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Tag Content
iUUCD ID IUUC-Itr-049024
Ensembl Protein ID ENSSTOP00000020124.1
UniProt Accession I3N6X8; I3N6X8_ICTTR
Genbank Protein ID ENSSTOP00000020124
Protein Name Histone-lysine N-methyltransferase 2A
Genbank Nucleotide ID AGTP01052950
Gene Name KMT2A
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSSTOG00000014405.2 ENSSTOT00000023049.1 ENSSTOP00000020124.1
ENSSTOG00000014405.2 ENSSTOT00000014428.2 ENSSTOP00000012923.2
ENSSTOG00000014405.2 ENSSTOT00000024563.1 ENSSTOP00000016054.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 8.90e-24 83.4 1399 1461
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedek...slveCekCrewfHpaClkls........veeelpnsekwiCpkCrs 53
           ++C++C+++++d++   ++++C kC++w+H +C +ls        + ++lp+s +++C +C++
   Q: 1399 NFCPLCDKCYDDDDyesKMMQCGKCDRWVHSKCENLSgtedemyeILSNLPESVAYTCVNCTE 1461
           79***********8888********************************************86 PP
   
Organism Ictidomys tridecemlineatus
Functional Description
(View)

Functional Description


     Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis. Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer. Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-ARNTL/BMAL1 to chromatin.
 Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis. Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer. Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-ARNTL/BMAL1 to chromatin.
Protein Sequence
(Fasta)
KTSPRKPRGR PRSGSDRNSA ILPDPSVFSP LNKSETKSGD KIKKKDSKSI EKKRGRPPTF 60
PGVKIKITHG KDISELPKGN KEDSLKKIKR TPSATFQQAT KIKKLRAGKL SPLKSKFKTG 120
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Protein Fasta Sequence


>IUUC-Itr-049024|E3,PHD|Ictidomys tridecemlineatus
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Nucleotide Sequence
(Fasta)
AGGCGGCAGC GGAGAGGTAA GGGGGCGAGG AACCCCCAGG TCCGGGGTCC CGACCCTCTG 60
AGGAGCCCCT TCCCCTCCCC CATCCTTGTT TGAGGAGCAT CCCAATTCTG GAACCATCCT 120
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Nucleotide Fasta Sequence


>IUUC-Itr-049024|E3,PHD|Ictidomys tridecemlineatus
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Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001487--Bromodomain
IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR016569--MeTrfase_trithorax
IPR019786--Zinc_finger_PHD-type_CS
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50014--BROMODOMAIN_2
PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS51058--ZF_CXXC
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF02008--zf-CXXC
SMART

SM00297--BROMO
SM00541--FYRN
SM00249--PHD
Gene Ontology

GO:0005829--C:cytosol
GO:0071339--C:MLL1 complex
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0045322--F:unmethylated CpG binding
GO:0008270--F:zinc ion binding
GO:0009952--P:anterior/posterior pattern specification
GO:0032922--P:circadian regulation of gene expression
GO:0060216--P:definitive hemopoiesis
GO:0006306--P:DNA methylation
GO:0035162--P:embryonic hemopoiesis
GO:0035640--P:exploration behavior
GO:0044648--P:histone H3-K4 dimethylation
GO:0080182--P:histone H3-K4 trimethylation
GO:0043984--P:histone H4-K16 acetylation
GO:0048873--P:homeostasis of number of cells within a tissue
GO:0008285--P:negative regulation of cell proliferation
GO:0018026--P:peptidyl-lysine monomethylation
GO:2001040--P:positive regulation of cellular response to drug
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032411--P:positive regulation of transporter activity
GO:0009791--P:post-embryonic development
GO:0006461--P:protein complex assembly
GO:0071440--P:regulation of histone H3-K14 acetylation
GO:1901674--P:regulation of histone H3-K27 acetylation
GO:2000615--P:regulation of histone H3-K9 acetylation
GO:0048172--P:regulation of short-term neuronal synaptic plasticity
GO:0048536--P:spleen development
GO:0006351--P:transcription, DNA-templated
GO:0008542--P:visual learning
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002274 Ailuropoda melanoleuca 92.87 0.00e+00 5334.00
IUUC-Apl-003478 Anas platyrhynchos 76.29 0.00e+00 3343.00
IUUC-Aca-005086 Anolis carolinensis 61.24 0.00e+00 2314.00
IUUC-Bta-012974 Bos taurus 92.05 0.00e+00 5295.00
IUUC-Cja-019226 Callithrix jacchus 91.67 0.00e+00 5296.00
IUUC-Cfa-021049 Canis familiaris 92.42 0.00e+00 5304.00
IUUC-Cpo-021459 Cavia porcellus 91.50 0.00e+00 3714.00
IUUC-Csa-023434 Chlorocebus sabaeus 93.09 0.00e+00 4876.00
IUUC-Cho-024652 Choloepus hoffmanni 87.78 0.00e+00 3230.00
IUUC-Cme-027224 Cyanidioschyzon merolae 34.18 3.00e-12 67.40
IUUC-Dre-028180 Danio rerio 63.02 0.00e+00 1076.00
IUUC-Dno-029068 Dasypus novemcinctus 89.28 0.00e+00 4999.00
IUUC-Dor-030550 Dipodomys ordii 85.46 0.00e+00 4419.00
IUUC-Ete-032834 Echinops telfairi 83.66 0.00e+00 2218.00
IUUC-Eca-033615 Equus caballus 93.55 0.00e+00 5210.00
IUUC-Eeu-035136 Erinaceus europaeus 91.56 0.00e+00 1115.00
IUUC-Fca-036453 Felis catus 91.35 0.00e+00 2511.00
IUUC-Fal-037256 Ficedula albicollis 76.06 0.00e+00 4353.00
IUUC-Gmo-038641 Gadus morhua 64.28 0.00e+00 1009.00
IUUC-Gga-040828 Gallus gallus 77.08 0.00e+00 4302.00
IUUC-Gac-041452 Gasterosteus aculeatus 66.38 0.00e+00 1062.00
IUUC-Ggo-045124 Gorilla gorilla 89.32 0.00e+00 4946.00
IUUC-Hsa-046143 Homo sapiens 93.22 0.00e+00 5237.00
IUUC-Lch-049704 Latimeria chalumnae 61.60 0.00e+00 3207.00
IUUC-Loc-052181 Lepisosteus oculatus 74.43 0.00e+00 1216.00
IUUC-Laf-053946 Loxodonta africana 92.59 0.00e+00 5087.00
IUUC-Mcc-055508 Macaca mulatta 93.58 0.00e+00 5241.00
IUUC-Meu-056485 Macropus eugenii 80.86 0.00e+00 2026.00
IUUC-Mga-059943 Meleagris gallopavo 73.49 0.00e+00 3918.00
IUUC-Mmr-061178 Microcebus murinus 91.63 0.00e+00 5241.00
IUUC-Mdo-063031 Monodelphis domestica 83.69 0.00e+00 3392.00
IUUC-Mmu-063650 Mus musculus 87.61 0.00e+00 3529.00
IUUC-Mpu-066495 Mustela putorius furo 92.75 0.00e+00 3992.00
IUUC-Mlu-068045 Myotis lucifugus 83.19 0.00e+00 4710.00
IUUC-Nle-069064 Nomascus leucogenys 93.41 0.00e+00 5333.00
IUUC-Opr-071043 Ochotona princeps 85.79 0.00e+00 3792.00
IUUC-Ont-072556 Oreochromis niloticus 61.23 0.00e+00 1040.00
IUUC-Oan-073324 Ornithorhynchus anatinus 75.62 0.00e+00 2063.00
IUUC-Ocu-074190 Oryctolagus cuniculus 90.51 0.00e+00 5118.00
IUUC-Ola-087176 Oryzias latipes 58.37 0.00e+00 1045.00
IUUC-Oga-088208 Otolemur garnettii 92.56 0.00e+00 5148.00
IUUC-Oar-090152 Ovis aries 91.99 0.00e+00 5344.00
IUUC-Ptr-091127 Pan troglodytes 93.27 0.00e+00 5204.00
IUUC-Pan-092679 Papio anubis 92.53 0.00e+00 4142.00
IUUC-Psi-094059 Pelodiscus sinensis 77.40 0.00e+00 4363.00
IUUC-Pma-094258 Petromyzon marinus 57.42 3.00e-174 604.00
IUUC-Pfo-096536 Poecilia formosa 67.87 0.00e+00 1023.00
IUUC-Pab-098262 Pongo abelii 93.33 0.00e+00 5293.00
IUUC-Pca-100358 Procavia capensis 86.88 0.00e+00 4751.00
IUUC-Pva-102522 Pteropus vampyrus 86.41 0.00e+00 4075.00
IUUC-Rno-105200 Rattus norvegicus 88.04 0.00e+00 3444.00
IUUC-Sha-107174 Sarcophilus harrisii 84.02 0.00e+00 4754.00
IUUC-Sar-113503 Sorex araneus 79.83 0.00e+00 2532.00
IUUC-Tgu-117047 Taeniopygia guttata 76.72 0.00e+00 4322.00
IUUC-Tru-118328 Takifugu rubripes 61.85 0.00e+00 1048.00
IUUC-Tsy-118953 Tarsius syrichta 88.78 0.00e+00 2625.00
IUUC-Tni-120837 Tetraodon nigroviridis 61.89 0.00e+00 1040.00
IUUC-Tbe-127950 Tupaia belangeri 87.98 0.00e+00 2421.00
IUUC-Ttr-128643 Tursiops truncatus 90.69 0.00e+00 5079.00
IUUC-Vpa-130660 Vicugna pacos 87.44 0.00e+00 1912.00
IUUC-Xtr-132869 Xenopus tropicalis 60.10 0.00e+00 2143.00
Created Date 25-Jun-2017

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