iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003295

Ensembl Protein ID

ENSAPLP00000002316.1

UniProt Accession

U3I4Z5; U3I4Z5_ANAPL

Genbank Protein ID

ENSAPLP00000002316

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADON01001350

Gene Name

HERC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000002766.1	ENSAPLT00000002904.1	ENSAPLP00000002316.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.90e-99	333.0	733	1056

Active Site

Position(s)	Description	Evidence
1025	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           d kk l+v fvgEe++d+gGv +ef+ l+++el +p++g+f+y e+++  ++ +++      e  +lF+++G+++g+a+++  ++dl
   Q: 733  DYKKPLKVIFVGEEAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEESRLIWFSDKTF-----EDSDLFHLIGVVCGLAIYNFTIVDL 814
           78999***********************************************98877.....689********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll+kk sl+dl+e++p++ + +++++++ e+diee+ ++l+f+++ e++g+t+ +eL+p+G++ipV ++N++++v+++
   Q: 815  HFPLALYKKLLNKKPSLDDLKELMPDVGRGMQQLLDYPEDDIEEA-FCLNFTITVENFGTTEIKELVPNGADIPVIKQNRQDFVDAY 900
           ***************************************9**998.***************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y++++++++ + af++Gf++v+  ++l+lF+++el+ ++ G++++d+++l+k+t+ykg+y +d+++i+ Fwev++e+  e++k+f
   Q: 901  VDYIFNKSVASLFSAFHAGFHKVCGGKVLQLFQPSELQAMVIGNTNYDWKELEKNTEYKGEYWADHSTIKIFWEVFHELPLEKKKQF 987
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G++ lk    vi+   + +  lP ++TCfn+L+LP+Y+ ke+lk+kL+ Ai++ +gF+l
   Q: 988  LLFLTGSDRIPILGMKCLK---LVIQPtGGGEGYLPVAHTCFNLLDLPKYTDKETLKSKLIQAIDHYEGFSL 1056
           *******************...6666658899**************************************97 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

MLCWGNASFG QLGLGGIDEE IVLEPRKSDF FLNKKVRDVG CGLRHTVFVL DDGTVYTCGC 60
NDLGQLGHEK ARKRPEHVGA LDAQNIVAVS CGEAHTLALN DKGQVYAWGL ATDGQLGLPG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTGTGCT GGGGAAATGC ATCGTTTGGA CAGCTTGGGT TGGGTGGAAT TGATGAAGAG 60
ATTGTTTTAG AACCGAGAAA AAGTGACTTT TTCTTAAATA AAAAGGTCAG AGATGTAGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0001650--C:fibrillar center
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007283--P:spermatogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001666	Ailuropoda melanoleuca	88.47	0.00e+00	1837.00
IUUC-Aca-004336	Anolis carolinensis	86.15	0.00e+00	1863.00
IUUC-Ame-010768	Astyanax mexicanus	73.02	0.00e+00	1580.00
IUUC-Bta-013279	Bos taurus	88.47	0.00e+00	1837.00
IUUC-Cja-019023	Callithrix jacchus	88.19	0.00e+00	1830.00
IUUC-Cfa-021074	Canis familiaris	88.56	0.00e+00	1839.00
IUUC-Cpo-021461	Cavia porcellus	86.23	0.00e+00	1788.00
IUUC-Csa-024261	Chlorocebus sabaeus	88.85	0.00e+00	1845.00
IUUC-Cho-024513	Choloepus hoffmanni	70.32	0.00e+00	1347.00
IUUC-Cin-025232	Ciona intestinalis	42.92	0.00e+00	837.00
IUUC-Dre-028829	Danio rerio	74.65	0.00e+00	1545.00
IUUC-Dno-029445	Dasypus novemcinctus	85.25	0.00e+00	1476.00
IUUC-Dor-030158	Dipodomys ordii	87.47	0.00e+00	815.00
IUUC-Dme-032103	Drosophila melanogaster	45.95	0.00e+00	903.00
IUUC-Ete-033072	Echinops telfairi	79.47	0.00e+00	1618.00
IUUC-Eca-033317	Equus caballus	87.15	0.00e+00	1810.00
IUUC-Fca-035682	Felis catus	87.90	0.00e+00	1817.00
IUUC-Fal-036969	Ficedula albicollis	95.65	0.00e+00	2042.00
IUUC-Gmo-038671	Gadus morhua	72.49	0.00e+00	1558.00
IUUC-Gga-041174	Gallus gallus	98.30	0.00e+00	2098.00
IUUC-Gac-042600	Gasterosteus aculeatus	73.07	0.00e+00	1508.00
IUUC-Ggo-044589	Gorilla gorilla	88.28	0.00e+00	1858.00
IUUC-Hsa-046772	Homo sapiens	88.28	0.00e+00	1856.00
IUUC-Lch-050147	Latimeria chalumnae	80.48	0.00e+00	1434.00
IUUC-Loc-052684	Lepisosteus oculatus	79.58	0.00e+00	1679.00
IUUC-Laf-053844	Loxodonta africana	87.81	0.00e+00	1825.00
IUUC-Mcc-055531	Macaca mulatta	86.78	0.00e+00	1830.00
IUUC-Mga-060151	Meleagris gallopavo	98.21	0.00e+00	1760.00
IUUC-Mmr-060954	Microcebus murinus	88.66	0.00e+00	1844.00
IUUC-Mdo-062246	Monodelphis domestica	85.66	0.00e+00	1666.00
IUUC-Mmu-063369	Mus musculus	86.86	0.00e+00	1838.00
IUUC-Mpu-065936	Mustela putorius furo	88.10	0.00e+00	1687.00
IUUC-Mlu-067326	Myotis lucifugus	88.28	0.00e+00	1805.00
IUUC-Nle-069453	Nomascus leucogenys	87.81	0.00e+00	1816.00
IUUC-Ont-071720	Oreochromis niloticus	73.91	0.00e+00	1546.00
IUUC-Oan-073464	Ornithorhynchus anatinus	87.89	0.00e+00	1709.00
IUUC-Ocu-074207	Oryctolagus cuniculus	85.59	0.00e+00	1669.00
IUUC-Ola-086762	Oryzias latipes	72.78	0.00e+00	1494.00
IUUC-Oga-088435	Otolemur garnettii	88.47	0.00e+00	1841.00
IUUC-Oar-089233	Ovis aries	88.56	0.00e+00	1837.00
IUUC-Ptr-091368	Pan troglodytes	88.47	0.00e+00	1860.00
IUUC-Pan-092300	Papio anubis	88.85	0.00e+00	1845.00
IUUC-Psi-093406	Pelodiscus sinensis	91.49	0.00e+00	1978.00
IUUC-Pma-094113	Petromyzon marinus	71.05	0.00e+00	1150.00
IUUC-Ppa-095354	Physcomitrella patens	33.58	6.00e-144	504.00
IUUC-Pfo-097021	Poecilia formosa	72.27	0.00e+00	1574.00
IUUC-Pab-098327	Pongo abelii	88.56	0.00e+00	1859.00
IUUC-Pca-101075	Procavia capensis	83.68	0.00e+00	743.00
IUUC-Pva-102909	Pteropus vampyrus	77.98	0.00e+00	1544.00
IUUC-Rno-105457	Rattus norvegicus	87.71	0.00e+00	1864.00
IUUC-Sha-106632	Sarcophilus harrisii	86.96	0.00e+00	1838.00
IUUC-Sar-113679	Sorex araneus	77.81	0.00e+00	1016.00
IUUC-Tgu-116849	Taeniopygia guttata	90.64	0.00e+00	1915.00
IUUC-Tru-118206	Takifugu rubripes	71.98	0.00e+00	1456.00
IUUC-Tsy-119521	Tarsius syrichta	75.61	0.00e+00	1471.00
IUUC-Tni-120233	Tetraodon nigroviridis	71.79	0.00e+00	1456.00
IUUC-Tbe-127941	Tupaia belangeri	78.30	0.00e+00	1042.00
IUUC-Vpa-130448	Vicugna pacos	88.00	0.00e+00	1830.00
IUUC-Xtr-132719	Xenopus tropicalis	71.21	0.00e+00	1399.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence