iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-065748

Ensembl Protein ID

ENSMPUP00000011691.1

UniProt Accession

M3YK34; M3YK34_MUSPF

Genbank Protein ID

ENSMPUP00000011691

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01040361

Gene Name

TRAF6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000011785.1	ENSMPUT00000011883.1	ENSMPUP00000011691.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	4.50e-07	29.9	66	127

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrli 65
           + + CpI l   r+ v +p+G+ + +++I k +++ g++cPv+++ l e++l P ++ +r i
   Q: 66   SKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREI 127
           5689*****************************999999*****************999977 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MSLLHCENSC GSSHSESDCC AAMTSSCSAA AKDDSVSGTA STGNLSSSFM EEVQGYDVEF 60
DPPLESKYEC PICLMALREA VQTPCGHRFC KACIIKSIRD AGHKCPVDNE ILLENQLFPD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGATTTAAG AATTCCCGAA GGTCAAGTGA TCTAACCCAG CTGGGGTTTT TTCCTGCTTG 60
GATAGGGAAG CTATAGAAAC GCTCCACCCA CCCGCCCACA CAGCCACCCA CACCCACACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027139--TRAF6
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:0005811--C:lipid particle
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0019886--P:antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045453--P:bone resorption
GO:0048468--P:cell development
GO:0071222--P:cellular response to lipopolysaccharide
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0070498--P:interleukin-1-mediated signaling pathway
GO:0043011--P:myeloid dendritic cell differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001843--P:neural tube closure
GO:0042475--P:odontogenesis of dentin-containing tooth
GO:0001503--P:ossification
GO:0030316--P:osteoclast differentiation
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045084--P:positive regulation of interleukin-12 biosynthetic process
GO:0032743--P:positive regulation of interleukin-2 production
GO:0045410--P:positive regulation of interleukin-6 biosynthetic process
GO:0043507--P:positive regulation of JUN kinase activity
GO:0031666--P:positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045672--P:positive regulation of osteoclast differentiation
GO:0002726--P:positive regulation of T cell cytokine production
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000679--P:positive regulation of transcription regulatory region DNA binding
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0051023--P:regulation of immunoglobulin secretion
GO:0050852--P:T cell receptor signaling pathway
GO:0042088--P:T-helper 1 type immune response

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001262	Ailuropoda melanoleuca	97.22	0.00e+00	1007.00
IUUC-Apl-004062	Anas platyrhynchos	75.27	0.00e+00	848.00
IUUC-Aca-004636	Anolis carolinensis	71.27	0.00e+00	783.00
IUUC-Ame-011682	Astyanax mexicanus	53.50	1.00e-165	576.00
IUUC-Bta-012692	Bos taurus	92.07	0.00e+00	999.00
IUUC-Cja-019426	Callithrix jacchus	89.83	0.00e+00	965.00
IUUC-Cfa-020948	Canis familiaris	95.71	0.00e+00	900.00
IUUC-Cpo-021378	Cavia porcellus	91.16	0.00e+00	973.00
IUUC-Csa-024045	Chlorocebus sabaeus	89.46	0.00e+00	971.00
IUUC-Cho-024973	Choloepus hoffmanni	75.40	9.00e-107	380.00
IUUC-Csv-026300	Ciona savignyi	41.15	6.00e-46	177.00
IUUC-Dre-027557	Danio rerio	57.09	5.00e-176	610.00
IUUC-Dno-030032	Dasypus novemcinctus	88.96	5.00e-149	520.00
IUUC-Dor-030790	Dipodomys ordii	89.09	0.00e+00	963.00
IUUC-Dse-031478	Dothistroma septosporum	23.18	8.00e-10	58.90
IUUC-Dme-031921	Drosophila melanogaster	26.74	1.00e-39	157.00
IUUC-Ete-032952	Echinops telfairi	84.07	5.00e-169	587.00
IUUC-Eca-033924	Equus caballus	88.77	0.00e+00	897.00
IUUC-Eeu-034734	Erinaceus europaeus	83.03	0.00e+00	869.00
IUUC-Fca-036222	Felis catus	87.08	0.00e+00	875.00
IUUC-Fal-036834	Ficedula albicollis	76.22	0.00e+00	749.00
IUUC-Fox-037935	Fusarium oxysporum	29.77	2.00e-22	100.00
IUUC-Gmo-039061	Gadus morhua	56.36	6.00e-86	311.00
IUUC-Ggr-040084	Gaeumannomyces graminis	27.68	6.00e-13	69.30
IUUC-Gga-040599	Gallus gallus	75.92	0.00e+00	858.00
IUUC-Gac-041977	Gasterosteus aculeatus	55.45	1.00e-166	579.00
IUUC-Ggo-044508	Gorilla gorilla	83.98	0.00e+00	889.00
IUUC-Hsa-046349	Homo sapiens	89.65	0.00e+00	1001.00
IUUC-Itr-047966	Ictidomys tridecemlineatus	89.28	0.00e+00	983.00
IUUC-Lch-049821	Latimeria chalumnae	67.80	0.00e+00	761.00
IUUC-Loc-051995	Lepisosteus oculatus	58.63	0.00e+00	638.00
IUUC-Laf-054115	Loxodonta africana	88.17	0.00e+00	966.00
IUUC-Mcc-055298	Macaca mulatta	89.46	0.00e+00	971.00
IUUC-Mor-057263	Magnaporthe oryzae	30.56	3.00e-18	86.30
IUUC-Mpo-057517	Magnaporthe poae	29.41	6.00e-15	75.50
IUUC-Mga-059340	Meleagris gallopavo	75.92	0.00e+00	834.00
IUUC-Mvi-060553	Microbotryum violaceum	27.23	6.00e-14	72.00
IUUC-Mmr-061063	Microcebus murinus	91.68	0.00e+00	969.00
IUUC-Mdo-062075	Monodelphis domestica	80.29	0.00e+00	907.00
IUUC-Mmu-063780	Mus musculus	85.95	0.00e+00	905.00
IUUC-Mlu-067888	Myotis lucifugus	89.46	0.00e+00	959.00
IUUC-Ncr-068632	Neurospora crassa	28.00	7.00e-16	79.00
IUUC-Nle-069234	Nomascus leucogenys	89.65	0.00e+00	976.00
IUUC-Opr-070393	Ochotona princeps	95.77	9.00e-123	433.00
IUUC-Ont-072459	Oreochromis niloticus	53.53	1.00e-175	609.00
IUUC-Oan-073578	Ornithorhynchus anatinus	82.72	0.00e+00	917.00
IUUC-Ocu-074201	Oryctolagus cuniculus	92.05	0.00e+00	990.00
IUUC-Ola-087319	Oryzias latipes	58.17	2.00e-89	323.00
IUUC-Olu-087748	Ostreococcus lucimarinus	23.74	7.00e-09	54.70
IUUC-Oga-087936	Otolemur garnettii	88.95	0.00e+00	962.00
IUUC-Oar-089379	Ovis aries	91.88	0.00e+00	1007.00
IUUC-Ptr-090758	Pan troglodytes	90.02	0.00e+00	975.00
IUUC-Pan-092590	Papio anubis	89.65	0.00e+00	972.00
IUUC-Psi-093948	Pelodiscus sinensis	71.96	0.00e+00	820.00
IUUC-Pma-094434	Petromyzon marinus	51.08	6.00e-76	278.00
IUUC-Pfo-096912	Poecilia formosa	53.79	5.00e-168	583.00
IUUC-Pab-097651	Pongo abelii	90.02	0.00e+00	978.00
IUUC-Pca-100958	Procavia capensis	85.20	0.00e+00	708.00
IUUC-Pva-103247	Pteropus vampyrus	92.06	6.00e-130	457.00
IUUC-Pte-104279	Pyrenophora teres	26.17	4.00e-13	70.10
IUUC-Rno-104994	Rattus norvegicus	85.03	0.00e+00	920.00
IUUC-Sha-106494	Sarcophilus harrisii	81.18	0.00e+00	920.00
IUUC-Sar-113375	Sorex araneus	87.64	0.00e+00	943.00
IUUC-Sre-115218	Sporisorium reilianum	25.97	3.00e-14	73.90
IUUC-Ssc-115417	Sus scrofa	92.61	0.00e+00	1001.00
IUUC-Tgu-117232	Taeniopygia guttata	75.23	0.00e+00	806.00
IUUC-Tru-118321	Takifugu rubripes	53.96	3.00e-167	581.00
IUUC-Tni-120475	Tetraodon nigroviridis	54.60	2.00e-165	575.00
IUUC-Tbe-127719	Tupaia belangeri	79.37	0.00e+00	835.00
IUUC-Ttr-129264	Tursiops truncatus	91.70	5.00e-128	451.00
IUUC-Uma-129620	Ustilago maydis	25.58	2.00e-16	81.30
IUUC-Vpa-130244	Vicugna pacos	91.30	2.00e-130	459.00
IUUC-Xtr-131948	Xenopus tropicalis	64.70	0.00e+00	743.00
IUUC-Xma-133132	Xiphophorus maculatus	56.81	7.00e-171	593.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence