iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Laf-054324

Ensembl Protein ID

ENSLAFP00000004540.3

UniProt Accession

G3SW68; G3SW68_LOXAF

Protein Name

Uncharacterized protein

Gene Name

DDX58

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000005416.3	ENSLAFT00000005417.3	ENSLAFP00000004540.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/CARD	2.10e-41	140.7	101	172

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/CARD

   S: 3    eeyrlllstlqdrvrklLdvtdvldkylseflleeekelilaaaetkgnmqaaelLLktL..vqkegWfrefl 73
           ee rlll +lq+++++ + + d+l  ++s +l+++e+e+i + + +kg m++ae+++++L  ++ke+W+++++
   Q: 101  EEHRLLLRRLQPEFKTSINPLDILP-EISQCLINQECEEIRQVCFNKGSMAGAEKMVECLvrSDKENWPKALK 172
           899**********************.********************************************985 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MTAEERRNLR TFGDYVRKTL DPTYILGYMT PWLREDEMQY IQAEKNNKGT VEAASAFFNF 60
LVELKEEGWF RGFLDALQRA GYTGLYEAFE SWDFQKIEKL EEHRLLLRRL QPEFKTSINP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACGGCCG AGGAGCGCAG GAATCTGCGC ACCTTCGGAG ACTACGTCAG GAAAACCCTG 60
GACCCTACCT ACATCCTGGG TTATATGACC CCCTGGTTGA GGGAAGGTGA GTGGTCCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0862--Zinc

Interpro

IPR031964--CARD_dom
IPR011545--DEAD/DEAH_box_helicase_dom
IPR011029--DEATH-like_dom
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR021673--RLR_CTR

PROSITE

PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS51789--RLR_CTR

Pfam

PF16739--CARD_2
PF00270--DEAD
PF00271--Helicase_C
PF11648--RIG-I_C-RD

SMART

SM00487--DEXDc
SM00490--HELICc

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005923--C:bicellular tight junction
GO:0005829--C:cytosol
GO:0032587--C:ruffle membrane
GO:0005524--F:ATP binding
GO:0003690--F:double-stranded DNA binding
GO:0003725--F:double-stranded RNA binding
GO:0016817--F:hydrolase activity, acting on acid anhydrides
GO:0003727--F:single-stranded RNA binding
GO:0008270--F:zinc ion binding
GO:0009597--P:detection of virus
GO:0045087--P:innate immune response
GO:0002230--P:positive regulation of defense response to virus by host
GO:0032725--P:positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032727--P:positive regulation of interferon-alpha production
GO:0032728--P:positive regulation of interferon-beta production
GO:0032755--P:positive regulation of interleukin-6 production
GO:0032757--P:positive regulation of interleukin-8 production
GO:0042993--P:positive regulation of transcription factor import into nucleus
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0030334--P:regulation of cell migration
GO:0043330--P:response to exogenous dsRNA
GO:0039529--P:RIG-I signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001898	Ailuropoda melanoleuca	78.37	0.00e+00	1480.00
IUUC-Apl-003966	Anas platyrhynchos	53.20	0.00e+00	917.00
IUUC-Aca-004499	Anolis carolinensis	47.26	0.00e+00	805.00
IUUC-Ame-011950	Astyanax mexicanus	42.99	0.00e+00	708.00
IUUC-Bta-012489	Bos taurus	79.64	0.00e+00	1472.00
IUUC-Cel-018230	Caenorhabditis elegans	29.57	3.00e-68	253.00
IUUC-Cja-018716	Callithrix jacchus	78.69	0.00e+00	1483.00
IUUC-Cfa-020269	Canis familiaris	80.26	0.00e+00	1526.00
IUUC-Cpo-022507	Cavia porcellus	73.38	0.00e+00	1387.00
IUUC-Csa-024209	Chlorocebus sabaeus	78.59	0.00e+00	1492.00
IUUC-Cho-025104	Choloepus hoffmanni	75.73	0.00e+00	1224.00
IUUC-Cin-025792	Ciona intestinalis	32.01	1.00e-79	290.00
IUUC-Dno-028954	Dasypus novemcinctus	80.43	0.00e+00	1472.00
IUUC-Eca-034039	Equus caballus	80.17	0.00e+00	1509.00
IUUC-Eeu-035009	Erinaceus europaeus	76.16	0.00e+00	810.00
IUUC-Fca-036169	Felis catus	80.94	0.00e+00	1549.00
IUUC-Fal-037579	Ficedula albicollis	53.11	0.00e+00	921.00
IUUC-Ggo-045318	Gorilla gorilla	77.20	0.00e+00	1349.00
IUUC-Hsa-046671	Homo sapiens	79.34	0.00e+00	1474.00
IUUC-Itr-047996	Ictidomys tridecemlineatus	74.11	0.00e+00	1390.00
IUUC-Lch-050461	Latimeria chalumnae	50.99	0.00e+00	885.00
IUUC-Loc-052582	Lepisosteus oculatus	48.24	0.00e+00	849.00
IUUC-Mcc-055390	Macaca mulatta	77.94	0.00e+00	1475.00
IUUC-Meu-056365	Macropus eugenii	64.84	1.00e-132	467.00
IUUC-Mmr-061407	Microcebus murinus	79.55	0.00e+00	1531.00
IUUC-Mmu-063939	Mus musculus	73.20	0.00e+00	1364.00
IUUC-Mpu-066226	Mustela putorius furo	78.08	0.00e+00	1382.00
IUUC-Mlu-068092	Myotis lucifugus	79.98	0.00e+00	1471.00
IUUC-Opr-070246	Ochotona princeps	62.52	0.00e+00	640.00
IUUC-Oan-072742	Ornithorhynchus anatinus	61.44	0.00e+00	990.00
IUUC-Ocu-073959	Oryctolagus cuniculus	72.81	0.00e+00	1379.00
IUUC-Oga-089173	Otolemur garnettii	78.16	0.00e+00	1464.00
IUUC-Oar-089369	Ovis aries	78.78	0.00e+00	1448.00
IUUC-Ptr-091032	Pan troglodytes	79.34	0.00e+00	1474.00
IUUC-Pan-092383	Papio anubis	78.59	0.00e+00	1489.00
IUUC-Psi-093432	Pelodiscus sinensis	56.58	0.00e+00	1072.00
IUUC-Pma-094367	Petromyzon marinus	41.57	1.00e-116	413.00
IUUC-Pab-098416	Pongo abelii	79.30	0.00e+00	1377.00
IUUC-Pca-101006	Procavia capensis	83.80	0.00e+00	687.00
IUUC-Pva-102966	Pteropus vampyrus	80.49	0.00e+00	1508.00
IUUC-Rno-105059	Rattus norvegicus	72.86	0.00e+00	887.00
IUUC-Ssl-108450	Sclerotinia sclerotiorum	28.43	2.00e-04	42.70
IUUC-Sar-113202	Sorex araneus	66.62	0.00e+00	1032.00
IUUC-Ssc-116120	Sus scrofa	78.46	0.00e+00	1445.00
IUUC-Tgu-117314	Taeniopygia guttata	52.17	0.00e+00	946.00
IUUC-Tsy-119453	Tarsius syrichta	77.88	0.00e+00	836.00
IUUC-Ttr-128421	Tursiops truncatus	77.53	0.00e+00	1219.00
IUUC-Vpa-130602	Vicugna pacos	78.62	0.00e+00	1397.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence