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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064245
UUCD1 version UUC-MuM-01073
Ensembl Protein ID ENSMUSP00000023580.6
UniProt Accession P57080; Q80ZT9; UBP25_MOUSE
Genbank Protein ID AAF32264.1; AAH48171.1; AAH63059.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 25; Deubiquitinating enzyme 25; Ubiquitin thioesterase 25; Ubiquitin-specific-processing protease 25
Genbank Nucleotide ID AF170563; BC048171; BC063059
Gene Name Usp25
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000022867.9 ENSMUST00000023580.6 ENSMUSP00000023580.6
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusPHOSIDA
mUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/USP USP 12401499
Classification
Family E-value Score Start End
DUB/USP 3.50e-64 218.2 169 656
UBD/Alpha-Helix/UBA 0.00059 21.0 19 54
UBD/Alpha-Helix/DUIM 0.013 16.7 97 115
Active Site
Position(s) Description Evidence
178 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
608 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs 85
           +GlkN+gNtC++ +v+Q+L+n+ e+r+l+l+    ++ ++l+++++++++ +++++l+ lf+ l+ +k+k+v+p++ +++lk++ ++ +
   Q: 169  VGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNykppSNAQDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFKS-N 256
           6******************************99988889999999999999*******************************99997.9 PP
   S: 86   gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlsl 174
            ++qqD++Ef++ lld le+++++                  + +ee +++k k+++++lF g++    + +   ++ + +e f +++l
   Q: 257  DSQQQDVSEFTHKLLDWLEDAFQM------------------KAEEETDEEKPKNPMVELFYGRFLAMGVLEG--KKFENTEMFGQYPL 325
           **********************33..................123456788999************8888754..44556899****** PP
   S: 175  pvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp 263
           +v+g +     +l++cLe+ + e e+e+   +++++  k+    +++++++lP+vL+++L+Rf+f+++ +++eki++k+efp+ L l++
   Q: 326  QVNGFK-----DLHECLEAAMIEGEIES---LHSDNSGKS---GQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDR 403
           ******.....9**************96...999998865...589******************************************* PP
   S: 264  fcts..................................................................................... 267
           ++++                                                                                     
   Q: 404  YMHRnreitrikreeikrlkdyltvlqqrlerylsygsgpkrfplvdvlqyalefasskpvctspvddidasssasgplpsqslpstte 492
           ****8888888888888888888888888888877777777777777777777777777777777777777777777776666655555 PP
   S: 268  peekqke.................................................................................. 274
           +     +                                                                                  
   Q: 493  Q-----Qgpcasdlpgssspasgaalplrsvihkpftqsrippdlpmhpaprhiteeelcvlesclhrwrteiendtrdlqesisrihr 576
           0.....15555555555555566666666666666666666666666666666666666666777777777777777777778888888 PP
   S: 275  ............kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
                       ++ Y+L+av+vH+G+++ GHY+ay+ +++++ W++++D  Vt++++ee ++++      ++aY+l+Y 
   Q: 577  tielmysdksmiQVPYRLHAVLVHEGQANAGHYWAYIFDHRESrWMKYNDIAVTKSSWEELVRDSFggyrnASAYCLMYI 656
           888888888888**************************966556***************99997779************6 PP
   

   UBD/Alpha-Helix/UBA
   S: 5    dkleqlve.MGF.dreealqaLraannnleaAveyL 38
             l+ql+e +G+ d +  +qaL ++n+nle Av++L
   Q: 19   TFLNQLREiTGInDAQILQQALKDSNGNLELAVAFL 54
           569*********6666888899999*********98 PP
   

   UBD/Alpha-Helix/DUIM
   S: 1    dEdeeLqlAlalSlqEeee 19
           d+ ++Lq+A+alSl E ++
   Q: 97   DDKDDLQRAIALSLAESNR 115
           6889************875 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Homodimer or oligomer (By similarity). Interacts with ACTA1 (via its C-terminus); the interaction occurs for all isoforms but is strongest for isoform USP25m in muscle differentiating cells. Interacts (isoform USP25m only) with MYBPC1; the interaction prevents proteasomal degradation of MYBPC1. Interacts (isoform USP25m only) with FLNC (via filament repeats 17-18, 20-21 and 24). Interacts with GAPDH. Interacts with SUMO3; the interaction sumoylates efficiently USP25. Interacts with SUMO2; the interaction sumoylates efficiently USP25. Interacts with SUMO1; the interaction only weakly sumoylates USP25. Interacts with SYK; phosphorylates USP25 and regulates USP25 intracellular levels (By similarity).
 Homodimer or oligomer (By similarity). Interacts with ACTA1 (via its C-terminus); the interaction occurs for all isoforms but is strongest for isoform USP25m in muscle differentiating cells. Interacts (isoform USP25m only) with MYBPC1; the interaction prevents proteasomal degradation of MYBPC1. Interacts (isoform USP25m only) with FLNC (via filament repeats 17-18, 20-21 and 24). Interacts with GAPDH. Interacts with SUMO3; the interaction sumoylates efficiently USP25. Interacts with SUMO2; the interaction sumoylates efficiently USP25. Interacts with SUMO1; the interaction only weakly sumoylates USP25. Interacts with SYK; phosphorylates USP25 and regulates USP25 intracellular levels (By similarity).
Protein Sequence
(Fasta)
MTVEQNVLQQ SAAQKHQQTF LNQLREITGI NDAQILQQAL KDSNGNLELA VAFLTAKNAK 60
TPPQEETGYY QTALPGNDRY ISVGSQADAN VIDLTGDDKD DLQRAIALSL AESNRAFRET 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064245|DUB,USP;UBD,UBA;UBD,DUIM|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGACAGGCG GGGCCGCCGC GGGGGCCATG ACCGTGGAGC AGAATGTGCT GCAGCAGAGC 60
GCGGCGCAGA AGGTGAGGCG CGGGCTGGTC GCCGCTCCTC GACGGGCCGC GTGGCCTCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064245|DUB,USP;UBD,UBA;UBD,DUIM|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR001394--Peptidase_C19_UCH
IPR009060--UBA-like
IPR003903--UIM_dom
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF00443--UCH
PF02809--UIM
SMART

SM00726--UIM
Gene Ontology

GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005634--C:nucleus
GO:0000502--C:proteasome complex
GO:0051117--F:ATPase binding
GO:0032183--F:SUMO binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0031625--F:ubiquitin protein ligase binding
GO:1904293--P:negative regulation of ERAD pathway
GO:0016579--P:protein deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:30940
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001340 Ailuropoda melanoleuca 91.07 0.00e+00 1939.00
IUUC-Apl-004030 Anas platyrhynchos 80.90 0.00e+00 1789.00
IUUC-Aca-004753 Anolis carolinensis 63.36 0.00e+00 967.00
IUUC-Ame-010624 Astyanax mexicanus 68.76 0.00e+00 1058.00
IUUC-Bta-013166 Bos taurus 92.69 0.00e+00 1925.00
IUUC-Cel-018346 Caenorhabditis elegans 27.82 2.00e-29 125.00
IUUC-Cja-019150 Callithrix jacchus 93.46 0.00e+00 1421.00
IUUC-Cfa-020649 Canis familiaris 93.20 0.00e+00 1427.00
IUUC-Cpo-021807 Cavia porcellus 90.71 0.00e+00 2013.00
IUUC-Csa-023388 Chlorocebus sabaeus 93.20 0.00e+00 1417.00
IUUC-Cho-024343 Choloepus hoffmanni 80.10 0.00e+00 966.00
IUUC-Cin-025302 Ciona intestinalis 37.98 4.00e-97 348.00
IUUC-Cgl-026575 Colletotrichum gloeosporioides 53.19 6.00e-10 60.50
IUUC-Dre-028016 Danio rerio 75.38 0.00e+00 1173.00
IUUC-Dno-029495 Dasypus novemcinctus 89.71 0.00e+00 1419.00
IUUC-Dor-030948 Dipodomys ordii 78.71 0.00e+00 1380.00
IUUC-Fca-035876 Felis catus 93.94 0.00e+00 1954.00
IUUC-Fal-036762 Ficedula albicollis 82.72 0.00e+00 1103.00
IUUC-Gmo-039490 Gadus morhua 71.42 0.00e+00 1506.00
IUUC-Gga-040817 Gallus gallus 83.29 0.00e+00 1330.00
IUUC-Gac-042473 Gasterosteus aculeatus 71.19 0.00e+00 1534.00
IUUC-Ggo-044939 Gorilla gorilla 89.34 0.00e+00 1885.00
IUUC-Hsa-046204 Homo sapiens 93.66 0.00e+00 1947.00
IUUC-Kpa-049349 Komagataella pastoris 28.27 4.00e-10 61.20
IUUC-Lch-049572 Latimeria chalumnae 78.23 0.00e+00 1203.00
IUUC-Loc-052070 Lepisosteus oculatus 74.51 0.00e+00 1197.00
IUUC-Lma-053078 Leptosphaeria maculans 30.56 4.00e-12 67.40
IUUC-Laf-054426 Loxodonta africana 92.76 0.00e+00 1793.00
IUUC-Mcc-055858 Macaca mulatta 93.46 0.00e+00 1448.00
IUUC-Mga-059808 Meleagris gallopavo 83.70 0.00e+00 1802.00
IUUC-Mmr-060987 Microcebus murinus 93.97 0.00e+00 1407.00
IUUC-Mpu-066304 Mustela putorius furo 92.32 0.00e+00 1399.00
IUUC-Mlu-067139 Myotis lucifugus 92.40 0.00e+00 1968.00
IUUC-Nle-069075 Nomascus leucogenys 93.56 0.00e+00 1942.00
IUUC-Ont-072150 Oreochromis niloticus 73.98 0.00e+00 1168.00
IUUC-Oan-073054 Ornithorhynchus anatinus 77.79 0.00e+00 1642.00
IUUC-Ocu-074102 Oryctolagus cuniculus 89.96 0.00e+00 1414.00
IUUC-Ola-086529 Oryzias latipes 68.95 0.00e+00 1474.00
IUUC-Oga-088939 Otolemur garnettii 92.26 0.00e+00 1924.00
IUUC-Oar-090266 Ovis aries 92.81 0.00e+00 1387.00
IUUC-Ptr-090546 Pan troglodytes 93.47 0.00e+00 1942.00
IUUC-Pan-092311 Papio anubis 93.33 0.00e+00 1447.00
IUUC-Psi-093459 Pelodiscus sinensis 88.96 0.00e+00 1161.00
IUUC-Pfo-096726 Poecilia formosa 73.29 0.00e+00 1151.00
IUUC-Pab-097608 Pongo abelii 90.77 0.00e+00 1901.00
IUUC-Pca-100718 Procavia capensis 88.13 0.00e+00 1208.00
IUUC-Pva-103150 Pteropus vampyrus 88.96 0.00e+00 1441.00
IUUC-Rno-105727 Rattus norvegicus 96.31 0.00e+00 1983.00
IUUC-Sha-107051 Sarcophilus harrisii 86.63 0.00e+00 1830.00
IUUC-Ssl-108532 Sclerotinia sclerotiorum 28.85 6.00e-09 57.00
IUUC-Sar-113097 Sorex araneus 83.58 0.00e+00 1777.00
IUUC-Ssc-115877 Sus scrofa 90.88 0.00e+00 1912.00
IUUC-Tgu-117473 Taeniopygia guttata 76.94 0.00e+00 1665.00
IUUC-Tru-118135 Takifugu rubripes 66.82 0.00e+00 1400.00
IUUC-Tsy-119471 Tarsius syrichta 86.40 0.00e+00 1730.00
IUUC-Tni-120139 Tetraodon nigroviridis 66.98 0.00e+00 1311.00
IUUC-Tbe-127549 Tupaia belangeri 87.13 0.00e+00 1832.00
IUUC-Ttr-128896 Tursiops truncatus 86.57 0.00e+00 1835.00
IUUC-Vda-129742 Verticillium dahliae 22.69 2.00e-13 72.40
IUUC-Vpa-130500 Vicugna pacos 90.52 0.00e+00 1300.00
IUUC-Xtr-132896 Xenopus tropicalis 79.56 0.00e+00 1707.00
Created Date 25-Jun-2017

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