iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-069313

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

ADFV01186800

Gene Name

USP44

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000005816.1	ENSNLET00000007392.1	ENSNLEP00000007043.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.50e-71	239.7	273	678

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.........kkkeklneenp...................................... 42
           tGl+NlgNtCYmNSvLQ+Ls++  +r+++l+                  ++                                      
   Q: 273  TGLRNLGNTCYMNSVLQVLSHLLIFRQCFLKldlnqslamT--------ASektrssckhppvtdtvvyqmnecqekdtgfvrsrqssl 353
           7******************************8665444441........2234556666778899999999999999999999999999 PP
   S: 43   ......................kepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.....gyeqqDaqEflaflldqle 104
                                 +++  +l+++l++lf+ + + +  +  p  ll++l+k+ ++++     ++++  a E+l+    +le
   Q: 354  ssglsggasksrkmeliqpkepTSQYISLCHELHTLFQVMCSWSLCYSFPFWLLHCLCKLLKQLHvfhvfSTQEAEAGELLEPKSLRLE 442
           999999998888888887777666667*************9888888888888888888888877555666666677777776666665 PP
   S: 105  eelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdl.Fqgqlk.sqikclecdnvssreepfldlslpvpgkeetkke...... 185
            +                  +l+++ ++++ k+ + l+++l ++ +++  q++cl+cdn+s++ epf+dlsl++p++ +++ +      
   Q: 443  PKS----------------LRLQQIIQNSNVKRVNVLMERLnLRNSYShLQVTCLACDNKSNTIEPFWDLSLEFPERYQCSGKdiasqp 515
           555................3455665666666666666654244444336889**********************99988777888888 PP
   S: 186  .slqdcLesftkeeelegenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls 262
             ++++L++ft++e l g+  y c++c++k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + L+++
   Q: 516  cLVTEMLAKFTETEALGGK-IYVCDQCNSKRRrfsskpvvlteAQKQLMICHLPQVLRLHLKRFRWSGR-NNREKIGVHVGFEEILNME 602
           89**************995.5*******999999999999999***********************998.7778*************** PP
   S: 263  pfctspeekqke..kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           p+c++++ k+ +  + +Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk + ++++ev++   ++aY+lfY++
   Q: 603  PYCCRETLKSLRpeCFIYDLSAVVMHHGkGFGSGHYTAYCYNSEGGfWVHCNDSKLSMCTMDEVCK---AQAYILFYTQ 678
           *****9988876779***************************9999********************...********98 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MLAMDKCKHV GELQLAQDHS SLNPQKWHCV DCNTTESIWA CLSCSYVACG RYIKEHALKH 60
FQESSHPVAL EVNEMYVFCY LCDDYVLNDN ATGDLKLLRS TLSAIKSQND HCTTRSGRFV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCTAGCAA TGGATAAGTG CAAACATGTT GGGGAACTGC AGCTTGCTCA AGACCATTCC 60
AGCCTCAACC CTCAGAAATG GCACTGTGTG GACTGCAACA CAACTGAGTC CATTTGGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:1904667--P:negative regulation of ubiquitin protein ligase activity
GO:0016579--P:protein deubiquitination
GO:0090231--P:regulation of spindle checkpoint
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001220	Ailuropoda melanoleuca	81.14	0.00e+00	1129.00
IUUC-Apl-003673	Anas platyrhynchos	66.07	0.00e+00	878.00
IUUC-Bta-012774	Bos taurus	78.64	0.00e+00	1089.00
IUUC-Cja-019619	Callithrix jacchus	82.66	0.00e+00	1132.00
IUUC-Cfa-020957	Canis familiaris	80.17	0.00e+00	1134.00
IUUC-Csa-023177	Chlorocebus sabaeus	84.47	0.00e+00	1154.00
IUUC-Cho-024877	Choloepus hoffmanni	73.65	0.00e+00	660.00
IUUC-Csv-025814	Ciona savignyi	40.28	2.00e-124	439.00
IUUC-Dno-029832	Dasypus novemcinctus	80.86	0.00e+00	1132.00
IUUC-Ete-032627	Echinops telfairi	77.15	0.00e+00	1070.00
IUUC-Eca-033863	Equus caballus	76.74	0.00e+00	1034.00
IUUC-Eeu-035225	Erinaceus europaeus	76.14	0.00e+00	1017.00
IUUC-Fca-036288	Felis catus	81.41	0.00e+00	1135.00
IUUC-Fal-037207	Ficedula albicollis	65.78	0.00e+00	840.00
IUUC-Gga-040457	Gallus gallus	64.48	0.00e+00	844.00
IUUC-Ggo-044926	Gorilla gorilla	87.24	0.00e+00	1189.00
IUUC-Hsa-046079	Homo sapiens	86.96	0.00e+00	1186.00
IUUC-Itr-048737	Ictidomys tridecemlineatus	80.86	0.00e+00	1110.00
IUUC-Laf-054491	Loxodonta africana	78.22	0.00e+00	1033.00
IUUC-Mcc-055694	Macaca mulatta	84.74	0.00e+00	1155.00
IUUC-Mga-059523	Meleagris gallopavo	64.22	0.00e+00	854.00
IUUC-Mmr-060885	Microcebus murinus	83.36	0.00e+00	1160.00
IUUC-Mdo-063018	Monodelphis domestica	70.07	0.00e+00	946.00
IUUC-Mmu-064012	Mus musculus	69.90	0.00e+00	914.00
IUUC-Mpu-066207	Mustela putorius furo	79.89	0.00e+00	1137.00
IUUC-Mlu-066929	Myotis lucifugus	76.49	0.00e+00	1005.00
IUUC-Opr-070375	Ochotona princeps	71.47	0.00e+00	929.00
IUUC-Oan-073030	Ornithorhynchus anatinus	67.63	0.00e+00	686.00
IUUC-Ocu-074836	Oryctolagus cuniculus	77.86	0.00e+00	1069.00
IUUC-Oga-088367	Otolemur garnettii	82.52	0.00e+00	1124.00
IUUC-Oar-089953	Ovis aries	79.92	0.00e+00	1122.00
IUUC-Ptr-090980	Pan troglodytes	87.24	0.00e+00	1190.00
IUUC-Pan-092748	Papio anubis	85.16	0.00e+00	1158.00
IUUC-Pab-098514	Pongo abelii	87.66	0.00e+00	1196.00
IUUC-Pva-102984	Pteropus vampyrus	78.36	0.00e+00	1058.00
IUUC-Rno-106019	Rattus norvegicus	69.89	0.00e+00	946.00
IUUC-Sha-106965	Sarcophilus harrisii	68.80	0.00e+00	937.00
IUUC-Ssc-115299	Sus scrofa	81.00	0.00e+00	1142.00
IUUC-Tbe-128084	Tupaia belangeri	75.69	0.00e+00	1033.00
IUUC-Ttr-128928	Tursiops truncatus	81.83	0.00e+00	1149.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence