iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fca-036337

Ensembl Protein ID

ENSFCAP00000010040.3

UniProt Accession

M3WDZ1; M3WDZ1_FELCA

Genbank Protein ID

ENSFCAP00000010040

Protein Name

Apoptotic protease-activating factor 1

Genbank Nucleotide ID

AANG02144894

Gene Name

APAF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000010807.3	ENSFCAT00000010810.3	ENSFCAP00000010040.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.10e-63	206.9	742	775
UBD/Beta-Prp	7.30e-115	383.2	670	916

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrt 32
           gHt+sv+ ++f +d +ll+s+s Dgt+k+WD+++
   Q: 742  GHTNSVNHCRFsPDdKLLASCSADGTLKLWDVKS 775
           8***********777****************987 PP

UBD/Beta-Prp

   S: 22   ksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk..ilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdk 108
           ++++at s d+++k+w+  tg l++ + +h+++v+++ f +++   +l+t+s+D ++k+wdl + +c  t+ gh++sv  ++fsp+++ 
   Q: 670  DRFIATCSVDKKVKIWNSMTGELVHIYDEHSEQVNCCHFTNNSHhlLLATASSDCFLKLWDLTQKECRNTMFGHTNSVNHCRFSPDDKL 758
           7899**************************************9999******************************************* PP
   S: 109  lvsGshdrtirvwdletgqclee............tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvys 185
           l+s s+d t+++wd+++  + e+            +++  + +v c +++ dg  ++ +++ +++ l+d+    ll +   gh++ ++ 
   Q: 759  LASCSADGTLKLWDVKSANERESinvkqfflnseePQEDMEVIVKCCSWSADGASIMVAAK-NKIFLFDIHASGLLAEIHTGHHSTIQY 846
           *******************99999**********99999999***********55555544.6899****888888888667******* PP
   S: 186  lsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgd 255
            +f+++ +  v +     v+lw++ +   v  ++gh ++v +v fsp++  +++ s+D++ir+W +++  
   Q: 847  CDFSPQNRLAVVALSQCCVELWNMDSCLKVADCRGHLSWVHCVMFSPDGSSFLTSSDDQTIRLWETKKVC 916
           *****9988888889999**********************************************866544 PP

Organism

Felis catus

Functional Description
(View)

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

Protein Sequence
(Fasta)

MDAKARNCLL QHREALEKDI KTSYIMDRMI NDGVLTVSEE EKVKNEPTQQ QRAALLIKMI 60
LKKDNYSYIS FYNALIHEGY KDLAGLLHGG IPVISSSNGG KDSVGGITSY VRTVLCEGGV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAATAACATT CAGTTTATTG TAACAAATCT TTTAACTTCA ACTCAGTCAC CAGTAGAGTA 60
TAATTCAAAA TTTAATACCA TCAAAAATGG TCTAAAGGAC ATCCAGGGTC CCTTCTAGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR017251--Apaf-1
IPR024977--Apc4_WD40_dom
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00619--CARD
PF00931--NB-ARC
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0043293--C:apoptosome
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008635--P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0030900--P:forebrain development
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0001843--P:neural tube closure
GO:0051402--P:neuron apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:1902510--P:regulation of apoptotic DNA fragmentation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001432	Ailuropoda melanoleuca	95.85	0.00e+00	2448.00
IUUC-Apl-004201	Anas platyrhynchos	70.45	0.00e+00	1823.00
IUUC-Aca-004638	Anolis carolinensis	68.90	0.00e+00	1816.00
IUUC-Ani-009285	Aspergillus nidulans	25.58	4.00e-68	253.00
IUUC-Ame-011062	Astyanax mexicanus	54.24	0.00e+00	1361.00
IUUC-Bta-012865	Bos taurus	92.00	0.00e+00	2385.00
IUUC-Cja-018815	Callithrix jacchus	80.94	0.00e+00	2041.00
IUUC-Cfa-020222	Canis familiaris	90.73	0.00e+00	2299.00
IUUC-Cpo-021524	Cavia porcellus	88.40	0.00e+00	2269.00
IUUC-Csa-023861	Chlorocebus sabaeus	91.36	0.00e+00	2322.00
IUUC-Cho-024484	Choloepus hoffmanni	80.90	0.00e+00	1214.00
IUUC-Dre-028006	Danio rerio	53.15	0.00e+00	1256.00
IUUC-Dno-029591	Dasypus novemcinctus	91.68	0.00e+00	2379.00
IUUC-Dor-030237	Dipodomys ordii	76.80	0.00e+00	1082.00
IUUC-Ete-032620	Echinops telfairi	85.32	0.00e+00	1097.00
IUUC-Eca-033569	Equus caballus	91.84	0.00e+00	2358.00
IUUC-Eeu-035354	Erinaceus europaeus	68.40	0.00e+00	637.00
IUUC-Fal-037077	Ficedula albicollis	70.16	0.00e+00	1820.00
IUUC-Gmo-039687	Gadus morhua	50.39	0.00e+00	915.00
IUUC-Ggr-039828	Gaeumannomyces graminis	24.32	9.00e-40	159.00
IUUC-Gga-040299	Gallus gallus	69.41	0.00e+00	1833.00
IUUC-Gac-041762	Gasterosteus aculeatus	51.61	0.00e+00	1268.00
IUUC-Ggo-045563	Gorilla gorilla	91.60	0.00e+00	2333.00
IUUC-Hsa-046771	Homo sapiens	91.20	0.00e+00	2325.00
IUUC-Lch-050200	Latimeria chalumnae	64.95	0.00e+00	1633.00
IUUC-Loc-052090	Lepisosteus oculatus	58.72	0.00e+00	1501.00
IUUC-Laf-053861	Loxodonta africana	90.57	0.00e+00	2334.00
IUUC-Mcc-055543	Macaca mulatta	91.92	0.00e+00	2336.00
IUUC-Meu-056688	Macropus eugenii	80.61	0.00e+00	2054.00
IUUC-Mga-059243	Meleagris gallopavo	69.86	0.00e+00	1850.00
IUUC-Mmr-061134	Microcebus murinus	86.38	0.00e+00	2008.00
IUUC-Mdo-062913	Monodelphis domestica	79.33	0.00e+00	2061.00
IUUC-Mmu-063811	Mus musculus	87.36	0.00e+00	2283.00
IUUC-Mpu-066780	Mustela putorius furo	95.76	0.00e+00	2416.00
IUUC-Mlu-067276	Myotis lucifugus	91.45	0.00e+00	2365.00
IUUC-Nle-069129	Nomascus leucogenys	91.12	0.00e+00	2326.00
IUUC-Opr-071007	Ochotona princeps	66.74	0.00e+00	1102.00
IUUC-Ont-071348	Oreochromis niloticus	54.73	0.00e+00	1389.00
IUUC-Oan-072717	Ornithorhynchus anatinus	81.17	0.00e+00	2121.00
IUUC-Ocu-074286	Oryctolagus cuniculus	91.26	0.00e+00	1980.00
IUUC-Ola-086895	Oryzias latipes	49.55	0.00e+00	1174.00
IUUC-Oga-088678	Otolemur garnettii	90.72	0.00e+00	2322.00
IUUC-Oar-089359	Ovis aries	91.12	0.00e+00	2350.00
IUUC-Ptr-091062	Pan troglodytes	91.20	0.00e+00	2326.00
IUUC-Pan-092528	Papio anubis	92.72	0.00e+00	1376.00
IUUC-Psi-093430	Pelodiscus sinensis	74.66	0.00e+00	1943.00
IUUC-Pma-094690	Petromyzon marinus	38.17	3.00e-146	512.00
IUUC-Pfo-097204	Poecilia formosa	54.13	0.00e+00	1361.00
IUUC-Pab-097690	Pongo abelii	91.52	0.00e+00	2332.00
IUUC-Pca-100778	Procavia capensis	71.78	0.00e+00	1178.00
IUUC-Pva-102870	Pteropus vampyrus	89.55	0.00e+00	2125.00
IUUC-Rno-104889	Rattus norvegicus	87.28	0.00e+00	2251.00
IUUC-Sha-107465	Sarcophilus harrisii	79.46	0.00e+00	2099.00
IUUC-Sar-113268	Sorex araneus	90.31	0.00e+00	666.00
IUUC-Ssc-115654	Sus scrofa	91.60	0.00e+00	2376.00
IUUC-Tgu-117302	Taeniopygia guttata	70.40	0.00e+00	1831.00
IUUC-Tru-118363	Takifugu rubripes	53.77	0.00e+00	1359.00
IUUC-Tsy-119007	Tarsius syrichta	86.80	0.00e+00	2214.00
IUUC-Tni-120910	Tetraodon nigroviridis	52.71	0.00e+00	1318.00
IUUC-Tur-126636	Triticum urartu	22.22	9.00e-23	102.00
IUUC-Tbe-127413	Tupaia belangeri	78.00	0.00e+00	1407.00
IUUC-Ttr-129213	Tursiops truncatus	85.28	0.00e+00	2155.00
IUUC-Vpa-130146	Vicugna pacos	86.99	0.00e+00	1649.00
IUUC-Xtr-132559	Xenopus tropicalis	60.97	0.00e+00	1552.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence