iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18927152

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	4.20e-07	30.0	12	68
E3 activity/RING/RING	3.80e-07	30.6	18	57

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlp.sGitydrssIekwlasggktcPvtrqplteedl..v 56
           v ee+ CpI   + +dP  +  + + + r +I +wl ++ + cPv+r +lt  +l  v
   Q: 12   VDEELTCPICSGVLEDPLQAVmCEHAFCRGCINEWLTRQPT-CPVDRNSLTTANLraV 68
           66899************98888***************9998.*********9998533 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC   ++d++  + C H+f++ C++ w        ++ +CP++r
   Q: 18   CPICSGVLEDPLQAVMCEHAFCRGCINEW------LTRQPTCPVDR 57
           **********666777*************......********987 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MGYDVNRFQG EVDEELTCPI CSGVLEDPLQ AVMCEHAFCR GCINEWLTRQ PTCPVDRNSL 60
TTANLRAVPR ILRNLLSRLS ITCDNAPYGC TAVLKLDAYN SHLDECIHNP KRPFPCEKGC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCAAGCTAAA CAGTTATTTT AAGAAGCCAT TTCTCGCGGA TTACAGCTGA AGTGCCATCC 60
TAGCTTTCCA ACACTACTCA GTCACACTAC ACAACACTGC ACTGACTGAA CCGAAAAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0436--Ligase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008974--TRAF-like
IPR015036--USP8_interacting
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF08941--USP8_interact

SMART

SM00184--RING

Gene Ontology

GO:0016881--F:acid-amino acid ligase activity
GO:0017022--F:myosin binding
GO:0031386--F:protein tag
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0000209--P:protein polyubiquitination
GO:0051445--P:regulation of meiotic cell cycle

KEGG

dme:Dmel_CG17033

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002398	Ailuropoda melanoleuca	57.46	7.00e-118	416.00
IUUC-Atr-003101	Amborella trichopoda	37.88	8.00e-07	46.60
IUUC-Apl-003568	Anas platyrhynchos	57.59	4.00e-115	406.00
IUUC-Aca-005119	Anolis carolinensis	58.10	5.00e-119	419.00
IUUC-Acl-008013	Aspergillus clavatus	42.50	4.00e-05	43.10
IUUC-Ani-009293	Aspergillus nidulans	43.90	1.00e-05	44.70
IUUC-Ame-010708	Astyanax mexicanus	57.46	1.00e-117	415.00
IUUC-Bgr-012191	Blumeria graminis	29.10	4.00e-10	58.50
IUUC-Bta-013428	Bos taurus	57.59	9.00e-114	402.00
IUUC-Bci-013998	Botrytis cinerea	31.73	3.00e-08	52.40
IUUC-Cja-019844	Callithrix jacchus	57.28	2.00e-116	410.00
IUUC-Cfa-021124	Canis familiaris	57.46	9.00e-118	415.00
IUUC-Cpo-022325	Cavia porcellus	57.46	7.00e-118	416.00
IUUC-Csa-023113	Chlorocebus sabaeus	57.46	9.00e-118	415.00
IUUC-Cho-024991	Choloepus hoffmanni	54.12	1.00e-66	244.00
IUUC-Cme-027114	Cyanidioschyzon merolae	42.86	8.00e-07	47.40
IUUC-Dre-028730	Danio rerio	57.46	1.00e-117	415.00
IUUC-Dno-028908	Dasypus novemcinctus	55.09	7.00e-102	362.00
IUUC-Dor-030411	Dipodomys ordii	57.14	1.00e-117	414.00
IUUC-Ete-032896	Echinops telfairi	49.81	9.00e-78	282.00
IUUC-Eca-034135	Equus caballus	57.46	9.00e-118	415.00
IUUC-Eeu-034675	Erinaceus europaeus	57.46	2.00e-117	414.00
IUUC-Fca-035612	Felis catus	57.46	9.00e-118	415.00
IUUC-Fal-037150	Ficedula albicollis	43.97	4.00e-27	114.00
IUUC-Gmo-039648	Gadus morhua	56.51	1.00e-116	412.00
IUUC-Ggr-040084	Gaeumannomyces graminis	33.03	5.00e-10	58.50
IUUC-Gga-040474	Gallus gallus	58.41	2.00e-119	421.00
IUUC-Gac-041951	Gasterosteus aculeatus	56.83	2.00e-117	414.00
IUUC-Ggo-045126	Gorilla gorilla	57.28	2.00e-116	410.00
IUUC-Hsa-046402	Homo sapiens	57.46	9.00e-118	415.00
IUUC-Itr-047895	Ictidomys tridecemlineatus	57.46	9.00e-118	415.00
IUUC-Kpa-049392	Komagataella pastoris	44.44	2.00e-09	55.50
IUUC-Lch-050266	Latimeria chalumnae	58.10	7.00e-119	419.00
IUUC-Loc-052547	Lepisosteus oculatus	58.73	6.00e-119	419.00
IUUC-Lma-053260	Leptosphaeria maculans	33.33	2.00e-07	50.80
IUUC-Laf-054332	Loxodonta africana	56.96	3.00e-116	410.00
IUUC-Mcc-055869	Macaca mulatta	57.46	9.00e-118	415.00
IUUC-Meu-056735	Macropus eugenii	55.09	9.00e-102	362.00
IUUC-Mpo-057517	Magnaporthe poae	33.94	3.00e-09	56.20
IUUC-Mla-059147	Melampsora laricipopulina	38.78	2.00e-15	75.90
IUUC-Mga-060100	Meleagris gallopavo	58.41	2.00e-119	421.00
IUUC-Mvi-060553	Microbotryum violaceum	35.58	4.00e-14	72.00
IUUC-Mmr-061382	Microcebus murinus	57.46	9.00e-118	415.00
IUUC-Mdo-062581	Monodelphis domestica	31.41	8.00e-21	95.50
IUUC-Mmu-064225	Mus musculus	57.46	7.00e-118	416.00
IUUC-Mpu-066709	Mustela putorius furo	57.46	9.00e-118	415.00
IUUC-Mlu-067168	Myotis lucifugus	57.78	3.00e-118	417.00
IUUC-Nle-070176	Nomascus leucogenys	57.46	9.00e-118	415.00
IUUC-Opr-070259	Ochotona princeps	57.78	4.00e-118	416.00
IUUC-Ont-071235	Oreochromis niloticus	57.78	9.00e-119	418.00
IUUC-Oan-072850	Ornithorhynchus anatinus	58.39	5.00e-52	196.00
IUUC-Ocu-074165	Oryctolagus cuniculus	57.78	4.00e-118	416.00
IUUC-Ola-086658	Oryzias latipes	57.78	3.00e-117	413.00
IUUC-Oga-088933	Otolemur garnettii	57.46	9.00e-118	415.00
IUUC-Oar-090089	Ovis aries	57.14	1.00e-117	414.00
IUUC-Ptr-091263	Pan troglodytes	57.46	9.00e-118	415.00
IUUC-Pan-092926	Papio anubis	57.46	9.00e-118	415.00
IUUC-Psi-093934	Pelodiscus sinensis	53.97	3.00e-106	377.00
IUUC-Pma-094578	Petromyzon marinus	53.94	5.00e-98	349.00
IUUC-Pfo-097431	Poecilia formosa	57.78	2.00e-118	417.00
IUUC-Pab-097852	Pongo abelii	57.46	9.00e-118	415.00
IUUC-Pca-100496	Procavia capensis	52.85	4.00e-101	360.00
IUUC-Pva-103157	Pteropus vampyrus	53.00	3.00e-66	243.00
IUUC-Pgr-103569	Puccinia graminis	35.92	4.00e-14	71.20
IUUC-Pte-104339	Pyrenophora teres	35.06	2.00e-07	50.40
IUUC-Pyt-104522	Pyrenophora triticirepentis	35.06	3.00e-07	50.10
IUUC-Rno-105928	Rattus norvegicus	57.46	4.00e-118	416.00
IUUC-Sha-107556	Sarcophilus harrisii	57.28	3.00e-116	410.00
IUUC-Ssl-108580	Sclerotinia sclerotiorum	34.78	3.00e-08	52.40
IUUC-Sar-113208	Sorex araneus	57.46	9.00e-118	415.00
IUUC-Sre-115218	Sporisorium reilianum	27.62	6.00e-06	45.40
IUUC-Ssc-116011	Sus scrofa	57.14	1.00e-117	414.00
IUUC-Tgu-116882	Taeniopygia guttata	40.40	1.00e-36	145.00
IUUC-Tru-117987	Takifugu rubripes	57.46	4.00e-118	416.00
IUUC-Tsy-118785	Tarsius syrichta	57.14	8.00e-116	409.00
IUUC-Tni-120165	Tetraodon nigroviridis	57.46	3.00e-118	417.00
IUUC-Tbe-127920	Tupaia belangeri	53.00	6.00e-68	249.00
IUUC-Ttr-129160	Tursiops truncatus	57.14	6.00e-118	416.00
IUUC-Vpa-130629	Vicugna pacos	57.46	9.00e-118	415.00
IUUC-Xtr-131895	Xenopus tropicalis	58.10	6.00e-120	422.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence