iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000023958.6	ENSDART00000029450.5	ENSDARP00000038991.4
ENSDARG00000023958.6	ENSDART00000134728.2	ENSDARP00000120112.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	4.10e-09	37.7	79	120

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++Cl +f  ++ ++ +pC+H+fh+ C+  w       +k+ +CPlCr
   Q: 79   CPVCLLEFeeQESVREMPCKHLFHTGCILPW------LNKTNSCPLCR 120
           ****9999554449*****************......**********8 PP

Organism

Danio rerio

Functional Description
(View)

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MASYFDEHDC EPTNPEEQYR QNALLELARS LMQGLDIDSG SFDLSDWDQR LPPPAAKAVV 60
QSLPVVIISP EQADKGVKCP VCLLEFEEQE SVREMPCKHL FHTGCILPWL NKTNSCPLCR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAAACTTGA AGAGATTTAT GTTTTTGGTT TGTTTGCAAT GCAGTAAAGT GTTTTTGTTA 60
GATAATGTTT ATATATACAG ATATATTTTA ATACATATTA ATTATATAAA TAACATATAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

dre:393276

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002024	Ailuropoda melanoleuca	62.89	7.00e-52	196.00
IUUC-Atr-002553	Amborella trichopoda	44.55	3.00e-21	97.10
IUUC-Aly-006228	Arabidopsis lyrata	47.83	1.00e-21	97.80
IUUC-Ath-007294	Arabidopsis thaliana	48.91	2.00e-22	100.00
IUUC-Ame-011175	Astyanax mexicanus	87.18	1.00e-74	271.00
IUUC-Bta-012728	Bos taurus	63.46	1.00e-50	191.00
IUUC-Bol-015586	Brassica oleracea	46.32	9.00e-21	94.40
IUUC-Cja-019559	Callithrix jacchus	64.10	9.00e-53	198.00
IUUC-Cfa-020880	Canis familiaris	63.46	5.00e-52	196.00
IUUC-Cpo-022238	Cavia porcellus	57.89	4.00e-47	180.00
IUUC-Csa-023787	Chlorocebus sabaeus	64.10	8.00e-53	199.00
IUUC-Cin-025410	Ciona intestinalis	43.42	9.00e-20	89.00
IUUC-Cne-026954	Cryptococcus neoformans	51.92	8.00e-13	68.90
IUUC-Dno-029183	Dasypus novemcinctus	65.38	4.00e-53	199.00
IUUC-Dor-030499	Dipodomys ordii	65.38	9.00e-52	195.00
IUUC-Dme-031824	Drosophila melanogaster	41.56	1.00e-21	95.50
IUUC-Ete-032501	Echinops telfairi	61.42	1.00e-38	151.00
IUUC-Eca-033768	Equus caballus	63.46	2.00e-51	194.00
IUUC-Eeu-035209	Erinaceus europaeus	62.04	4.00e-42	163.00
IUUC-Fca-036074	Felis catus	63.52	2.00e-51	194.00
IUUC-Gmo-038882	Gadus morhua	85.44	1.00e-74	271.00
IUUC-Gac-042217	Gasterosteus aculeatus	88.68	1.00e-77	281.00
IUUC-Gma-044264	Glycine max	45.71	1.00e-21	98.20
IUUC-Ggo-044890	Gorilla gorilla	64.10	4.00e-53	200.00
IUUC-Hsa-045980	Homo sapiens	64.10	3.00e-53	200.00
IUUC-Itr-048618	Ictidomys tridecemlineatus	65.38	2.00e-56	211.00
IUUC-Lch-049758	Latimeria chalumnae	77.07	2.00e-71	261.00
IUUC-Lpe-050786	Leersia perrieri	51.19	9.00e-22	97.80
IUUC-Loc-052244	Lepisosteus oculatus	76.25	3.00e-72	263.00
IUUC-Laf-054225	Loxodonta africana	60.95	2.00e-50	191.00
IUUC-Meu-056718	Macropus eugenii	71.15	5.00e-65	239.00
IUUC-Mtr-058205	Medicago truncatula	43.24	3.00e-17	83.60
IUUC-Mvi-060468	Microbotryum violaceum	52.83	2.00e-11	65.10
IUUC-Mmr-061195	Microcebus murinus	62.18	3.00e-51	194.00
IUUC-Mdo-062131	Monodelphis domestica	64.91	1.00e-60	225.00
IUUC-Mmu-063803	Mus musculus	56.91	7.00e-35	140.00
IUUC-Mpu-066689	Mustela putorius furo	62.59	1.00e-43	168.00
IUUC-Mlu-067441	Myotis lucifugus	56.47	7.00e-47	179.00
IUUC-Nle-069091	Nomascus leucogenys	61.29	5.00e-50	189.00
IUUC-Opr-070653	Ochotona princeps	64.10	1.00e-51	195.00
IUUC-Ont-071833	Oreochromis niloticus	78.98	3.00e-74	270.00
IUUC-Oan-073246	Ornithorhynchus anatinus	75.64	5.00e-71	259.00
IUUC-Ocu-074317	Oryctolagus cuniculus	64.10	1.00e-51	195.00
IUUC-Ogu-078441	Oryza glumaepatula	47.73	4.00e-21	96.70
IUUC-Ola-087215	Oryzias latipes	85.99	4.00e-74	270.00
IUUC-Oga-088998	Otolemur garnettii	57.40	5.00e-38	150.00
IUUC-Oar-089622	Ovis aries	63.46	6.00e-54	202.00
IUUC-Ptr-091537	Pan troglodytes	64.10	4.00e-53	200.00
IUUC-Pan-091865	Papio anubis	64.10	1.00e-52	198.00
IUUC-Pfo-097473	Poecilia formosa	90.45	5.00e-83	299.00
IUUC-Pab-097986	Pongo abelii	64.10	4.00e-53	200.00
IUUC-Pop-099046	Populus trichocarpa	47.42	2.00e-21	97.10
IUUC-Pca-100492	Procavia capensis	64.74	9.00e-53	199.00
IUUC-Pva-102641	Pteropus vampyrus	64.74	2.00e-53	201.00
IUUC-Rno-105300	Rattus norvegicus	62.87	1.00e-52	198.00
IUUC-Sce-106438	Saccharomyces cerevisiae	35.94	2.00e-06	48.10
IUUC-Sha-106578	Sarcophilus harrisii	70.73	3.00e-62	230.00
IUUC-Smo-109226	Selaginella moellendorffii	42.37	2.00e-21	97.80
IUUC-Sly-110986	Solanum lycopersicum	50.00	4.00e-20	92.00
IUUC-Stu-112432	Solanum tuberosum	47.37	4.00e-22	99.00
IUUC-Sar-112952	Sorex araneus	61.61	1.00e-33	134.00
IUUC-Sbi-113983	Sorghum bicolor	52.44	9.00e-22	97.40
IUUC-Ssc-115694	Sus scrofa	64.74	1.00e-52	198.00
IUUC-Tni-120075	Tetraodon nigroviridis	88.54	1.00e-80	291.00
IUUC-Tme-126970	Tuber melanosporum	51.92	2.00e-12	67.40
IUUC-Ttr-129081	Tursiops truncatus	62.82	1.00e-51	194.00
IUUC-Vpa-130305	Vicugna pacos	62.83	3.00e-35	139.00
IUUC-Vvi-130952	Vitis vinifera	45.10	1.00e-20	94.40
IUUC-Xtr-132897	Xenopus tropicalis	70.06	4.00e-59	220.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence