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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045954
Ensembl Protein ID ENSP00000425730.1
UniProt Accession Q6IE81; D3DNY0; D3DNY1; Q4W5D5; Q6ZSL7; Q8NC41; Q96JL8; Q96SQ1; Q9H692; JADE1_HUMAN
Genbank Protein ID AAM95612.1; BAB55239.1; BAB15371.1; BAC11335.1; BAC86931.1; AAY40997.1; EAX05171.1; EAX05173.1; EAX05175.1; EAX05176.1; AAH32376.1; BAB47436.1; CAE30500.1
Protein Name Protein Jade-1; Jade family PHD finger protein 1; PHD finger protein 17
Genbank Nucleotide ID AF520952; AK027620; AK026132; AK074986; AK127326; AC108024; AC093783; CH471056; CH471056; CH471056; BC032376; AB058710; BN000287
Gene Name JADE1; KIAA1807; PHF17
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000077684.15 ENST00000511647.5 ENSP00000423737.1
ENSG00000077684.15 ENST00000452328.6 ENSP00000388015.2
ENSG00000077684.15 ENST00000512960.5 ENSP00000425730.1
ENSG00000077684.15 ENST00000511925.5 ENSP00000421778.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 3.10e-10 41.7 204 251
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedek.slveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           +vC vC++++ ++  ++v C+kC+ ++H+aC ++    ++p+ + w C+ C 
   Q: 204  VVCDVCQSPDGEDGnEMVFCDKCNICVHQACYGIL---KVPEGS-WLCRTCA 251
           69******99887569*******************...*****8.******5 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function.
 Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function.
Protein Sequence
(Fasta)
MKRGRLPSSS EDSDDNGSLS TTWSQNSRSQ HRRSSCSRHE DRKPSEVFRT DLITAMKLHD 60
SYQLNPDEYY VLADPWRQEW EKGVQVPVSP GTIPQPVARV VSEEKSLMFI RPKKYIVSSG 120
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Protein Fasta Sequence


>IUUC-Hsa-045954|E3,PHD|Homo sapiens
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Nucleotide Sequence
(Fasta)
CGTTTTGGCA AGGGATTAAA GTGCTCCCCC CTGTGGCAGC AGTGACCCAG AAATGAGTTT 60
GATTCACATA GTCCTTCCTC CATAACAAGC CAAACGCCAG ACCGAGAGTG CCTCCGTGCG 120
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Nucleotide Fasta Sequence


>IUUC-Hsa-045954|E3,PHD|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0010--Activator
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR019542--Enhancer_polycomb-like_N
IPR034732--EPHD
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51805--EPHD
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF10513--EPL1
SMART

SM00249--PHD
Gene Ontology

GO:0036064--C:ciliary basal body
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0000123--C:histone acetyltransferase complex
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0001105--F:RNA polymerase II transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0043966--P:histone H3 acetylation
GO:0043983--P:histone H4-K12 acetylation
GO:0043981--P:histone H4-K5 acetylation
GO:0043982--P:histone H4-K8 acetylation
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0030308--P:negative regulation of cell growth
GO:2000134--P:negative regulation of G1/S transition of mitotic cell cycle
GO:0006950--P:response to stress
KEGG hsa:79960
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001854 Ailuropoda melanoleuca 96.56 0.00e+00 1641.00
IUUC-Apl-003904 Anas platyrhynchos 81.43 0.00e+00 1320.00
IUUC-Aca-004650 Anolis carolinensis 79.15 0.00e+00 1318.00
IUUC-Bta-013212 Bos taurus 95.49 0.00e+00 1562.00
IUUC-Bci-013740 Botrytis cinerea 47.83 1.00e-11 65.50
IUUC-Cja-019342 Callithrix jacchus 98.91 0.00e+00 1645.00
IUUC-Cfa-021159 Canis familiaris 95.38 0.00e+00 1618.00
IUUC-Cpo-022179 Cavia porcellus 97.03 0.00e+00 1630.00
IUUC-Csa-024123 Chlorocebus sabaeus 99.53 0.00e+00 1651.00
IUUC-Dno-028951 Dasypus novemcinctus 97.27 0.00e+00 1656.00
IUUC-Dor-030376 Dipodomys ordii 92.11 1.00e-166 579.00
IUUC-Fca-035825 Felis catus 96.56 0.00e+00 1677.00
IUUC-Fal-037191 Ficedula albicollis 81.04 0.00e+00 1376.00
IUUC-Gga-040453 Gallus gallus 83.16 0.00e+00 1111.00
IUUC-Ggo-044730 Gorilla gorilla 99.76 0.00e+00 1659.00
IUUC-Itr-047942 Ictidomys tridecemlineatus 92.88 0.00e+00 1494.00
IUUC-Lch-050370 Latimeria chalumnae 66.71 0.00e+00 1040.00
IUUC-Loc-052824 Lepisosteus oculatus 60.22 0.00e+00 973.00
IUUC-Laf-053741 Loxodonta africana 96.68 0.00e+00 1627.00
IUUC-Mcc-055206 Macaca mulatta 99.51 0.00e+00 1650.00
IUUC-Meu-055951 Macropus eugenii 77.04 0.00e+00 766.00
IUUC-Mga-059286 Meleagris gallopavo 80.10 0.00e+00 1265.00
IUUC-Mvi-060566 Microbotryum violaceum 30.77 1.00e-14 77.00
IUUC-Mmr-061461 Microcebus murinus 96.92 0.00e+00 1603.00
IUUC-Mdo-062145 Monodelphis domestica 81.79 0.00e+00 1363.00
IUUC-Mmu-063766 Mus musculus 91.71 0.00e+00 1517.00
IUUC-Mpu-066859 Mustela putorius furo 95.20 0.00e+00 1529.00
IUUC-Mlu-068114 Myotis lucifugus 90.18 0.00e+00 1299.00
IUUC-Nle-069678 Nomascus leucogenys 99.64 0.00e+00 1657.00
IUUC-Ont-072674 Oreochromis niloticus 67.96 0.00e+00 733.00
IUUC-Ocu-074755 Oryctolagus cuniculus 95.97 0.00e+00 1625.00
IUUC-Ola-086618 Oryzias latipes 53.77 0.00e+00 731.00
IUUC-Olu-087752 Ostreococcus lucimarinus 46.94 8.00e-39 152.00
IUUC-Oga-089141 Otolemur garnettii 97.82 0.00e+00 1620.00
IUUC-Oar-089329 Ovis aries 95.49 0.00e+00 1599.00
IUUC-Ptr-091632 Pan troglodytes 100.00 0.00e+00 1661.00
IUUC-Pan-091906 Papio anubis 99.64 0.00e+00 1652.00
IUUC-Pfo-096495 Poecilia formosa 51.22 0.00e+00 742.00
IUUC-Pab-098033 Pongo abelii 99.51 0.00e+00 1646.00
IUUC-Pva-102586 Pteropus vampyrus 91.46 0.00e+00 1459.00
IUUC-Sha-106818 Sarcophilus harrisii 88.17 0.00e+00 1142.00
IUUC-Ssl-108594 Sclerotinia sclerotiorum 40.54 2.00e-07 52.80
IUUC-Smo-109236 Selaginella moellendorffii 39.71 4.00e-39 157.00
IUUC-Sre-115128 Sporisorium reilianum 34.18 2.00e-11 65.90
IUUC-Ssc-116244 Sus scrofa 96.44 0.00e+00 1632.00
IUUC-Tgu-117051 Taeniopygia guttata 80.09 0.00e+00 1333.00
IUUC-Tru-118032 Takifugu rubripes 68.03 0.00e+00 659.00
IUUC-Tni-120429 Tetraodon nigroviridis 67.51 0.00e+00 718.00
IUUC-Tre-122041 Trichoderma reesei 42.86 7.00e-14 73.90
IUUC-Ttr-129299 Tursiops truncatus 96.44 0.00e+00 1644.00
IUUC-Uma-129405 Ustilago maydis 32.65 1.00e-11 66.20
IUUC-Xtr-132813 Xenopus tropicalis 66.67 0.00e+00 1053.00
IUUC-Xma-133556 Xiphophorus maculatus 52.52 0.00e+00 753.00
Created Date 25-Jun-2017

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