iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091382

UUCD1 version

UUC-PaT-00354

Ensembl Protein ID

ENSPTRP00000016213.5

UniProt Accession

H2QDP6; H2QDP6_PANTR

Genbank Protein ID

JAA15588.1; JAA29958.1

Protein Name

SMAD specific E3 ubiquitin protein ligase 2

Genbank Nucleotide ID

AACZ03108518; GABD01003142

Gene Name

SMURF2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000009546.5	ENSPTRT00000017504.5	ENSPTRP00000016213.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.60e-129	432.1	415	747

Active Site

Position(s)	Description	Evidence
716	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl krl+++f+gEegld+gGv+re+l+lls+e+ np++glf+ys +d +tlq+npds + npehl++F+f+Gr++g+a+++g+++d 
   Q: 415  PKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMGMAVFHGHYIDG 502
           678999*****************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+d+e vdp+l++sl +i+en   di+   ld tf+v+++ +ge+ ++eLkp+G++ipV++eNk+eYv+l+v+
   Q: 503  GFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILEN---DITGV-LDHTFCVEHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVN 587
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfnevip++ll+ F+e+elel+icG  +idv+d+k +t+ k+ +t+ds+ ++wFw+++e f++e r+++LqFv
   Q: 588  WRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKH-CTPDSNIVKWFWKAVEFFDEERRARLLQFV 675
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgssr+Pl+Gf++l+    prlf+i++ da +++lP+++TCfn++++P+Y+s+e+l+ekLl+Aieet gF +
   Q: 676  TGSSRVPLQGFKALQgaagPRLFTIHQiDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAV 747
           **********************************************************************76 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MSNPGGRRNG PVKLRLTVLC AKNLVKKDFF RLPDPFAKVV VDGSGQCHST DTVKNTLDPK 60
WNQHYDLYIG KSDSVTISVW NHKKIHKKQG AGFLGCVRLL SNAINRLKDT GYQRLDLCKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGTTCTGCT CCGGCGCCGC CGAGCACCGC CCGCTTCAGC CGACCAGCCC CGTCGGCTAC 60
TGGGCCTCGC CGAGACGAGA GGAGGGAAAG GCCTCGGCGG CCGCGAGGAG GCGGCGGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0016607--C:nuclear speck
GO:0000151--C:ubiquitin ligase complex
GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:1901165--P:positive regulation of trophoblast cell migration
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001305	Ailuropoda melanoleuca	99.05	0.00e+00	1498.00
IUUC-Apl-003513	Anas platyrhynchos	97.68	0.00e+00	1478.00
IUUC-Aca-005358	Anolis carolinensis	97.21	0.00e+00	1502.00
IUUC-Ame-011320	Astyanax mexicanus	87.86	0.00e+00	1389.00
IUUC-Bta-013399	Bos taurus	99.45	0.00e+00	1491.00
IUUC-Cja-019355	Callithrix jacchus	98.92	0.00e+00	1504.00
IUUC-Cpo-022200	Cavia porcellus	99.45	0.00e+00	1499.00
IUUC-Cin-025126	Ciona intestinalis	65.79	0.00e+00	971.00
IUUC-Csv-026339	Ciona savignyi	64.91	0.00e+00	1005.00
IUUC-Dre-027650	Danio rerio	90.46	0.00e+00	1433.00
IUUC-Dno-029534	Dasypus novemcinctus	99.47	0.00e+00	1528.00
IUUC-Ete-032715	Echinops telfairi	94.66	0.00e+00	1408.00
IUUC-Eca-033580	Equus caballus	99.73	0.00e+00	1503.00
IUUC-Eeu-034945	Erinaceus europaeus	97.56	0.00e+00	1390.00
IUUC-Fal-037275	Ficedula albicollis	96.90	0.00e+00	1469.00
IUUC-Gga-041060	Gallus gallus	94.29	0.00e+00	1431.00
IUUC-Gac-041295	Gasterosteus aculeatus	91.67	0.00e+00	1399.00
IUUC-Hsa-046726	Homo sapiens	100.00	0.00e+00	1537.00
IUUC-Lch-050026	Latimeria chalumnae	95.49	0.00e+00	1467.00
IUUC-Loc-051760	Lepisosteus oculatus	88.52	0.00e+00	1375.00
IUUC-Laf-053753	Loxodonta africana	99.59	0.00e+00	1501.00
IUUC-Mcc-054815	Macaca mulatta	99.73	0.00e+00	1533.00
IUUC-Meu-056436	Macropus eugenii	76.13	0.00e+00	1102.00
IUUC-Mmr-060806	Microcebus murinus	99.45	0.00e+00	1499.00
IUUC-Mdo-062805	Monodelphis domestica	97.46	0.00e+00	1493.00
IUUC-Mmu-064034	Mus musculus	99.20	0.00e+00	1523.00
IUUC-Mpu-066762	Mustela putorius furo	99.05	0.00e+00	1497.00
IUUC-Mlu-066981	Myotis lucifugus	99.59	0.00e+00	1500.00
IUUC-Nle-069804	Nomascus leucogenys	100.00	0.00e+00	1531.00
IUUC-Opr-070591	Ochotona princeps	93.97	0.00e+00	1397.00
IUUC-Ont-071239	Oreochromis niloticus	91.99	0.00e+00	1407.00
IUUC-Oan-072699	Ornithorhynchus anatinus	95.71	0.00e+00	1498.00
IUUC-Ocu-074913	Oryctolagus cuniculus	99.73	0.00e+00	1534.00
IUUC-Ola-086597	Oryzias latipes	85.62	0.00e+00	1285.00
IUUC-Olu-087813	Ostreococcus lucimarinus	41.95	2.00e-84	305.00
IUUC-Oga-089116	Otolemur garnettii	95.90	0.00e+00	1432.00
IUUC-Oar-089366	Ovis aries	99.18	0.00e+00	1493.00
IUUC-Psi-093298	Pelodiscus sinensis	97.96	0.00e+00	1457.00
IUUC-Pma-094354	Petromyzon marinus	73.51	0.00e+00	1125.00
IUUC-Pfo-096071	Poecilia formosa	90.40	0.00e+00	1421.00
IUUC-Pab-098682	Pongo abelii	100.00	0.00e+00	1537.00
IUUC-Pop-099520	Populus trichocarpa	45.32	7.00e-92	334.00
IUUC-Pca-100516	Procavia capensis	89.83	0.00e+00	637.00
IUUC-Pva-102754	Pteropus vampyrus	98.49	0.00e+00	1462.00
IUUC-Rno-105600	Rattus norvegicus	99.06	0.00e+00	1292.00
IUUC-Sha-107144	Sarcophilus harrisii	97.36	0.00e+00	1355.00
IUUC-Spo-108171	Schizosaccharomyces pombe	40.37	9.00e-164	570.00
IUUC-Sar-113122	Sorex araneus	88.36	0.00e+00	1281.00
IUUC-Tgu-117112	Taeniopygia guttata	97.08	0.00e+00	1497.00
IUUC-Tru-118497	Takifugu rubripes	88.99	0.00e+00	1366.00
IUUC-Tsy-118819	Tarsius syrichta	99.03	0.00e+00	1038.00
IUUC-Tni-120781	Tetraodon nigroviridis	89.77	0.00e+00	1179.00
IUUC-Tme-126897	Tuber melanosporum	39.30	3.00e-153	535.00
IUUC-Tbe-127371	Tupaia belangeri	89.28	0.00e+00	1220.00
IUUC-Ttr-129305	Tursiops truncatus	91.68	0.00e+00	1288.00
IUUC-Vpa-130591	Vicugna pacos	89.32	0.00e+00	1302.00
IUUC-Xtr-132979	Xenopus tropicalis	77.06	0.00e+00	1105.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence