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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046556
UUCD1 version UUC-HoS-00266
Ensembl Protein ID ENSP00000369855.4
UniProt Accession Q96DX5; A8K8A5; Q9BVF5; Q9NWS5; Q9Y4T3; ASB9_HUMAN
Genbank Protein ID BAA91302.1; BAF84959.1; CAB45706.2; EAW98871.1; EAW98874.1; AAH01244.1; AAH13172.1
Protein Name Ankyrin repeat and SOCS box protein 9
Genbank Nucleotide ID AK000643; AK292270; AL080091; CH471074; CH471074; BC001244; BC013172
Gene Name ASB9
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000102048.15 ENST00000477346.6 ENSP00000473542.1
ENSG00000102048.15 ENST00000380483.7 ENSP00000369850.3
ENSG00000102048.15 ENST00000380485.7 ENSP00000369852.3
ENSG00000102048.15 ENST00000380488.8 ENSP00000369855.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusUniProtBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box SOCS 17148442
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 1.30e-17 65.1 246 293
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box
   S: 2    sklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLly 49
           ++l+l r+ p+SL++LCRl+Ir+c+g+q++++i+kL LP++Lk++Ll+
   Q: 246  AQLFLEREGPPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLH 293
           689999*****************************************9 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A.
 Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A.
Protein Sequence
(Fasta)
MDGKQGGMDG SKPAGPRDFP GIRLLSNPLM GDAVSDWSPM HEAAIHGHQL SLRNLISQGW 60
AVNIITADHV SPLHEACLGG HLSCVKILLK HGAQVNGVTA DWHTPLFNAC VSGSWDCVNL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046556|E3,SOCS|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTACAGATGG CCAGGGCGTG CTGTGCATGT TACTGTGCAA GCAATTCAGC AGGGCTGCTG 60
CAAAACCAGC TTTCTCAGCT CTGGGTGCTC GGGCTTGTCT CCATAACAAG CTACCATGTA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046556|E3,SOCS|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0496--Mitochondrion
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001496--SOCS_box
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50225--SOCS
Pfam

PF12796--Ank_2
PF07525--SOCS_box
SMART

SM00248--ANK
SM00969--SOCS_box
Gene Ontology

GO:0005739--C:mitochondrion
GO:0035556--P:intracellular signal transduction
GO:0045732--P:positive regulation of protein catabolic process
GO:0016567--P:protein ubiquitination
KEGG hsa:140462
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001511 Ailuropoda melanoleuca 78.91 1.00e-132 465.00
IUUC-Apl-004034 Anas platyrhynchos 65.98 5.00e-112 397.00
IUUC-Aca-004804 Anolis carolinensis 61.56 1.00e-105 375.00
IUUC-Bta-013012 Bos taurus 75.51 1.00e-128 452.00
IUUC-Cja-019500 Callithrix jacchus 83.33 6.00e-146 509.00
IUUC-Cfa-020277 Canis familiaris 78.38 1.00e-126 445.00
IUUC-Cpo-022413 Cavia porcellus 74.49 3.00e-129 454.00
IUUC-Csa-023256 Chlorocebus sabaeus 94.90 4.00e-164 570.00
IUUC-Dno-030092 Dasypus novemcinctus 72.36 1.00e-117 416.00
IUUC-Dor-030215 Dipodomys ordii 66.55 2.00e-117 415.00
IUUC-Ete-032417 Echinops telfairi 69.79 1.00e-95 342.00
IUUC-Eca-033417 Equus caballus 80.95 1.00e-139 489.00
IUUC-Eeu-034447 Erinaceus europaeus 51.74 3.00e-76 278.00
IUUC-Fca-035857 Felis catus 73.47 9.00e-125 439.00
IUUC-Fal-037651 Ficedula albicollis 67.91 4.00e-113 400.00
IUUC-Gmo-039177 Gadus morhua 43.85 5.00e-56 210.00
IUUC-Gga-040657 Gallus gallus 65.95 2.00e-104 371.00
IUUC-Gac-041598 Gasterosteus aculeatus 47.35 6.00e-67 247.00
IUUC-Ggo-044466 Gorilla gorilla 97.63 3.00e-167 580.00
IUUC-Itr-048278 Ictidomys tridecemlineatus 83.15 6.00e-137 479.00
IUUC-Lch-049860 Latimeria chalumnae 61.34 3.00e-98 351.00
IUUC-Laf-054389 Loxodonta africana 80.61 8.00e-122 429.00
IUUC-Mcc-055379 Macaca mulatta 95.24 1.00e-164 572.00
IUUC-Meu-056744 Macropus eugenii 66.31 2.00e-108 385.00
IUUC-Mga-059201 Meleagris gallopavo 70.63 6.00e-102 363.00
IUUC-Mmr-060754 Microcebus murinus 80.07 3.00e-129 454.00
IUUC-Mdo-062259 Monodelphis domestica 69.33 4.00e-92 330.00
IUUC-Mmu-063265 Mus musculus 74.15 1.00e-125 442.00
IUUC-Mpu-065935 Mustela putorius furo 76.87 5.00e-130 457.00
IUUC-Mlu-066959 Myotis lucifugus 73.04 7.00e-125 439.00
IUUC-Nle-069305 Nomascus leucogenys 96.94 2.00e-166 578.00
IUUC-Opr-070484 Ochotona princeps 77.06 3.00e-115 407.00
IUUC-Ont-072570 Oreochromis niloticus 47.40 9.00e-71 260.00
IUUC-Oan-073662 Ornithorhynchus anatinus 67.35 9.00e-116 409.00
IUUC-Ocu-074056 Oryctolagus cuniculus 79.93 2.00e-129 454.00
IUUC-Ola-087123 Oryzias latipes 48.35 1.00e-66 246.00
IUUC-Oga-089102 Otolemur garnettii 75.00 7.00e-132 462.00
IUUC-Oar-090040 Ovis aries 76.79 2.00e-128 451.00
IUUC-Ptr-090773 Pan troglodytes 99.66 2.00e-172 598.00
IUUC-Pan-092542 Papio anubis 95.58 3.00e-165 573.00
IUUC-Psi-093549 Pelodiscus sinensis 65.99 7.00e-112 396.00
IUUC-Pva-102452 Pteropus vampyrus 71.08 8.00e-119 419.00
IUUC-Rno-105267 Rattus norvegicus 75.51 8.00e-128 449.00
IUUC-Sha-107096 Sarcophilus harrisii 69.65 1.00e-104 372.00
IUUC-Sar-113377 Sorex araneus 67.79 3.00e-59 220.00
IUUC-Ssc-115817 Sus scrofa 80.00 5.00e-86 310.00
IUUC-Tgu-117418 Taeniopygia guttata 65.51 5.00e-106 377.00
IUUC-Tru-117578 Takifugu rubripes 48.89 4.00e-67 248.00
IUUC-Tsy-118843 Tarsius syrichta 71.43 2.00e-117 415.00
IUUC-Tbe-127670 Tupaia belangeri 77.45 5.00e-123 433.00
IUUC-Ttr-129029 Tursiops truncatus 78.91 3.00e-126 444.00
IUUC-Vpa-130055 Vicugna pacos 81.29 1.00e-138 485.00
IUUC-Xtr-132425 Xenopus tropicalis 59.70 4.00e-93 334.00
Created Date 25-Jun-2017

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