iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/Other	23.99	5.00e-09	56.20	IUUC-Sce-106216

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD (By similarity).

Protein Sequence
(Fasta)

MTDDKDVLRD VWFGRIPTCF TLYQDEITER EAEPYYLLLP RVSYLTLVTD KVKKHFQKVM 60
RQEDVSEIWF EYEGTPLKWH YPIGLLFDLL ASSSALPWNI TVHFKSFPEK DLLHCPSKDA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGGGTGACT GGACCTACGG TGGGCGCCCG GCGCTGCGGT TCACTCTGGT TCCGAGGGCG 60
GAAGTGCCCG TCGGGCTGTT TTCTGACCCG GGCGGCAGCA CTGTGCGGCT GCGCGCGCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0053--Apoptosis
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0391--Immunity
KW-0399--Innate immunity
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-1185--Reference proteome
KW-0832--Ubl conjugation

Interpro

IPR007239--Atg5

Pfam

PF04106--APG5

Gene Ontology

GO:0034274--C:Atg12-Atg5-Atg16 complex
GO:0005776--C:autophagosome
GO:0005930--C:axoneme
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0044233--C:ER-mitochondrion membrane contact site
GO:0016020--C:membrane
GO:0034045--C:pre-autophagosomal structure membrane
GO:0035973--P:aggrephagy
GO:0019883--P:antigen processing and presentation of endogenous antigen
GO:0006915--P:apoptotic process
GO:0000045--P:autophagosome assembly
GO:0006914--P:autophagy
GO:0001974--P:blood vessel remodeling
GO:0019725--P:cellular homeostasis
GO:0006995--P:cellular response to nitrogen starvation
GO:0071500--P:cellular response to nitrosative stress
GO:0009267--P:cellular response to starvation
GO:0060047--P:heart contraction
GO:0045087--P:innate immune response
GO:0016236--P:macroautophagy
GO:0000422--P:mitophagy
GO:0043066--P:negative regulation of apoptotic process
GO:0060548--P:negative regulation of cell death
GO:2000619--P:negative regulation of histone H4-K16 acetylation
GO:0050765--P:negative regulation of phagocytosis
GO:0031397--P:negative regulation of protein ubiquitination
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0032480--P:negative regulation of type I interferon production
GO:0039689--P:negative stranded viral RNA replication
GO:0045060--P:negative thymic T cell selection
GO:0044804--P:nucleophagy
GO:0048840--P:otolith development
GO:0070257--P:positive regulation of mucus secretion
GO:0043687--P:post-translational protein modification
GO:0061739--P:protein lipidation involved in autophagosome assembly
GO:1902017--P:regulation of cilium assembly
GO:0002739--P:regulation of cytokine secretion involved in immune response
GO:2000377--P:regulation of reactive oxygen species metabolic process
GO:0051279--P:regulation of release of sequestered calcium ion into cytosol
GO:0042493--P:response to drug
GO:0009620--P:response to fungus
GO:0042311--P:vasodilation
GO:0055015--P:ventricular cardiac muscle cell development

KEGG

mmu:11793

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000583	Aegilops tauschii	33.53	4.00e-25	110.00
IUUC-Aml-002403	Ailuropoda melanoleuca	96.03	9.00e-156	542.00
IUUC-Atr-002645	Amborella trichopoda	26.71	2.00e-23	103.00
IUUC-Apl-003611	Anas platyrhynchos	88.73	2.00e-153	534.00
IUUC-Aca-004411	Anolis carolinensis	88.49	1.00e-150	525.00
IUUC-Aly-005636	Arabidopsis lyrata	27.88	8.00e-28	117.00
IUUC-Ath-006959	Arabidopsis thaliana	28.18	7.00e-28	117.00
IUUC-Ago-007978	Ashbya gossypii	25.20	4.00e-07	48.50
IUUC-Acl-008328	Aspergillus clavatus	25.30	4.00e-19	88.60
IUUC-Afl-008638	Aspergillus flavus	25.24	1.00e-25	110.00
IUUC-Afu-009042	Aspergillus fumigatus	26.28	4.00e-27	115.00
IUUC-Ani-009364	Aspergillus nidulans	29.58	5.00e-23	101.00
IUUC-Aor-009889	Aspergillus oryzae	25.24	2.00e-25	109.00
IUUC-Ate-010511	Aspergillus terreus	31.18	5.00e-10	56.20
IUUC-Ame-011644	Astyanax mexicanus	87.34	8.00e-38	147.00
IUUC-Bgr-012153	Blumeria graminis	28.52	2.00e-17	83.20
IUUC-Bta-012360	Bos taurus	97.48	9.00e-87	311.00
IUUC-Bci-013723	Botrytis cinerea	26.64	2.00e-16	79.30
IUUC-Bdi-014520	Brachypodium distachyon	23.67	2.00e-22	100.00
IUUC-Bol-016053	Brassica oleracea	27.16	3.00e-30	125.00
IUUC-Bra-017072	Brassica rapa	26.95	3.00e-30	125.00
IUUC-Cel-018529	Caenorhabditis elegans	36.00	7.00e-38	150.00
IUUC-Cja-019569	Callithrix jacchus	97.45	3.00e-158	550.00
IUUC-Cfa-020473	Canis familiaris	96.73	2.00e-157	548.00
IUUC-Cpo-021421	Cavia porcellus	95.64	2.00e-155	541.00
IUUC-Cre-022862	Chlamydomonas reinhardtii	29.31	3.00e-18	85.10
IUUC-Csa-024197	Chlorocebus sabaeus	97.09	1.00e-157	548.00
IUUC-Cho-024521	Choloepus hoffmanni	94.14	5.00e-131	459.00
IUUC-Cin-025119	Ciona intestinalis	45.08	7.00e-64	236.00
IUUC-Csv-026192	Ciona savignyi	45.90	8.00e-66	243.00
IUUC-Cgl-026686	Colletotrichum gloeosporioides	23.36	6.00e-09	54.70
IUUC-Dre-028466	Danio rerio	80.00	2.00e-134	471.00
IUUC-Dse-031228	Dothistroma septosporum	27.45	4.00e-31	128.00
IUUC-Dme-031703	Drosophila melanogaster	48.34	1.00e-72	266.00
IUUC-Ete-032482	Echinops telfairi	95.82	7.00e-133	466.00
IUUC-Eca-034036	Equus caballus	97.45	1.00e-157	548.00
IUUC-Eeu-035235	Erinaceus europaeus	98.11	9.00e-87	313.00
IUUC-Fca-036263	Felis catus	96.73	3.00e-157	546.00
IUUC-Fal-037064	Ficedula albicollis	88.73	1.00e-152	531.00
IUUC-Fox-037813	Fusarium oxysporum	25.09	6.00e-16	77.80
IUUC-Fso-038139	Fusarium solani	25.96	2.00e-17	82.80
IUUC-Gmo-039509	Gadus morhua	81.08	3.00e-111	394.00
IUUC-Ggr-040111	Gaeumannomyces graminis	25.78	3.00e-14	72.80
IUUC-Gga-040517	Gallus gallus	89.09	2.00e-152	531.00
IUUC-Gac-042270	Gasterosteus aculeatus	70.80	2.00e-116	411.00
IUUC-Gma-044400	Glycine max	36.75	3.00e-24	105.00
IUUC-Ggo-045048	Gorilla gorilla	96.00	1.00e-155	542.00
IUUC-Hsa-046744	Homo sapiens	96.73	4.00e-157	546.00
IUUC-Kpa-049174	Komagataella pastoris	24.00	5.00e-16	78.20
IUUC-Lch-049475	Latimeria chalumnae	86.91	7.00e-147	512.00
IUUC-Lpe-051283	Leersia perrieri	35.46	1.00e-23	105.00
IUUC-Loc-052446	Lepisosteus oculatus	82.55	3.00e-141	494.00
IUUC-Lma-053278	Leptosphaeria maculans	27.76	4.00e-31	128.00
IUUC-Laf-054020	Loxodonta africana	96.03	4.00e-156	543.00
IUUC-Mcc-055176	Macaca mulatta	96.73	4.00e-157	546.00
IUUC-Mor-057164	Magnaporthe oryzae	26.98	2.00e-17	82.80
IUUC-Mpo-057428	Magnaporthe poae	26.73	1.00e-13	70.10
IUUC-Mtr-058424	Medicago truncatula	36.59	4.00e-24	104.00
IUUC-Mla-058872	Melampsora laricipopulina	29.41	5.00e-30	125.00
IUUC-Mga-059859	Meleagris gallopavo	89.09	2.00e-152	531.00
IUUC-Mmr-061482	Microcebus murinus	96.73	2.00e-157	548.00
IUUC-Mdo-062371	Monodelphis domestica	92.73	1.00e-157	548.00
IUUC-Mac-065332	Musa acuminata	36.00	4.00e-26	112.00
IUUC-Mpu-066783	Mustela putorius furo	96.36	1.00e-156	545.00
IUUC-Mlu-068165	Myotis lucifugus	93.50	3.00e-152	530.00
IUUC-Nfi-068578	Neosartorya fischeri	27.39	2.00e-28	119.00
IUUC-Ncr-068636	Neurospora crassa	24.24	4.00e-12	65.90
IUUC-Nle-069740	Nomascus leucogenys	97.09	2.00e-157	547.00
IUUC-Opr-070802	Ochotona princeps	98.11	2.00e-86	311.00
IUUC-Ont-072222	Oreochromis niloticus	79.27	3.00e-135	474.00
IUUC-Oan-072760	Ornithorhynchus anatinus	93.40	4.00e-112	397.00
IUUC-Ocu-074844	Oryctolagus cuniculus	93.02	2.00e-96	344.00
IUUC-Oba-075834	Oryza barthii	33.33	7.00e-25	108.00
IUUC-Obr-076230	Oryza brachyantha	33.01	8.00e-15	74.30
IUUC-Ogl-077554	Oryza glaberrima	33.33	7.00e-25	108.00
IUUC-Ogu-078687	Oryza glumaepatula	33.33	5.00e-25	108.00
IUUC-Oin-079677	Oryza indica	26.10	2.00e-26	113.00
IUUC-Olo-081078	Oryza longistaminata	36.11	4.00e-25	109.00
IUUC-Ome-081548	Oryza meridionalis	33.90	9.00e-28	119.00
IUUC-Oni-082050	Oryza nivara	33.90	2.00e-25	110.00
IUUC-Opu-083609	Oryza punctata	33.71	2.00e-25	110.00
IUUC-Oru-085057	Oryza rufipogon	33.90	3.00e-25	109.00
IUUC-Osa-085917	Oryza sativa	33.90	3.00e-25	109.00
IUUC-Ola-087032	Oryzias latipes	79.27	1.00e-133	468.00
IUUC-Olu-087877	Ostreococcus lucimarinus	28.24	7.00e-03	33.10
IUUC-Oga-088468	Otolemur garnettii	96.75	9.00e-161	558.00
IUUC-Oar-089751	Ovis aries	96.00	3.00e-156	543.00
IUUC-Ptr-091064	Pan troglodytes	96.73	4.00e-157	546.00
IUUC-Pan-092505	Papio anubis	96.39	7.00e-156	542.00
IUUC-Psi-093086	Pelodiscus sinensis	90.22	7.00e-154	536.00
IUUC-Pno-094825	Phaeosphaeria nodorum	27.76	2.00e-27	115.00
IUUC-Ppa-095419	Physcomitrella patens	33.73	5.00e-26	112.00
IUUC-Pfo-096224	Poecilia formosa	79.27	2.00e-133	468.00
IUUC-Pab-098501	Pongo abelii	96.73	3.00e-156	543.00
IUUC-Pop-099243	Populus trichocarpa	26.67	4.00e-25	108.00
IUUC-Ppe-101255	Prunus persica	27.32	2.00e-27	116.00
IUUC-Pva-102828	Pteropus vampyrus	95.64	2.00e-155	540.00
IUUC-Pgr-103672	Puccinia graminis	29.37	3.00e-26	112.00
IUUC-Ptt-104013	Puccinia triticina	27.13	2.00e-22	100.00
IUUC-Pyt-104615	Pyrenophora triticirepentis	28.01	3.00e-29	122.00
IUUC-Rno-106089	Rattus norvegicus	96.33	2.00e-136	478.00
IUUC-Sce-106216	Saccharomyces cerevisiae	23.99	5.00e-12	64.70
IUUC-Sha-106484	Sarcophilus harrisii	93.45	8.00e-158	549.00
IUUC-Sja-107699	Schizosaccharomyces japonicus	27.61	8.00e-27	113.00
IUUC-Spo-108177	Schizosaccharomyces pombe	28.11	3.00e-22	99.00
IUUC-Ssl-108475	Sclerotinia sclerotiorum	26.99	3.00e-16	79.00
IUUC-Smo-109473	Selaginella moellendorffii	27.22	1.00e-23	103.00
IUUC-Sit-110736	Setaria italica	34.03	4.00e-29	122.00
IUUC-Sly-111657	Solanum lycopersicum	37.80	6.00e-28	118.00
IUUC-Sar-113050	Sorex araneus	80.75	2.00e-106	377.00
IUUC-Sbi-114258	Sorghum bicolor	34.50	3.00e-26	112.00
IUUC-Sre-114902	Sporisorium reilianum	31.19	4.00e-23	102.00
IUUC-Ssc-116166	Sus scrofa	90.18	3.00e-147	514.00
IUUC-Tgu-116814	Taeniopygia guttata	88.73	1.00e-152	532.00
IUUC-Tru-118172	Takifugu rubripes	78.91	3.00e-133	467.00
IUUC-Tsy-119010	Tarsius syrichta	82.55	2.00e-133	468.00
IUUC-Tni-120397	Tetraodon nigroviridis	80.48	2.00e-101	361.00
IUUC-Tca-121283	Theobroma cacao	28.49	1.00e-27	117.00
IUUC-Tvi-122545	Trichoderma virens	24.05	1.00e-13	70.10
IUUC-Tae-122685	Triticum aestivum	32.75	7.00e-25	107.00
IUUC-Tur-126407	Triticum urartu	35.33	4.00e-25	108.00
IUUC-Tme-126913	Tuber melanosporum	31.12	1.00e-39	156.00
IUUC-Tbe-127738	Tupaia belangeri	89.80	2.00e-105	374.00
IUUC-Ttr-128528	Tursiops truncatus	96.00	9.00e-156	542.00
IUUC-Uma-129625	Ustilago maydis	27.65	1.00e-20	94.70
IUUC-Vda-129906	Verticillium dahliae	24.30	3.00e-11	62.00
IUUC-Vpa-130223	Vicugna pacos	94.91	2.00e-150	524.00
IUUC-Vvi-131617	Vitis vinifera	35.98	2.00e-25	110.00
IUUC-Xtr-132288	Xenopus tropicalis	85.82	7.00e-145	506.00
IUUC-Xma-134214	Xiphophorus maculatus	82.90	6.00e-97	346.00
IUUC-Yli-134377	Yarrowia lipolytica	25.37	2.00e-12	66.20
IUUC-Zma-135108	Zea mays	35.42	6.00e-24	104.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence