iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Csa-024035

Ensembl Protein ID

ENSCSAP00000011276.1

UniProt Accession

A0A0D9RRN7; A0A0D9RRN7_CHLSB

Genbank Protein ID

ENSCSAP00000011276

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AQIB01131825

Gene Name

USP19

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAG00000015179.1	ENSCSAT00000013270.1	ENSCSAP00000011276.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.40e-115	384.8	527	1244

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl NlgNtC+mNSv+Q+Lsn++elr+++++ +++ ++n +np ++ g+l+  ++ l+++lwk++++a++p++l+++++++a++f+g
   Q: 527  TGLVNLGNTCFMNSVIQSLSNTRELRDFFHDrSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTG 613
           7*****************************999****************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           y+q+DaqEf+aflld+l+e+l++ +nkp++e+ ++d   ++de     a++++k++n+s+i+dlFqgq+ks+++c+ c++vs +++p
   Q: 614  YAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSD--GRPDEvvaeeAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDP 698
           ********************************9999..6666666777*************************************** PP
   S: 169  fldlslpvpgkeetkke...................................................................... 185
           fl+l++p+p+k++  +                                                                       
   Q: 699  FLYLPVPLPQKQKVLPVfyfarephskpikflvsvskenstasevldslsqsvrvkpenlrlaeviknrfhrvflpshsldtvspsd 785
           ************87666********************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 786  mllcfellspelakervvvlevqqrpqvpsvpiskcaacqrkqqsedeklkrctrcyrvgycnqlcqkthwpdhkglcrpenigypf 872
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 873  lvsvpasrltyarlaqllegyarysvsvfqppfqpgrmalesqspgcttllstgsleagdserdpiqppelqlvtpmaegdtglprv 959
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 960  waapdrgpvpstsgisseilasgptevgslpvgervsrpeaavpgyqhpseamnahtpqffiykidssnreqrledkgdtplelgdd 1046
           *************************************************************************************** PP
   S: 186  ..........................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevL 230
                                                     +l++cL+ ft++e l  e+++yc++ck+++ea+k+l l++lP+vL
   Q: 1047 cslalvwrnnerlqefvlvaskelecaedpgsageaaraghfTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVL 1133
           *************************************************************************************** PP
   S: 231  ilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk........Wll 308
           i++LkRfsf++  +++ kin+ vefp + Ldls+fc+ ++e+q    +Y+L+av++H+G++ +GHY+a+++  +++        W l
   Q: 1134 IVQLKRFSFRSFIWRD-KINDLVEFPVRnLDLSKFCIGQKEEQ--LPSYDLYAVINHYGGMIGGHYTACARLPNDRssqrsdvgWRL 1217
           ************8886.**********9**********99888..9**************************544445566777*** PP
   S: 309  fdDskVtevkeeevleetgstaYvlfYkrr 338
           fdDs+Vt+v+e++v++   + aYvlfY+rr
   Q: 1218 FDDSTVTTVDESQVVT---RYAYVLFYRRR 1244
           ****************...********996 PP

Organism

Chlorocebus sabaeus

Protein Sequence
(Fasta)

MSGGASATGP RRGPPGLEDA TSKKKQKDRA NQESKDGDPR KELLLDWRQS AEEVIVKLHV 60
GVGPLQLEDV DAAFTDTDCV VRFAGGQQWG GVFYAEIKSS CAKVQTCKGS LLHLTLPKKV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGGAACCGG AACCGACCTG ACGCCGGAAC CGGAACGGAG AGCGGGTTGC CAGGGCCCGA 60
AGAGGGCTGG CTGCGGCGGT CTCGCTTGGT GAGTGGAGCG GGCTGTAACT CGCCTGCTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR007052--CS_dom
IPR008978--HSP20-like_chaperone
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND

PROSITE

PS51203--CS
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2

Pfam

PF04969--CS
PF00443--UCH
PF01753--zf-MYND

Gene Ontology

GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1901799--P:negative regulation of proteasomal protein catabolic process
GO:0048642--P:negative regulation of skeletal muscle tissue development
GO:0050821--P:protein stabilization
GO:1900037--P:regulation of cellular response to hypoxia
GO:1904292--P:regulation of ERAD pathway
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001999	Ailuropoda melanoleuca	93.49	0.00e+00	2293.00
IUUC-Apl-003368	Anas platyrhynchos	69.87	0.00e+00	1685.00
IUUC-Aca-004267	Anolis carolinensis	67.17	0.00e+00	1704.00
IUUC-Ame-010970	Astyanax mexicanus	70.34	0.00e+00	1348.00
IUUC-Bta-012905	Bos taurus	87.45	0.00e+00	2271.00
IUUC-Cel-018257	Caenorhabditis elegans	43.24	2.00e-92	334.00
IUUC-Cja-018789	Callithrix jacchus	94.95	0.00e+00	2339.00
IUUC-Cfa-021004	Canis familiaris	92.56	0.00e+00	2289.00
IUUC-Cpo-021529	Cavia porcellus	89.56	0.00e+00	2269.00
IUUC-Cho-025036	Choloepus hoffmanni	83.89	0.00e+00	1209.00
IUUC-Cin-025451	Ciona intestinalis	43.41	9.00e-86	311.00
IUUC-Csv-025931	Ciona savignyi	36.59	4.00e-111	395.00
IUUC-Dre-028556	Danio rerio	68.74	0.00e+00	1325.00
IUUC-Dno-029240	Dasypus novemcinctus	88.85	0.00e+00	2132.00
IUUC-Dor-030495	Dipodomys ordii	95.60	0.00e+00	1204.00
IUUC-Ete-032741	Echinops telfairi	91.81	0.00e+00	1863.00
IUUC-Eca-033661	Equus caballus	92.08	0.00e+00	2305.00
IUUC-Eeu-034648	Erinaceus europaeus	89.15	0.00e+00	806.00
IUUC-Fca-035646	Felis catus	93.33	0.00e+00	2268.00
IUUC-Fal-037094	Ficedula albicollis	68.27	0.00e+00	1737.00
IUUC-Gmo-038869	Gadus morhua	72.59	0.00e+00	858.00
IUUC-Gga-041170	Gallus gallus	66.16	0.00e+00	1678.00
IUUC-Gac-041901	Gasterosteus aculeatus	67.90	0.00e+00	1324.00
IUUC-Ggo-044708	Gorilla gorilla	97.72	0.00e+00	2349.00
IUUC-Hsa-046791	Homo sapiens	97.32	0.00e+00	2052.00
IUUC-Itr-048892	Ictidomys tridecemlineatus	91.98	0.00e+00	2206.00
IUUC-Lch-050456	Latimeria chalumnae	53.36	0.00e+00	1170.00
IUUC-Loc-052861	Lepisosteus oculatus	57.49	0.00e+00	1153.00
IUUC-Laf-053788	Loxodonta africana	91.15	0.00e+00	2224.00
IUUC-Mcc-055693	Macaca mulatta	98.11	0.00e+00	2464.00
IUUC-Meu-055921	Macropus eugenii	78.85	0.00e+00	1476.00
IUUC-Mga-059879	Meleagris gallopavo	69.34	0.00e+00	1670.00
IUUC-Mmr-060802	Microcebus murinus	94.00	0.00e+00	2305.00
IUUC-Mdo-061856	Monodelphis domestica	82.55	0.00e+00	1568.00
IUUC-Mmu-063874	Mus musculus	89.91	0.00e+00	2262.00
IUUC-Mpu-066166	Mustela putorius furo	93.49	0.00e+00	2262.00
IUUC-Nle-070161	Nomascus leucogenys	97.31	0.00e+00	2409.00
IUUC-Opr-071015	Ochotona princeps	92.26	0.00e+00	1928.00
IUUC-Ont-072308	Oreochromis niloticus	66.64	0.00e+00	1382.00
IUUC-Oan-072723	Ornithorhynchus anatinus	65.72	0.00e+00	1583.00
IUUC-Ocu-073938	Oryctolagus cuniculus	93.78	0.00e+00	2271.00
IUUC-Ola-086375	Oryzias latipes	69.14	0.00e+00	1362.00
IUUC-Oga-088297	Otolemur garnettii	93.20	0.00e+00	2219.00
IUUC-Oar-089675	Ovis aries	81.56	0.00e+00	1991.00
IUUC-Ptr-091621	Pan troglodytes	97.13	0.00e+00	2052.00
IUUC-Pan-092118	Papio anubis	99.45	0.00e+00	2489.00
IUUC-Pma-094154	Petromyzon marinus	52.02	3.00e-115	409.00
IUUC-Pfo-097246	Poecilia formosa	59.07	0.00e+00	1422.00
IUUC-Pab-098551	Pongo abelii	96.36	0.00e+00	2032.00
IUUC-Pca-100158	Procavia capensis	87.16	0.00e+00	2194.00
IUUC-Pva-103160	Pteropus vampyrus	92.33	0.00e+00	2269.00
IUUC-Rno-105355	Rattus norvegicus	90.13	0.00e+00	2270.00
IUUC-Sha-107057	Sarcophilus harrisii	75.39	0.00e+00	1822.00
IUUC-Sar-113011	Sorex araneus	89.17	0.00e+00	1507.00
IUUC-Ssc-115761	Sus scrofa	92.87	0.00e+00	2310.00
IUUC-Tgu-116956	Taeniopygia guttata	64.41	0.00e+00	795.00
IUUC-Tru-118739	Takifugu rubripes	67.24	0.00e+00	1363.00
IUUC-Tsy-118827	Tarsius syrichta	88.23	0.00e+00	1259.00
IUUC-Tni-119921	Tetraodon nigroviridis	59.97	0.00e+00	1408.00
IUUC-Tbe-128017	Tupaia belangeri	91.00	0.00e+00	1910.00
IUUC-Ttr-128869	Tursiops truncatus	92.21	0.00e+00	2261.00
IUUC-Vpa-130427	Vicugna pacos	95.73	0.00e+00	931.00
IUUC-Xtr-132734	Xenopus tropicalis	60.83	0.00e+00	1547.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence