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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046465
Ensembl Protein ID ENSP00000366161.5
UniProt Accession O76080; A8K484; ZFAN5_HUMAN
Genbank Protein ID AAC61801.1; AAC42601.1; AAC42602.1; BAF83538.1; CAD13440.1; EAW62533.1; AAH11018.1; AAH27707.1; AAH73131.1
Protein Name AN1-type zinc finger protein 5; Zinc finger A20 domain-containing protein 2; Zinc finger protein 216
Genbank Nucleotide ID AF062072; AF062346; AF062347; AK290849; AL135924; CH471089; BC011018; BC027707; BC073131
Gene Name ZFAND5; ZA20D2; ZNF216
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000107372.12 ENST00000376962.9 ENSP00000366161.5
ENSG00000107372.12 ENST00000376956.3 ENSP00000366155.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACRepTar
miRNAMapSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTInWeb_IM
Disease-associated Information
GWASdbOMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/ZnF/ZnF_A20 ZnF_A20 21923101
Classification
Family E-value Score Start End
UBD/ZnF/ZnF_A20 2.70e-20 73.6 8 42
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/ZnF/ZnF_A20
   S: 1    dpskllCkkgCgfYGnpetngyCSkCyreelrrrr 35
           +p+++lC++gCgfYGnp+tng+CS+Cy+e+l+r++
   Q: 8    TPGPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQQ 42
           69*******************************96 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.
 Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.
Protein Sequence
(Fasta)
MAQETNQTPG PMLCSTGCGF YGNPRTNGMC SVCYKEHLQR QQNSGRMSPM GTASGSNSPT 60
SDSASVQRAD TSLNNCEGAA GSTSEKSRNV PVAALPVTQQ MTEMSISRED KITTPKTEVS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046465|UBD,ZnF_A20|Homo sapiens
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Nucleotide Sequence
(Fasta)
ACAGCCCGGG CGCCGGGCGG CGAGTGCGTT AGTCGGCCGG GACGCGGAGC TGTGTGCATC 60
TCCTACGCGG GCTCGCTCGC TCCCGGGAGC CGCGCAGCTT CCCCGGCGGT GGCAGGAGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046465|UBD,ZnF_A20|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR002653--Znf_A20
IPR000058--Znf_AN1
PROSITE

PS51036--ZF_A20
PS51039--ZF_AN1
Pfam

PF01754--zf-A20
PF01428--zf-AN1
SMART

SM00259--ZnF_A20
SM00154--ZnF_AN1
Gene Ontology

GO:0005737--C:cytoplasm
GO:0003677--F:DNA binding
GO:0008270--F:zinc ion binding
GO:0060324--P:face development
GO:0010761--P:fibroblast migration
GO:0001701--P:in utero embryonic development
GO:0048008--P:platelet-derived growth factor receptor signaling pathway
GO:0003016--P:respiratory system process
GO:0048705--P:skeletal system morphogenesis
GO:0048745--P:smooth muscle tissue development
GO:0001944--P:vasculature development
KEGG hsa:7763
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001163 Aegilops tauschii 32.37 4.00e-27 114.00
IUUC-Aml-002088 Ailuropoda melanoleuca 99.53 1.00e-103 369.00
IUUC-Atr-002750 Amborella trichopoda 66.13 1.00e-22 99.00
IUUC-Apl-003370 Anas platyrhynchos 92.06 4.00e-99 353.00
IUUC-Aca-004848 Anolis carolinensis 91.55 6.00e-92 329.00
IUUC-Aly-006499 Arabidopsis lyrata 29.06 2.00e-21 95.10
IUUC-Ath-006840 Arabidopsis thaliana 33.00 1.00e-24 105.00
IUUC-Ame-011611 Astyanax mexicanus 67.29 3.00e-59 221.00
IUUC-Bta-012511 Bos taurus 98.59 7.00e-102 362.00
IUUC-Bdi-014584 Brachypodium distachyon 35.68 1.00e-30 125.00
IUUC-Cel-018374 Caenorhabditis elegans 36.45 4.00e-32 130.00
IUUC-Cja-019481 Callithrix jacchus 100.00 1.00e-102 365.00
IUUC-Cfa-020427 Canis familiaris 100.00 5.00e-103 366.00
IUUC-Cpo-021969 Cavia porcellus 100.00 4.00e-103 367.00
IUUC-Csa-024124 Chlorocebus sabaeus 100.00 5.00e-103 366.00
IUUC-Cho-024982 Choloepus hoffmanni 88.73 5.00e-97 346.00
IUUC-Cin-025685 Ciona intestinalis 42.93 5.00e-37 147.00
IUUC-Dre-028143 Danio rerio 62.84 2.00e-75 275.00
IUUC-Dno-029194 Dasypus novemcinctus 98.12 1.00e-101 362.00
IUUC-Dor-031104 Dipodomys ordii 99.06 2.00e-102 364.00
IUUC-Ete-032527 Echinops telfairi 97.65 2.00e-101 361.00
IUUC-Eca-034160 Equus caballus 99.53 1.00e-102 365.00
IUUC-Eeu-034800 Erinaceus europaeus 98.12 8.00e-88 316.00
IUUC-Fca-035481 Felis catus 100.00 5.00e-103 366.00
IUUC-Fal-036728 Ficedula albicollis 90.14 8.00e-109 385.00
IUUC-Gmo-039236 Gadus morhua 67.14 9.00e-76 276.00
IUUC-Gga-040753 Gallus gallus 81.78 7.00e-84 303.00
IUUC-Gac-042356 Gasterosteus aculeatus 65.89 3.00e-68 250.00
IUUC-Gma-043085 Glycine max 35.92 7.00e-27 113.00
IUUC-Ggo-044975 Gorilla gorilla 99.53 4.00e-102 363.00
IUUC-Hvu-047179 Hordeum vulgare 36.27 2.00e-28 118.00
IUUC-Itr-047997 Ictidomys tridecemlineatus 96.71 2.00e-98 351.00
IUUC-Lch-049431 Latimeria chalumnae 83.33 6.00e-88 316.00
IUUC-Lpe-051068 Leersia perrieri 33.49 8.00e-28 116.00
IUUC-Loc-051838 Lepisosteus oculatus 71.89 3.00e-83 300.00
IUUC-Laf-054572 Loxodonta africana 99.06 8.00e-109 386.00
IUUC-Meu-056305 Macropus eugenii 96.97 2.00e-93 334.00
IUUC-Mtr-058809 Medicago truncatula 35.78 4.00e-28 117.00
IUUC-Mga-059903 Meleagris gallopavo 80.37 2.00e-82 298.00
IUUC-Mdo-062494 Monodelphis domestica 97.18 5.00e-104 370.00
IUUC-Mmu-063632 Mus musculus 98.59 5.00e-102 363.00
IUUC-Mac-064854 Musa acuminata 32.69 2.00e-26 111.00
IUUC-Mpu-065918 Mustela putorius furo 99.53 1.00e-103 369.00
IUUC-Mlu-067594 Myotis lucifugus 99.53 5.00e-103 366.00
IUUC-Nle-069326 Nomascus leucogenys 97.65 2.00e-112 397.00
IUUC-Opr-071113 Ochotona princeps 96.71 2.00e-100 358.00
IUUC-Ont-071860 Oreochromis niloticus 66.20 2.00e-72 265.00
IUUC-Oan-073601 Ornithorhynchus anatinus 92.02 4.00e-88 317.00
IUUC-Ocu-073952 Oryctolagus cuniculus 99.06 2.00e-101 361.00
IUUC-Oba-075600 Oryza barthii 32.06 2.00e-28 118.00
IUUC-Obr-076269 Oryza brachyantha 33.33 3.00e-28 118.00
IUUC-Ogl-077456 Oryza glaberrima 32.06 2.00e-28 118.00
IUUC-Ogu-078105 Oryza glumaepatula 32.06 2.00e-28 118.00
IUUC-Oin-079326 Oryza indica 32.06 2.00e-28 118.00
IUUC-Olo-081039 Oryza longistaminata 32.06 2.00e-28 118.00
IUUC-Ome-081197 Oryza meridionalis 32.06 4.00e-28 117.00
IUUC-Oni-082851 Oryza nivara 32.06 3.00e-28 118.00
IUUC-Opu-083820 Oryza punctata 31.58 2.00e-28 118.00
IUUC-Oru-084563 Oryza rufipogon 32.06 2.00e-28 118.00
IUUC-Osa-085931 Oryza sativa 32.06 2.00e-28 118.00
IUUC-Ola-087109 Oryzias latipes 68.22 3.00e-79 287.00
IUUC-Oga-088394 Otolemur garnettii 99.06 2.00e-103 367.00
IUUC-Oar-089649 Ovis aries 98.59 7.00e-102 362.00
IUUC-Pan-092692 Papio anubis 100.00 5.00e-103 366.00
IUUC-Psi-093090 Pelodiscus sinensis 93.43 6.00e-88 316.00
IUUC-Pma-094271 Petromyzon marinus 51.97 7.00e-58 216.00
IUUC-Pfo-096087 Poecilia formosa 66.36 1.00e-69 255.00
IUUC-Pab-098585 Pongo abelii 100.00 5.00e-103 366.00
IUUC-Pop-099528 Populus trichocarpa 37.02 8.00e-28 116.00
IUUC-Pca-100951 Procavia capensis 100.00 6.00e-89 319.00
IUUC-Ppe-101886 Prunus persica 33.50 7.00e-29 119.00
IUUC-Pva-102118 Pteropus vampyrus 99.53 6.00e-102 363.00
IUUC-Pyt-104769 Pyrenophora triticirepentis 33.33 1.00e-03 37.70
IUUC-Rno-105890 Rattus norvegicus 98.12 9.00e-102 362.00
IUUC-Sha-106942 Sarcophilus harrisii 97.65 1.00e-114 405.00
IUUC-Smo-109137 Selaginella moellendorffii 58.02 2.00e-23 102.00
IUUC-Sit-110684 Setaria italica 34.93 8.00e-31 126.00
IUUC-Sly-111440 Solanum lycopersicum 37.02 1.00e-29 122.00
IUUC-Stu-112819 Solanum tuberosum 36.76 3.00e-26 111.00
IUUC-Sar-113241 Sorex araneus 98.59 3.00e-101 360.00
IUUC-Sbi-114497 Sorghum bicolor 36.67 2.00e-28 118.00
IUUC-Ssc-115824 Sus scrofa 99.53 2.00e-102 364.00
IUUC-Tgu-116588 Taeniopygia guttata 93.43 5.00e-116 409.00
IUUC-Tru-118060 Takifugu rubripes 65.12 5.00e-73 266.00
IUUC-Tsy-119054 Tarsius syrichta 91.55 2.00e-87 315.00
IUUC-Tni-120082 Tetraodon nigroviridis 65.73 7.00e-77 280.00
IUUC-Tca-121832 Theobroma cacao 36.06 2.00e-26 111.00
IUUC-Tae-123386 Triticum aestivum 36.27 1.00e-28 119.00
IUUC-Tur-126864 Triticum urartu 33.33 1.00e-27 116.00
IUUC-Tbe-127974 Tupaia belangeri 98.86 1.00e-91 328.00
IUUC-Ttr-129163 Tursiops truncatus 99.06 7.00e-101 360.00
IUUC-Vpa-130351 Vicugna pacos 99.53 4.00e-102 363.00
IUUC-Vvi-131696 Vitis vinifera 35.12 4.00e-28 117.00
IUUC-Xtr-132723 Xenopus tropicalis 88.26 7.00e-93 333.00
IUUC-Xma-134104 Xiphophorus maculatus 67.14 2.00e-72 264.00
Created Date 25-Jun-2017

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