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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046255
UUCD1 version UUC-HoS-00120
Ensembl Protein ID ENSP00000171111.4
UniProt Accession Q14145; B3KPD5; Q6LEP0; Q8WTX1; Q9BPY9; KEAP1_HUMAN
Genbank Protein ID AAK43722.1; AAK43722.1; AAK43722.1; AAK43722.1; AAK43722.1; AAK51082.1; BAA09481.3; BAG51647.1; AAH02417.1; AAH02930.1; AAH15945.1; AAH21957.2
Protein Name Kelch-like ECH-associated protein 1; Cytosolic inhibitor of Nrf2; Kelch-like protein 19
Genbank Nucleotide ID AF361892; AF361888; AF361889; AF361890; AF361891; AF361886; D50922; AK056204; AC011461; BC002930; BC015945; BC021957
Gene Name KEAP1; INRF2; KIAA0132; KLHL19
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000079999.13 ENST00000171111.9 ENSP00000171111.4
ENSG00000079999.13 ENST00000592478.5 ENSP00000468014.1
ENSG00000079999.13 ENST00000590593.1 ENSP00000467601.1
ENSG00000079999.13 ENST00000585845.1 ENSP00000466704.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
OMIM
Drug and target
DrugBankGRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPHOSIDABioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box BTB_3-box 17046835; 19818716; 20930034; 20865015; 26195781
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 1.70e-16 62.0 77 148
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 3.30e-09 35.9 181 211
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvv....g.geeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +Dv+l+v    +   +f ahk+vLa+sS+vF+a+f+++l+e+   + v i+++ p+v++ l++F Yt ++++ 
   Q: 77   CDVTLQVkyqdApAAQFMAHKVVLASSSPVFKAMFTNGLREQG-MEVVSIEGIHPKVMERLIEFAYTASISMG 148
           8******77552699**************************98.***********************998875 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           ++N++gi  fA++ +c +L+++a+++i  hF
   Q: 181  PSNAIGIANFAEQIGCVELHQRAREYIYMHF 211
           89****************************9 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
 Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
Protein Sequence
(Fasta)
MQPDPRPSGA GACCRFLPLQ SQCPEGAGDA VMYASTECKA EVTPSQHGNR TFSYTLEDHT 60
KQAFGIMNEL RLSQQLCDVT LQVKYQDAPA AQFMAHKVVL ASSSPVFKAM FTNGLREQGM 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046255|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GATTGCGCCA CTGCACTCCA GCCTGGGCGT GCAGATCAGA GCGAGACCTT GTCTCTAAAG 60
GAAAAAAAAA AAGAAAGAAA GAAAGAAAAG AAAAGAAAAG AAAACCTAGC GAGGTAGATA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046255|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0880--Kelch repeat
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR030563--KEAP1
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0005884--C:actin filament
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005815--C:microtubule organizing center
GO:0030496--C:midbody
GO:0005654--C:nucleoplasm
GO:0008134--F:transcription factor binding
GO:0071353--P:cellular response to interleukin-4
GO:0042994--P:cytoplasmic sequestering of transcription factor
GO:0001701--P:in utero embryonic development
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0010499--P:proteasomal ubiquitin-independent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0016567--P:protein ubiquitination
GO:0045604--P:regulation of epidermal cell differentiation
GO:0006351--P:transcription, DNA-templated
KEGG hsa:9817
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001377 Ailuropoda melanoleuca 97.60 0.00e+00 1277.00
IUUC-Aca-005389 Anolis carolinensis 86.00 0.00e+00 1083.00
IUUC-Ame-010749 Astyanax mexicanus 78.74 0.00e+00 974.00
IUUC-Bta-013505 Bos taurus 97.60 0.00e+00 1276.00
IUUC-Cja-018823 Callithrix jacchus 98.24 0.00e+00 1288.00
IUUC-Cfa-021202 Canis familiaris 97.60 0.00e+00 1276.00
IUUC-Cpo-021830 Cavia porcellus 96.12 0.00e+00 840.00
IUUC-Csa-023728 Chlorocebus sabaeus 99.04 0.00e+00 1297.00
IUUC-Cin-025195 Ciona intestinalis 55.00 0.00e+00 677.00
IUUC-Csv-026155 Ciona savignyi 53.59 2.00e-180 625.00
IUUC-Dre-027388 Danio rerio 77.25 0.00e+00 948.00
IUUC-Dno-029066 Dasypus novemcinctus 85.28 0.00e+00 1086.00
IUUC-Dor-030674 Dipodomys ordii 94.89 0.00e+00 831.00
IUUC-Dme-032165 Drosophila melanogaster 49.73 3.00e-161 562.00
IUUC-Ete-032255 Echinops telfairi 93.96 2.00e-98 352.00
IUUC-Eca-034381 Equus caballus 93.76 0.00e+00 1208.00
IUUC-Eeu-034791 Erinaceus europaeus 92.36 0.00e+00 821.00
IUUC-Fca-036067 Felis catus 97.76 0.00e+00 1280.00
IUUC-Gmo-039691 Gadus morhua 77.21 0.00e+00 953.00
IUUC-Gga-040266 Gallus gallus 79.53 0.00e+00 999.00
IUUC-Gac-041866 Gasterosteus aculeatus 77.46 0.00e+00 957.00
IUUC-Ggo-044719 Gorilla gorilla 100.00 0.00e+00 1310.00
IUUC-Itr-048457 Ictidomys tridecemlineatus 97.28 0.00e+00 1273.00
IUUC-Lch-049646 Latimeria chalumnae 82.88 0.00e+00 1041.00
IUUC-Loc-052296 Lepisosteus oculatus 56.79 0.00e+00 641.00
IUUC-Laf-054579 Loxodonta africana 97.12 0.00e+00 1275.00
IUUC-Mcc-055315 Macaca mulatta 99.04 0.00e+00 1297.00
IUUC-Meu-056288 Macropus eugenii 87.82 0.00e+00 1119.00
IUUC-Mmr-061639 Microcebus murinus 96.96 0.00e+00 1276.00
IUUC-Mdo-062072 Monodelphis domestica 94.07 0.00e+00 1222.00
IUUC-Mmu-063622 Mus musculus 94.07 0.00e+00 1239.00
IUUC-Mpu-066737 Mustela putorius furo 95.03 0.00e+00 1236.00
IUUC-Mlu-068173 Myotis lucifugus 97.12 0.00e+00 1270.00
IUUC-Nle-069336 Nomascus leucogenys 63.81 0.00e+00 734.00
IUUC-Opr-070432 Ochotona princeps 96.66 0.00e+00 1224.00
IUUC-Ont-072160 Oreochromis niloticus 77.31 0.00e+00 947.00
IUUC-Oan-072691 Ornithorhynchus anatinus 80.50 0.00e+00 976.00
IUUC-Ocu-073798 Oryctolagus cuniculus 96.15 0.00e+00 1267.00
IUUC-Ola-086367 Oryzias latipes 74.70 0.00e+00 917.00
IUUC-Oga-088231 Otolemur garnettii 97.28 0.00e+00 1276.00
IUUC-Oar-089227 Ovis aries 96.31 0.00e+00 1252.00
IUUC-Ptr-091460 Pan troglodytes 100.00 0.00e+00 1310.00
IUUC-Pan-092713 Papio anubis 99.04 0.00e+00 1297.00
IUUC-Pfo-096468 Poecilia formosa 78.10 0.00e+00 954.00
IUUC-Pab-098357 Pongo abelii 99.68 0.00e+00 1304.00
IUUC-Pca-100837 Procavia capensis 95.51 0.00e+00 1249.00
IUUC-Pva-103249 Pteropus vampyrus 94.87 0.00e+00 1210.00
IUUC-Rno-106086 Rattus norvegicus 93.59 0.00e+00 1226.00
IUUC-Sha-107245 Sarcophilus harrisii 93.91 0.00e+00 1221.00
IUUC-Sar-112985 Sorex araneus 95.67 0.00e+00 1256.00
IUUC-Ssc-115756 Sus scrofa 98.08 0.00e+00 1284.00
IUUC-Tgu-116838 Taeniopygia guttata 53.93 2.00e-119 422.00
IUUC-Tru-117644 Takifugu rubripes 77.82 0.00e+00 976.00
IUUC-Tni-120245 Tetraodon nigroviridis 78.19 0.00e+00 963.00
IUUC-Tbe-127472 Tupaia belangeri 98.78 2.00e-149 522.00
IUUC-Ttr-128953 Tursiops truncatus 96.09 0.00e+00 707.00
IUUC-Vpa-130683 Vicugna pacos 94.38 0.00e+00 1104.00
IUUC-Xtr-132827 Xenopus tropicalis 76.28 0.00e+00 952.00
Created Date 25-Jun-2017

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