iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
circBase	microRNA	TRANSFAC	RepTar
miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UFD/PB1	1.00e-17	65.2	19	100

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UFD/PB1

   S: 2    vrvkvsykgeirsfaldlekpgkfedLlkavrtltelkn.sevalkYeDedGDlvtlksDedldkavslla...skksllrlliq 82
           +r+k+ ++g+++ +++++ ++++f+d+l+++ +   l++ +++a++YeDedGD++t++sDe++++++s+++   ++++++ +li+
   Q: 19   IRIKIPNSGAVD-WTVHSGPQLLFRDVLDVIGQ--VLPEaTTTAFEYEDEDGDRITVRSDEEMKAMLSYYYstvMEQQVNGQLIE 100
           89*********8.9*******************..****9******************************9**888888888886 PP

Organism

Mus musculus

Functional Description
(View)

Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.

Protein Sequence
(Fasta)

MLWLALGPFC AMENQVLVIR IKIPNSGAVD WTVHSGPQLL FRDVLDVIGQ VLPEATTTAF 60
EYEDEDGDRI TVRSDEEMKA MLSYYYSTVM EQQVNGQLIE PLQIFPRACK PPGERNIHGL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTTCCGGAG TAACAGCGGT CTAACGGCCG CCTTCCTCCT CCTCTCGCCG CCACCTCCGC 60
TGCCGGGACG CGGGCCTCAG TCGGACGATC CTGCACGCGC CGCGCCCTCC GGTTCCGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000270--PB1_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS51745--PB1
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST

Pfam

PF00564--PB1
PF00069--Pkinase

SMART

SM00666--PB1
SM00220--S_TKc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005819--C:spindle
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0004713--F:protein tyrosine kinase activity
GO:0004702--F:signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0000187--P:activation of MAPK activity
GO:0071363--P:cellular response to growth factor stimulus
GO:0070375--P:ERK5 cascade
GO:0007507--P:heart development
GO:0000165--P:MAPK cascade
GO:0090051--P:negative regulation of cell migration involved in sprouting angiogenesis
GO:2000342--P:negative regulation of chemokine (C-X-C motif) ligand 2 production
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001240--P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0034115--P:negative regulation of heterotypic cell-cell adhesion
GO:0045415--P:negative regulation of interleukin-8 biosynthetic process
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0060761--P:negative regulation of response to cytokine stimulus
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030307--P:positive regulation of cell growth
GO:0050679--P:positive regulation of epithelial cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter

KEGG

mmu:23938

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001360	Ailuropoda melanoleuca	97.54	0.00e+00	911.00
IUUC-Ame-011344	Astyanax mexicanus	61.30	6.00e-149	520.00
IUUC-Bta-013163	Bos taurus	97.54	0.00e+00	872.00
IUUC-Cja-019978	Callithrix jacchus	97.32	0.00e+00	910.00
IUUC-Cfa-020966	Canis familiaris	97.32	0.00e+00	909.00
IUUC-Cpo-021409	Cavia porcellus	96.43	0.00e+00	901.00
IUUC-Cre-022653	Chlamydomonas reinhardtii	35.94	1.00e-50	194.00
IUUC-Csa-024057	Chlorocebus sabaeus	97.77	0.00e+00	912.00
IUUC-Cin-025732	Ciona intestinalis	47.01	7.00e-102	364.00
IUUC-Csv-026157	Ciona savignyi	47.30	8.00e-99	353.00
IUUC-Dre-028281	Danio rerio	78.60	0.00e+00	653.00
IUUC-Dno-029823	Dasypus novemcinctus	95.73	0.00e+00	651.00
IUUC-Dor-031066	Dipodomys ordii	97.79	8.00e-106	377.00
IUUC-Eca-033333	Equus caballus	95.73	0.00e+00	879.00
IUUC-Gga-040887	Gallus gallus	91.98	0.00e+00	804.00
IUUC-Ggo-044887	Gorilla gorilla	97.77	0.00e+00	912.00
IUUC-Hsa-047038	Homo sapiens	97.77	0.00e+00	912.00
IUUC-Itr-048806	Ictidomys tridecemlineatus	97.54	0.00e+00	911.00
IUUC-Lch-049414	Latimeria chalumnae	89.01	0.00e+00	823.00
IUUC-Loc-052592	Lepisosteus oculatus	82.44	0.00e+00	717.00
IUUC-Laf-054533	Loxodonta africana	96.42	0.00e+00	896.00
IUUC-Mcc-055537	Macaca mulatta	97.54	0.00e+00	910.00
IUUC-Meu-056484	Macropus eugenii	83.82	0.00e+00	668.00
IUUC-Mga-059477	Meleagris gallopavo	91.33	0.00e+00	816.00
IUUC-Mmr-061306	Microcebus murinus	97.77	0.00e+00	910.00
IUUC-Mdo-061813	Monodelphis domestica	95.84	0.00e+00	773.00
IUUC-Nle-069351	Nomascus leucogenys	97.58	0.00e+00	837.00
IUUC-Opr-070735	Ochotona princeps	96.02	0.00e+00	896.00
IUUC-Ont-072335	Oreochromis niloticus	77.03	0.00e+00	701.00
IUUC-Ocu-074413	Oryctolagus cuniculus	97.54	0.00e+00	911.00
IUUC-Ola-086909	Oryzias latipes	78.21	0.00e+00	700.00
IUUC-Oga-088949	Otolemur garnettii	96.65	0.00e+00	716.00
IUUC-Oar-089529	Ovis aries	97.77	0.00e+00	912.00
IUUC-Ptr-090951	Pan troglodytes	97.77	0.00e+00	912.00
IUUC-Pan-091891	Papio anubis	97.99	0.00e+00	914.00
IUUC-Psi-093134	Pelodiscus sinensis	90.49	0.00e+00	722.00
IUUC-Pfo-097277	Poecilia formosa	77.93	0.00e+00	696.00
IUUC-Pab-098107	Pongo abelii	97.77	0.00e+00	912.00
IUUC-Pca-101027	Procavia capensis	79.19	0.00e+00	697.00
IUUC-Pva-102374	Pteropus vampyrus	90.40	0.00e+00	776.00
IUUC-Rno-105325	Rattus norvegicus	99.11	0.00e+00	922.00
IUUC-Sha-107478	Sarcophilus harrisii	95.30	0.00e+00	890.00
IUUC-Ssc-115454	Sus scrofa	98.36	2.00e-69	253.00
IUUC-Tru-117913	Takifugu rubripes	77.80	0.00e+00	683.00
IUUC-Tsy-119406	Tarsius syrichta	96.14	0.00e+00	823.00
IUUC-Tni-120439	Tetraodon nigroviridis	77.06	0.00e+00	682.00
IUUC-Tbe-127650	Tupaia belangeri	72.95	2.00e-162	565.00
IUUC-Ttr-128626	Tursiops truncatus	97.99	0.00e+00	913.00
IUUC-Xtr-131841	Xenopus tropicalis	83.45	0.00e+00	733.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence