iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Ath-007343

UUCD1 version

UUC-ArT-01705

Ensembl Protein ID

AT1G32850.1

UniProt Accession

Q9MAQ3; UBP11_ARATH

Genbank Protein ID

AAF31287.1; AEE31532.1

Protein Name

Putative ubiquitin carboxyl-terminal hydrolase 11; Deubiquitinating enzyme 11; Ubiquitin thioesterase 11; Ubiquitin-specific-processing protease 11

Genbank Nucleotide ID

AC006424; CP002684

Gene Name

UBP11; At1g32850; F9L11.5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT1G32850	AT1G32850.1	AT1G32850.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.00e-110	371.0	302	879

Active Site

Position(s)	Description	Evidence
310	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
838	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflafl 99
           Gl+NlgNtC+mNS+LQcL+++p++ e++l+ +++++n++np ++ gel+ ++ +l+++lw+s ++ v+pr+++++l+++a++fsgy+q+D+qE+lafl
   Q: 302  GLQNLGNTCFMNSTLQCLAHTPPIVEYFLQDYRSDINAKNPLGMRGELAIAFGELLRKLWSSGQNTVAPRAFKTKLARFAPQFSGYNQHDSQEMLAFL 399
           9************************************************************************************************* PP
   S: 100  ldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke....... 185
           ld+l+e+l+k k+kp+ e++++d +   d+     +++ +k +n+s+i+d+Fqgq+ks+++c++c+++s +++pf++lslp+p++++++++       
   Q: 400  LDGLHEDLNKVKRKPYIEAKDSDGRP--DDevaeeKWKYHKARNDSVIVDVFQGQYKSTLVCPDCGKISITFDPFMYLSLPLPSSRTRSMTvtvfygd 495
           *******************9999443..3334666***************************************************99888******* PP
   S: 186  .................................................................................................. 185
                                                                                                             
   Q: 496  gshlpmpytvtvpkdgscrdlsnalgtaccldndeslllaevydhkvfkyyenprellngikdnehivayrfkqmhkgpgkvkleilhgeqekssdrg 593
           ************************************************************************************************** PP
   S: 186  .................................................................................................. 185
                                                                                                             
   Q: 594  pkcfgtplvtyinkeplsgtdiatsisgllsplrrvhmscvvnsgnenghvpdessrsilsrdtetedndrelslsllrdyysfnlqplesdsvvnpg 691
           ************************************************************************************************** PP
   S: 186  ..........................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfse 241
                                                     sl +cLe+f +ee l  ++++yc+ ck++++a+kkl+l+klP++L++hLkRf++s+
   Q: 692  svtkvlvkwnekehekydssylndlpkvhknvlakktmqegiSLFSCLEAFLAEEPLGPDDMWYCPGCKEHRQANKKLDLWKLPDILVFHLKRFTYSR 789
           **********************************************************************************************9977 PP
   S: 242  eqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
             ++++ki++ v+f ++ Ldls+++ +++ +   ++ YeL+a+ +H+G+l++GHY+ay+k  ++ kW++fdDs+V++v+e+e+++   s aYvlfY+r
   Q: 790  --YFKNKIDTLVNFHIHdLDLSKYVKNEDGQ---SYLYELYAISNHYGGLGGGHYTAYAKLmDETKWYNFDDSRVSAVNESEIKT---SAAYVLFYQR 879
           ..6999*******************996644...8*************************956667*******************...********98 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Protein Sequence
(Fasta)

MTLITDSESI GVCESSYTPE EERRIVTELN NEAEADLKEG NLYFVISNRW YTRWQRFVGL 60
LTEEFRSGEP SEVTRPGPID NHDIIDSESD ASDPQLRMML EEGVDYTLVQ QEVWRKLVKW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACATTAA TCACTGATTC TGAATCCATC GGAGTTTGTG AATCCTCCTA TACTCCTGAG 60
GAAGAGAGAC GTATTGTCAC CGAGCTTAAT AACGAAGCCG AGGCTGATTT GAAAGAGGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF06337--DUSP
PF00443--UCH

SMART

SM00695--DUSP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT1G32850

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-004068	Anas platyrhynchos	35.28	9.00e-127	447.00
IUUC-Aca-004459	Anolis carolinensis	34.49	2.00e-128	452.00
IUUC-Aly-006315	Arabidopsis lyrata	90.19	0.00e+00	1529.00
IUUC-Afl-008507	Aspergillus flavus	42.42	2.00e-50	194.00
IUUC-Aor-009949	Aspergillus oryzae	42.42	8.00e-51	195.00
IUUC-Ate-010323	Aspergillus terreus	42.11	2.00e-50	194.00
IUUC-Ame-011064	Astyanax mexicanus	49.84	1.00e-88	321.00
IUUC-Bol-015570	Brassica oleracea	72.41	0.00e+00	1246.00
IUUC-Cfa-020599	Canis familiaris	36.86	6.00e-147	514.00
IUUC-Cre-022582	Chlamydomonas reinhardtii	63.54	6.00e-72	263.00
IUUC-Cme-027338	Cyanidioschyzon merolae	56.39	1.00e-70	260.00
IUUC-Ete-032970	Echinops telfairi	60.09	2.00e-75	276.00
IUUC-Eca-034012	Equus caballus	40.65	4.00e-125	441.00
IUUC-Fca-035373	Felis catus	37.10	5.00e-147	514.00
IUUC-Fal-037634	Ficedula albicollis	38.59	1.00e-153	536.00
IUUC-Gga-040729	Gallus gallus	38.23	8.00e-154	537.00
IUUC-Lma-052981	Leptosphaeria maculans	28.45	1.00e-52	202.00
IUUC-Laf-053803	Loxodonta africana	37.00	7.00e-147	514.00
IUUC-Mla-058848	Melampsora laricipopulina	46.97	2.00e-62	234.00
IUUC-Mga-059300	Meleagris gallopavo	38.37	2.00e-147	516.00
IUUC-Mvi-060324	Microbotryum violaceum	34.29	2.00e-79	290.00
IUUC-Mpu-066920	Mustela putorius furo	36.86	1.00e-145	509.00
IUUC-Mlu-068088	Myotis lucifugus	42.00	2.00e-127	449.00
IUUC-Opr-070740	Ochotona princeps	41.69	3.00e-129	455.00
IUUC-Ont-072573	Oreochromis niloticus	37.42	1.00e-109	390.00
IUUC-Oan-073363	Ornithorhynchus anatinus	41.63	5.00e-125	441.00
IUUC-Ocu-074242	Oryctolagus cuniculus	37.82	4.00e-105	375.00
IUUC-Olu-087717	Ostreococcus lucimarinus	42.16	6.00e-128	450.00
IUUC-Psi-093942	Pelodiscus sinensis	35.54	4.00e-144	504.00
IUUC-Pno-094890	Phaeosphaeria nodorum	29.05	1.00e-54	208.00
IUUC-Pab-098522	Pongo abelii	41.95	8.00e-127	447.00
IUUC-Pgr-103546	Puccinia graminis	38.40	2.00e-56	214.00
IUUC-Ptt-103847	Puccinia triticina	35.61	2.00e-55	210.00
IUUC-Pte-104102	Pyrenophora teres	28.85	8.00e-53	202.00
IUUC-Sce-106170	Saccharomyces cerevisiae	37.01	3.00e-53	203.00
IUUC-Sha-106937	Sarcophilus harrisii	41.75	6.00e-129	454.00
IUUC-Spo-108292	Schizosaccharomyces pombe	30.11	3.00e-86	312.00
IUUC-Sar-113542	Sorex araneus	41.91	2.00e-126	446.00
IUUC-Tgu-117267	Taeniopygia guttata	38.12	1.00e-152	533.00
IUUC-Tru-118634	Takifugu rubripes	39.09	3.00e-104	372.00
IUUC-Tni-120107	Tetraodon nigroviridis	36.82	1.00e-93	337.00
IUUC-Tme-127062	Tuber melanosporum	31.35	3.00e-71	263.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence