iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000006695.7	ENSRNOT00000085995.1	ENSRNOP00000072645.1
ENSRNOG00000006695.7	ENSRNOT00000045314.3	ENSRNOP00000047637.3

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/ZnF/NZF	3.70e-11	42.7	193	219
ULD/UDP/UBQ/UBQ_Other	6.60e-07	29.5	70	120

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 3    aqWaCsaCTflNePeavkCemCsrpRg 29
            +W+C+ CTf+N+P +++CemC+r R+
   Q: 193  VGWQCPGCTFINKPTRPGCEMCCRARP 219
           68************************8 PP

ULD/UDP/UBQ/UBQ_Other

   S: 14   tlk..vnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLadyglk 62
           t++  v p++tVa LK++++   g+pp  q++++ G+ L +d  tL ++g++
   Q: 70   TIWltVRPDMTVASLKDMVFLDYGFPPSLQQWVV-GQRLaRDQETLHSHGIR 120
           445559****************************.55555**********96 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MDEKTKKAEE MALSLARAVA GGDEQAAIKY ATWLAEQKVP LRVQVKPEVS PTQDIRLCVS 60
VEDAYMHTVT IWLTVRPDMT VASLKDMVFL DYGFPPSLQQ WVVGQRLARD QETLHSHGIR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCTGGAATT AGTGGTCGGC CAAGGGGCAC CTAAACCAAG TGTCTCTGGT CCGCCAGACC 60
ATGTGGTGGA GCGTGCGTGC CAGGAACAGT CTAGTGGTCT GCTCCAGCGG GTGACCCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0418--Kinase
KW-0479--Metal-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002867--IBR_dom
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR027370--Znf-RING_LisH
IPR001876--Znf_RanBP2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50053--UBIQUITIN_2
PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF01485--IBR
PF13445--zf-RING_UBOX

SMART

SM00184--RING
SM00547--ZnF_RBZ

Gene Ontology

GO:0071797--C:LUBAC complex
GO:0016301--F:kinase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0060546--P:negative regulation of necroptotic process
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:0042346--P:positive regulation of NF-kappaB import into nucleus
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0097039--P:protein linear polyubiquitination
GO:0050852--P:T cell receptor signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001540	Ailuropoda melanoleuca	87.84	0.00e+00	821.00
IUUC-Apl-003627	Anas platyrhynchos	56.76	3.00e-16	76.30
IUUC-Aca-004507	Anolis carolinensis	65.20	3.00e-154	538.00
IUUC-Ame-011008	Astyanax mexicanus	51.87	1.00e-141	496.00
IUUC-Bta-013247	Bos taurus	89.02	0.00e+00	848.00
IUUC-Bci-013637	Botrytis cinerea	26.34	3.00e-13	70.90
IUUC-Cja-018880	Callithrix jacchus	90.00	0.00e+00	864.00
IUUC-Cfa-020477	Canis familiaris	89.80	0.00e+00	854.00
IUUC-Cpo-021558	Cavia porcellus	89.22	0.00e+00	848.00
IUUC-Csa-024129	Chlorocebus sabaeus	90.39	0.00e+00	835.00
IUUC-Cin-025630	Ciona intestinalis	39.81	1.00e-81	296.00
IUUC-Csv-026069	Ciona savignyi	51.60	6.00e-74	270.00
IUUC-Dre-027591	Danio rerio	52.05	2.00e-139	489.00
IUUC-Dno-029015	Dasypus novemcinctus	87.06	0.00e+00	819.00
IUUC-Dor-030313	Dipodomys ordii	82.60	0.00e+00	734.00
IUUC-Ete-032908	Echinops telfairi	76.60	0.00e+00	706.00
IUUC-Eca-034295	Equus caballus	75.65	0.00e+00	707.00
IUUC-Eeu-034454	Erinaceus europaeus	82.37	3.00e-110	392.00
IUUC-Fca-036380	Felis catus	90.00	0.00e+00	852.00
IUUC-Fal-037440	Ficedula albicollis	56.60	2.00e-14	70.10
IUUC-Gmo-038561	Gadus morhua	52.74	4.00e-118	417.00
IUUC-Gga-040198	Gallus gallus	40.31	1.00e-28	120.00
IUUC-Gac-041319	Gasterosteus aculeatus	51.37	2.00e-136	479.00
IUUC-Ggo-044456	Gorilla gorilla	62.04	4.00e-145	508.00
IUUC-Hsa-045738	Homo sapiens	90.98	0.00e+00	835.00
IUUC-Itr-049042	Ictidomys tridecemlineatus	90.57	0.00e+00	841.00
IUUC-Lch-050269	Latimeria chalumnae	45.01	3.00e-114	405.00
IUUC-Loc-052776	Lepisosteus oculatus	50.75	7.00e-135	474.00
IUUC-Laf-054269	Loxodonta africana	86.86	0.00e+00	832.00
IUUC-Mcc-055669	Macaca mulatta	90.98	0.00e+00	840.00
IUUC-Mga-059615	Meleagris gallopavo	54.69	3.00e-17	79.30
IUUC-Mmr-061562	Microcebus murinus	89.36	0.00e+00	744.00
IUUC-Mdo-062263	Monodelphis domestica	75.78	0.00e+00	728.00
IUUC-Mmu-064325	Mus musculus	96.85	0.00e+00	902.00
IUUC-Mpu-066385	Mustela putorius furo	89.80	0.00e+00	855.00
IUUC-Mlu-067000	Myotis lucifugus	88.41	0.00e+00	826.00
IUUC-Nle-069812	Nomascus leucogenys	90.59	0.00e+00	833.00
IUUC-Opr-070575	Ochotona princeps	92.16	3.00e-103	369.00
IUUC-Ont-072405	Oreochromis niloticus	51.40	2.00e-135	475.00
IUUC-Ocu-074358	Oryctolagus cuniculus	80.31	0.00e+00	758.00
IUUC-Ola-086403	Oryzias latipes	53.24	2.00e-137	482.00
IUUC-Oga-087986	Otolemur garnettii	88.04	0.00e+00	810.00
IUUC-Oar-089600	Ovis aries	87.25	0.00e+00	848.00
IUUC-Ptr-091224	Pan troglodytes	90.78	0.00e+00	834.00
IUUC-Pan-092739	Papio anubis	91.18	0.00e+00	843.00
IUUC-Pma-094407	Petromyzon marinus	47.46	3.00e-124	438.00
IUUC-Pfo-097161	Poecilia formosa	51.89	1.00e-131	462.00
IUUC-Pab-098627	Pongo abelii	90.78	0.00e+00	829.00
IUUC-Pca-100641	Procavia capensis	86.58	0.00e+00	767.00
IUUC-Pva-102670	Pteropus vampyrus	88.04	0.00e+00	830.00
IUUC-Pte-104234	Pyrenophora teres	25.41	2.00e-11	63.50
IUUC-Sha-107342	Sarcophilus harrisii	75.58	0.00e+00	743.00
IUUC-Sar-113425	Sorex araneus	85.32	1.00e-108	386.00
IUUC-Ssc-115904	Sus scrofa	88.44	3.00e-85	306.00
IUUC-Tru-118096	Takifugu rubripes	50.39	2.00e-137	482.00
IUUC-Tni-119873	Tetraodon nigroviridis	49.80	2.00e-136	479.00
IUUC-Tbe-127578	Tupaia belangeri	87.89	0.00e+00	674.00
IUUC-Ttr-129107	Tursiops truncatus	89.22	0.00e+00	815.00
IUUC-Vpa-130353	Vicugna pacos	90.28	7.00e-114	403.00
IUUC-Xtr-132168	Xenopus tropicalis	42.66	4.00e-93	335.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence