iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037366

Ensembl Protein ID

ENSFALP00000005338.1

UniProt Accession

U3JRD4; U3JRD4_FICAL

Genbank Protein ID

ENSFALP00000005338

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTO01021085

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000005109.1	ENSFALT00000005364.1	ENSFALP00000005338.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.80e-76	257.4	528	853

Active Site

Position(s)	Description	Evidence
823	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 9    levefvgEegldlgGvtreflallskelqnpd......lglflysendketlqpnpdsglknp..ehlklFeflGrllgkalqdgrlld 89
           +e++f  E  +d+gG +r+ la +s+el+ ++      l++f++++n+ + +  ++d+++ np  + +  +e++G+++g al+ +++l 
   Q: 528  WECKFIAEGIIDQGGGFRDSLADMSEELCPSSadtpvpLPFFVRTSNQGNGTGEARDMYVPNPscKDFPKYEWIGQIMGAALRGKEFLV 616
           45*****************************9999*99**********************9998889999******************* PP
   S: 90   lplsksfyklllgkklsl.edleevdpelykslkeikenaesdieelgldltfs...vseeilgetkeeeLkpgGenipVtneNkeeYv 174
           l l+ +++k+l g+++s+ +d+++vd+ l+k l+ ++ +     ++ +++++f    + +++l++++ +eL+p+G+n+ V +e+++e++
   Q: 617  LALPGFVWKQLTGEEVSWsKDFPAVDSVLVKLLEVMEVM-----DKDTFEFKFGnelTYTTVLSDQRMVELIPNGSNTAVRYEDRREFI 700
           *************************************77.....333455555533445567999************************ PP
   S: 175  klvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +lv ++rl+e  keq+ a+++G+ +v+p+ +l+l+t++ele  +cG++ei+v++lk+ t++++ +++++  +q+Fwe+l++f++e+r++
   Q: 701  RLVQKARLEE-SKEQIMAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEITVDALKRLTRFED-FEPQDTRVQYFWEALNNFTNEDRSR 787
           *********9.9*************************************************76.************************* PP
   S: 264  fLqFvTgssrlPlgGfaelkprlfvirk...dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           fL+FvTg+srlP+        r++++++   ++++d lP+s+TC ++L LP+Y + ++++ekL+yA  ++ +++
   Q: 788  FLRFVTGRSRLPA--------RIYIYPDkmgSETTDALPESSTCSSTLFLPNYATAKVCEEKLRYAAYNCVAID 853
           ************5........66677767888899*********************************998776 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

RRGVGVRSAM RTDGEAPHQI LGRLRFLLQC SECFRRAQAL PPALCYVPRE VQYKICKDPA 60
AAAARSLLSV WDSPGPARGG KRAARATIEG RKGALGQAQQ GNAAAASRDG PGPASLDRRL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGCGCGGAG TCGGTGTCCG GAGCGCGATG AGGACGGACG GGGAGGCACC GCACCAGATC 60
CTGGGCCGGC TGCGGTTCCT GCTGCAGTGC AGCGAGTGCT TCCGCCGCGC CCAGGCGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR004939--APC_su10/DOC_dom
IPR008979--Galactose-bd-like
IPR000569--HECT_dom

PROSITE

PS51284--DOC
PS50237--HECT

Pfam

PF03256--ANAPC10
PF00632--HECT

SMART

SM01337--APC10
SM00119--HECTc

Gene Ontology

GO:0048471--C:perinuclear region of cytoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001229	Ailuropoda melanoleuca	77.67	0.00e+00	1351.00
IUUC-Apl-003715	Anas platyrhynchos	96.89	0.00e+00	1471.00
IUUC-Aca-004377	Anolis carolinensis	84.63	0.00e+00	1449.00
IUUC-Ame-011918	Astyanax mexicanus	66.63	0.00e+00	1157.00
IUUC-Bta-012736	Bos taurus	78.02	0.00e+00	1366.00
IUUC-Cja-019926	Callithrix jacchus	77.79	0.00e+00	1363.00
IUUC-Cfa-020753	Canis familiaris	87.35	0.00e+00	1069.00
IUUC-Cpo-021415	Cavia porcellus	77.44	0.00e+00	1355.00
IUUC-Csa-023096	Chlorocebus sabaeus	77.56	0.00e+00	1358.00
IUUC-Dre-028746	Danio rerio	72.53	0.00e+00	1230.00
IUUC-Dno-029293	Dasypus novemcinctus	86.82	0.00e+00	980.00
IUUC-Dor-031113	Dipodomys ordii	87.34	0.00e+00	1130.00
IUUC-Ete-032601	Echinops telfairi	73.49	0.00e+00	1189.00
IUUC-Eca-034198	Equus caballus	76.06	0.00e+00	1347.00
IUUC-Eeu-034708	Erinaceus europaeus	87.72	0.00e+00	834.00
IUUC-Fca-035478	Felis catus	78.92	0.00e+00	1352.00
IUUC-Gmo-039020	Gadus morhua	78.93	0.00e+00	1075.00
IUUC-Gga-040332	Gallus gallus	92.73	0.00e+00	1587.00
IUUC-Gac-042336	Gasterosteus aculeatus	72.37	0.00e+00	1280.00
IUUC-Ggo-045382	Gorilla gorilla	77.56	0.00e+00	1358.00
IUUC-Hsa-046562	Homo sapiens	77.56	0.00e+00	1358.00
IUUC-Itr-048208	Ictidomys tridecemlineatus	77.67	0.00e+00	1358.00
IUUC-Lch-049606	Latimeria chalumnae	71.29	0.00e+00	893.00
IUUC-Loc-052448	Lepisosteus oculatus	65.32	0.00e+00	1112.00
IUUC-Laf-054507	Loxodonta africana	77.12	0.00e+00	1362.00
IUUC-Mcc-055690	Macaca mulatta	77.44	0.00e+00	1356.00
IUUC-Meu-055970	Macropus eugenii	78.56	0.00e+00	1325.00
IUUC-Mga-059654	Meleagris gallopavo	97.53	0.00e+00	1455.00
IUUC-Mmr-061069	Microcebus murinus	77.67	0.00e+00	1360.00
IUUC-Mdo-062547	Monodelphis domestica	89.60	0.00e+00	774.00
IUUC-Mmu-063096	Mus musculus	77.67	0.00e+00	1367.00
IUUC-Mpu-065846	Mustela putorius furo	77.79	0.00e+00	1363.00
IUUC-Mlu-067992	Myotis lucifugus	84.17	0.00e+00	1325.00
IUUC-Nle-069565	Nomascus leucogenys	76.51	0.00e+00	1256.00
IUUC-Opr-070853	Ochotona princeps	73.55	0.00e+00	911.00
IUUC-Ont-071628	Oreochromis niloticus	71.99	0.00e+00	1248.00
IUUC-Ocu-074094	Oryctolagus cuniculus	77.56	0.00e+00	1360.00
IUUC-Ola-087384	Oryzias latipes	71.51	0.00e+00	1281.00
IUUC-Oga-088224	Otolemur garnettii	77.67	0.00e+00	1365.00
IUUC-Oar-090043	Ovis aries	77.33	0.00e+00	1338.00
IUUC-Ptr-090852	Pan troglodytes	77.44	0.00e+00	1356.00
IUUC-Pan-092787	Papio anubis	77.44	0.00e+00	1357.00
IUUC-Psi-092986	Pelodiscus sinensis	76.92	0.00e+00	1036.00
IUUC-Pma-094416	Petromyzon marinus	41.37	9.00e-173	600.00
IUUC-Pfo-096720	Poecilia formosa	72.19	0.00e+00	1286.00
IUUC-Pab-098325	Pongo abelii	74.66	0.00e+00	1010.00
IUUC-Pca-100885	Procavia capensis	72.24	0.00e+00	1066.00
IUUC-Pva-102829	Pteropus vampyrus	64.30	0.00e+00	1060.00
IUUC-Rno-104882	Rattus norvegicus	78.02	0.00e+00	1365.00
IUUC-Sha-106811	Sarcophilus harrisii	83.02	4.00e-108	384.00
IUUC-Sar-113020	Sorex araneus	75.30	0.00e+00	654.00
IUUC-Ssc-115436	Sus scrofa	82.96	2.00e-137	481.00
IUUC-Tgu-117042	Taeniopygia guttata	95.29	0.00e+00	1586.00
IUUC-Tru-118419	Takifugu rubripes	70.95	0.00e+00	1202.00
IUUC-Tsy-118829	Tarsius syrichta	76.88	0.00e+00	800.00
IUUC-Tni-120410	Tetraodon nigroviridis	59.16	0.00e+00	959.00
IUUC-Tbe-128113	Tupaia belangeri	87.47	0.00e+00	711.00
IUUC-Ttr-128167	Tursiops truncatus	73.95	0.00e+00	1271.00
IUUC-Xtr-132910	Xenopus tropicalis	68.43	0.00e+00	1119.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence