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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-106090
UUCD1 version UUC-RaN-00534
Ensembl Protein ID ENSRNOP00000035419.5
UniProt Accession Q6MFY8; TRI40_RAT
Genbank Protein ID CAE84059.1
Protein Name Tripartite motif-containing protein 40; Probable E3 NEDD8-protein ligase; RING finger protein 35
Genbank Nucleotide ID BX883051
Gene Name Trim40; Rnf35
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000000783.7 ENSRNOT00000029070.6 ENSRNOP00000035419.5
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 4.40e-08 33.9 12 55
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iCl+++k+  ++++C H+f++ Cl  ++   k s s+  +CP+Cr
   Q: 12   CPICLDPLKE-AVSTDCRHLFCRMCLiRHM--DKASVSGVLSCPVCR 55
           ********99.999***********96666..67799*********8 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     May function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway. Promotes neddylation of IKBKG/NEMO, stabilizing NFKBIA, and inhibiting of NF-kappaB nuclear translocation and activity (By similarity).
 May function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway. Promotes neddylation of IKBKG/NEMO, stabilizing NFKBIA, and inhibiting of NF-kappaB nuclear translocation and activity (By similarity).
Protein Sequence
(Fasta)
MVPLDKDNQD ICPICLDPLK EAVSTDCRHL FCRMCLIRHM DKASVSGVLS CPVCRKPCSE 60
TVLGDNYICH THQKRVCRFC ESSRHLLCEE CLQSPEHRAH TELSIENAIS HYKERLNRRS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-106090|E3,RING|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTGGACAGTG GCTTGAAGTC CAGGCCTGAG TCCGCTCTAT CTTGCTCCAG ATCCGCTTCC 60
ACTGAACCCT CTCACCTGGG ACTATCTGGC CTTCAAAAGA TCCAGTGGGG AGACTAGTGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-106090|E3,RING|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000315--Znf_B-box
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00097--zf-C3HC4
SMART

SM00184--RING
Gene Ontology

GO:0008385--C:IkappaB kinase complex
GO:0008270--F:zinc ion binding
GO:0030308--P:negative regulation of cell growth
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0042177--P:negative regulation of protein catabolic process
GO:1900181--P:negative regulation of protein localization to nucleus
GO:0045116--P:protein neddylation
KEGG rno:365528
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001427 Ailuropoda melanoleuca 49.79 9.00e-45 173.00
IUUC-Afl-008526 Aspergillus flavus 41.38 8.00e-08 50.10
IUUC-Ate-010384 Aspergillus terreus 40.74 7.00e-07 47.00
IUUC-Bta-012543 Bos taurus 52.25 4.00e-54 204.00
IUUC-Cja-018793 Callithrix jacchus 54.62 2.00e-56 212.00
IUUC-Csa-023101 Chlorocebus sabaeus 62.13 2.00e-76 278.00
IUUC-Cho-024926 Choloepus hoffmanni 59.15 4.00e-20 91.70
IUUC-Cme-027149 Cyanidioschyzon merolae 34.51 8.00e-07 49.30
IUUC-Dno-029338 Dasypus novemcinctus 49.78 2.00e-43 168.00
IUUC-Dor-030164 Dipodomys ordii 58.41 6.00e-61 226.00
IUUC-Dse-031337 Dothistroma septosporum 39.62 4.00e-07 48.90
IUUC-Ete-032446 Echinops telfairi 43.46 7.00e-43 167.00
IUUC-Eca-034042 Equus caballus 66.09 4.00e-79 287.00
IUUC-Eeu-034444 Erinaceus europaeus 52.68 9.00e-56 209.00
IUUC-Ggo-044410 Gorilla gorilla 58.40 2.00e-76 278.00
IUUC-Hsa-046211 Homo sapiens 58.40 1.00e-76 278.00
IUUC-Itr-048126 Ictidomys tridecemlineatus 56.73 6.00e-66 243.00
IUUC-Kpa-049242 Komagataella pastoris 36.71 1.00e-07 49.70
IUUC-Laf-054019 Loxodonta africana 49.79 2.00e-48 185.00
IUUC-Mcc-054616 Macaca mulatta 67.09 8.00e-86 309.00
IUUC-Meu-055981 Macropus eugenii 36.62 5.00e-29 120.00
IUUC-Mdo-062958 Monodelphis domestica 42.01 7.00e-33 133.00
IUUC-Mmu-063571 Mus musculus 85.43 4.00e-118 416.00
IUUC-Nle-069843 Nomascus leucogenys 57.04 5.00e-23 99.80
IUUC-Opr-071083 Ochotona princeps 53.97 1.00e-65 242.00
IUUC-Ocu-073939 Oryctolagus cuniculus 61.30 9.00e-62 229.00
IUUC-Oga-088040 Otolemur garnettii 63.71 6.00e-72 263.00
IUUC-Oar-089914 Ovis aries 56.96 1.00e-66 246.00
IUUC-Ptr-091240 Pan troglodytes 54.03 1.00e-67 249.00
IUUC-Pan-092095 Papio anubis 66.37 6.00e-81 293.00
IUUC-Pab-098406 Pongo abelii 60.34 6.00e-76 276.00
IUUC-Pca-101043 Procavia capensis 51.53 1.00e-57 216.00
IUUC-Pva-102651 Pteropus vampyrus 63.18 4.00e-81 294.00
IUUC-Ssc-115942 Sus scrofa 58.40 3.00e-72 265.00
IUUC-Tsy-119497 Tarsius syrichta 59.75 3.00e-76 278.00
IUUC-Tbe-127279 Tupaia belangeri 59.00 1.00e-57 216.00
Created Date 25-Jun-2017

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