• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064203
UUCD1 version UUC-MuM-00278
Ensembl Protein ID ENSMUSP00000027393.7
UniProt Accession O70445; A2VCQ1; BARD1_MOUSE
Genbank Protein ID AAC18095.1; AAI28371.1; AAI28372.1
Protein Name BRCA1-associated RING domain protein 1; RING-type E3 ubiquitin transferase BARD1
Genbank Nucleotide ID AF057157; BC128370; BC128371
Gene Name Bard1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000026196.7 ENSMUST00000027393.7 ENSMUSP00000027393.7
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 26.91 9.00e-14 75.90 IUUC-Cel-018312
E3 activity/RING/RING 70.25 0.00e+00 1023.00 IUUC-Hsa-045826
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.
 E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.
Protein Sequence
(Fasta)
MPRRPPRVCS GNQPAPVPAM EPATDGLWAH SRAALARLEK LLRCSRCANI LKEPVCLGGC 60
EHIFCSGCIS DCVGSGCPVC YTPAWILDLK INRQLDSMIQ LSSKLQNLLH DNKDSKDNTS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064203|E3,RING|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCCTCCTAGG GCCACAGGCC TAGGTGACTT CTCCCCACGC CTCCTCAACC CCGCGCCTTG 60
GCACTTTGGT TTCCGCGGTC CGCCCTACAC CTCCTGAGGG CGTGGCCTCT CAAGCCTCGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064203|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR033097--BARD1
IPR001357--BRCT_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50172--BRCT
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF12796--Ank_2
PRINTS

PR01415--ANKYRIN
SMART

SM00248--ANK
SM00292--BRCT
Gene Ontology

GO:0070531--C:BRCA1-A complex
GO:0031436--C:BRCA1-BARD1 complex
GO:0005737--C:cytoplasm
GO:0016607--C:nuclear speck
GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0046982--F:protein heterodimerization activity
GO:0042803--F:protein homodimerization activity
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0043066--P:negative regulation of apoptotic process
GO:0046826--P:negative regulation of protein export from nucleus
GO:0043065--P:positive regulation of apoptotic process
GO:0085020--P:protein K6-linked ubiquitination
GO:0042325--P:regulation of phosphorylation
KEGG mmu:12021
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000225 Aegilops tauschii 35.37 6.00e-19 89.70
IUUC-Aml-002346 Ailuropoda melanoleuca 69.55 0.00e+00 1007.00
IUUC-Atr-002625 Amborella trichopoda 29.02 2.00e-19 92.00
IUUC-Apl-004108 Anas platyrhynchos 66.04 1.00e-143 503.00
IUUC-Aca-005387 Anolis carolinensis 45.26 0.00e+00 633.00
IUUC-Ath-006986 Arabidopsis thaliana 34.66 1.00e-20 95.50
IUUC-Ame-011716 Astyanax mexicanus 53.41 2.00e-58 220.00
IUUC-Bta-013417 Bos taurus 69.82 0.00e+00 1003.00
IUUC-Bdi-014760 Brachypodium distachyon 30.54 8.00e-20 92.80
IUUC-Bol-016476 Brassica oleracea 34.46 3.00e-18 87.40
IUUC-Bra-017176 Brassica rapa 32.93 1.00e-19 92.40
IUUC-Cel-018312 Caenorhabditis elegans 26.99 7.00e-15 75.90
IUUC-Cja-019415 Callithrix jacchus 70.03 0.00e+00 1055.00
IUUC-Cfa-020351 Canis familiaris 68.95 0.00e+00 918.00
IUUC-Cpo-021746 Cavia porcellus 68.22 0.00e+00 988.00
IUUC-Csa-023450 Chlorocebus sabaeus 71.34 0.00e+00 1008.00
IUUC-Csv-025987 Ciona savignyi 37.13 5.00e-54 205.00
IUUC-Dno-029038 Dasypus novemcinctus 61.10 0.00e+00 873.00
IUUC-Dor-030826 Dipodomys ordii 67.81 0.00e+00 899.00
IUUC-Ete-033061 Echinops telfairi 62.15 0.00e+00 875.00
IUUC-Eca-033710 Equus caballus 65.98 0.00e+00 686.00
IUUC-Eeu-035266 Erinaceus europaeus 53.40 3.00e-151 528.00
IUUC-Fca-035414 Felis catus 71.30 0.00e+00 1072.00
IUUC-Fal-037357 Ficedula albicollis 48.29 0.00e+00 650.00
IUUC-Gga-040255 Gallus gallus 66.76 8.00e-141 494.00
IUUC-Gma-044372 Glycine max 32.85 3.00e-18 88.20
IUUC-Ggo-045300 Gorilla gorilla 70.16 0.00e+00 1040.00
IUUC-Hsa-045826 Homo sapiens 70.42 0.00e+00 1022.00
IUUC-Itr-048456 Ictidomys tridecemlineatus 72.59 0.00e+00 1048.00
IUUC-Lch-050674 Latimeria chalumnae 59.43 1.00e-134 474.00
IUUC-Lpe-050895 Leersia perrieri 34.01 3.00e-17 84.30
IUUC-Laf-054591 Loxodonta africana 66.62 0.00e+00 984.00
IUUC-Mcc-055017 Macaca mulatta 66.28 0.00e+00 928.00
IUUC-Mtr-058400 Medicago truncatula 38.12 4.00e-24 107.00
IUUC-Mga-059484 Meleagris gallopavo 48.28 1.00e-175 610.00
IUUC-Mmr-061544 Microcebus murinus 71.34 0.00e+00 1082.00
IUUC-Mdo-062408 Monodelphis domestica 53.52 0.00e+00 733.00
IUUC-Mac-065131 Musa acuminata 29.95 6.00e-20 93.20
IUUC-Mpu-066899 Mustela putorius furo 71.08 0.00e+00 1006.00
IUUC-Mlu-067781 Myotis lucifugus 66.80 0.00e+00 907.00
IUUC-Nle-069031 Nomascus leucogenys 70.50 0.00e+00 1059.00
IUUC-Opr-070889 Ochotona princeps 62.98 2.00e-152 533.00
IUUC-Ont-072557 Oreochromis niloticus 49.59 1.00e-108 387.00
IUUC-Ocu-074785 Oryctolagus cuniculus 69.50 0.00e+00 1012.00
IUUC-Oba-075953 Oryza barthii 36.55 4.00e-20 93.20
IUUC-Obr-076308 Oryza brachyantha 36.73 2.00e-19 92.00
IUUC-Ogl-076938 Oryza glaberrima 36.55 4.00e-20 93.20
IUUC-Ogu-078659 Oryza glumaepatula 39.47 1.00e-15 79.00
IUUC-Oin-079086 Oryza indica 39.47 1.00e-15 78.60
IUUC-Olo-080264 Oryza longistaminata 39.47 4.00e-15 77.80
IUUC-Ome-081445 Oryza meridionalis 30.32 7.00e-16 79.70
IUUC-Oni-082364 Oryza nivara 36.55 4.00e-20 93.20
IUUC-Opu-083700 Oryza punctata 35.37 2.00e-18 88.20
IUUC-Oru-085093 Oryza rufipogon 39.47 2.00e-15 78.60
IUUC-Osa-085434 Oryza sativa 36.55 3.00e-20 93.60
IUUC-Olu-087823 Ostreococcus lucimarinus 35.48 2.00e-16 77.40
IUUC-Oga-088383 Otolemur garnettii 66.19 0.00e+00 897.00
IUUC-Oar-089357 Ovis aries 69.13 0.00e+00 1055.00
IUUC-Ptr-090959 Pan troglodytes 70.42 0.00e+00 1020.00
IUUC-Pan-092160 Papio anubis 70.96 0.00e+00 1031.00
IUUC-Psi-093036 Pelodiscus sinensis 48.03 7.00e-162 564.00
IUUC-Pab-098198 Pongo abelii 70.42 0.00e+00 1011.00
IUUC-Pop-099956 Populus trichocarpa 33.11 3.00e-19 91.30
IUUC-Ppe-101676 Prunus persica 40.46 7.00e-20 93.20
IUUC-Pva-102243 Pteropus vampyrus 70.47 0.00e+00 1047.00
IUUC-Rno-104832 Rattus norvegicus 89.06 0.00e+00 1263.00
IUUC-Sha-107601 Sarcophilus harrisii 66.76 2.00e-150 526.00
IUUC-Sit-110609 Setaria italica 31.29 7.00e-16 79.70
IUUC-Sly-111863 Solanum lycopersicum 29.82 2.00e-21 97.80
IUUC-Stu-112154 Solanum tuberosum 35.71 9.00e-21 95.90
IUUC-Sar-113493 Sorex araneus 57.84 6.00e-60 225.00
IUUC-Sbi-114470 Sorghum bicolor 29.73 2.00e-18 88.60
IUUC-Ssc-115611 Sus scrofa 69.79 0.00e+00 1015.00
IUUC-Tgu-116812 Taeniopygia guttata 49.41 0.00e+00 689.00
IUUC-Tru-117996 Takifugu rubripes 38.09 2.00e-121 429.00
IUUC-Tsy-119446 Tarsius syrichta 56.26 0.00e+00 786.00
IUUC-Tni-120842 Tetraodon nigroviridis 38.35 4.00e-130 459.00
IUUC-Tca-121417 Theobroma cacao 37.16 4.00e-22 100.00
IUUC-Tae-124838 Triticum aestivum 35.37 9.00e-19 89.40
IUUC-Tur-126725 Triticum urartu 35.37 9.00e-19 89.40
IUUC-Tbe-127550 Tupaia belangeri 64.95 0.00e+00 758.00
IUUC-Ttr-128364 Tursiops truncatus 69.43 0.00e+00 948.00
IUUC-Vpa-130659 Vicugna pacos 65.94 0.00e+00 828.00
IUUC-Xtr-131846 Xenopus tropicalis 44.35 3.00e-170 592.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved