iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-092118

Ensembl Protein ID

ENSPANP00000008058.1

UniProt Accession

A0A096N6F8; A0A096N6F8_PAPAN

Genbank Protein ID

ENSPANP00000008058

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHZZ01098183

Gene Name

USP19

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000008390.1	ENSPANT00000020663.1	ENSPANP00000008058.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.80e-115	384.4	667	1384

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl NlgNtC+mNSv+Q+Lsn++elr+++++ +++ ++n +np ++ g+l+  ++ l+++lwk++++a++p++l+++++++a++f+g
   Q: 667  TGLVNLGNTCFMNSVIQSLSNTRELRDFFHDrSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTG 753
           7*****************************999****************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           y+q+DaqEf+aflld+l+e+l++ +nkp++e+ ++d   ++de     a++++k++n+s+i+dlFqgq+ks+++c+ c++vs +++p
   Q: 754  YAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSD--GRPDEvvaeeAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDP 838
           ********************************9999..6666666777*************************************** PP
   S: 169  fldlslpvpgkeetkke...................................................................... 185
           fl+l++p+p+k++  +                                                                       
   Q: 839  FLYLPVPLPQKQKVLPVfyfarephskpikflvsvskenstasevldslsqsvrvkpenlrlaeviknrfhrvflpshsldtvspsd 925
           ************87666********************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 926  mllcfellspelakervvvlevqqrpqvpsvpiskcaacqrkqqsedeklkrctrcyrvgycnqlcqkthwpdhkglcrpenigypf 1012
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 1013 lvsvpasrltyarlaqllegyarysvsvfqppfqpgrmalesqspgcttllstgsleagdserdpiqppelqlvtpmaegdtglprv 1099
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 1100 waapdrgpvpstsgisseilasgptevgslpagervsrpeaavpgyqhpseamnahtpqffiykidssnreqrledkgdtplelgdd 1186
           *************************************************************************************** PP
   S: 186  ..........................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevL 230
                                                     +l++cL+ ft++e l  e+++yc++ck+++ea+k+l l++lP+vL
   Q: 1187 cslalvwrnnerlqefvlvaskelecaedpgsageaaraghfTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVL 1273
           *************************************************************************************** PP
   S: 231  ilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk........Wll 308
           i++LkRfsf++  +++ kin+ vefp + Ldls+fc+ ++e+q    +Y+L+av++H+G++ +GHY+a+++  +++        W l
   Q: 1274 IVQLKRFSFRSFIWRD-KINDLVEFPVRnLDLSKFCIGQKEEQ--LPSYDLYAVINHYGGMIGGHYTACARLPNDRssqrsdvgWRL 1357
           ************8886.**********9**********99888..9**************************544445566777*** PP
   S: 309  fdDskVtevkeeevleetgstaYvlfYkrr 338
           fdDs+Vt+v+e++v++   + aYvlfY+rr
   Q: 1358 FDDSTVTTVDESQVVT---RYAYVLFYRRR 1384
           ****************...********996 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

PERRAGCQGP KRAGCGGLAR LLVPCWRIWP RRVAKIAGPG RKRRSPDPDA VAGPGALWLS 60
TKRLKMSGGA SATGPRRGPP GLEDATSKKK QKDRANQESK DGDPRKGIQI GVWEMTFLLF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGGAACGGA GAGCGGGTTG CCAGGGCCCG AAGAGGGCTG GCTGCGGCGG TCTCGCTCGG 60
TGAGTGGAGC GGGCTGCAAC TCGCCTGCTT GGCCGCAGCG GGGAGGCCGC AACGCGCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR007052--CS_dom
IPR008978--HSP20-like_chaperone
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND

PROSITE

PS51203--CS
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2

Pfam

PF04969--CS
PF00443--UCH
PF01753--zf-MYND

Gene Ontology

GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1901799--P:negative regulation of proteasomal protein catabolic process
GO:0048642--P:negative regulation of skeletal muscle tissue development
GO:0050821--P:protein stabilization
GO:1900037--P:regulation of cellular response to hypoxia
GO:1904292--P:regulation of ERAD pathway
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001999	Ailuropoda melanoleuca	90.51	0.00e+00	2505.00
IUUC-Apl-003368	Anas platyrhynchos	66.78	0.00e+00	1783.00
IUUC-Aca-004267	Anolis carolinensis	67.59	0.00e+00	1663.00
IUUC-Ame-010970	Astyanax mexicanus	70.34	0.00e+00	1348.00
IUUC-Bta-012905	Bos taurus	89.81	0.00e+00	2466.00
IUUC-Cel-018257	Caenorhabditis elegans	43.24	1.00e-92	335.00
IUUC-Cja-018789	Callithrix jacchus	93.73	0.00e+00	2455.00
IUUC-Cfa-021004	Canis familiaris	90.05	0.00e+00	2505.00
IUUC-Cpo-021529	Cavia porcellus	86.20	0.00e+00	2265.00
IUUC-Csa-024035	Chlorocebus sabaeus	99.45	0.00e+00	2490.00
IUUC-Cho-025036	Choloepus hoffmanni	79.05	0.00e+00	1207.00
IUUC-Cin-025451	Ciona intestinalis	43.41	9.00e-86	311.00
IUUC-Csv-025931	Ciona savignyi	36.59	4.00e-111	395.00
IUUC-Dre-028556	Danio rerio	68.74	0.00e+00	1326.00
IUUC-Dno-029240	Dasypus novemcinctus	90.28	0.00e+00	2077.00
IUUC-Dor-030495	Dipodomys ordii	95.76	0.00e+00	1203.00
IUUC-Ete-032741	Echinops telfairi	91.81	0.00e+00	1860.00
IUUC-Eca-033661	Equus caballus	88.88	0.00e+00	2306.00
IUUC-Eeu-034648	Erinaceus europaeus	89.79	0.00e+00	811.00
IUUC-Fca-035646	Felis catus	90.61	0.00e+00	2504.00
IUUC-Fal-037094	Ficedula albicollis	68.99	0.00e+00	1700.00
IUUC-Gmo-038869	Gadus morhua	72.59	0.00e+00	858.00
IUUC-Gga-041170	Gallus gallus	66.79	0.00e+00	1646.00
IUUC-Gac-041901	Gasterosteus aculeatus	65.90	0.00e+00	1322.00
IUUC-Ggo-044708	Gorilla gorilla	95.45	0.00e+00	2489.00
IUUC-Hsa-046791	Homo sapiens	97.70	0.00e+00	2058.00
IUUC-Itr-048892	Ictidomys tridecemlineatus	89.04	0.00e+00	2272.00
IUUC-Lch-050456	Latimeria chalumnae	51.08	0.00e+00	1158.00
IUUC-Loc-052861	Lepisosteus oculatus	57.40	0.00e+00	1152.00
IUUC-Laf-053788	Loxodonta africana	88.00	0.00e+00	2223.00
IUUC-Mcc-055693	Macaca mulatta	96.03	0.00e+00	2603.00
IUUC-Meu-055921	Macropus eugenii	78.95	0.00e+00	1476.00
IUUC-Mga-059879	Meleagris gallopavo	66.11	0.00e+00	1706.00
IUUC-Mmr-060802	Microcebus murinus	91.04	0.00e+00	2393.00
IUUC-Mdo-061856	Monodelphis domestica	79.57	0.00e+00	1566.00
IUUC-Mmu-063874	Mus musculus	86.21	0.00e+00	2253.00
IUUC-Mpu-066166	Mustela putorius furo	90.46	0.00e+00	2501.00
IUUC-Nle-070161	Nomascus leucogenys	95.22	0.00e+00	2547.00
IUUC-Opr-071015	Ochotona princeps	92.55	0.00e+00	1931.00
IUUC-Ont-072308	Oreochromis niloticus	67.29	0.00e+00	1382.00
IUUC-Oan-072723	Ornithorhynchus anatinus	66.38	0.00e+00	1552.00
IUUC-Ocu-073938	Oryctolagus cuniculus	89.82	0.00e+00	2462.00
IUUC-Ola-086375	Oryzias latipes	60.49	0.00e+00	1400.00
IUUC-Oga-088297	Otolemur garnettii	90.67	0.00e+00	2316.00
IUUC-Oar-089675	Ovis aries	79.64	0.00e+00	2167.00
IUUC-Ptr-091621	Pan troglodytes	97.51	0.00e+00	2058.00
IUUC-Pma-094154	Petromyzon marinus	52.02	3.00e-115	409.00
IUUC-Pfo-097246	Poecilia formosa	59.00	0.00e+00	1425.00
IUUC-Pab-098551	Pongo abelii	96.74	0.00e+00	2036.00
IUUC-Pca-100158	Procavia capensis	84.21	0.00e+00	2195.00
IUUC-Pva-103160	Pteropus vampyrus	88.89	0.00e+00	2267.00
IUUC-Rno-105355	Rattus norvegicus	86.49	0.00e+00	2261.00
IUUC-Sha-107057	Sarcophilus harrisii	71.99	0.00e+00	1947.00
IUUC-Sar-113011	Sorex araneus	89.53	0.00e+00	1509.00
IUUC-Ssc-115761	Sus scrofa	90.10	0.00e+00	2502.00
IUUC-Tgu-116956	Taeniopygia guttata	64.85	0.00e+00	794.00
IUUC-Tru-118739	Takifugu rubripes	67.24	0.00e+00	1364.00
IUUC-Tsy-118827	Tarsius syrichta	82.80	0.00e+00	1256.00
IUUC-Tni-119921	Tetraodon nigroviridis	60.53	0.00e+00	1391.00
IUUC-Tbe-128017	Tupaia belangeri	91.38	0.00e+00	1915.00
IUUC-Ttr-128869	Tursiops truncatus	88.51	0.00e+00	2243.00
IUUC-Vpa-130427	Vicugna pacos	95.94	0.00e+00	932.00
IUUC-Xtr-132734	Xenopus tropicalis	61.08	0.00e+00	1620.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence