iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-046094

UUCD1 version

UUC-HoS-00859

Ensembl Protein ID

ENSP00000362609.3

UniProt Accession

Q96BR9; Q8IUL5; Q8IWR9; Q8N2Y5; Q96BX0; ZBT8A_HUMAN

Genbank Protein ID

AAN40800.1; AAN77376.1; BAC11050.1; CAI20023.1; CAI20024.1; EAX07521.1; EAX07522.1; AAH15067.1; AAH15239.1; AAH29654.1

Protein Name

Zinc finger and BTB domain-containing protein 8A; BTB/POZ and zinc-finger domain-containing factor; BTB/POZ and zinc-finger domains factor on chromosome 1

Genbank Nucleotide ID

AF548353; AY157873; AK074546; AL033529; AL033529; CH471059; CH471059; BC015067; BC015239; BC029654

Gene Name

ZBTB8A; BOZF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000160062.14	ENST00000373510.8	ENSP00000362609.3
ENSG00000160062.14	ENST00000316459.4	ENSP00000317561.4

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
GWASdb	GWAS Central
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	4.20e-14	54.3	24	90

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +D+ + v+g++f+ah+ vL asS +F+ l++++ +e+ +  + +++  +p+ f ++l+F+Y+gkl++
   Q: 24   CDCSILVEGKVFKAHRNVLFASSGYFKMLLSQNSKETSQPTTATFQAFSPDTFTVILDFVYSGKLSL 90
           8**********************************888788888889*****************986 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MEISSHQSHL LQQLNEQRRQ DVFCDCSILV EGKVFKAHRN VLFASSGYFK MLLSQNSKET 60
SQPTTATFQA FSPDTFTVIL DFVYSGKLSL TGQNVIEVMS AASFLQMTDV ISVCKTFIKS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCAAATACC TTTTGTTTCT CTCACGTTGG GGCTACTTGT TTTAGGGCGC AAAGGAACGG 60
CCTCGAAAGG GGGTCCTTCC CCAGCCGAGA ACCAGGAATC TTCCCTCGGC CCGCGCGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:653121

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001850	Ailuropoda melanoleuca	86.79	0.00e+00	749.00
IUUC-Apl-003231	Anas platyrhynchos	73.31	3.00e-134	471.00
IUUC-Aca-004794	Anolis carolinensis	68.55	1.00e-153	536.00
IUUC-Aly-005751	Arabidopsis lyrata	26.67	7.00e-03	35.80
IUUC-Ame-011665	Astyanax mexicanus	45.94	5.00e-94	338.00
IUUC-Bta-013057	Bos taurus	87.68	0.00e+00	809.00
IUUC-Bol-016188	Brassica oleracea	31.76	3.00e-08	53.50
IUUC-Cja-019989	Callithrix jacchus	97.28	0.00e+00	849.00
IUUC-Cfa-020866	Canis familiaris	94.78	0.00e+00	808.00
IUUC-Cpo-022548	Cavia porcellus	91.61	0.00e+00	754.00
IUUC-Csa-023375	Chlorocebus sabaeus	99.55	0.00e+00	875.00
IUUC-Cho-024440	Choloepus hoffmanni	86.16	0.00e+00	695.00
IUUC-Dre-027626	Danio rerio	46.31	6.00e-89	321.00
IUUC-Dno-030021	Dasypus novemcinctus	93.44	0.00e+00	792.00
IUUC-Dor-031116	Dipodomys ordii	85.49	0.00e+00	730.00
IUUC-Eca-033905	Equus caballus	95.69	0.00e+00	828.00
IUUC-Fca-036562	Felis catus	94.78	0.00e+00	839.00
IUUC-Fal-036662	Ficedula albicollis	71.73	0.00e+00	629.00
IUUC-Gmo-038907	Gadus morhua	69.11	3.00e-45	176.00
IUUC-Gga-040388	Gallus gallus	53.29	6.00e-128	451.00
IUUC-Gac-041383	Gasterosteus aculeatus	66.67	2.00e-48	186.00
IUUC-Ggo-045496	Gorilla gorilla	86.62	0.00e+00	713.00
IUUC-Itr-048286	Ictidomys tridecemlineatus	92.52	0.00e+00	791.00
IUUC-Lch-050008	Latimeria chalumnae	63.74	1.00e-146	513.00
IUUC-Loc-052392	Lepisosteus oculatus	47.20	6.00e-105	374.00
IUUC-Laf-053626	Loxodonta africana	94.56	0.00e+00	807.00
IUUC-Meu-056315	Macropus eugenii	81.90	0.00e+00	724.00
IUUC-Mga-059828	Meleagris gallopavo	72.77	0.00e+00	666.00
IUUC-Mmr-061265	Microcebus murinus	93.65	0.00e+00	817.00
IUUC-Mdo-062713	Monodelphis domestica	74.38	0.00e+00	684.00
IUUC-Mmu-063523	Mus musculus	81.86	0.00e+00	730.00
IUUC-Mpu-066095	Mustela putorius furo	94.33	0.00e+00	831.00
IUUC-Mlu-067305	Myotis lucifugus	94.33	0.00e+00	813.00
IUUC-Nle-069613	Nomascus leucogenys	99.77	0.00e+00	877.00
IUUC-Opr-070693	Ochotona princeps	88.01	0.00e+00	791.00
IUUC-Ont-071284	Oreochromis niloticus	47.81	5.00e-88	318.00
IUUC-Oan-073189	Ornithorhynchus anatinus	81.57	0.00e+00	706.00
IUUC-Ocu-074442	Oryctolagus cuniculus	90.02	0.00e+00	796.00
IUUC-Oga-088205	Otolemur garnettii	87.00	0.00e+00	819.00
IUUC-Oar-089255	Ovis aries	95.24	0.00e+00	843.00
IUUC-Ptr-090862	Pan troglodytes	99.55	0.00e+00	876.00
IUUC-Pan-092028	Papio anubis	98.87	0.00e+00	869.00
IUUC-Psi-093132	Pelodiscus sinensis	72.92	0.00e+00	681.00
IUUC-Pfo-096788	Poecilia formosa	45.83	9.00e-102	363.00
IUUC-Pab-098334	Pongo abelii	99.77	0.00e+00	868.00
IUUC-Pca-100730	Procavia capensis	84.35	0.00e+00	726.00
IUUC-Pva-103084	Pteropus vampyrus	94.10	0.00e+00	791.00
IUUC-Rno-105164	Rattus norvegicus	86.85	0.00e+00	770.00
IUUC-Sha-107306	Sarcophilus harrisii	73.90	0.00e+00	693.00
IUUC-Ssc-115340	Sus scrofa	94.56	0.00e+00	839.00
IUUC-Tgu-117389	Taeniopygia guttata	77.88	0.00e+00	645.00
IUUC-Tru-118311	Takifugu rubripes	46.59	2.00e-86	312.00
IUUC-Tsy-119469	Tarsius syrichta	82.54	0.00e+00	669.00
IUUC-Tni-120508	Tetraodon nigroviridis	60.38	3.00e-52	199.00
IUUC-Ttr-129129	Tursiops truncatus	94.78	0.00e+00	835.00
IUUC-Vpa-130726	Vicugna pacos	94.66	0.00e+00	649.00
IUUC-Xtr-131889	Xenopus tropicalis	47.77	2.00e-107	382.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence