iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	Phospho.ELM
UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	22537386
UBD/Alpha-Helix/UIM	UIM	22537386

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	8.60e-07	30.0	13	52
UBD/Alpha-Helix/UIM	0.12	13.7	285	301
ULD/UDP/UFD/UBX	2.50e-19	70.7	411	485

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlve.MGFdreealqaLraa.nnnleaAveyLldg 41
           ++ +++q+++ +G   e + +++++a nnnle+Av+++ldg
   Q: 13   LKGLIQQFTAiTG-ASESVGKHMLEAcNNNLEMAVTMFLDG 52
           6789*********.9999*******99************97 PP

UBD/Alpha-Helix/UIM

   S: 1    dEdeeLqlAlalSlqEe 17
           +Ed++L+ A++ SlqE 
   Q: 285  SEDSQLEAAIRASLQET 301
           7**************96 PP

ULD/UDP/UFD/UBX

   S: 4    eqatlqiRlpdGkrlvrkFpssttleqiyqfveyllvessdpFeLvspfPrrtlkpeehmstlqeagLvpsgsllv 79
           ++a+l +R+pdGkr + ++p++++l +++++v+ ++++++++FeL+++fPrr+l++ +++ tlqeagL+p+++++v
   Q: 411  PKAQLMLRYPDGKREQITLPEQAKLLALVKHVQ-SKGYPNERFELLTNFPRRKLSHLDYDITLQEAGLCPQETVFV 485
           59*******************************.****************************************98 PP

Organism

Mus musculus

Functional Description
(View)

Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates (By similarity).

Protein Sequence
(Fasta)

MAAHGGSAAS SALKGLIQQF TAITGASESV GKHMLEACNN NLEMAVTMFL DGGGIAEEPS 60
TSSASVSTVR PHTEEEVRAP IPQKQEILVE PEPLFGAPKR RRPARSIFDG FRDFQTETIR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGTTGTTGT TCCGCGGCGG CGGCGGCGGC GGTAAGATGG CTGCCCACGG GGGCTCCGCG 60
GCGTCGTCGG CGCTGAAGGG GTTAATCCAG CAGTTCACCG CCATCACCGG TAAGAGACGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome

Interpro

IPR012336--Thioredoxin-like_fold
IPR006577--UAS
IPR009060--UBA-like
IPR029071--Ubiquitin-rel_dom
IPR001012--UBX_dom

PROSITE

PS50033--UBX

Pfam

PF00789--UBX

SMART

SM00594--UAS
SM00166--UBX

Gene Ontology

GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0008134--F:transcription factor binding
GO:0043130--F:ubiquitin binding
GO:0031625--F:ubiquitin protein ligase binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000182	Aegilops tauschii	36.75	5.00e-36	145.00
IUUC-Aml-001944	Ailuropoda melanoleuca	98.08	0.00e+00	897.00
IUUC-Atr-002562	Amborella trichopoda	36.84	5.00e-37	148.00
IUUC-Apl-003869	Anas platyrhynchos	88.52	0.00e+00	827.00
IUUC-Aca-004442	Anolis carolinensis	89.10	0.00e+00	813.00
IUUC-Aly-006399	Arabidopsis lyrata	28.81	2.00e-30	127.00
IUUC-Ath-006586	Arabidopsis thaliana	29.66	4.00e-33	135.00
IUUC-Ago-007718	Ashbya gossypii	40.72	3.00e-28	119.00
IUUC-Acl-008032	Aspergillus clavatus	36.76	4.00e-25	109.00
IUUC-Afl-008654	Aspergillus flavus	30.41	1.00e-25	111.00
IUUC-Afu-008821	Aspergillus fumigatus	31.78	9.00e-26	111.00
IUUC-Ani-009458	Aspergillus nidulans	33.80	2.00e-27	117.00
IUUC-Ang-009569	Aspergillus niger	32.41	1.00e-27	117.00
IUUC-Aor-010044	Aspergillus oryzae	30.41	1.00e-25	111.00
IUUC-Ate-010483	Aspergillus terreus	31.05	7.00e-27	115.00
IUUC-Bgr-012199	Blumeria graminis	34.43	7.00e-28	118.00
IUUC-Bta-012363	Bos taurus	97.05	0.00e+00	900.00
IUUC-Bci-013929	Botrytis cinerea	35.59	2.00e-28	120.00
IUUC-Bdi-014936	Brachypodium distachyon	33.58	9.00e-37	147.00
IUUC-Bol-016354	Brassica oleracea	32.18	6.00e-35	142.00
IUUC-Bra-016632	Brassica rapa	32.03	6.00e-35	142.00
IUUC-Cja-019055	Callithrix jacchus	93.38	0.00e+00	837.00
IUUC-Cfa-020168	Canis familiaris	98.74	0.00e+00	920.00
IUUC-Cpo-021430	Cavia porcellus	97.06	0.00e+00	894.00
IUUC-Cre-022974	Chlamydomonas reinhardtii	30.30	5.00e-26	112.00
IUUC-Csa-023976	Chlorocebus sabaeus	97.68	0.00e+00	904.00
IUUC-Cho-025035	Choloepus hoffmanni	90.36	0.00e+00	728.00
IUUC-Cin-025322	Ciona intestinalis	43.25	1.00e-64	240.00
IUUC-Csv-025965	Ciona savignyi	47.67	2.00e-70	259.00
IUUC-Dre-027359	Danio rerio	72.44	0.00e+00	701.00
IUUC-Dno-029627	Dasypus novemcinctus	98.03	0.00e+00	876.00
IUUC-Dor-031133	Dipodomys ordii	85.30	0.00e+00	675.00
IUUC-Dse-031560	Dothistroma septosporum	39.86	3.00e-28	120.00
IUUC-Dme-031981	Drosophila melanogaster	29.53	6.00e-37	148.00
IUUC-Ete-033025	Echinops telfairi	91.60	4.00e-175	607.00
IUUC-Eca-034228	Equus caballus	98.53	0.00e+00	920.00
IUUC-Eeu-034469	Erinaceus europaeus	86.42	0.00e+00	761.00
IUUC-Fca-036404	Felis catus	98.73	0.00e+00	914.00
IUUC-Fal-036686	Ficedula albicollis	84.97	0.00e+00	769.00
IUUC-Fox-037758	Fusarium oxysporum	35.43	2.00e-29	123.00
IUUC-Fso-038081	Fusarium solani	36.57	5.00e-30	125.00
IUUC-Gmo-038652	Gadus morhua	82.85	3.00e-146	512.00
IUUC-Ggr-039845	Gaeumannomyces graminis	28.16	7.00e-28	118.00
IUUC-Gga-040734	Gallus gallus	87.77	7.00e-157	546.00
IUUC-Gac-041490	Gasterosteus aculeatus	65.79	1.00e-179	622.00
IUUC-Gma-043403	Glycine max	34.39	8.00e-37	148.00
IUUC-Ggo-044872	Gorilla gorilla	89.15	0.00e+00	796.00
IUUC-Hsa-046827	Homo sapiens	97.69	0.00e+00	914.00
IUUC-Hvu-047400	Hordeum vulgare	36.71	4.00e-37	148.00
IUUC-Itr-048785	Ictidomys tridecemlineatus	97.51	0.00e+00	842.00
IUUC-Kpa-049161	Komagataella pastoris	31.79	1.00e-35	144.00
IUUC-Lch-049556	Latimeria chalumnae	69.50	0.00e+00	645.00
IUUC-Lpe-051673	Leersia perrieri	38.30	4.00e-34	139.00
IUUC-Loc-051741	Lepisosteus oculatus	85.90	5.00e-152	531.00
IUUC-Lma-053009	Leptosphaeria maculans	34.85	3.00e-31	129.00
IUUC-Laf-054106	Loxodonta africana	94.49	0.00e+00	901.00
IUUC-Mcc-054866	Macaca mulatta	97.49	0.00e+00	912.00
IUUC-Meu-056868	Macropus eugenii	86.76	6.00e-180	623.00
IUUC-Mor-057056	Magnaporthe oryzae	30.81	2.00e-25	110.00
IUUC-Mpo-057332	Magnaporthe poae	30.37	4.00e-26	112.00
IUUC-Mtr-058153	Medicago truncatula	35.83	3.00e-38	152.00
IUUC-Mla-059046	Melampsora laricipopulina	31.82	1.20e-01	30.00
IUUC-Mga-059940	Meleagris gallopavo	89.29	0.00e+00	794.00
IUUC-Mmr-060737	Microcebus murinus	97.90	0.00e+00	916.00
IUUC-Mdo-062970	Monodelphis domestica	94.34	0.00e+00	769.00
IUUC-Mac-065522	Musa acuminata	35.85	1.00e-37	150.00
IUUC-Mpu-065853	Mustela putorius furo	98.31	0.00e+00	910.00
IUUC-Mlu-068056	Myotis lucifugus	97.02	0.00e+00	850.00
IUUC-Nfi-068479	Neosartorya fischeri	33.76	2.00e-25	110.00
IUUC-Ncr-068638	Neurospora crassa	28.41	1.00e-27	118.00
IUUC-Nle-070140	Nomascus leucogenys	91.86	0.00e+00	840.00
IUUC-Opr-071163	Ochotona princeps	85.68	0.00e+00	650.00
IUUC-Ont-071318	Oreochromis niloticus	65.85	2.00e-178	618.00
IUUC-Oan-072847	Ornithorhynchus anatinus	85.31	5.00e-79	286.00
IUUC-Ocu-074018	Oryctolagus cuniculus	98.10	0.00e+00	912.00
IUUC-Oba-074980	Oryza barthii	34.57	1.00e-35	144.00
IUUC-Obr-076741	Oryza brachyantha	38.83	2.00e-34	139.00
IUUC-Ogl-077363	Oryza glaberrima	34.57	9.00e-36	144.00
IUUC-Ogu-078011	Oryza glumaepatula	34.57	1.00e-35	144.00
IUUC-Oin-079454	Oryza indica	34.57	1.00e-35	144.00
IUUC-Olo-080898	Oryza longistaminata	35.86	1.00e-31	130.00
IUUC-Ome-081479	Oryza meridionalis	34.57	1.00e-35	144.00
IUUC-Oni-082128	Oryza nivara	36.36	1.00e-32	134.00
IUUC-Opu-083967	Oryza punctata	38.18	1.00e-19	92.00
IUUC-Oru-084233	Oryza rufipogon	34.57	8.00e-36	144.00
IUUC-Osa-085483	Oryza sativa	34.57	1.00e-35	144.00
IUUC-Ola-087217	Oryzias latipes	69.69	0.00e+00	628.00
IUUC-Oga-088688	Otolemur garnettii	98.32	0.00e+00	919.00
IUUC-Oar-090133	Ovis aries	98.53	0.00e+00	920.00
IUUC-Pan-092026	Papio anubis	88.36	0.00e+00	879.00
IUUC-Psi-093468	Pelodiscus sinensis	90.83	0.00e+00	633.00
IUUC-Pma-094180	Petromyzon marinus	52.97	4.00e-129	454.00
IUUC-Pno-095137	Phaeosphaeria nodorum	32.21	3.00e-32	133.00
IUUC-Ppa-095977	Physcomitrella patens	38.67	9.00e-33	134.00
IUUC-Pfo-097017	Poecilia formosa	68.05	0.00e+00	640.00
IUUC-Pab-098140	Pongo abelii	97.69	0.00e+00	914.00
IUUC-Pop-098981	Populus trichocarpa	32.13	2.00e-37	150.00
IUUC-Pca-100856	Procavia capensis	85.89	0.00e+00	818.00
IUUC-Ppe-101162	Prunus persica	43.90	6.00e-30	124.00
IUUC-Pva-103250	Pteropus vampyrus	89.31	0.00e+00	812.00
IUUC-Pte-104178	Pyrenophora teres	31.41	2.00e-31	130.00
IUUC-Pyt-104744	Pyrenophora triticirepentis	31.52	1.00e-31	130.00
IUUC-Rno-105201	Rattus norvegicus	99.58	0.00e+00	929.00
IUUC-Sce-106451	Saccharomyces cerevisiae	38.32	1.00e-24	107.00
IUUC-Sha-107343	Sarcophilus harrisii	94.04	0.00e+00	853.00
IUUC-Sja-107754	Schizosaccharomyces japonicus	33.07	2.00e-34	140.00
IUUC-Spo-108295	Schizosaccharomyces pombe	31.49	9.00e-37	147.00
IUUC-Sit-109720	Setaria italica	34.32	1.00e-34	141.00
IUUC-Sly-111080	Solanum lycopersicum	33.81	3.00e-39	156.00
IUUC-Stu-112704	Solanum tuberosum	40.31	3.00e-39	156.00
IUUC-Sar-113160	Sorex araneus	95.07	1.00e-149	523.00
IUUC-Sbi-114212	Sorghum bicolor	34.60	2.00e-33	136.00
IUUC-Ssc-116258	Sus scrofa	96.85	0.00e+00	902.00
IUUC-Tgu-116707	Taeniopygia guttata	89.53	0.00e+00	801.00
IUUC-Tru-118460	Takifugu rubripes	66.73	0.00e+00	627.00
IUUC-Tsy-119242	Tarsius syrichta	91.24	0.00e+00	817.00
IUUC-Tni-120184	Tetraodon nigroviridis	69.93	5.00e-158	550.00
IUUC-Tca-121697	Theobroma cacao	30.22	3.00e-36	146.00
IUUC-Tre-122170	Trichoderma reesei	32.11	4.00e-31	129.00
IUUC-Tvi-122652	Trichoderma virens	33.73	1.00e-32	134.00
IUUC-Tae-124106	Triticum aestivum	37.18	2.00e-36	147.00
IUUC-Tur-126601	Triticum urartu	36.71	8.00e-36	144.00
IUUC-Tme-126975	Tuber melanosporum	28.19	6.00e-24	105.00
IUUC-Tbe-128096	Tupaia belangeri	83.75	1.00e-127	449.00
IUUC-Ttr-128699	Tursiops truncatus	96.44	0.00e+00	891.00
IUUC-Vda-129909	Verticillium dahliae	46.43	2.00e-19	90.10
IUUC-Vpa-130207	Vicugna pacos	99.33	2.00e-173	601.00
IUUC-Vvi-130875	Vitis vinifera	33.08	4.00e-36	145.00
IUUC-Xtr-132737	Xenopus tropicalis	80.43	0.00e+00	702.00
IUUC-Xma-133046	Xiphophorus maculatus	68.61	0.00e+00	640.00
IUUC-Yli-134393	Yarrowia lipolytica	38.59	8.00e-34	138.00
IUUC-Zma-135572	Zea mays	33.89	4.00e-33	135.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence