iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Nle-069863

Ensembl Protein ID

ENSNLEP00000001708.1

UniProt Accession

G1QL94; G1QL94_NOMLE

Genbank Protein ID

ENSNLEP00000001708

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADFV01041071

Gene Name

VAV3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000001245.2	ENSNLET00000001810.1	ENSNLEP00000001708.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	6.20e-15	54.9	816	867

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ yd+ a +  eL+l kGdvv++   +   +gW++g  e +g+ G fP+ +ve+
   Q: 816  IARYDFCARDMRELSLLKGDVVKIY-TKLSANGWWRG--EVNGRVGWFPSTYVEE 867
           688*********************9.99999******..9*************86 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

CAQWLIHCKV LPANHRVTWD SVQVFDLAQT LRDGVLLCQL LKNLRAHSIN VNEINLRPHM 60
SHFLCLKNIR TFLTACCETF GMRKSELFEA FDLFDVRDFG KVIETLSRLS RTPIALATGI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGCCGCATC CTTGCCGCCT GCCCCGGCCC ACCCGCGTCC CGGAGCCGTC GGGCATGGAG 60
CCGTGGAATT TTGCGCGCAG TGGCTCATCC ATTGCAAGGT GCTGCCCGCC AACCACCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR022613--CAMSAP_CH
IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF11971--CAMSAP_CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF00018--SH3_1
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00109--C1
SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005622--C:intracellular
GO:0046872--F:metal ion binding
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0050853--P:B cell receptor signaling pathway
GO:0006974--P:cellular response to DNA damage stimulus
GO:0035556--P:intracellular signal transduction
GO:0030890--P:positive regulation of B cell proliferation
GO:0008361--P:regulation of cell size
GO:0035023--P:regulation of Rho protein signal transduction
GO:0042493--P:response to drug

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001362	Ailuropoda melanoleuca	92.41	0.00e+00	1561.00
IUUC-Apl-003734	Anas platyrhynchos	83.02	0.00e+00	1328.00
IUUC-Aca-004477	Anolis carolinensis	84.70	0.00e+00	1446.00
IUUC-Ame-011279	Astyanax mexicanus	62.80	0.00e+00	1064.00
IUUC-Bta-012722	Bos taurus	91.71	0.00e+00	1549.00
IUUC-Cel-018578	Caenorhabditis elegans	28.27	2.00e-67	250.00
IUUC-Cja-018941	Callithrix jacchus	94.69	0.00e+00	1593.00
IUUC-Cfa-020266	Canis familiaris	92.77	0.00e+00	1408.00
IUUC-Cpo-021966	Cavia porcellus	91.38	0.00e+00	1360.00
IUUC-Csa-023892	Chlorocebus sabaeus	94.44	0.00e+00	1477.00
IUUC-Cin-025115	Ciona intestinalis	35.41	2.00e-128	453.00
IUUC-Csv-025995	Ciona savignyi	34.25	3.00e-139	489.00
IUUC-Dre-028199	Danio rerio	66.40	0.00e+00	1118.00
IUUC-Dno-029474	Dasypus novemcinctus	92.41	0.00e+00	1560.00
IUUC-Eca-033961	Equus caballus	92.77	0.00e+00	1438.00
IUUC-Eeu-034719	Erinaceus europaeus	78.12	0.00e+00	663.00
IUUC-Fca-036572	Felis catus	92.12	0.00e+00	1537.00
IUUC-Fal-036802	Ficedula albicollis	86.77	0.00e+00	1528.00
IUUC-Gmo-039409	Gadus morhua	66.21	0.00e+00	1118.00
IUUC-Gga-040884	Gallus gallus	81.82	0.00e+00	1421.00
IUUC-Gac-041395	Gasterosteus aculeatus	67.93	0.00e+00	1195.00
IUUC-Ggo-044460	Gorilla gorilla	93.16	0.00e+00	1408.00
IUUC-Hsa-046099	Homo sapiens	98.27	0.00e+00	1680.00
IUUC-Itr-048144	Ictidomys tridecemlineatus	96.11	0.00e+00	1477.00
IUUC-Lch-049650	Latimeria chalumnae	73.03	1.00e-105	375.00
IUUC-Loc-052487	Lepisosteus oculatus	69.83	0.00e+00	1191.00
IUUC-Laf-054564	Loxodonta africana	91.48	0.00e+00	1550.00
IUUC-Mcc-054622	Macaca mulatta	97.58	0.00e+00	1670.00
IUUC-Meu-056680	Macropus eugenii	81.82	0.00e+00	1379.00
IUUC-Mga-060013	Meleagris gallopavo	78.99	0.00e+00	1361.00
IUUC-Mmr-061251	Microcebus murinus	94.71	0.00e+00	1671.00
IUUC-Mdo-061875	Monodelphis domestica	89.30	0.00e+00	1527.00
IUUC-Mmu-063735	Mus musculus	90.79	0.00e+00	1561.00
IUUC-Mpu-065856	Mustela putorius furo	92.75	0.00e+00	1564.00
IUUC-Mlu-068108	Myotis lucifugus	92.98	0.00e+00	1513.00
IUUC-Opr-070372	Ochotona princeps	84.65	0.00e+00	1029.00
IUUC-Ont-072286	Oreochromis niloticus	68.43	0.00e+00	1181.00
IUUC-Ocu-074194	Oryctolagus cuniculus	93.10	0.00e+00	1568.00
IUUC-Ola-086336	Oryzias latipes	67.09	0.00e+00	1170.00
IUUC-Oga-089104	Otolemur garnettii	56.01	0.00e+00	932.00
IUUC-Oar-089272	Ovis aries	91.60	0.00e+00	1588.00
IUUC-Ptr-090652	Pan troglodytes	92.54	0.00e+00	1581.00
IUUC-Pan-092550	Papio anubis	98.10	0.00e+00	1509.00
IUUC-Psi-093784	Pelodiscus sinensis	84.03	0.00e+00	1338.00
IUUC-Pma-094372	Petromyzon marinus	52.00	0.00e+00	672.00
IUUC-Ppa-095161	Physcomitrella patens	43.64	3.00e-09	56.20
IUUC-Pfo-097308	Poecilia formosa	70.30	0.00e+00	1244.00
IUUC-Pab-098698	Pongo abelii	92.52	0.00e+00	1583.00
IUUC-Pva-102262	Pteropus vampyrus	92.06	0.00e+00	1496.00
IUUC-Rno-105421	Rattus norvegicus	90.33	0.00e+00	1566.00
IUUC-Sha-107325	Sarcophilus harrisii	89.18	0.00e+00	1542.00
IUUC-Sar-113456	Sorex araneus	88.03	0.00e+00	1492.00
IUUC-Ssc-115338	Sus scrofa	54.81	0.00e+00	859.00
IUUC-Tgu-116595	Taeniopygia guttata	79.36	0.00e+00	1358.00
IUUC-Tru-118577	Takifugu rubripes	67.90	0.00e+00	1120.00
IUUC-Tsy-119429	Tarsius syrichta	85.01	0.00e+00	1310.00
IUUC-Tni-119951	Tetraodon nigroviridis	65.79	0.00e+00	1101.00
IUUC-Tbe-127995	Tupaia belangeri	83.00	8.00e-173	600.00
IUUC-Ttr-128281	Tursiops truncatus	92.06	0.00e+00	1551.00
IUUC-Xtr-132427	Xenopus tropicalis	69.87	0.00e+00	1244.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence