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Tag Content
UUCD2 ID IUUC-Dre-028513
UUCD1 version UUC-DaR-00078
Ensembl Protein ID ENSDARP00000081798.4
UniProt Accession F6P346; F6P346_DANRE
Genbank Protein ID ENSDARP00000081798
Protein Name E3 ubiquitin-protein ligase
Genbank Nucleotide ID BX890570
Gene Name wwp2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSDARG00000061345.5 ENSDART00000136640.2 ENSDARP00000112571.1
ENSDARG00000061345.5 ENSDART00000139582.2 ENSDARP00000122529.1
ENSDARG00000061345.5 ENSDART00000087364.4 ENSDARP00000081798.4
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 1.90e-132 442.7 534 866
Active Site
Position(s) Description Evidence
835 Glycyl thioester intermediate {ECO:0000256|PIRSR:PIRSR001569-1,
ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 534  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 621
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+kk +l+dle++dpe+y+s++++ken   d+ee+g++l f ++ eilg++++++Lk +Gen+ Vt++NkeeY+ l+++
   Q: 622  GFTLPFYKRMLNKKPTLKDLESIDPEFYNSIMWVKEN---DLEECGVELYFAQDMEILGKVTTHQLKDDGENELVTQDNKEEYIGLLTD 707
           ***********************************99...************************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev+ple+l++F+e+elel++cG++eid++d++k+t y++ yt++s++i+wFw+v++e+++e+r ++LqFv
   Q: 708  WRFTRGVEEQTKAFLDGFNEVVPLEWLRYFDEKELELMLCGMQEIDLNDWQKNTIYRH-YTKNSKQIHWFWQVVKEMDNEKRIRLLQFV 795
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfael     p++f+i k +++++lP+s+TCfn+L+LP+Y++ e+l+ekLl+Aieet+gF++
   Q: 796  TGTCRLPVGGFAELIgsngPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKNLEQLREKLLFAIEETEGFGQ 866
           *********************************************************************96 PP
   
Organism Danio rerio
Protein Sequence
(Fasta)
MAAASVSQSA SIQAIEKSQL TLKVLSAKPQ SPKLPNRHSR LSSFVEVTAD GLSSETKKTG 60
KRSGHLELQW NEDLTLNVTP QSRLDLKVWS CHTLRKELLG SATIDLLDTL RTHDGKMENV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dre-028513|E3,HECT|Danio rerio
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTCGTTCGTG GCCCCAGTTC TAGTAAGTCT TGCTACCGAG TTTTTTGATC TTGTTCTTGT 60
ATTTTTTTGC TAAAGTCTAA CGTTAGTTTG TAAAGTTATT GTTTCTGAGC CTTGTCTCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dre-028513|E3,HECT|Danio rerio
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00168--C2
PF00632--HECT
PF00397--WW
SMART

SM00239--C2
SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0060021--P:palate development
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001575 Ailuropoda melanoleuca 91.00 0.00e+00 1134.00
IUUC-Apl-003912 Anas platyrhynchos 71.05 0.00e+00 1129.00
IUUC-Aca-004291 Anolis carolinensis 73.53 0.00e+00 1296.00
IUUC-Bta-013231 Bos taurus 91.53 0.00e+00 1125.00
IUUC-Cja-019455 Callithrix jacchus 74.37 0.00e+00 1291.00
IUUC-Cfa-021017 Canis familiaris 74.66 0.00e+00 1292.00
IUUC-Cpo-021988 Cavia porcellus 74.22 0.00e+00 1285.00
IUUC-Csa-023549 Chlorocebus sabaeus 74.25 0.00e+00 1301.00
IUUC-Dno-028976 Dasypus novemcinctus 75.06 0.00e+00 1296.00
IUUC-Dor-030176 Dipodomys ordii 91.53 0.00e+00 1119.00
IUUC-Eca-033949 Equus caballus 72.63 0.00e+00 1271.00
IUUC-Eeu-034529 Erinaceus europaeus 91.00 0.00e+00 966.00
IUUC-Fca-036236 Felis catus 91.18 0.00e+00 1143.00
IUUC-Fal-036948 Ficedula albicollis 93.01 0.00e+00 1143.00
IUUC-Gmo-038842 Gadus morhua 93.47 0.00e+00 1112.00
IUUC-Gga-040617 Gallus gallus 91.98 0.00e+00 1159.00
IUUC-Gac-041338 Gasterosteus aculeatus 92.65 0.00e+00 1133.00
IUUC-Ggo-045278 Gorilla gorilla 74.43 0.00e+00 1303.00
IUUC-Hsa-046148 Homo sapiens 74.71 0.00e+00 1303.00
IUUC-Itr-047945 Ictidomys tridecemlineatus 91.42 0.00e+00 1050.00
IUUC-Lch-050663 Latimeria chalumnae 75.83 0.00e+00 1353.00
IUUC-Loc-052604 Lepisosteus oculatus 79.13 0.00e+00 1389.00
IUUC-Laf-053944 Loxodonta africana 91.18 0.00e+00 1142.00
IUUC-Mcc-055655 Macaca mulatta 74.25 0.00e+00 1302.00
IUUC-Meu-055953 Macropus eugenii 79.34 0.00e+00 971.00
IUUC-Mga-060190 Meleagris gallopavo 91.81 0.00e+00 1159.00
IUUC-Mmr-060896 Microcebus murinus 74.07 0.00e+00 1300.00
IUUC-Mdo-062536 Monodelphis domestica 74.05 0.00e+00 1309.00
IUUC-Mmu-064017 Mus musculus 91.53 0.00e+00 1130.00
IUUC-Mpu-066608 Mustela putorius furo 72.33 0.00e+00 1234.00
IUUC-Mlu-067623 Myotis lucifugus 72.94 0.00e+00 1253.00
IUUC-Nle-069496 Nomascus leucogenys 72.79 0.00e+00 1258.00
IUUC-Opr-071054 Ochotona princeps 91.53 0.00e+00 1117.00
IUUC-Ont-071279 Oreochromis niloticus 83.18 0.00e+00 1435.00
IUUC-Oan-073512 Ornithorhynchus anatinus 72.37 0.00e+00 1271.00
IUUC-Ocu-074271 Oryctolagus cuniculus 73.52 0.00e+00 1289.00
IUUC-Ola-087237 Oryzias latipes 92.33 0.00e+00 1114.00
IUUC-Oga-088164 Otolemur garnettii 91.71 0.00e+00 1128.00
IUUC-Oar-089698 Ovis aries 91.53 0.00e+00 1125.00
IUUC-Ptr-091306 Pan troglodytes 73.91 0.00e+00 1279.00
IUUC-Pan-092814 Papio anubis 71.44 0.00e+00 1228.00
IUUC-Pfo-096709 Poecilia formosa 79.84 0.00e+00 1389.00
IUUC-Pab-098494 Pongo abelii 91.70 0.00e+00 1125.00
IUUC-Pca-100596 Procavia capensis 82.26 0.00e+00 996.00
IUUC-Pva-103154 Pteropus vampyrus 91.76 0.00e+00 1081.00
IUUC-Rno-104954 Rattus norvegicus 74.74 0.00e+00 1155.00
IUUC-Sha-106781 Sarcophilus harrisii 74.03 0.00e+00 1313.00
IUUC-Ssc-116307 Sus scrofa 86.51 0.00e+00 1067.00
IUUC-Tgu-116530 Taeniopygia guttata 86.95 0.00e+00 1038.00
IUUC-Tru-118287 Takifugu rubripes 93.32 0.00e+00 1110.00
IUUC-Tni-120801 Tetraodon nigroviridis 77.05 0.00e+00 1311.00
IUUC-Tbe-127793 Tupaia belangeri 81.83 0.00e+00 971.00
IUUC-Ttr-128275 Tursiops truncatus 91.36 0.00e+00 1123.00
IUUC-Xtr-132866 Xenopus tropicalis 87.87 0.00e+00 1102.00
Created Date 25-Jun-2017

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