iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066780

Ensembl Protein ID

ENSMPUP00000011357.1

UniProt Accession

M3YJ50; M3YJ50_MUSPF

Genbank Protein ID

ENSMPUP00000011357

Protein Name

Apoptotic protease-activating factor 1

Genbank Nucleotide ID

AEYP01012181

Gene Name

APAF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000011447.1	ENSMPUT00000011545.1	ENSMPUP00000011357.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.90e-63	207.5	742	777
UBD/Beta-Prp	4.20e-118	393.9	666	942

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gHt+sv+ ++f +d +ll+s+s Dgt+k+WD+++ +
   Q: 742  GHTNSVNHCRFsPDdKLLASCSADGTLKLWDVKSAN 777
           8***********777****************98765 PP

UBD/Beta-Prp

   S: 18   fspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk..ilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfsp 104
           fs d++++at s d+++k+w+  tg l+r + +h+++v+++ f ++++  +l+t+s+D ++k+wdl++ +c  t+ gh++sv  ++fsp
   Q: 666  FSTDDRFIATCSVDKKVKIWNSMTGELVRIYDEHSEQVNCCHFANNSQylLLATASSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSP 754
           899*********************************************9999************************************* PP
   S: 105  sgdklvsGshdrtirvwdletgqclee............tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtd 181
           +++ l+s s+d t+++wd+++  + ++            +++  + +v c +++ dg  ++ +++ +++ l+d+ t+ ll +   gh++
   Q: 755  DDKLLASCSADGTLKLWDVKSANERKSidvkqfflnseePQEDMEVIVKCCSWSADGARIMVAAK-NKIFLFDIHTNGLLAEIHTGHHS 842
           **********************999999**********99999999***********66665554.6799*************888*** PP
   S: 182  svyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisv 270
            ++  +f+++    v +     v+lw++ +   v  ++gh ++v +v fsp++  +++ s+D++ir+W +++   ++++ l  ++ i v
   Q: 843  TIQYCDFSPQNHLAVVALSQCCVELWNMDSCLKVADCRGHLSWVHCVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAIVL--KQEIDV 929
           *********8766666667779**********************************************7665555555555..456666 PP
   S: 271  avlsfgdnvlvlgse 285
            +   ++ v+vl+++
   Q: 930  VF--QENEVMVLAAD 942
           66..55666666654 PP

Organism

Mustela putorius furo

Functional Description
(View)

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

Protein Sequence
(Fasta)

MDAKARNCLL QHREALEKDI KTSYIMDRMI NDGVLTVSEE EKVKNEPTQQ QRAALLIKMI 60
LKKDNYSYIS FYNALIHEGY KDLAALLQSG IPVISSSSGG KDSVGGITSY VKTVLCEGGV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAGGCTCCAG GCACAGTGTG GGGTTTGACC TTACACCCTG AGATCAAGAG TCACATGCCG 60
AACTGACTGA GCCACCGAGG GACCCCTGTG GATATTTTTG CATACATATG TGAATGTCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR017251--Apaf-1
IPR001315--CARD
IPR003143--Cyt_cd1_C
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00619--CARD
PF00931--NB-ARC
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0043293--C:apoptosome
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008635--P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0030900--P:forebrain development
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0001843--P:neural tube closure
GO:0051402--P:neuron apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:1902510--P:regulation of apoptotic DNA fragmentation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001432	Ailuropoda melanoleuca	97.68	0.00e+00	2483.00
IUUC-Apl-004201	Anas platyrhynchos	71.09	0.00e+00	1831.00
IUUC-Aca-004638	Anolis carolinensis	69.54	0.00e+00	1819.00
IUUC-Ani-009285	Aspergillus nidulans	25.94	4.00e-70	260.00
IUUC-Ame-011062	Astyanax mexicanus	54.32	0.00e+00	1364.00
IUUC-Bta-012865	Bos taurus	91.44	0.00e+00	2376.00
IUUC-Cja-018815	Callithrix jacchus	81.10	0.00e+00	2048.00
IUUC-Cfa-020222	Canis familiaris	92.16	0.00e+00	2325.00
IUUC-Cpo-021524	Cavia porcellus	88.56	0.00e+00	2269.00
IUUC-Csa-023861	Chlorocebus sabaeus	91.36	0.00e+00	2324.00
IUUC-Cho-024484	Choloepus hoffmanni	81.30	0.00e+00	1221.00
IUUC-Dre-028006	Danio rerio	53.08	0.00e+00	1255.00
IUUC-Dno-029591	Dasypus novemcinctus	91.60	0.00e+00	2383.00
IUUC-Dor-030237	Dipodomys ordii	76.80	0.00e+00	1085.00
IUUC-Ete-032620	Echinops telfairi	84.52	0.00e+00	1090.00
IUUC-Eca-033569	Equus caballus	92.00	0.00e+00	2363.00
IUUC-Eeu-035354	Erinaceus europaeus	67.36	0.00e+00	630.00
IUUC-Fca-036337	Felis catus	95.76	0.00e+00	2482.00
IUUC-Fal-037077	Ficedula albicollis	70.96	0.00e+00	1828.00
IUUC-Gmo-039687	Gadus morhua	50.88	0.00e+00	929.00
IUUC-Ggr-039828	Gaeumannomyces graminis	23.01	3.00e-40	161.00
IUUC-Gga-040299	Gallus gallus	69.65	0.00e+00	1834.00
IUUC-Gac-041762	Gasterosteus aculeatus	52.00	0.00e+00	1280.00
IUUC-Ggo-045563	Gorilla gorilla	91.60	0.00e+00	2334.00
IUUC-Hsa-046771	Homo sapiens	91.20	0.00e+00	2328.00
IUUC-Lch-050200	Latimeria chalumnae	65.84	0.00e+00	1650.00
IUUC-Loc-052090	Lepisosteus oculatus	59.19	0.00e+00	1509.00
IUUC-Laf-053861	Loxodonta africana	90.41	0.00e+00	2330.00
IUUC-Mcc-055543	Macaca mulatta	91.92	0.00e+00	2338.00
IUUC-Meu-056688	Macropus eugenii	81.01	0.00e+00	2062.00
IUUC-Mga-059243	Meleagris gallopavo	70.33	0.00e+00	1855.00
IUUC-Mmr-061134	Microcebus murinus	85.68	0.00e+00	1993.00
IUUC-Mdo-062913	Monodelphis domestica	79.65	0.00e+00	2063.00
IUUC-Mmu-063811	Mus musculus	87.52	0.00e+00	2288.00
IUUC-Mlu-067276	Myotis lucifugus	90.89	0.00e+00	2357.00
IUUC-Nfi-068459	Neosartorya fischeri	27.88	2.00e-58	221.00
IUUC-Nle-069129	Nomascus leucogenys	91.28	0.00e+00	2331.00
IUUC-Opr-071007	Ochotona princeps	66.86	0.00e+00	1113.00
IUUC-Ont-071348	Oreochromis niloticus	54.96	0.00e+00	1397.00
IUUC-Oan-072717	Ornithorhynchus anatinus	81.09	0.00e+00	2118.00
IUUC-Ocu-074286	Oryctolagus cuniculus	91.26	0.00e+00	1992.00
IUUC-Ola-086895	Oryzias latipes	49.79	0.00e+00	1186.00
IUUC-Oga-088678	Otolemur garnettii	90.64	0.00e+00	2325.00
IUUC-Oar-089359	Ovis aries	90.72	0.00e+00	2343.00
IUUC-Ptr-091062	Pan troglodytes	91.20	0.00e+00	2327.00
IUUC-Pan-092528	Papio anubis	91.90	0.00e+00	1363.00
IUUC-Psi-093430	Pelodiscus sinensis	74.90	0.00e+00	1947.00
IUUC-Pma-094690	Petromyzon marinus	38.95	4.00e-150	525.00
IUUC-Pfo-097204	Poecilia formosa	54.99	0.00e+00	1381.00
IUUC-Pab-097690	Pongo abelii	91.68	0.00e+00	2335.00
IUUC-Pca-100778	Procavia capensis	70.61	0.00e+00	1164.00
IUUC-Pva-102870	Pteropus vampyrus	89.46	0.00e+00	2127.00
IUUC-Rno-104889	Rattus norvegicus	87.12	0.00e+00	2249.00
IUUC-Sha-107465	Sarcophilus harrisii	79.62	0.00e+00	2102.00
IUUC-Sar-113268	Sorex araneus	89.46	0.00e+00	663.00
IUUC-Ssc-115654	Sus scrofa	90.80	0.00e+00	2360.00
IUUC-Tgu-117302	Taeniopygia guttata	71.20	0.00e+00	1845.00
IUUC-Tru-118363	Takifugu rubripes	53.93	0.00e+00	1370.00
IUUC-Tsy-119007	Tarsius syrichta	86.88	0.00e+00	2222.00
IUUC-Tni-120910	Tetraodon nigroviridis	52.71	0.00e+00	1324.00
IUUC-Tbe-127413	Tupaia belangeri	77.67	0.00e+00	1407.00
IUUC-Ttr-129213	Tursiops truncatus	84.96	0.00e+00	2152.00
IUUC-Vpa-130146	Vicugna pacos	86.88	0.00e+00	1651.00
IUUC-Xtr-132559	Xenopus tropicalis	61.61	0.00e+00	1564.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence