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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046717
UUCD1 version UUC-HoS-01012
Ensembl Protein ID ENSP00000312397.4
UniProt Accession Q9UH77; B2RBK7; Q9UH75; Q9UH76; Q9ULU0; Q9Y6V6; KLHL3_HUMAN
Genbank Protein ID AAF20938.1; AAF20939.1; AAF20995.1; BAA86443.1; BAG37254.1; AAB97127.1; EAW62183.1
Protein Name Kelch-like protein 3
Genbank Nucleotide ID AF208068; AF208069; AF208070; AB032955; AK314707; AC004021; AC092318
Gene Name KLHL3; KIAA1129
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000146021.14 ENST00000309755.8 ENSP00000312397.4
ENSG00000146021.14 ENST00000504208.5 ENSP00000423585.1
ENSG00000146021.14 ENST00000505853.1 ENSP00000426173.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box BTB_3-box 23387299; 23665031; 23962426
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 1.90e-21 77.9 50 116
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 1.30e-11 43.5 149 180
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +Dv++v +++e++ah++vLaa+S++F a+f+++++esk  +++eikdv+ + ++ l++++Yt +++ +
   Q: 50   CDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESK-AKKIEIKDVDGQTLSKLIDYIYTAEIEVT 116
           8*************************************.************************99876 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           + Nclgi++fAd ++c+dL ++a+ ++++hF+
   Q: 149  PTNCLGIRAFADVHTCTDLLQQANAYAEQHFP 180
           78*****************************6 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation.
 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation.
Protein Sequence
(Fasta)
MEGESVKLSS QTLIQAGDDE KNQRTITVNP AHMGKAFKVM NELRSKQLLC DVMIVAEDVE 60
IEAHRVVLAA CSPYFCAMFT GDMSESKAKK IEIKDVDGQT LSKLIDYIYT AEIEVTEENV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046717|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GATTCTTTGC AGCCTAGACA GAGGAGGCAG GAGCCCCAGG GGCGGGCTAA TCGCCTGGGC 60
TGGGGATGCC TGGGCAGATG CAGAGGAAGC TGGAAAGGTG GCAGTGCACC TGGGTCGCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046717|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0009--Actin-binding
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0225--Disease mutation
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005198--F:structural molecule activity
GO:0072156--P:distal tubule morphogenesis
GO:0050801--P:ion homeostasis
GO:0070936--P:protein K48-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0070294--P:renal sodium ion absorption
KEGG hsa:26249
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001632 Ailuropoda melanoleuca 97.95 0.00e+00 1168.00
IUUC-Apl-003965 Anas platyrhynchos 94.68 0.00e+00 1110.00
IUUC-Aca-004912 Anolis carolinensis 93.53 0.00e+00 1096.00
IUUC-Ame-010670 Astyanax mexicanus 79.73 0.00e+00 947.00
IUUC-Bta-013354 Bos taurus 98.63 0.00e+00 1176.00
IUUC-Bra-017771 Brassica rapa 29.82 5.00e-13 70.10
IUUC-Cel-018136 Caenorhabditis elegans 42.62 2.00e-132 466.00
IUUC-Cja-019183 Callithrix jacchus 94.31 0.00e+00 1032.00
IUUC-Cfa-020465 Canis familiaris 97.09 0.00e+00 1160.00
IUUC-Cpo-022115 Cavia porcellus 98.97 0.00e+00 1182.00
IUUC-Csa-024219 Chlorocebus sabaeus 99.49 0.00e+00 1198.00
IUUC-Csv-026032 Ciona savignyi 60.61 0.00e+00 704.00
IUUC-Cgl-026620 Colletotrichum gloeosporioides 30.42 3.00e-24 105.00
IUUC-Dre-028524 Danio rerio 75.32 0.00e+00 950.00
IUUC-Dno-029075 Dasypus novemcinctus 99.29 0.00e+00 1144.00
IUUC-Dor-030156 Dipodomys ordii 81.23 0.00e+00 948.00
IUUC-Ete-033064 Echinops telfairi 83.02 0.00e+00 861.00
IUUC-Eca-033887 Equus caballus 98.45 0.00e+00 1169.00
IUUC-Eeu-035244 Erinaceus europaeus 78.88 0.00e+00 930.00
IUUC-Fca-035375 Felis catus 97.61 0.00e+00 1162.00
IUUC-Fal-037119 Ficedula albicollis 96.22 0.00e+00 1070.00
IUUC-Fso-038219 Fusarium solani 39.06 2.00e-10 57.00
IUUC-Gga-041094 Gallus gallus 95.80 0.00e+00 1106.00
IUUC-Gac-042585 Gasterosteus aculeatus 78.18 0.00e+00 910.00
IUUC-Ggo-045485 Gorilla gorilla 99.49 0.00e+00 1192.00
IUUC-Itr-048605 Ictidomys tridecemlineatus 98.63 0.00e+00 1176.00
IUUC-Lch-050246 Latimeria chalumnae 86.99 0.00e+00 1008.00
IUUC-Laf-053700 Loxodonta africana 96.93 0.00e+00 1157.00
IUUC-Mcc-054732 Macaca mulatta 99.60 0.00e+00 1028.00
IUUC-Mga-059994 Meleagris gallopavo 94.88 0.00e+00 999.00
IUUC-Mdo-062923 Monodelphis domestica 97.27 0.00e+00 1171.00
IUUC-Mmu-063842 Mus musculus 97.27 0.00e+00 1164.00
IUUC-Mpu-066380 Mustela putorius furo 97.79 0.00e+00 1178.00
IUUC-Mlu-067922 Myotis lucifugus 98.27 0.00e+00 1158.00
IUUC-Nle-069761 Nomascus leucogenys 99.66 0.00e+00 1199.00
IUUC-Opr-070287 Ochotona princeps 89.44 0.00e+00 1050.00
IUUC-Ont-071654 Oreochromis niloticus 80.70 0.00e+00 959.00
IUUC-Ocu-074957 Oryctolagus cuniculus 98.29 0.00e+00 1165.00
IUUC-Ola-086853 Oryzias latipes 79.30 0.00e+00 908.00
IUUC-Oga-088559 Otolemur garnettii 98.30 0.00e+00 1181.00
IUUC-Oar-089925 Ovis aries 98.30 0.00e+00 1182.00
IUUC-Ptr-091487 Pan troglodytes 100.00 0.00e+00 1202.00
IUUC-Pan-091705 Papio anubis 99.49 0.00e+00 1198.00
IUUC-Psi-093478 Pelodiscus sinensis 91.67 0.00e+00 1056.00
IUUC-Pfo-097450 Poecilia formosa 80.70 0.00e+00 900.00
IUUC-Pab-097618 Pongo abelii 99.83 0.00e+00 1199.00
IUUC-Pca-100739 Procavia capensis 88.80 0.00e+00 659.00
IUUC-Sha-106935 Sarcophilus harrisii 98.93 0.00e+00 756.00
IUUC-Ssc-115599 Sus scrofa 98.45 0.00e+00 1171.00
IUUC-Tgu-117001 Taeniopygia guttata 95.58 0.00e+00 1090.00
IUUC-Tru-118078 Takifugu rubripes 79.55 0.00e+00 950.00
IUUC-Tsy-119161 Tarsius syrichta 86.79 0.00e+00 914.00
IUUC-Tni-120888 Tetraodon nigroviridis 77.14 0.00e+00 889.00
IUUC-Tbe-127285 Tupaia belangeri 83.90 0.00e+00 682.00
IUUC-Ttr-128884 Tursiops truncatus 83.24 2.00e-154 539.00
Created Date 25-Jun-2017

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