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Tag Content
UUCD2 ID IUUC-Cpo-021988
UUCD1 version UUC-CaP-00454
Ensembl Protein ID ENSCPOP00000009169.2
UniProt Accession H0VGD4; H0VGD4_CAVPO
Genbank Protein ID ENSCPOP00000009169
Protein Name E3 ubiquitin-protein ligase
Genbank Nucleotide ID AAKN02026467
Gene Name WWP2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSCPOG00000010208.3 ENSCPOT00000010301.2 ENSCPOP00000009169.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 4.50e-135 450.3 537 869
Active Site
Position(s) Description Evidence
838 Glycyl thioester intermediate {ECO:0000256|PIRSR:PIRSR001569-1,
ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 537  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 624
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+k+ +l+dle++dpe+y+s+ +iken   ++ee+gl+l f ++ eilg+++++eLk+gGe+i+Vt+eNkeeY+ l+++
   Q: 625  GFTLPFYKRMLNKRPTLKDLESIDPEFYNSILWIKEN---NLEECGLELFFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTD 710
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev ple+l++F+e+elel++cG++eid++d++k+t y++ yt++s++iqwFw+v++e+++e+r ++LqFv
   Q: 711  WRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKNTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFV 798
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfael     p++f+i k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLlyA+eet+gF++
   Q: 799  TGTCRLPVGGFAELIgsngPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAVEETEGFGQ 869
           *********************************************************************96 PP
   
Organism Cavia porcellus
Protein Sequence
(Fasta)
MASASSSRPG VALPFEKSQL TLKVVSAKPK VHNRQPRINS YVEVAVDGLP SETKKTGKRI 60
GSSELLWNEI IVLNVTAQSH LDLKVWSCHT LRNELLGTAS VNLSNVLKNN GGKMENTQLT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cpo-021988|E3,HECT|Cavia porcellus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGCATCTG CCAGCTCCAG CCGGCCAGGA GTGGCTCTCC CTTTTGAGAA ATCTCAGCTT 60
ACCCTGAAAG GTGAGTGGCT CGTGTCACAT GCATGTCACT GGAGGTCCAG CTTCGTGTTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cpo-021988|E3,HECT|Cavia porcellus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00632--HECT
PF00397--WW
SMART

SM00239--C2
SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0051224--P:negative regulation of protein transport
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0032410--P:negative regulation of transporter activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001575 Ailuropoda melanoleuca 95.07 0.00e+00 1630.00
IUUC-Apl-003912 Anas platyrhynchos 76.51 0.00e+00 1235.00
IUUC-Aca-004291 Anolis carolinensis 80.41 0.00e+00 1427.00
IUUC-Bta-013231 Bos taurus 94.48 0.00e+00 1586.00
IUUC-Cel-018299 Caenorhabditis elegans 67.01 0.00e+00 832.00
IUUC-Cja-019455 Callithrix jacchus 95.29 0.00e+00 1670.00
IUUC-Cfa-021017 Canis familiaris 95.75 0.00e+00 1622.00
IUUC-Csa-023549 Chlorocebus sabaeus 95.29 0.00e+00 1680.00
IUUC-Cin-025212 Ciona intestinalis 72.15 0.00e+00 876.00
IUUC-Dre-028513 Danio rerio 91.59 0.00e+00 1135.00
IUUC-Dno-028976 Dasypus novemcinctus 94.95 0.00e+00 1664.00
IUUC-Dor-030176 Dipodomys ordii 93.14 0.00e+00 1515.00
IUUC-Dme-032041 Drosophila melanogaster 68.14 0.00e+00 870.00
IUUC-Eca-033949 Equus caballus 95.52 0.00e+00 1635.00
IUUC-Eeu-034529 Erinaceus europaeus 87.84 0.00e+00 1374.00
IUUC-Fca-036236 Felis catus 95.17 0.00e+00 1670.00
IUUC-Fal-036948 Ficedula albicollis 77.54 0.00e+00 1323.00
IUUC-Gmo-038842 Gadus morhua 88.89 0.00e+00 1068.00
IUUC-Gga-040617 Gallus gallus 79.76 0.00e+00 1436.00
IUUC-Gac-041338 Gasterosteus aculeatus 69.39 0.00e+00 1249.00
IUUC-Ggo-045278 Gorilla gorilla 95.98 0.00e+00 1692.00
IUUC-Hsa-046148 Homo sapiens 95.98 0.00e+00 1692.00
IUUC-Itr-047945 Ictidomys tridecemlineatus 98.32 0.00e+00 1123.00
IUUC-Lch-050663 Latimeria chalumnae 78.48 0.00e+00 1390.00
IUUC-Loc-052604 Lepisosteus oculatus 76.40 0.00e+00 1318.00
IUUC-Laf-053944 Loxodonta africana 94.94 0.00e+00 1656.00
IUUC-Mcc-055655 Macaca mulatta 95.40 0.00e+00 1681.00
IUUC-Meu-055953 Macropus eugenii 79.70 0.00e+00 1385.00
IUUC-Mga-060190 Meleagris gallopavo 80.36 0.00e+00 1439.00
IUUC-Mmr-060896 Microcebus murinus 96.18 0.00e+00 1637.00
IUUC-Mdo-062536 Monodelphis domestica 90.60 0.00e+00 1607.00
IUUC-Mmu-064017 Mus musculus 95.29 0.00e+00 1645.00
IUUC-Mpu-066608 Mustela putorius furo 93.35 0.00e+00 1582.00
IUUC-Mlu-067623 Myotis lucifugus 92.77 0.00e+00 1592.00
IUUC-Nle-069496 Nomascus leucogenys 94.03 0.00e+00 1644.00
IUUC-Opr-071054 Ochotona princeps 84.22 0.00e+00 1426.00
IUUC-Ont-071279 Oreochromis niloticus 73.55 0.00e+00 1286.00
IUUC-Oan-073512 Ornithorhynchus anatinus 87.37 0.00e+00 1481.00
IUUC-Ocu-074271 Oryctolagus cuniculus 95.22 0.00e+00 1618.00
IUUC-Ola-087237 Oryzias latipes 66.99 0.00e+00 1155.00
IUUC-Oga-088164 Otolemur garnettii 96.55 0.00e+00 1689.00
IUUC-Oar-089698 Ovis aries 94.83 0.00e+00 1597.00
IUUC-Ptr-091306 Pan troglodytes 94.71 0.00e+00 1662.00
IUUC-Pan-092814 Papio anubis 91.86 0.00e+00 1591.00
IUUC-Pfo-096709 Poecilia formosa 72.35 0.00e+00 1277.00
IUUC-Pab-098494 Pongo abelii 90.62 0.00e+00 1596.00
IUUC-Pca-100596 Procavia capensis 83.69 0.00e+00 1385.00
IUUC-Pva-103154 Pteropus vampyrus 90.61 0.00e+00 1567.00
IUUC-Rno-104954 Rattus norvegicus 94.72 0.00e+00 1407.00
IUUC-Sha-106781 Sarcophilus harrisii 91.17 0.00e+00 1657.00
IUUC-Ssc-116307 Sus scrofa 82.74 0.00e+00 1441.00
IUUC-Tgu-116530 Taeniopygia guttata 75.00 0.00e+00 1180.00
IUUC-Tru-118287 Takifugu rubripes 89.63 0.00e+00 1070.00
IUUC-Tsy-119097 Tarsius syrichta 83.10 0.00e+00 1234.00
IUUC-Tni-120801 Tetraodon nigroviridis 71.06 0.00e+00 1208.00
IUUC-Tbe-127793 Tupaia belangeri 84.37 0.00e+00 1444.00
IUUC-Ttr-128275 Tursiops truncatus 91.38 0.00e+00 1554.00
IUUC-Uma-129332 Ustilago maydis 46.53 7.00e-143 501.00
IUUC-Xtr-132866 Xenopus tropicalis 82.54 0.00e+00 1135.00
Created Date 25-Jun-2017

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