• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Tag Content
UUCD2 ID IUUC-Ssc-115756
UUCD1 version UUC-SuS-00692
Ensembl Protein ID ENSSSCP00000014495.2
UniProt Accession Q684M4; KEAP1_PIG
Genbank Protein ID CAG15151.1
Protein Name Kelch-like ECH-associated protein 1; Cytosolic inhibitor of Nrf2
Genbank Nucleotide ID AJ632303
Gene Name KEAP1; INRF2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSSSCG00000023667.1 ENSSSCT00000014896.2 ENSSSCP00000014495.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 7.20e-17 61.8 77 148
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 7.00e-09 34.9 181 211
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvv....g.geeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +Dv+l+v    +   +f ahk+vLa+sS+vF+a+f+++l+e+   + v i+++ p+v++ l++F Yt ++++ 
   Q: 77   CDVTLQVkyedApAAQFMAHKVVLASSSPVFKAMFTNGLREQG-MEVVSIEGIHPKVMERLIEFAYTASISMG 148
           8******66652699**************************98.***********************998875 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           ++N++gi  fA++ +c +L+++a+++i  hF
   Q: 181  PSNAIGIANFAEQIGCAELHQRAREYIYMHF 211
           89****************************9 PP
   
Organism Sus scrofa
Functional Description
(View)

Functional Description


     Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).
 Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).
Protein Sequence
(Fasta)
MQPEPRPSGA GAHTQFLPLR SQRPEGAGDT VMYASTECKA EVTPSQHGNR TFSYTLEDHT 60
KQAFGIMNEL RLSQQLCDVT LQVKYEDAPA AQFMAHKVVL ASSSPVFKAM FTNGLREQGM 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Ssc-115756|E3,BTB_3-box|Sus scrofa
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TCATGGTGAC CTGCGCGCGT TCCGCACCTC CCCCCTGCAC GCTGCGATGG AGGCGCCTGG 60
GCCTGGGCGA CGGAGGCGGA GCCCGAGAGC GGCCATGGCG GGGTGAGTGA GGCGGCCTGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ssc-115756|E3,BTB_3-box|Sus scrofa
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0880--Kelch repeat
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR030563--KEAP1
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0008134--F:transcription factor binding
GO:0042994--P:cytoplasmic sequestering of transcription factor
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0010499--P:proteasomal ubiquitin-independent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0006351--P:transcription, DNA-templated
KEGG ssc:100136900; ssc:100738260
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001377 Ailuropoda melanoleuca 99.04 0.00e+00 1298.00
IUUC-Aca-005389 Anolis carolinensis 86.51 0.00e+00 1090.00
IUUC-Ame-010749 Astyanax mexicanus 78.74 0.00e+00 974.00
IUUC-Bta-013505 Bos taurus 99.04 0.00e+00 1300.00
IUUC-Cja-018823 Callithrix jacchus 97.44 0.00e+00 1278.00
IUUC-Cfa-021202 Canis familiaris 99.04 0.00e+00 1297.00
IUUC-Cpo-021830 Cavia porcellus 96.84 0.00e+00 848.00
IUUC-Csa-023728 Chlorocebus sabaeus 97.60 0.00e+00 1278.00
IUUC-Cin-025195 Ciona intestinalis 55.17 0.00e+00 679.00
IUUC-Csv-026155 Ciona savignyi 53.77 0.00e+00 627.00
IUUC-Dre-027388 Danio rerio 77.25 0.00e+00 950.00
IUUC-Dno-029066 Dasypus novemcinctus 86.08 0.00e+00 1099.00
IUUC-Dor-030674 Dipodomys ordii 95.62 0.00e+00 839.00
IUUC-Dme-032165 Drosophila melanogaster 49.73 8.00e-162 563.00
IUUC-Ete-032255 Echinops telfairi 94.51 1.00e-99 356.00
IUUC-Eca-034381 Equus caballus 94.91 0.00e+00 1223.00
IUUC-Eeu-034791 Erinaceus europaeus 92.59 0.00e+00 820.00
IUUC-Fca-036067 Felis catus 98.72 0.00e+00 1295.00
IUUC-Gmo-039691 Gadus morhua 77.21 0.00e+00 952.00
IUUC-Gga-040266 Gallus gallus 80.03 0.00e+00 1007.00
IUUC-Gac-041866 Gasterosteus aculeatus 77.29 0.00e+00 956.00
IUUC-Ggo-044719 Gorilla gorilla 98.08 0.00e+00 1284.00
IUUC-Hsa-046255 Homo sapiens 98.08 0.00e+00 1284.00
IUUC-Itr-048457 Ictidomys tridecemlineatus 97.44 0.00e+00 1273.00
IUUC-Lch-049646 Latimeria chalumnae 83.22 0.00e+00 1044.00
IUUC-Loc-052296 Lepisosteus oculatus 57.14 0.00e+00 645.00
IUUC-Laf-054579 Loxodonta africana 97.60 0.00e+00 1283.00
IUUC-Mcc-055315 Macaca mulatta 97.60 0.00e+00 1278.00
IUUC-Meu-056288 Macropus eugenii 90.30 0.00e+00 1130.00
IUUC-Mmr-061639 Microcebus murinus 97.60 0.00e+00 1284.00
IUUC-Mdo-062072 Monodelphis domestica 94.71 0.00e+00 1232.00
IUUC-Mmu-063622 Mus musculus 94.55 0.00e+00 1245.00
IUUC-Mpu-066737 Mustela putorius furo 96.47 0.00e+00 1256.00
IUUC-Mlu-068173 Myotis lucifugus 98.40 0.00e+00 1292.00
IUUC-Nle-069336 Nomascus leucogenys 57.71 0.00e+00 632.00
IUUC-Opr-070432 Ochotona princeps 97.16 0.00e+00 1228.00
IUUC-Ont-072160 Oreochromis niloticus 77.48 0.00e+00 951.00
IUUC-Oan-072691 Ornithorhynchus anatinus 81.18 0.00e+00 985.00
IUUC-Ocu-073798 Oryctolagus cuniculus 96.63 0.00e+00 1273.00
IUUC-Ola-086367 Oryzias latipes 74.70 0.00e+00 917.00
IUUC-Oga-088231 Otolemur garnettii 98.24 0.00e+00 1288.00
IUUC-Oar-089227 Ovis aries 97.76 0.00e+00 1275.00
IUUC-Ptr-091460 Pan troglodytes 98.08 0.00e+00 1284.00
IUUC-Pan-092713 Papio anubis 97.60 0.00e+00 1278.00
IUUC-Pfo-096468 Poecilia formosa 78.27 0.00e+00 957.00
IUUC-Pab-098357 Pongo abelii 98.24 0.00e+00 1288.00
IUUC-Pca-100837 Procavia capensis 96.15 0.00e+00 1259.00
IUUC-Pva-103249 Pteropus vampyrus 95.99 0.00e+00 1229.00
IUUC-Rno-106086 Rattus norvegicus 94.07 0.00e+00 1232.00
IUUC-Sha-107245 Sarcophilus harrisii 94.23 0.00e+00 1228.00
IUUC-Sar-112985 Sorex araneus 96.15 0.00e+00 1261.00
IUUC-Tgu-116838 Taeniopygia guttata 53.93 6.00e-119 420.00
IUUC-Tru-117644 Takifugu rubripes 77.11 0.00e+00 977.00
IUUC-Tni-120245 Tetraodon nigroviridis 78.19 0.00e+00 964.00
IUUC-Tbe-127472 Tupaia belangeri 99.18 9.00e-151 526.00
IUUC-Ttr-128953 Tursiops truncatus 98.32 0.00e+00 727.00
IUUC-Vpa-130683 Vicugna pacos 95.96 0.00e+00 1125.00
IUUC-Xtr-132827 Xenopus tropicalis 76.28 0.00e+00 953.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved