iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Uma-129332

Ensembl Protein ID

KIS72250

UniProt Accession

A0A0D1EDG8; A0A0D1EDG8_USTMA

Genbank Protein ID

KIS72250.1

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

CM003140

Gene Name

UMAG_00663

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
UMAG_00663	KIS72250	KIS72250

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.60e-124	414.1	517	848

Active Site

Position(s)	Description	Evidence
817	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklllg 102
           ++dlkkrl+++f gE+gld+gG++ref++lls+e++np ++lf+ys+ d++tlq+np+sg+ npehl++F+f+Gr+lg+a++++r+ld+ +  sfyk++l+
   Q: 517  PNDLKKRLMIKFDGEDGLDYGGLSREFFFLLSHEMFNPFYCLFEYSAHDNYTLQINPHSGI-NPEHLNYFKFIGRVLGLAIFHRRFLDAYFIVSFYKMILK 616
           689*********************************************************9.89************************************* PP
   S: 103  kklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfnevipl 203
           kk++l+dle+vd+++++sl+++++n   +ie + ++ tf++ e+++ge+ ++eLk gGe+++Vt eNk+eYv+l++e+r+ ++++eq++af +Gf+e+ip+
   Q: 617  KKITLSDLESVDADYHRSLQWMLDN---SIEGI-VEETFTAVEDKFGEMVTVELKKGGEEVEVTDENKKEYVDLMTEWRISKRVEEQFKAFISGFTELIPQ 713
           ***********************99...89998.999**************************************************************** PP
   S: 204  ellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPs 300
           +l+++F+e+elelli G++eidv+d+kk+t y+g +te+++++qwFw++++++  e+++++LqF+Tg+sr+P++Gf++l+    pr+f+i+k+++ ++lP+
   Q: 714  DLINVFDERELELLIGGMSEIDVDDWKKFTDYRG-FTEQDQVVQWFWQCVRAWPTEKKSRLLQFATGTSRIPVNGFKDLQgsdgPRRFTIEKSGDVNQLPK 813
           ********************************76.****************************************************************** PP
   S: 301  snTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           s+TCfn+++LP+Y+s e+l++kL +Aiee+ gF+ 
   Q: 814  SHTCFNRIDLPPYPSFETLESKLALAIEEGMGFGN 848
           *********************************85 PP

Organism

Ustilago maydis

Protein Sequence
(Fasta)

MVNPRAPGSL SRKIRITVVA ADGLAKRDVF RLPDPFAIVT VDGEQTHSTS VIKKTLNPYW 60
NDSFDVNVTD SSVIAVQIFD QKKFKKRDQG FLGVINIRVA DVLDLELGGK RLLNKELKKS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTGAATC CTCGAGCTCC CGGCAGTCTC TCGAGAAAGA TCCGCATCAC TGTGGTCGCC 60
GCTGATGGCC TGGCCAAGCG TGATGTCTTT CGCCTTCCCG ATCCTTTTGC CATTGTCACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005934--C:cellular bud tip
GO:0010008--C:endosome membrane
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005794--C:Golgi apparatus
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0035091--F:phosphatidylinositol binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0034644--P:cellular response to UV
GO:0006333--P:chromatin assembly or disassembly
GO:0032511--P:late endosome to vacuole transport via multivesicular body sorting pathway
GO:0007005--P:mitochondrion organization
GO:0016973--P:poly(A)+ mRNA export from nucleus
GO:0045723--P:positive regulation of fatty acid biosynthetic process
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0048260--P:positive regulation of receptor-mediated endocytosis
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032956--P:regulation of actin cytoskeleton organization
GO:0010794--P:regulation of dolichol biosynthetic process
GO:0032443--P:regulation of ergosterol biosynthetic process
GO:0031384--P:regulation of initiation of mating projection growth
GO:0010793--P:regulation of mRNA export from nucleus
GO:0010796--P:regulation of multivesicular body size
GO:0006808--P:regulation of nitrogen utilization
GO:0019220--P:regulation of phosphate metabolic process
GO:2000203--P:regulation of ribosomal large subunit export from nucleus
GO:2000232--P:regulation of rRNA processing
GO:2000238--P:regulation of tRNA export from nucleus
GO:2000235--P:regulation of tRNA processing
GO:0010795--P:regulation of ubiquinone biosynthetic process
GO:0042493--P:response to drug
GO:0034517--P:ribophagy
GO:0070086--P:ubiquitin-dependent endocytosis
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

KEGG

uma:UMAG_00663

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001201	Ailuropoda melanoleuca	47.46	5.00e-159	553.00
IUUC-Apl-003886	Anas platyrhynchos	46.28	2.00e-156	544.00
IUUC-Aca-005388	Anolis carolinensis	46.68	2.00e-149	521.00
IUUC-Ago-007742	Ashbya gossypii	67.05	0.00e+00	863.00
IUUC-Acl-008273	Aspergillus clavatus	71.96	0.00e+00	893.00
IUUC-Afl-008713	Aspergillus flavus	63.26	0.00e+00	1019.00
IUUC-Afu-009103	Aspergillus fumigatus	62.05	0.00e+00	1003.00
IUUC-Ani-009259	Aspergillus nidulans	63.41	0.00e+00	1040.00
IUUC-Ang-009738	Aspergillus niger	64.14	0.00e+00	1048.00
IUUC-Aor-010053	Aspergillus oryzae	73.58	2.00e-138	482.00
IUUC-Ate-010529	Aspergillus terreus	64.53	0.00e+00	1034.00
IUUC-Ame-011138	Astyanax mexicanus	52.06	8.00e-142	496.00
IUUC-Bgr-012148	Blumeria graminis	62.94	0.00e+00	1008.00
IUUC-Bta-012857	Bos taurus	36.85	1.00e-157	548.00
IUUC-Bci-013785	Botrytis cinerea	63.50	0.00e+00	1021.00
IUUC-Cel-018299	Caenorhabditis elegans	45.50	2.00e-151	528.00
IUUC-Cja-019448	Callithrix jacchus	43.29	7.00e-150	523.00
IUUC-Cfa-020728	Canis familiaris	37.14	4.00e-161	560.00
IUUC-Cpo-021988	Cavia porcellus	46.70	2.00e-155	541.00
IUUC-Csa-023805	Chlorocebus sabaeus	41.62	6.00e-149	519.00
IUUC-Cho-024695	Choloepus hoffmanni	43.68	6.00e-158	549.00
IUUC-Cin-025212	Ciona intestinalis	45.90	1.00e-152	532.00
IUUC-Csv-026256	Ciona savignyi	45.85	6.00e-152	529.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	61.38	0.00e+00	1013.00
IUUC-Cne-026849	Cryptococcus neoformans	65.56	0.00e+00	1116.00
IUUC-Dre-028245	Danio rerio	39.78	4.00e-157	546.00
IUUC-Dno-029618	Dasypus novemcinctus	46.60	4.00e-150	523.00
IUUC-Dor-030176	Dipodomys ordii	46.60	2.00e-153	535.00
IUUC-Dse-031241	Dothistroma septosporum	63.05	0.00e+00	1065.00
IUUC-Dme-032166	Drosophila melanogaster	49.04	2.00e-144	505.00
IUUC-Ete-032779	Echinops telfairi	44.73	2.00e-138	484.00
IUUC-Eca-033949	Equus caballus	46.60	1.00e-155	541.00
IUUC-Eeu-035247	Erinaceus europaeus	46.41	5.00e-151	526.00
IUUC-Fca-035420	Felis catus	37.24	6.00e-163	566.00
IUUC-Fal-036948	Ficedula albicollis	46.45	1.00e-153	535.00
IUUC-Fox-037774	Fusarium oxysporum	61.23	0.00e+00	993.00
IUUC-Fso-038393	Fusarium solani	61.14	0.00e+00	983.00
IUUC-Gmo-039679	Gadus morhua	46.79	3.00e-151	527.00
IUUC-Ggr-040107	Gaeumannomyces graminis	62.04	0.00e+00	1011.00
IUUC-Gga-040617	Gallus gallus	45.97	2.00e-154	538.00
IUUC-Gac-042607	Gasterosteus aculeatus	46.13	2.00e-148	518.00
IUUC-Ggo-045001	Gorilla gorilla	41.05	2.00e-150	524.00
IUUC-Hsa-046544	Homo sapiens	41.05	2.00e-150	525.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	41.38	5.00e-150	523.00
IUUC-Kpa-049273	Komagataella pastoris	58.05	0.00e+00	951.00
IUUC-Lch-050663	Latimeria chalumnae	43.71	1.00e-154	538.00
IUUC-Loc-052645	Lepisosteus oculatus	47.20	6.00e-153	533.00
IUUC-Lma-052980	Leptosphaeria maculans	60.00	1.00e-172	597.00
IUUC-Laf-053551	Loxodonta africana	46.09	1.00e-148	518.00
IUUC-Mcc-055655	Macaca mulatta	46.60	1.00e-154	538.00
IUUC-Meu-056436	Macropus eugenii	45.32	3.00e-118	417.00
IUUC-Mor-057097	Magnaporthe oryzae	62.15	0.00e+00	1040.00
IUUC-Mpo-057442	Magnaporthe poae	59.07	0.00e+00	916.00
IUUC-Mla-058996	Melampsora laricipopulina	66.36	0.00e+00	1123.00
IUUC-Mga-059362	Meleagris gallopavo	47.12	3.00e-156	544.00
IUUC-Mvi-060395	Microbotryum violaceum	67.06	0.00e+00	1073.00
IUUC-Mmr-060896	Microcebus murinus	46.77	9.00e-156	542.00
IUUC-Mdo-062536	Monodelphis domestica	46.18	1.00e-152	532.00
IUUC-Mmu-063202	Mus musculus	43.94	3.00e-150	524.00
IUUC-Mpu-066567	Mustela putorius furo	47.52	2.00e-157	548.00
IUUC-Mlu-068148	Myotis lucifugus	47.63	5.00e-159	553.00
IUUC-Nfi-068427	Neosartorya fischeri	72.47	0.00e+00	898.00
IUUC-Ncr-068918	Neurospora crassa	70.80	0.00e+00	866.00
IUUC-Nle-069188	Nomascus leucogenys	41.18	3.00e-150	524.00
IUUC-Opr-071044	Ochotona princeps	46.74	5.00e-151	526.00
IUUC-Ont-071798	Oreochromis niloticus	47.81	6.00e-158	549.00
IUUC-Oan-073019	Ornithorhynchus anatinus	47.18	3.00e-151	527.00
IUUC-Ocu-074271	Oryctolagus cuniculus	46.94	1.00e-154	538.00
IUUC-Ola-087467	Oryzias latipes	45.65	1.00e-152	531.00
IUUC-Oga-088164	Otolemur garnettii	46.87	5.00e-156	543.00
IUUC-Oar-089317	Ovis aries	46.52	3.00e-148	517.00
IUUC-Ptr-090484	Pan troglodytes	41.05	2.00e-150	525.00
IUUC-Pan-092117	Papio anubis	41.32	1.00e-150	525.00
IUUC-Psi-093618	Pelodiscus sinensis	46.27	7.00e-154	536.00
IUUC-Pma-094364	Petromyzon marinus	51.65	2.00e-140	490.00
IUUC-Pno-095118	Phaeosphaeria nodorum	63.26	0.00e+00	1048.00
IUUC-Pfo-096768	Poecilia formosa	51.34	2.00e-142	498.00
IUUC-Pab-098494	Pongo abelii	46.60	2.00e-155	541.00
IUUC-Pca-100596	Procavia capensis	45.16	6.00e-148	516.00
IUUC-Pva-102811	Pteropus vampyrus	46.09	5.00e-147	513.00
IUUC-Pgr-103620	Puccinia graminis	73.26	0.00e+00	939.00
IUUC-Ptt-103806	Puccinia triticina	72.36	0.00e+00	801.00
IUUC-Pte-104016	Pyrenophora teres	73.60	0.00e+00	903.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	73.60	0.00e+00	903.00
IUUC-Rno-106125	Rattus norvegicus	46.77	5.00e-149	520.00
IUUC-Sce-106289	Saccharomyces cerevisiae	68.64	0.00e+00	871.00
IUUC-Sha-106781	Sarcophilus harrisii	37.56	1.00e-155	542.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	56.84	0.00e+00	915.00
IUUC-Spo-108171	Schizosaccharomyces pombe	62.14	0.00e+00	1011.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	71.19	0.00e+00	899.00
IUUC-Sar-113761	Sorex araneus	46.52	2.00e-155	541.00
IUUC-Sre-114929	Sporisorium reilianum	94.01	0.00e+00	1456.00
IUUC-Ssc-115368	Sus scrofa	46.27	9.00e-148	516.00
IUUC-Tgu-117474	Taeniopygia guttata	45.02	3.00e-153	533.00
IUUC-Tru-118610	Takifugu rubripes	52.48	2.00e-148	518.00
IUUC-Tsy-119492	Tarsius syrichta	45.72	6.00e-150	523.00
IUUC-Tni-119993	Tetraodon nigroviridis	45.76	1.00e-147	515.00
IUUC-Tre-122203	Trichoderma reesei	62.87	0.00e+00	1011.00
IUUC-Tvi-122595	Trichoderma virens	62.85	0.00e+00	1021.00
IUUC-Tme-126897	Tuber melanosporum	70.08	0.00e+00	844.00
IUUC-Tbe-127793	Tupaia belangeri	48.45	1.00e-136	479.00
IUUC-Ttr-128275	Tursiops truncatus	46.94	6.00e-155	539.00
IUUC-Vda-129753	Verticillium dahliae	60.66	0.00e+00	981.00
IUUC-Vpa-130503	Vicugna pacos	51.97	1.00e-140	492.00
IUUC-Xtr-132859	Xenopus tropicalis	45.69	4.00e-152	530.00
IUUC-Xma-133797	Xiphophorus maculatus	51.45	4.00e-144	503.00
IUUC-Yli-134668	Yarrowia lipolytica	69.27	0.00e+00	889.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence