iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.80e-27	95.4	256	306

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 8    vlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
           v + +++ + deLt ++Gd+v+v+     + +W++++  +++k G++P  F e
   Q: 256  VRHAFSGRQGDELTVNAGDTVRVL--RMVNDEWVMCKDPDTEKTGIVPVGFLE 306
           679*********************..9999******************99976 PP

Organism

Caenorhabditis elegans

Protein Sequence
(Fasta)

MAHLSWVRIS NATQDPETRC SVAQDQIVKV VREEGDWCHI QTIEGVSGRV PRVLTLPIVD 60
PKRQPDEQVY CSIEAYTSIR SDDLSFAEFS IFVAKPSRSN PGYLDGFLVN DNAVQIGRRG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTGCAGTAT GGCCCACCTC TCGTGGGTAA GAATTTCAAA TGCCACACAA GATCCCGAAA 60
CGCGGTGTTC TGTAGCCCAA GATCAGATTG TTAAGGTGGT CCGTGAGGAG GGGGATTGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR000219--DH-domain
IPR001452--SH3_domain

PROSITE

PS50010--DH_2
PS50002--SH3

Pfam

PF00621--RhoGEF
PF00018--SH3_1
PF14604--SH3_9

SMART

SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005622--C:intracellular
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0043547--P:positive regulation of GTPase activity
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction

KEGG

cel:CELE_Y37A1B.17

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002128	Ailuropoda melanoleuca	26.03	1.00e-28	121.00
IUUC-Apl-003934	Anas platyrhynchos	28.88	5.00e-32	132.00
IUUC-Aca-005005	Anolis carolinensis	27.71	5.00e-32	132.00
IUUC-Afu-008915	Aspergillus fumigatus	28.32	6.00e-07	48.10
IUUC-Ame-011361	Astyanax mexicanus	25.42	2.00e-31	131.00
IUUC-Bta-013210	Bos taurus	26.52	2.00e-29	124.00
IUUC-Cja-019104	Callithrix jacchus	24.15	1.00e-21	98.60
IUUC-Cfa-020960	Canis familiaris	26.28	3.00e-29	123.00
IUUC-Cpo-022440	Cavia porcellus	24.88	3.00e-28	120.00
IUUC-Csa-023391	Chlorocebus sabaeus	26.03	2.00e-28	120.00
IUUC-Dre-027932	Danio rerio	26.50	3.00e-32	133.00
IUUC-Dno-029750	Dasypus novemcinctus	25.60	7.00e-27	115.00
IUUC-Dor-031109	Dipodomys ordii	23.70	3.00e-24	107.00
IUUC-Ete-032660	Echinops telfairi	24.31	4.00e-26	113.00
IUUC-Eca-033433	Equus caballus	26.52	3.00e-29	123.00
IUUC-Eeu-034929	Erinaceus europaeus	26.28	1.00e-19	91.70
IUUC-Fca-035859	Felis catus	26.52	3.00e-29	123.00
IUUC-Fal-036653	Ficedula albicollis	28.77	1.00e-31	131.00
IUUC-Gmo-038948	Gadus morhua	20.96	3.00e-24	106.00
IUUC-Gga-040279	Gallus gallus	28.19	5.00e-36	145.00
IUUC-Gac-041641	Gasterosteus aculeatus	25.84	6.00e-31	129.00
IUUC-Ggo-044900	Gorilla gorilla	24.03	4.00e-22	98.60
IUUC-Hsa-046063	Homo sapiens	26.03	2.00e-28	120.00
IUUC-Itr-049071	Ictidomys tridecemlineatus	23.72	2.00e-24	107.00
IUUC-Lch-049865	Latimeria chalumnae	28.21	4.00e-27	116.00
IUUC-Loc-051754	Lepisosteus oculatus	23.96	2.00e-31	130.00
IUUC-Laf-054037	Loxodonta africana	22.98	2.00e-23	103.00
IUUC-Mcc-055002	Macaca mulatta	26.03	2.00e-28	120.00
IUUC-Meu-056420	Macropus eugenii	23.18	2.00e-15	77.80
IUUC-Mga-059868	Meleagris gallopavo	28.47	3.00e-31	129.00
IUUC-Mmr-060767	Microcebus murinus	25.79	8.00e-29	122.00
IUUC-Mdo-061939	Monodelphis domestica	24.70	2.00e-26	114.00
IUUC-Mmu-063980	Mus musculus	25.24	4.00e-28	119.00
IUUC-Mpu-065913	Mustela putorius furo	26.28	6.00e-29	122.00
IUUC-Mlu-067340	Myotis lucifugus	26.27	6.00e-29	122.00
IUUC-Nfi-068447	Neosartorya fischeri	27.75	1.00e-06	47.00
IUUC-Nle-069343	Nomascus leucogenys	25.48	2.00e-28	120.00
IUUC-Opr-070694	Ochotona princeps	24.20	2.00e-25	110.00
IUUC-Ont-071844	Oreochromis niloticus	24.78	3.00e-30	127.00
IUUC-Ocu-074406	Oryctolagus cuniculus	24.70	3.00e-28	120.00
IUUC-Ola-087343	Oryzias latipes	25.54	8.00e-34	137.00
IUUC-Oga-088847	Otolemur garnettii	26.03	4.00e-28	119.00
IUUC-Oar-089817	Ovis aries	25.85	8.00e-30	125.00
IUUC-Ptr-090508	Pan troglodytes	24.03	5.00e-22	98.20
IUUC-Pan-092104	Papio anubis	26.52	4.00e-29	123.00
IUUC-Pma-094663	Petromyzon marinus	26.39	4.00e-27	116.00
IUUC-Pfo-096714	Poecilia formosa	24.66	7.00e-32	132.00
IUUC-Pab-097918	Pongo abelii	26.09	2.00e-28	120.00
IUUC-Pva-102490	Pteropus vampyrus	25.06	1.00e-26	114.00
IUUC-Rno-105908	Rattus norvegicus	24.46	4.00e-28	119.00
IUUC-Sha-107509	Sarcophilus harrisii	23.94	4.00e-26	112.00
IUUC-Ssc-115250	Sus scrofa	26.28	3.00e-30	127.00
IUUC-Tru-118279	Takifugu rubripes	26.00	3.00e-36	146.00
IUUC-Tni-120459	Tetraodon nigroviridis	26.25	4.00e-35	141.00
IUUC-Ttr-129096	Tursiops truncatus	24.83	4.00e-23	103.00
IUUC-Vpa-130643	Vicugna pacos	23.45	3.00e-21	97.10
IUUC-Xtr-131979	Xenopus tropicalis	25.91	3.00e-30	126.00
IUUC-Xma-133320	Xiphophorus maculatus	24.37	7.00e-32	132.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence