012645	Bos taurus	90.57	0.00e+00	1015.00
IUUC-Cel-018682	Caenorhabditis elegans	57.91	1.00e-149	522.00
IUUC-Cja-019027	Callithrix jacchus	90.39	0.00e+00	1013.00
IUUC-Cfa-021163	Canis familiaris	90.39	0.00e+00	1013.00
IUUC-Cpo-022315	Cavia porcellus	90.39	0.00e+00	1013.00
IUUC-Csa-023721	Chlorocebus sabaeus	90.39	0.00e+00	1014.00
IUUC-Cho-025014	Choloepus hoffmanni	90.39	0.00e+00	1013.00
IUUC-Dre-027985	Danio rerio	94.82	0.00e+00	1078.00
IUUC-Dno-030043	Dasypus novemcinctus	75.84	0.00e+00	893.00
IUUC-Dor-031035	Dipodomys ordii	89.09	0.00e+00	994.00
IUUC-Dme-031976	Drosophila melanogaster	62.08	2.00e-165	575.00
IUUC-Eeu-034582	Erinaceus europaeus	87.46	1.00e-180	625.00
IUUC-Fca-035582	Felis catus	90.39	0.00e+00	1013.00
IUUC-Fal-037320	Ficedula albicollis	85.58	0.00e+00	947.00
IUUC-Gmo-038992	Gadus morhua	95.21	0.00e+00	1071.00
IUUC-Gga-041262	Gallus gallus	85.58	0.00e+00	947.00
IUUC-Gac-042461	Gasterosteus aculeatus	96.67	0.00e+00	1094.00
IUUC-Ggo-044469	Gorilla gorilla	90.39	0.00e+00	1014.00
IUUC-Hsa-045723	Homo sapiens	90.39	0.00e+00	1014.00
IUUC-Itr-048519	Ictidomys tridecemlineatus	90.39	0.00e+00	1013.00
IUUC-Lch-049825	Latimeria chalumnae	89.09	0.00e+00	993.00
IUUC-Loc-052531	Lepisosteus oculatus	91.87	0.00e+00	1050.00
IUUC-Laf-053659	Loxodonta africana	90.39	0.00e+00	1012.00
IUUC-Mcc-055039	Macaca mulatta	84.62	0.00e+00	941.00
IUUC-Mga-060067	Meleagris gallopavo	90.96	0.00e+00	1016.00
IUUC-Mmr-061194	Microcebus murinus	90.39	0.00e+00	1013.00
IUUC-Mdo-062628	Monodelphis domestica	90.57	0.00e+00	1015.00
IUUC-Mmu-063896	Mus musculus	90.76	0.00e+00	1017.00
IUUC-Mpu-066333	Mustela putorius furo	90.57	0.00e+00	1016.00
IUUC-Mlu-067315	Myotis lucifugus	90.39	0.00e+00	1013.00
IUUC-Nle-068978	Nomascus leucogenys	85.03	0.00e+00	942.00
IUUC-Ont-072516	Oreochromis niloticus	98.15	0.00e+00	1110.00
IUUC-Oan-073714	Ornithorhynchus anatinus	94.51	0.00e+00	910.00
IUUC-Ocu-074284	Oryctolagus cuniculus	90.39	0.00e+00	1014.00
IUUC-Ola-087431	Oryzias latipes	97.78	0.00e+00	1101.00
IUUC-Oga-088789	Otolemur garnettii	84.84	0.00e+00	939.00
IUUC-Oar-089408	Ovis aries	90.57	0.00e+00	1015.00
IUUC-Ptr-091068	Pan troglodytes	90.39	0.00e+00	1014.00
IUUC-Pan-092217	Papio anubis	90.39	0.00e+00	1014.00
IUUC-Psi-093602	Pelodiscus sinensis	90.76	0.00e+00	1017.00
IUUC-Pfo-097084	Poecilia formosa	97.97	0.00e+00	1105.00
IUUC-Pab-097673	Pongo abelii	90.02	0.00e+00	1010.00
IUUC-Pca-100245	Procavia capensis	90.20	0.00e+00	919.00
IUUC-Pva-102645	Pteropus vampyrus	89.44	0.00e+00	986.00
IUUC-Rno-105372	Rattus norvegicus	90.57	0.00e+00	1015.00
IUUC-Sha-107637	Sarcophilus harrisii	90.57	0.00e+00	1010.00
IUUC-Sar-113016	Sorex araneus	79.85	0.00e+00	873.00
IUUC-Ssc-116389	Sus scrofa	90.20	0.00e+00	1012.00
IUUC-Tgu-117206	Taeniopygia guttata	85.58	0.00e+00	947.00
IUUC-Tni-120031	Tetraodon nigroviridis	98.71	0.00e+00	1110.00
IUUC-Tbe-127707	Tupaia belangeri	89.92	0.00e+00	922.00
IUUC-Ttr-129145	Tursiops truncatus	90.39	0.00e+00	1013.00
IUUC-Vpa-130815	Vicugna pacos	88.10	0.00e+00	962.00
IUUC-Xtr-132293	Xenopus tropicalis	84.84	0.00e+00	940.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence