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Tag Content
UUCD2 ID IUUC-Cja-019177
UUCD1 version UUC-CaJ-01120
Ensembl Protein ID ENSCJAP00000044123.1
UniProt Accession F7H4I8; F7H4I8_CALJA
Genbank Protein ID ENSCJAP00000015635
Protein Name Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16
Genbank Nucleotide ID ACFV01081409
Gene Name USP16
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSCJAG00000008437.2 ENSCJAT00000056588.1 ENSCJAP00000044123.1
ENSCJAG00000008437.2 ENSCJAT00000016456.1 ENSCJAP00000015573.1
ENSCJAG00000008437.2 ENSCJAT00000054153.1 ENSCJAP00000050655.1
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 6.90e-90 302.6 196 824
Active Site
Position(s) Description Evidence
205 Nucleophile ECO:0000256|HAMAP-Rule:MF_03062}
761 Proton acceptor ECO:0000256|HAMAP-Rule:MF_03062}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle..........kkkeklneenp............kepkgellkslqklfeelwkskkka 67
           +Gl+NlgNtC++N+v+Q Ls++p lrell+e          +         p             ep g+l+ ++ ++++e++++kk+ 
   Q: 196  KGLSNLGNTCFFNAVMQNLSQTPVLRELLKEvkmsgtivkiE---------PpdlaltepleinLEPPGPLTLAMSQFLNEMQETKKGI 275
           5******************************86555555540.........24555555555658899********************* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlk 151
           v+p+el+++++k+a++f+gy+qqD+qE+l++lld+++ e +++ +k + +++++++++l++e     ++++kkk+ +s+++++F+g+l+
   Q: 276  VTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEElknkvKDYEKKKSIPSFVDRIFGGELT 364
           *************************************************************99999999999***************** PP
   S: 152  sqikclecdnvssreepfldlslpvpgkeetkke....................................................... 185
           s+i+c +c++vs  +e+fldlslpv ++++ kk+                                                       
   Q: 365  STIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSvndknlkktmededkdseeekdndsyikersdipsgtskhlqkkakkqakkqakn 453
           *****************************99999******************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 454  qrrqqkiqgkvlhlsdictidhpedseyeaemslqgevdiksshisqedvmhkencvnqkdlngqekmiesvtdnqksteevdmkninm 542
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 543  dndlevlsssptecnrnlngaylkegtngemdissgfknlnlnaalhpdeinieilndshtsgtkvyevvnedpetafctlanrevfst 631
           ***************************************************************************************** PP
   S: 186  ...slqdcLesftkeeelegenkyycekckkkqe.................aekklklkklPevLilhLkRfsfseeqksrekinkkve 254
              s+q+cL +ft++e+l+++nk+ ce c+++q                  a+k++ ++  P+vL+lhLkRf  ++++ + +k+nk+++
   Q: 632  decSIQHCLYQFTRNEKLRDANKLLCEVCTRRQCngpkanikgerkhvytnAKKQMLISLAPPVLTLHLKRF--QQAGFNLRKVNKHIK 718
           ******************************888899999999999999999*********************..9999*********** PP
   S: 255  fpleLdlspfctspeekqke...kkkYeLiavvvHsGslssGHYvayvkn.......................ekgkWllfdDskVtev 317
           fp+ Ldl+pfct ++++++e   ++ Y+L++vv HsG+++sGHY+ay+k                        +kg+W++++D++V++v
   Q: 719  FPEILDLAPFCTLKCKNVAEentRVLYSLYGVVEHSGTMRSGHYTAYAKArtanshlsnlvlhgdipqdfemeSKGQWFHISDTHVQAV 807
           *************9999887777999************************999999999999999999999888999************ PP
   S: 318  keeevleetgstaYvlfYkr 337
           + ++vl+   s+aY+lfY+r
   Q: 808  PTSKVLN---SQAYLLFYER 824
           *******...********98 PP
   
Organism Callithrix jacchus
Functional Description
(View)

Functional Description


     Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
 Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
Protein Sequence
(Fasta)
MGKKRTKGKT VPIDDSSEAL EPLCRHIRKG LEQGNLKKAL VNVEWNICQD CKTDNKVKDK 60
SEEETEEKPS VWLCLKCGHQ GCGRNSQEQH ALKHYMTPRS EPHCLVLSLD NWSVWCYICD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cja-019177|DUB,USP|Callithrix jacchus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TAGCCGCTTC CCATAATGCC GCGTTCCGGA AGTTTTTGCT TTCCAGGGGT CACTCTGGCT 60
TCAGCTCCGT CGCTCTCAAT TCGCCACCAG AAGGAAGACA GAGCTGGCTG CCCAGCCCAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cja-019177|DUB,USP|Callithrix jacchus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF00443--UCH
PF02148--zf-UBP
SMART

SM00290--ZnF_UBP
Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0006974--P:cellular response to DNA damage stimulus
GO:0070537--P:histone H2A K63-linked deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045901--P:positive regulation of translational elongation
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG cjc:100414126
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000997 Aegilops tauschii 36.28 3.00e-28 120.00
IUUC-Aml-001931 Ailuropoda melanoleuca 92.14 0.00e+00 1416.00
IUUC-Atr-003015 Amborella trichopoda 31.89 4.00e-36 146.00
IUUC-Apl-004145 Anas platyrhynchos 64.03 0.00e+00 919.00
IUUC-Aca-004314 Anolis carolinensis 59.04 0.00e+00 890.00
IUUC-Aly-006422 Arabidopsis lyrata 28.75 1.00e-29 125.00
IUUC-Ath-006732 Arabidopsis thaliana 31.12 5.00e-33 136.00
IUUC-Afl-008729 Aspergillus flavus 29.26 2.00e-14 73.90
IUUC-Aor-009965 Aspergillus oryzae 29.26 7.00e-15 75.90
IUUC-Ame-011659 Astyanax mexicanus 49.55 2.00e-110 393.00
IUUC-Bta-013362 Bos taurus 90.93 0.00e+00 1410.00
IUUC-Bdi-014465 Brachypodium distachyon 32.22 1.00e-30 129.00
IUUC-Bol-015941 Brassica oleracea 30.00 1.00e-32 135.00
IUUC-Bra-016751 Brassica rapa 29.29 1.00e-30 128.00
IUUC-Cfa-020051 Canis familiaris 92.14 0.00e+00 1430.00
IUUC-Cpo-021886 Cavia porcellus 82.05 0.00e+00 1303.00
IUUC-Csa-024103 Chlorocebus sabaeus 96.37 0.00e+00 1541.00
IUUC-Cho-024315 Choloepus hoffmanni 78.82 4.00e-131 461.00
IUUC-Cin-025775 Ciona intestinalis 51.77 2.00e-39 154.00
IUUC-Csv-026075 Ciona savignyi 52.40 2.00e-60 226.00
IUUC-Cme-027348 Cyanidioschyzon merolae 39.46 3.00e-20 93.60
IUUC-Dre-028388 Danio rerio 48.12 0.00e+00 648.00
IUUC-Dno-029409 Dasypus novemcinctus 89.12 0.00e+00 1412.00
IUUC-Dor-030443 Dipodomys ordii 78.76 0.00e+00 654.00
IUUC-Ete-032807 Echinops telfairi 84.45 0.00e+00 692.00
IUUC-Eca-033479 Equus caballus 92.26 0.00e+00 1465.00
IUUC-Eeu-034835 Erinaceus europaeus 83.87 0.00e+00 670.00
IUUC-Fca-036320 Felis catus 92.38 0.00e+00 1474.00
IUUC-Fal-037029 Ficedula albicollis 60.57 0.00e+00 855.00
IUUC-Gmo-039480 Gadus morhua 53.32 8.00e-115 407.00
IUUC-Gga-040527 Gallus gallus 64.21 0.00e+00 919.00
IUUC-Gac-042343 Gasterosteus aculeatus 46.92 0.00e+00 644.00
IUUC-Gma-043919 Glycine max 28.05 2.00e-31 131.00
IUUC-Ggo-045598 Gorilla gorilla 96.00 0.00e+00 1531.00
IUUC-Hsa-046598 Homo sapiens 95.88 0.00e+00 1524.00
IUUC-Hvu-047146 Hordeum vulgare 35.90 3.00e-27 117.00
IUUC-Itr-047951 Ictidomys tridecemlineatus 92.14 0.00e+00 1460.00
IUUC-Lch-050536 Latimeria chalumnae 52.50 0.00e+00 746.00
IUUC-Lpe-050703 Leersia perrieri 28.70 8.00e-28 119.00
IUUC-Loc-051814 Lepisosteus oculatus 57.49 2.00e-127 449.00
IUUC-Laf-053732 Loxodonta africana 87.59 0.00e+00 1422.00
IUUC-Mcc-054661 Macaca mulatta 96.73 0.00e+00 1545.00
IUUC-Meu-055967 Macropus eugenii 73.58 7.00e-159 554.00
IUUC-Mga-059551 Meleagris gallopavo 63.23 0.00e+00 931.00
IUUC-Mvi-060391 Microbotryum violaceum 32.31 2.00e-19 91.30
IUUC-Mmr-061747 Microcebus murinus 93.33 0.00e+00 1441.00
IUUC-Mdo-062220 Monodelphis domestica 69.17 0.00e+00 1048.00
IUUC-Mmu-063582 Mus musculus 82.87 0.00e+00 1274.00
IUUC-Mac-064941 Musa acuminata 32.84 1.00e-37 151.00
IUUC-Mpu-066339 Mustela putorius furo 91.29 0.00e+00 1460.00
IUUC-Mlu-067511 Myotis lucifugus 85.97 0.00e+00 1343.00
IUUC-Nle-069252 Nomascus leucogenys 96.61 0.00e+00 1543.00
IUUC-Opr-070969 Ochotona princeps 86.71 0.00e+00 1325.00
IUUC-Ont-071786 Oreochromis niloticus 51.06 2.00e-116 413.00
IUUC-Ocu-074704 Oryctolagus cuniculus 89.41 0.00e+00 1414.00
IUUC-Oba-075094 Oryza barthii 30.49 2.00e-30 128.00
IUUC-Obr-076743 Oryza brachyantha 30.86 1.00e-30 129.00
IUUC-Ogl-077739 Oryza glaberrima 30.49 1.00e-30 128.00
IUUC-Ogu-078851 Oryza glumaepatula 30.49 2.00e-30 128.00
IUUC-Oin-079402 Oryza indica 30.49 2.00e-30 128.00
IUUC-Olo-080431 Oryza longistaminata 30.49 2.00e-30 128.00
IUUC-Ome-081580 Oryza meridionalis 30.49 2.00e-30 127.00
IUUC-Oni-082644 Oryza nivara 30.49 2.00e-30 128.00
IUUC-Opu-083452 Oryza punctata 29.57 5.00e-30 126.00
IUUC-Oru-084546 Oryza rufipogon 30.49 2.00e-30 128.00
IUUC-Osa-085858 Oryza sativa 30.49 2.00e-30 128.00
IUUC-Oga-088713 Otolemur garnettii 91.17 0.00e+00 1450.00
IUUC-Oar-089887 Ovis aries 91.41 0.00e+00 1427.00
IUUC-Ptr-091670 Pan troglodytes 96.37 0.00e+00 1536.00
IUUC-Pan-092293 Papio anubis 96.73 0.00e+00 1545.00
IUUC-Psi-093101 Pelodiscus sinensis 67.22 0.00e+00 954.00
IUUC-Pfo-097202 Poecilia formosa 46.23 0.00e+00 640.00
IUUC-Pab-098773 Pongo abelii 95.50 0.00e+00 1188.00
IUUC-Pop-099136 Populus trichocarpa 30.23 5.00e-39 156.00
IUUC-Pca-101069 Procavia capensis 69.41 0.00e+00 1150.00
IUUC-Ppe-101794 Prunus persica 30.61 3.00e-34 140.00
IUUC-Pva-103092 Pteropus vampyrus 88.27 0.00e+00 688.00
IUUC-Rno-105237 Rattus norvegicus 83.72 0.00e+00 1285.00
IUUC-Sha-106889 Sarcophilus harrisii 73.55 0.00e+00 1124.00
IUUC-Ssl-108648 Sclerotinia sclerotiorum 27.10 3.00e-12 67.00
IUUC-Sit-110283 Setaria italica 32.36 2.00e-30 127.00
IUUC-Sly-111487 Solanum lycopersicum 29.61 6.00e-39 156.00
IUUC-Stu-112820 Solanum tuberosum 29.38 1.00e-37 152.00
IUUC-Sar-113530 Sorex araneus 83.33 0.00e+00 1314.00
IUUC-Sbi-113785 Sorghum bicolor 38.31 9.00e-25 109.00
IUUC-Ssc-116091 Sus scrofa 91.34 0.00e+00 1406.00
IUUC-Tgu-117478 Taeniopygia guttata 60.38 0.00e+00 883.00
IUUC-Tru-118640 Takifugu rubripes 53.73 4.00e-119 422.00
IUUC-Tsy-119042 Tarsius syrichta 79.36 0.00e+00 932.00
IUUC-Tni-120015 Tetraodon nigroviridis 46.75 0.00e+00 631.00
IUUC-Tca-121701 Theobroma cacao 28.17 1.00e-37 152.00
IUUC-Tae-125785 Triticum aestivum 29.01 8.00e-27 115.00
IUUC-Tur-126788 Triticum urartu 28.70 1.00e-26 115.00
IUUC-Tbe-127309 Tupaia belangeri 77.92 0.00e+00 1119.00
IUUC-Ttr-128271 Tursiops truncatus 91.54 0.00e+00 1451.00
IUUC-Vpa-130674 Vicugna pacos 91.63 0.00e+00 1343.00
IUUC-Xtr-131869 Xenopus tropicalis 52.26 0.00e+00 791.00
IUUC-Xma-134195 Xiphophorus maculatus 45.51 0.00e+00 639.00
IUUC-Zma-135157 Zea mays 30.86 1.00e-27 118.00
Created Date 25-Jun-2017

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