iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059523

UUCD1 version

UUC-MeG-00843

Ensembl Protein ID

ENSMGAP00000011968.2

UniProt Accession

G1NFZ7; G1NFZ7_MELGA

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP44

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000011439.2	ENSMGAT00000012852.2	ENSMGAP00000011968.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.80e-98	329.6	275	683

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...kkkeklneenp............................................ 42
           tGl+NlgNtCYmNS+LQ+Ls++  +re++l+   ++++      +                                            
   Q: 275  TGLRNLGNTCYMNSILQVLSHLLIFRECFLKldlNQTQ------Ellataasgktrsssrrssitastlqvnenqekgrgsssvrrtnl 357
           7******************************5552222......22334557888888889999999999999999************* PP
   S: 43   ......................kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkk 109
                                 ++++ +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ lld++++el  
   Q: 358  ssglsggasksrnmeliqprepSSKHISLCHELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKVQQEL-- 444
           ********9999999999999999999************************************************************.. PP
   S: 110  eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke........slqdc 190
                  e+++++  +l   a++k  k+  ++++++F+gql sq++cl+cdn+s++ epf+dlsl++p++ +++ +         l+++
   Q: 445  -------ETTGTRYPALIPAAQRKLIKQVLNVVNNIFHGQLLSQVTCLACDNKSNTIEPFWDLSLEFPERYHCNGKemasqypcPLTEM 526
           .......7788888999999************************************************9999987799999******** PP
   S: 191  Lesftkeeelegenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctsp 268
           L++ft++e leg+  y c++c+ k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v+f + L+++p+c+++
   Q: 527  LAKFTETEALEGKI-YACDQCNTKRRkfsskpvilteAQKQLMVCRLPQVLRLHLKRFRWSGR-NHREKIGVHVNFDQILNMEPYCCRE 613
           ***********965.*******999999999999999***********************997.8889********************8 PP
   S: 269  eekqke..kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           + k+    + +Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk + +++eev++   ++aY+lfY +
   Q: 614  SLKSLLpdCFIYDLSAVVMHHGkGFGSGHYTAYCYNSEGGfWVHCNDSKLNMCTMEEVCK---AQAYILFYSQ 683
           877654669***************************9999********************...********87 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

ILTMDKCKHI GRLRLAQDHS ILNPQKWHCV DCNTTESVWA CLSCSHVACG RYIEEHALKH 60
FQENGHPVAL EVNELYVFCY LCDDYVLNDN ATGDIKLLRS TLSAIKSQKY ECTTRSGRTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTCTAACAA TGGATAAGTG TAAGCACATA GGACGCCTGC GACTGGCCCA AGATCACTCC 60
ATTCTGAATC CACAGAAATG GCATTGCGTG GACTGCAATA CTACCGAGTC TGTGTGGGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:1904667--P:negative regulation of ubiquitin protein ligase activity
GO:0016579--P:protein deubiquitination
GO:0090231--P:regulation of spindle checkpoint
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001220	Ailuropoda melanoleuca	76.30	0.00e+00	1066.00
IUUC-Apl-003673	Anas platyrhynchos	94.98	0.00e+00	1295.00
IUUC-Aca-004434	Anolis carolinensis	83.24	0.00e+00	1151.00
IUUC-Ame-010986	Astyanax mexicanus	69.83	0.00e+00	927.00
IUUC-Bta-012774	Bos taurus	75.04	0.00e+00	1061.00
IUUC-Cja-019619	Callithrix jacchus	74.05	0.00e+00	1045.00
IUUC-Cfa-020957	Canis familiaris	75.18	0.00e+00	1062.00
IUUC-Cpo-022233	Cavia porcellus	60.70	0.00e+00	807.00
IUUC-Csa-023177	Chlorocebus sabaeus	74.37	0.00e+00	1044.00
IUUC-Cho-024877	Choloepus hoffmanni	71.73	0.00e+00	659.00
IUUC-Cin-025587	Ciona intestinalis	50.00	3.00e-114	405.00
IUUC-Csv-025814	Ciona savignyi	45.40	4.00e-154	538.00
IUUC-Dre-027878	Danio rerio	71.19	0.00e+00	895.00
IUUC-Dno-029832	Dasypus novemcinctus	74.61	0.00e+00	1056.00
IUUC-Ete-032627	Echinops telfairi	73.22	0.00e+00	1031.00
IUUC-Eca-033863	Equus caballus	73.80	0.00e+00	1035.00
IUUC-Eeu-035225	Erinaceus europaeus	71.29	0.00e+00	983.00
IUUC-Fca-036288	Felis catus	74.89	0.00e+00	1048.00
IUUC-Fal-037207	Ficedula albicollis	88.81	0.00e+00	1227.00
IUUC-Gga-040457	Gallus gallus	99.02	0.00e+00	1298.00
IUUC-Gac-042595	Gasterosteus aculeatus	55.06	0.00e+00	711.00
IUUC-Ggo-044926	Gorilla gorilla	74.19	0.00e+00	1041.00
IUUC-Hsa-046079	Homo sapiens	74.19	0.00e+00	1040.00
IUUC-Itr-048737	Ictidomys tridecemlineatus	74.08	0.00e+00	1039.00
IUUC-Lch-050260	Latimeria chalumnae	74.93	0.00e+00	1002.00
IUUC-Loc-051981	Lepisosteus oculatus	81.84	0.00e+00	732.00
IUUC-Laf-054491	Loxodonta africana	75.18	0.00e+00	1030.00
IUUC-Mcc-055694	Macaca mulatta	74.51	0.00e+00	1045.00
IUUC-Meu-055971	Macropus eugenii	52.30	6.00e-111	394.00
IUUC-Mmr-060885	Microcebus murinus	75.56	0.00e+00	1070.00
IUUC-Mdo-063018	Monodelphis domestica	83.94	0.00e+00	1137.00
IUUC-Mmu-064012	Mus musculus	67.32	0.00e+00	926.00
IUUC-Mpu-066207	Mustela putorius furo	75.18	0.00e+00	1070.00
IUUC-Mlu-066929	Myotis lucifugus	74.37	0.00e+00	996.00
IUUC-Nle-069313	Nomascus leucogenys	65.65	0.00e+00	872.00
IUUC-Opr-070375	Ochotona princeps	71.00	0.00e+00	960.00
IUUC-Ont-071637	Oreochromis niloticus	69.97	0.00e+00	924.00
IUUC-Oan-073030	Ornithorhynchus anatinus	83.48	0.00e+00	917.00
IUUC-Ocu-074836	Oryctolagus cuniculus	72.92	0.00e+00	1007.00
IUUC-Olu-087697	Ostreococcus lucimarinus	34.25	1.00e-42	166.00
IUUC-Oga-088367	Otolemur garnettii	75.46	0.00e+00	1043.00
IUUC-Oar-089953	Ovis aries	74.89	0.00e+00	1069.00
IUUC-Ptr-090980	Pan troglodytes	74.19	0.00e+00	1041.00
IUUC-Pan-092748	Papio anubis	75.04	0.00e+00	1055.00
IUUC-Psi-094078	Pelodiscus sinensis	89.25	0.00e+00	968.00
IUUC-Pfo-096413	Poecilia formosa	56.51	0.00e+00	732.00
IUUC-Pab-098514	Pongo abelii	75.75	0.00e+00	1047.00
IUUC-Pca-100449	Procavia capensis	63.57	0.00e+00	835.00
IUUC-Pva-102984	Pteropus vampyrus	75.94	0.00e+00	1073.00
IUUC-Rno-106019	Rattus norvegicus	68.93	0.00e+00	959.00
IUUC-Sha-106965	Sarcophilus harrisii	83.43	0.00e+00	1131.00
IUUC-Ssc-115299	Sus scrofa	75.60	0.00e+00	1077.00
IUUC-Tgu-117160	Taeniopygia guttata	86.73	0.00e+00	1169.00
IUUC-Tru-118156	Takifugu rubripes	66.95	0.00e+00	894.00
IUUC-Tsy-118814	Tarsius syrichta	63.43	0.00e+00	823.00
IUUC-Tni-119733	Tetraodon nigroviridis	64.67	0.00e+00	894.00
IUUC-Tbe-128084	Tupaia belangeri	71.02	0.00e+00	1007.00
IUUC-Ttr-128928	Tursiops truncatus	76.16	0.00e+00	1073.00
IUUC-Vpa-130706	Vicugna pacos	76.61	0.00e+00	1062.00
IUUC-Xtr-132061	Xenopus tropicalis	80.43	0.00e+00	1043.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence