iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000015640.1	ENSOART00000017025.1	ENSOARP00000016787.1
ENSOARG00000015640.1	ENSOART00000017030.1	ENSOARP00000016792.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.80e-108	362.0	703	1056

Active Site

Position(s)	Description	Evidence
1036	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvg.....EegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalq 83
           ++++k +++v+fv+     E+g+d++Gv++efl++++k++++p l+lf+++++d++ l+p+p+s++++ ++l+lFef+G++lgka++
   Q: 703  QHAMKGVIRVKFVNdlgvdEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDER-LYPSPTSYIHE-NYLQLFEFVGKMLGKAVY 787
           7899********************************************99987665.59*******76.****************** PP
   S: 84   dgrlldlplsksfyklllgk.....klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipV 165
           +g ++d+p++++f+++llg+       s+++l+++d+e+yk+l++ik++ + di +lgl+l++  +e+++g+  ++eL+pgG++ipV
   Q: 788  EGIVVDVPFASFFLSQLLGHhhsvfYSSVDELPSLDSEFYKNLTSIKRY-DGDIADLGLTLSY--DEDVMGQLVCHELVPGGKTIPV 871
           ********************777777999********************.6788887777766..6999****************** PP
   S: 166  tneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketkykggytedspaiqwFwe 251
           tneNk +Y++l++++r++++ik+q++a+ +Gf+++i++e++++F++ el+ li+G+ +eid+edlkk+t y gg++ ++++i+w+w+
   Q: 872  TNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDnAEIDLEDLKKHTVYYGGFHGSHRVIIWLWD 958
           ********************************************************9****************************** PP
   S: 252  vl.eefsseerkafLqFvTgssrlPlgGfaelk........................prlfvirkdasddrlPssnTCfnyLkLPeY 313
           +l ++f+ +er++fL+FvT++sr Pl Gfa+lk                        + +f+irk +   rlP+s+TCfn+LkLP+Y
   Q: 959  ILaSDFTPDERAMFLKFVTSCSRPPLLGFAYLKppfsircvevsddqdtgdtlgsvlRGFFTIRKREPGGRLPTSSTCFNLLKLPNY 1045
           **99*************************************************************8888****************** PP
   S: 314  sskeilkekLl 324
           s+k++l+ekL+
   Q: 1046 SKKSVLREKLR 1056
           **********7 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MFTVSQTSRA WFIDRARQAR EERLVQKERE RAAVEIQAHV RSFLCRRRLQ REIRREIDEF 60
FKAEDSGSSR RSALCIFKIA RKLLFLFRIK EDNERFEKLC RCVLSSMEAE NEPKVWYVSL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAAGACAAG CTCCTCTGAA GTGAGAAGCC GCCCTCAGCC GTGAGTCCTG TGTAAGCTCA 60
CTAATGATTA CCTGACATTT CTGCATCACC AGCAGGTCCT CAGGTGAGAA GACTCTATTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR000569--HECT_dom
IPR000048--IQ_motif_EF-hand-BS

PROSITE

PS50237--HECT
PS50096--IQ

Pfam

PF00632--HECT
PF00612--IQ

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000128	Aegilops tauschii	38.36	1.00e-99	358.00
IUUC-Aml-002107	Ailuropoda melanoleuca	96.50	0.00e+00	2053.00
IUUC-Apl-003328	Anas platyrhynchos	88.75	0.00e+00	1823.00
IUUC-Aly-005794	Arabidopsis lyrata	38.21	4.00e-104	372.00
IUUC-Ath-007269	Arabidopsis thaliana	38.57	7.00e-107	382.00
IUUC-Bta-013547	Bos taurus	98.68	0.00e+00	2128.00
IUUC-Bdi-014502	Brachypodium distachyon	37.89	6.00e-104	372.00
IUUC-Bol-015093	Brassica oleracea	39.31	3.00e-108	386.00
IUUC-Bra-016722	Brassica rapa	39.12	2.00e-108	387.00
IUUC-Cel-018447	Caenorhabditis elegans	38.74	0.00e+00	662.00
IUUC-Cja-019855	Callithrix jacchus	95.74	0.00e+00	2037.00
IUUC-Cfa-020066	Canis familiaris	95.62	0.00e+00	2072.00
IUUC-Cpo-021504	Cavia porcellus	94.42	0.00e+00	2031.00
IUUC-Csa-023579	Chlorocebus sabaeus	95.65	0.00e+00	2039.00
IUUC-Cho-024430	Choloepus hoffmanni	85.90	0.00e+00	1551.00
IUUC-Cin-025750	Ciona intestinalis	47.22	0.00e+00	953.00
IUUC-Csv-026016	Ciona savignyi	47.69	0.00e+00	996.00
IUUC-Dre-028271	Danio rerio	80.36	0.00e+00	1715.00
IUUC-Dno-029054	Dasypus novemcinctus	96.22	0.00e+00	2048.00
IUUC-Dor-030938	Dipodomys ordii	87.23	0.00e+00	1827.00
IUUC-Dme-031602	Drosophila melanogaster	47.25	0.00e+00	932.00
IUUC-Ete-033041	Echinops telfairi	75.96	0.00e+00	1345.00
IUUC-Eca-034411	Equus caballus	96.59	0.00e+00	2051.00
IUUC-Eeu-035201	Erinaceus europaeus	85.56	0.00e+00	811.00
IUUC-Fca-036594	Felis catus	95.27	0.00e+00	2027.00
IUUC-Fal-037317	Ficedula albicollis	83.97	0.00e+00	1821.00
IUUC-Gmo-039412	Gadus morhua	76.66	0.00e+00	1684.00
IUUC-Gga-040149	Gallus gallus	87.72	0.00e+00	1850.00
IUUC-Gac-042088	Gasterosteus aculeatus	79.72	0.00e+00	1773.00
IUUC-Gma-042728	Glycine max	39.82	5.00e-106	379.00
IUUC-Ggo-045279	Gorilla gorilla	95.74	0.00e+00	2038.00
IUUC-Hsa-045660	Homo sapiens	95.46	0.00e+00	2032.00
IUUC-Itr-048021	Ictidomys tridecemlineatus	92.93	0.00e+00	1037.00
IUUC-Lch-050664	Latimeria chalumnae	82.08	0.00e+00	1787.00
IUUC-Loc-052791	Lepisosteus oculatus	82.50	0.00e+00	1758.00
IUUC-Laf-053902	Loxodonta africana	96.03	0.00e+00	2051.00
IUUC-Mcc-054730	Macaca mulatta	95.55	0.00e+00	2038.00
IUUC-Meu-056527	Macropus eugenii	79.17	0.00e+00	1638.00
IUUC-Mtr-057671	Medicago truncatula	38.91	2.00e-106	380.00
IUUC-Mga-059260	Meleagris gallopavo	87.28	0.00e+00	1845.00
IUUC-Mmr-060804	Microcebus murinus	94.05	0.00e+00	1978.00
IUUC-Mdo-062575	Monodelphis domestica	83.21	0.00e+00	1749.00
IUUC-Mmu-063636	Mus musculus	90.93	0.00e+00	1894.00
IUUC-Mpu-066677	Mustela putorius furo	96.12	0.00e+00	1942.00
IUUC-Mlu-067952	Myotis lucifugus	95.27	0.00e+00	1978.00
IUUC-Nle-069153	Nomascus leucogenys	95.46	0.00e+00	2032.00
IUUC-Opr-070554	Ochotona princeps	93.49	0.00e+00	1845.00
IUUC-Ont-071372	Oreochromis niloticus	80.91	0.00e+00	1752.00
IUUC-Oan-073327	Ornithorhynchus anatinus	71.02	0.00e+00	738.00
IUUC-Ocu-074183	Oryctolagus cuniculus	94.81	0.00e+00	2003.00
IUUC-Oin-080058	Oryza indica	38.18	4.00e-103	369.00
IUUC-Ome-081741	Oryza meridionalis	33.38	8.00e-96	345.00
IUUC-Oru-085128	Oryza rufipogon	36.75	1.00e-95	344.00
IUUC-Ola-087337	Oryzias latipes	79.96	0.00e+00	1687.00
IUUC-Oga-088342	Otolemur garnettii	95.18	0.00e+00	1960.00
IUUC-Ptr-091661	Pan troglodytes	95.74	0.00e+00	2038.00
IUUC-Pan-092728	Papio anubis	95.37	0.00e+00	2033.00
IUUC-Psi-093251	Pelodiscus sinensis	87.29	0.00e+00	1733.00
IUUC-Pma-094195	Petromyzon marinus	70.18	0.00e+00	1431.00
IUUC-Pfo-097472	Poecilia formosa	80.43	0.00e+00	1756.00
IUUC-Pab-098570	Pongo abelii	95.65	0.00e+00	2038.00
IUUC-Pca-100110	Procavia capensis	83.35	0.00e+00	1724.00
IUUC-Pva-102887	Pteropus vampyrus	91.12	0.00e+00	1906.00
IUUC-Rno-106028	Rattus norvegicus	87.92	0.00e+00	1796.00
IUUC-Sha-107331	Sarcophilus harrisii	84.64	0.00e+00	1774.00
IUUC-Sit-109811	Setaria italica	34.25	2.00e-103	370.00
IUUC-Sly-111013	Solanum lycopersicum	39.03	8.00e-103	368.00
IUUC-Sar-113287	Sorex araneus	86.18	0.00e+00	729.00
IUUC-Sbi-114433	Sorghum bicolor	33.87	4.00e-104	372.00
IUUC-Ssc-116103	Sus scrofa	96.88	0.00e+00	2055.00
IUUC-Tgu-117275	Taeniopygia guttata	87.35	0.00e+00	1833.00
IUUC-Tru-118681	Takifugu rubripes	79.40	0.00e+00	1766.00
IUUC-Tsy-118985	Tarsius syrichta	90.86	0.00e+00	1013.00
IUUC-Tni-120850	Tetraodon nigroviridis	90.72	0.00e+00	751.00
IUUC-Tca-121770	Theobroma cacao	38.16	3.00e-106	380.00
IUUC-Tur-126086	Triticum urartu	38.36	3.00e-99	357.00
IUUC-Tbe-127461	Tupaia belangeri	91.01	0.00e+00	1877.00
IUUC-Ttr-129269	Tursiops truncatus	96.50	0.00e+00	2038.00
IUUC-Vpa-130523	Vicugna pacos	77.96	3.00e-130	459.00
IUUC-Vvi-131524	Vitis vinifera	38.32	4.00e-104	373.00
IUUC-Xtr-132146	Xenopus tropicalis	83.41	0.00e+00	1805.00
IUUC-Xma-133526	Xiphophorus maculatus	80.06	0.00e+00	1753.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence