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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046029
UUCD1 version UUC-HoS-00055
Ensembl Protein ID ENSP00000392787.2
UniProt Accession P14373; A2BE15; Q5RJA8; Q5ST26; Q6LA73; Q6NXR9; Q9BZY6; Q9UJL3; TRI27_HUMAN
Genbank Protein ID AAA36564.1; AAG50172.1; AAG50173.1; CAI17553.1; CAI18381.1; CAI18618.1; CAI18618.1; CAI18619.1; CAI18619.1; CAI18645.1; CAI18645.1; CAI18646.1; CAI18646.1; CAM24901.1; CAM25659.1; CAM25871.1; CAM25871.1; CAM25872.1; CAM25872.1; CAM26230.1; CAM26230.1; CAM26231.1; CAM26231.1; CAQ07942.1; CAQ07943.1; CAB06480.2; CAB06480.2; CAI19959.1; CAI19959.1; EAX03176.1; EAX03177.1; AAH13580.1; AAH66924.1
Protein Name Zinc finger protein RFP; RING finger protein 76; RING-type E3 ubiquitin transferase TRIM27; Ret finger protein; Tripartite motif-containing protein 27
Genbank Nucleotide ID J03407; AF230393; AF230394; AL662859; AL662871; BX000360; BX537153; BX000360; BX537153; BX537153; BX000360; BX537153; BX000360; AL662859; AL662871; BX005144; BX119924; BX005144; BX119924; BX119924; BX005144; BX119924; BX005144; CR759942; CR759942; Z84474; Z84476; Z84476; Z84474; CH471081; CH471081; BC013580; BC066924
Gene Name TRIM27; RFP; RNF76
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000234495.7 ENST00000437160.6 ENSP00000392787.2
ENSG00000234495.7 ENST00000412687.6 ENSP00000416281.2
ENSG00000234495.7 ENST00000417993.1 ENSP00000398020.1
Annotation
Cancer Mutation
TCGACOSMICCGAPIntOGen
mRNA Expression
ArrayExpressTCGAICGCCOSMIC
THPAHPM
DNA & RNA Element
UTRdbCircNetRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPHOSIDAmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 20145714; 23404503
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.00016 23.7 16 57
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C++Cl+ f + p+ l+CgH ++  Cl  +w      + ++ +CP Cr
   Q: 16   CPVCLQYFAE-PMMLDCGHNICCACLaRCW----GTAETNVSCPQCR 57
           ********99.999****************....99**********8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA.
 E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA.
Protein Sequence
(Fasta)
MASGSVAECL QQETTCPVCL QYFAEPMMLD CGHNICCACL ARCWGTAETN VSCPQCRETF 60
PQRHMRPNRH LANVTQLVKQ LRTERPSGPG GEMGVCEKHR EPLKLYCEED QMPICVVCDR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046029|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
GTTTACGCTG CCGCCGGCAT CCGCTCGGAC GCGGCCACGT TGTCTTGCGC GCTTTGCCCG 60
CCTGGCCCTG GGACTCTGAC CCTCGGCTAC CCTTTCCTGC CCCACTAGCG TGGCCGCGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046029|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0160--Chromosomal rearrangement
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0967--Endosome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0813--Transport
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR020457--Znf_B-box_chordata
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box
PRINTS

PR01406--BBOXZNFINGER
PR01407--BUTYPHLNCDUF
SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0005768--C:endosome
GO:0001650--C:fibrillar center
GO:0005887--C:integral component of plasma membrane
GO:0016020--C:membrane
GO:0031965--C:nuclear membrane
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0003677--F:DNA binding
GO:0042802--F:identical protein binding
GO:0046872--F:metal ion binding
GO:0003676--F:nucleic acid binding
GO:0004714--F:transmembrane receptor protein tyrosine kinase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0034314--P:Arp2/3 complex-mediated actin nucleation
GO:0008283--P:cell proliferation
GO:0045087--P:innate immune response
GO:0072643--P:interferon-gamma secretion
GO:0002820--P:negative regulation of adaptive immune response
GO:0090281--P:negative regulation of calcium ion import
GO:0045814--P:negative regulation of gene expression, epigenetic
GO:1900041--P:negative regulation of interleukin-2 secretion
GO:0006469--P:negative regulation of protein kinase activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0032720--P:negative regulation of tumor necrosis factor production
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0051127--P:positive regulation of actin nucleation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0070534--P:protein K63-linked ubiquitination
GO:0070206--P:protein trimerization
GO:0042147--P:retrograde transport, endosome to Golgi
GO:0007283--P:spermatogenesis
GO:0006351--P:transcription, DNA-templated
KEGG hsa:5987
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001890 Ailuropoda melanoleuca 98.62 0.00e+00 971.00
IUUC-Apl-003609 Anas platyrhynchos 40.29 6.00e-97 347.00
IUUC-Ame-011639 Astyanax mexicanus 34.42 2.00e-69 256.00
IUUC-Bta-013520 Bos taurus 99.42 0.00e+00 985.00
IUUC-Cja-019557 Callithrix jacchus 97.47 0.00e+00 967.00
IUUC-Cfa-020583 Canis familiaris 98.57 0.00e+00 924.00
IUUC-Cpo-021738 Cavia porcellus 90.25 0.00e+00 879.00
IUUC-Csa-023502 Chlorocebus sabaeus 100.00 0.00e+00 990.00
IUUC-Cho-024563 Choloepus hoffmanni 95.84 3.00e-179 621.00
IUUC-Dno-029747 Dasypus novemcinctus 96.59 0.00e+00 910.00
IUUC-Dor-030243 Dipodomys ordii 96.88 0.00e+00 935.00
IUUC-Ete-032749 Echinops telfairi 84.55 0.00e+00 796.00
IUUC-Eca-034246 Equus caballus 99.47 0.00e+00 694.00
IUUC-Eeu-034481 Erinaceus europaeus 88.50 0.00e+00 867.00
IUUC-Fca-036152 Felis catus 98.66 0.00e+00 688.00
IUUC-Gac-042288 Gasterosteus aculeatus 37.58 2.00e-75 276.00
IUUC-Ggo-044987 Gorilla gorilla 90.25 0.00e+00 875.00
IUUC-Itr-048438 Ictidomys tridecemlineatus 99.42 0.00e+00 960.00
IUUC-Laf-054488 Loxodonta africana 99.61 0.00e+00 980.00
IUUC-Mcc-055352 Macaca mulatta 100.00 0.00e+00 990.00
IUUC-Mmr-060883 Microcebus murinus 99.61 0.00e+00 985.00
IUUC-Mmu-064242 Mus musculus 98.83 0.00e+00 981.00
IUUC-Mpu-065958 Mustela putorius furo 99.03 0.00e+00 982.00
IUUC-Mlu-068005 Myotis lucifugus 85.54 0.00e+00 654.00
IUUC-Nle-069710 Nomascus leucogenys 99.72 0.00e+00 644.00
IUUC-Opr-071200 Ochotona princeps 99.03 0.00e+00 976.00
IUUC-Ocu-074081 Oryctolagus cuniculus 98.02 0.00e+00 846.00
IUUC-Ola-087166 Oryzias latipes 33.58 5.00e-70 258.00
IUUC-Oga-088784 Otolemur garnettii 99.61 0.00e+00 986.00
IUUC-Oar-089433 Ovis aries 99.42 0.00e+00 985.00
IUUC-Ptr-090595 Pan troglodytes 100.00 0.00e+00 990.00
IUUC-Pan-092027 Papio anubis 100.00 0.00e+00 990.00
IUUC-Psi-093179 Pelodiscus sinensis 47.36 4.00e-116 411.00
IUUC-Pfo-096858 Poecilia formosa 33.77 8.00e-69 254.00
IUUC-Pab-098331 Pongo abelii 100.00 0.00e+00 990.00
IUUC-Pca-101091 Procavia capensis 99.61 0.00e+00 986.00
IUUC-Pva-103141 Pteropus vampyrus 99.48 0.00e+00 715.00
IUUC-Rno-105507 Rattus norvegicus 98.44 0.00e+00 976.00
IUUC-Sar-113713 Sorex araneus 90.23 0.00e+00 897.00
IUUC-Ssc-115594 Sus scrofa 99.41 0.00e+00 983.00
IUUC-Tru-118630 Takifugu rubripes 34.27 8.00e-72 264.00
IUUC-Tsy-119235 Tarsius syrichta 99.22 0.00e+00 702.00
IUUC-Tni-120295 Tetraodon nigroviridis 37.37 7.00e-75 274.00
IUUC-Tbe-127796 Tupaia belangeri 88.64 6.00e-139 487.00
IUUC-Ttr-128738 Tursiops truncatus 99.46 0.00e+00 692.00
Created Date 25-Jun-2017

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